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Dennis G Moledina, MD, PhD, FASN

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Associate Professor of Medicine (Nephrology)

Titles

Director, Kidney BioBank, Internal Medicine

Contact Info

Clinical and Translational Research Accelerator (CTRA)

60 Temple St., Ste. 6C

New Haven, CT 06510

United States

About

Titles

Associate Professor of Medicine (Nephrology)

Director, Kidney BioBank, Internal Medicine

Biography

Dr. Dennis Moledina, MD PhD FASN is physician-scientist with board-certification in Internal Medicine with sub-specialization in Nephrology. He is an associate professor in the department of internal medicine (section of nephrology) at the Yale School of Medicine. He provides attending physician services at the Yale-New Haven Hospital in New Haven, CT in both nephrology and internal medicine. He completed clinical and post-doctoral fellowships in nephrology at Yale and earned his PhD in investigative medicine from the Yale Graduate School of Arts and Sciences. He has independent research funding from the NIH to develop diagnostic testing and tools for various subtypes of acute kidney injury. He is particularly interested in improving non-invasive diagnosis of acute interstitial nephritis, which is one of the few causes of acute kidney injury with diagnosis-specific management. He is a coinvestigator in NIH-funded multicenter consortia including Kidney Precision Medicine Program (KPMP) and Care of outpatients with acute kidney injury (COPE-AKI). He directs the Yale Kidney BioBank which is a biorepository that has collected samples from over 1200 participants with kidney biopsy confirmed diagnoses.

Appointments

Education & Training

PhD
Yale Graduate School of Arts and Sciences, Investigative Medicine (2018)
Postdoctoral Fellow
Yale School of Medicine (2018)
Clinical Fellow
Yale School of Medicine (2015)
Resident Physician
NYU Grossman Long Island School of Medicine (2013)
MD
M.P. Shah Medical College (2009)

Research

Overview

Dr. Moledina is a board-certified nephrologist and a clinical researcher focused on improving understanding of human acute kidney injury (AKI) through biomarkers. He obtained training in clinical investigation through a post-doctoral fellowship in Nephrology research as well as a PhD in Investigative Medicine at Yale. His research experience includes leading the enrollment of a cohort of over 850 participants who underwent a kidney biopsy at Yale with simultaneous collection of biosamples with histologically-confirmed diagnosis. In this cohort, he identified diagnostic and prognostic biomarkers of AIN. He also evaluated participant perspectives towards donating tissue to research and factors for safe procurement of such tissue. He is a co-investigator at the Yale recruitment site of the NIDDK-sponsored Kidney Precision Medicine Program that obtains kidney tissue for research from participants with acute kidney injury. In this consortium, he serves as the co-chair of the “Laboratory sub-committee,” led the creation of the “biospecimen collection manual of operations,” and participated in the design of the overall protocol. Additionally, he is a co-investigator in NIH-funded cohorts studying AKI including the Translational Research Investigating Biomarker Endpoints in Acute Kidney Injury (TRIBE-AKI) study, the Assessment, Serial Evaluation, and Subsequent Sequelae in Acute Kidney Injury (ASSESS AKI) study, and Care of Outpatients with AKI (COPE-AKI). He directs the Yale Kidney BioBank, which is currently recruiting participants undergoing a kidney biopsy and banking biosamples to support research efforts of other investigators.

Medical Subject Headings (MeSH)

Acute Kidney Injury; Biomarkers; Biopsy, Needle; Kidney; Kidney Diseases; Nephritis, Interstitial; Nephrology; Translational Research, Biomedical

Research at a Glance

Yale Co-Authors

Frequent collaborators of Dennis G Moledina's published research.

Publications

Featured Publications

2024

Academic Achievements and Community Involvement

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    Ad-hoc reviewer

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    Reviewer

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    Abstract Grader

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    Co-Chair

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    Co-Chair

Clinical Care

Overview

Dennis Moledina, MD, PhD, is a nephrologist (kidney specialist) who directs the Yale Kidney BioBank, which collects samples of kidney tissue, DNA, plasma, and urine to better understand kidney diseases and develop treatments.

Dr. Moledina's work revolves around evaluating biomarkers for acute interstitial nephritis, a lesion that causes a decline in kidney function, and acute kidney injury. He is the recipient of several National Institutes of Health (NIH) research awards and enrolls study participants in NIH-funded consortia, including the Kidney Precision Medicine Program (KPMP) and care of outpatients with acute kidney injury (COPE-AKI).

He obtained clinical training through a clinical fellowship in nephrology and research training through postdoctoral fellowship and an investigative medicine doctorate at Yale University. Notably, his research experience includes leading the enrollment of a group of more than 750 participants concurrent with their kidney biopsy to create the Yale Kidney BioBank. In this group, he has identified diagnostic and prognostic biomarkers of acute interstitial nephritis.

Dr. Moledina is a fellow of the American Society of Nephrology. This designation honors members who have distinguished themselves through excellent work and clinical practice.

Clinical Specialties

Nephrology; Internal Medicine

Get In Touch

Contacts

Appointment Number
Mailing Address

Clinical and Translational Research Accelerator (CTRA)

60 Temple St., Ste. 6C

New Haven, CT 06510

United States

Locations

  • The Anlyan Center

    Lab

    300 Cedar Street, Rm S470

    New Haven, CT 06519

  • Temple Medical Center (60 Temple)

    Lab

    60 Temple Street, Ste 6C

    New Haven, CT 06510