Dae Yup Han, PhD, DABR
Assistant Professor of Therapeutic RadiologyCards
Appointments
Contact Info
About
Titles
Assistant Professor of Therapeutic Radiology
Biography
Dae Yup Han, Ph.D., DABR, is an Assistant Professor in the Department of Therapeutic Radiology at Yale School of Medicine and a faculty member of the Yale Medical Physics Residency Program. He is board-certified in Therapeutic Medical Physics by the American Board of Radiology (DABR), with academic and clinical interests in the translational implementation of advanced brachytherapy and image-guided radiation therapy.
Dr. Han received his Ph.D. in Electrical Engineering from the University of California, San Diego, with an emphasis in medical physics. He subsequently completed a CAMPEP-accredited medical physics certificate program at the University of California, Los Angeles, followed by residency training in medical physics at the University of California, San Francisco. His academic and research background is broadly multi-disciplinary, encompassing electrical engineering, applied physics, computational modeling, and clinical radiation oncology. His experience includes both system-level research and clinical commissioning, with a particular focus on the translation of novel technologies into routine clinical practice.
He has authored numerous peer-reviewed publications and delivered invited presentations at national and international conferences on topics including intravascular brachytherapy, dynamic modulated brachytherapy, and PET-guided radiation therapy. He actively collaborates with academic, clinical, and industry partners to advance innovation in radiation oncology.
Appointments
Therapeutic Radiology
Assistant ProfessorPrimary
Other Departments & Organizations
Education & Training
- Medical Physics Resident
- University of California, San Francisco
- PhD
- University of California, San Diego, Electrical and Computer Engineering / Electrical Engineering
- CAMPEP Cert.
- Universtiy of California, Los Angeles
- MS
- University of California, San Deigo, Electrical and Computer Engineering / Electrical Engineering
Board Certifications
Therapeutic Medical Physics
- Certification Organization
- American Board of Radiology
- Original Certification Date
- 2021
Research
Overview
Dr. Han’s current research focuses on the development and clinical translation of technologies that integrate imaging, computation, and radiation delivery. Areas of active investigation include:
- Development of multi-modality image-guided target tracking systems for adaptive radiotherapy, utilizing PET, MRI, and X-ray.
- Design of intravascular brachytherapy treatment planning systems, incorporating IVUS/OCT-based imaging and personalized dosimetric modeling.
- Development of novel brachytherapy applicators, including directionally-shielded systems and strategies for clinical implementation.
These efforts represent a cross-disciplinary approach to advancing radiation oncology through innovation at the intersection of engineering, physics, and medicine.
Medical Research Interests
Research at a Glance
Yale Co-Authors
Publications Timeline
Research Interests
Emily Draeger, PhD, DABR
Zhe Jay Chen, PhD, FAAPM
Brachytherapy
Monte Carlo Method
Radiotherapy, Intensity-Modulated
Radiotherapy, Image-Guided
Publications
Featured Publications
Direction-Modulated Brachytherapy for High-Dose-Rate Treatment of Cervical Cancer. I: Theoretical Design
Han D, Webster M, Scanderbeg D, Yashar C, Choi D, Song B, Devic S, Ravi A, Song W. Direction-Modulated Brachytherapy for High-Dose-Rate Treatment of Cervical Cancer. I: Theoretical Design. International Journal Of Radiation Oncology • Biology • Physics 2014, 89: 666-673. PMID: 24751413, DOI: 10.1016/j.ijrobp.2014.02.039.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsMeSH KeywordsAdultAlgorithmsBrachytherapyColon, SigmoidEquipment DesignFemaleHumansIridium RadioisotopesMagnetic Resonance ImagingMiddle AgedMonte Carlo MethodOrgans at RiskRadiation InjuriesRadiotherapy DosageRadiotherapy Planning, Computer-AssistedRectumTungstenUrinary BladderUterine Cervical NeoplasmsYoung AdultConceptsCervical cancerHigh-risk clinical target volume D90Sizeable patient populationSimilar target coveragePlan qualityTreatment plan qualityPatient populationPrescription doseHigh doseRate brachytherapyImproved organClinical validationAnatomic informationPatient casesTarget coverageCancerBrachytherapyOvoid applicatorsPeripheral holesDose distributionDwell positionsBladderD2ccRectumDoseDirection Modulated Brachytherapy for Treatment of Cervical Cancer. II: Comparative Planning Study With Intracavitary and Intracavitary–Interstitial Techniques
Han DY, Safigholi H, Soliman A, Ravi A, Leung E, Scanderbeg DJ, Liu Z, Owrangi A, Song WY. Direction Modulated Brachytherapy for Treatment of Cervical Cancer. II: Comparative Planning Study With Intracavitary and Intracavitary–Interstitial Techniques. International Journal Of Radiation Oncology • Biology • Physics 2016, 96: 440-448. PMID: 27598809, DOI: 10.1016/j.ijrobp.2016.06.015.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsComparative planning studyCervical cancerGroupe Européen de Curiethérapie-European SocietyOriginal clinical plansCervical cancer patientsTandem applicatorUse of needlesOncology recommendationsCancer patientsAdaptive brachytherapyClinical practiceClinical plansPotential clinical translationPlan qualityPatientsCancerClinical translationBrachytherapyNeedle applicatorConsistent improvementD90 valuesStandard tandemPlanning studiesStandard applicatorsTotal numberTreatment Delivery Technology for Brachytherapy
Cunha J, Han D. Treatment Delivery Technology for Brachytherapy. 2017, 41-67. DOI: 10.1007/978-3-319-44827-5_3.ChaptersResection Cavity Contraction Effects in the Use of Radioactive Sources (1-25 versus Cs-131) for Intra-Operative Brain Implants
Han D, Ma L, Braunstein S, Raleigh D, Sneed P, McDermott M, McDermott M. Resection Cavity Contraction Effects in the Use of Radioactive Sources (1-25 versus Cs-131) for Intra-Operative Brain Implants. Cureus 2018, 10: e2079. PMID: 29560292, PMCID: PMC5856410, DOI: 10.7759/cureus.2079.Peer-Reviewed Original ResearchCitationsAltmetricConceptsResection cavityConsecutive patient casesResection cavity volumeSurgical resection cavityBiological effective dose (BED) calculationRate brachytherapy implantsBrain implantsDose distributionAccumulative dosesImplant procedureDose variabilityMagnetic resonance imagesEffective dose calculationPatient casesD10 valuesCs-131Significant differencesBrachytherapy implantsResonance imagesContractionMonthsImplantsBED calculationsD90Static volume
2023
Dosimetric response of Gafchromic™ EBT‐XD film to therapeutic protons
Guan F, Wang X, Yang M, Draeger E, Han D, Iga K, Guo F, Perles L, Li Y, Sahoo N, Mohan R, Chen Z. Dosimetric response of Gafchromic™ EBT‐XD film to therapeutic protons. Precision Radiation Oncology 2023, 7: 15-26. PMID: 37868341, PMCID: PMC10586355, DOI: 10.1002/pro6.1187.Peer-Reviewed Original ResearchCitationsConceptsLinear energy transferEBT-XD filmsTherapeutic protonsFilm calibrationProton linear energy transferUltra-high Dose Rate FLASH RadiotherapyDynamic dose rangeMV photon beamDose-averaged LET valuesDose rate dependenceProton beamlineProton beamPhoton beamsFLASH beamSpot scanning proton beamsDosimetric responseLET dependenceFLASH radiotherapyHigh-dose applicationFilm responseLET valuesEnergy transferBeamProtonsGafchromic
2022
Frequency of errors in the transfer of treatment parameters from the treatment planning system to the oncology information system in a multi‐vendor environment
Donahue W, Draeger E, Han D, Chen Z. Frequency of errors in the transfer of treatment parameters from the treatment planning system to the oncology information system in a multi‐vendor environment. Journal Of Applied Clinical Medical Physics 2022, 24: e13868. PMID: 36527239, PMCID: PMC10113690, DOI: 10.1002/acm2.13868.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsInformation systemsTransfer of dataPlanning systemSoftware systemsOncology information systemMultiple vendorsData transferField labelsData inputTimer settingsNumber of errorsTechnological advancementsErrorSystemVendorsAdvancementTreatment planning systemFrequency of errorsMOSAIQCommon errorsLabelsInformation
2019
Dynamic Modulated Brachytherapy (DMBT) Balloon Applicator for Accelerated Partial Breast Irradiation
Guy C, Oh S, Han D, Kim S, Arthur D, Song W. Dynamic Modulated Brachytherapy (DMBT) Balloon Applicator for Accelerated Partial Breast Irradiation. International Journal Of Radiation Oncology • Biology • Physics 2019, 104: 953-961. PMID: 30910767, DOI: 10.1016/j.ijrobp.2019.03.026.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsPartial breast irradiationTreatment planBreast irradiationTarget coverageEarly-stage breast cancerAccelerated Partial Breast IrradiationInstitutional review board approvalCurrent treatment planSimilar target coverageReview board approvalNew treatment planDose regimensClinical treatment plansBreast cancerMean reductionBalloon deviceBoard approvalBalloon volumeDosimetric advantagesBalloon applicatorDosimetric changesClinical plansBalloon surfaceTreatment deliveryPatientsOptimizing beam models for dosimetric accuracy over a wide range of treatments
Chen J, Morin O, Weethee B, Perez-Andujar A, Phillips J, Held M, Kearny V, Han D, Cheung J, Chuang C, Valdes G, Sudhyadhom A, Solberg T. Optimizing beam models for dosimetric accuracy over a wide range of treatments. Physica Medica 2019, 58: 47-53. PMID: 30824149, DOI: 10.1016/j.ejmp.2019.01.011.Peer-Reviewed Original ResearchCitations
2018
Direction modulated brachytherapy (DMBT) tandem applicator for cervical cancer treatment: Choosing the optimal shielding material
Safigholi H, Han DY, Soliman A, Song WY. Direction modulated brachytherapy (DMBT) tandem applicator for cervical cancer treatment: Choosing the optimal shielding material. Medical Physics 2018, 45: 3524-3533. PMID: 29858499, DOI: 10.1002/mp.13030.Peer-Reviewed Original ResearchCitations
2017
Quantitative CT assessment of a novel direction-modulated brachytherapy tandem applicator
Elzibak AH, Kager PM, Soliman A, Paudel MR, Safigholi H, Han DY, Karotki A, Ravi A, Song WY. Quantitative CT assessment of a novel direction-modulated brachytherapy tandem applicator. Brachytherapy 2017, 17: 465-475. PMID: 29174936, DOI: 10.1016/j.brachy.2017.10.006.Peer-Reviewed Original ResearchCitations
Academic Achievements & Community Involvement
Activities
activity Medical Physics
2022 - PresentJournal ServiceAssociate Editoractivity Medical Physics
2012 - PresentJournal ServiceRevieweractivity Nature – Scientific Reports
2019 - PresentJournal ServiceRevieweractivity Journal of Applied Clinical Medical Physic
2020 - PresentJournal ServiceRevieweractivity Japanese Journal of Clinical Oncology
2021 - PresentJournal ServiceReviewer