Lloyd G. Cantley, MD
C. N. H. Long Professor of Medicine (Nephrology) and Professor of Cellular And Molecular PhysiologyCards
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Vice Chair, Research
Co-director of Education, Yale Center for Clinical Investigation
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Are You a Patient?
View this doctor's clinical profile on the Yale Medicine website for information about the services we offer and making an appointment.
View Doctor ProfileAdditional Titles
Vice Chair, Research
Co-director of Education, Yale Center for Clinical Investigation
Contact Info
Are You a Patient?
View this doctor's clinical profile on the Yale Medicine website for information about the services we offer and making an appointment.
View Doctor ProfileAdditional Titles
Vice Chair, Research
Co-director of Education, Yale Center for Clinical Investigation
Contact Info
About
Titles
C. N. H. Long Professor of Medicine (Nephrology) and Professor of Cellular And Molecular Physiology
Vice Chair, Research; Co-director of Education, Yale Center for Clinical Investigation
Biography
Dr. Cantley performed his clinical Internal Medicine training at the University of North Carolina followed by Nephrology fellowship training at the Beth Israel and Brigham and Women's Hospitals in Boston. He then entered research training at Harvard in the laboratories of Dr. Franklin Epstein and Dr. Guido Guidotti before accepting a faculty position at the Beth Israel. In 2000 Dr. Cantley moved from Harvard to Yale where he established his research focus on the reparative tubular responses to kidney injury.
Appointments
Nephrology
ProfessorPrimaryCellular & Molecular Physiology
ProfessorSecondary
Other Departments & Organizations
- Cantley Lab
- Cellular & Molecular Physiology
- Center for Biomedical Data Science
- Graduate Program in Cellular and Molecular Physiology
- Internal Medicine
- Liver Center
- Molecular Medicine, Pharmacology, and Physiology
- Nephrology
- Program in Translational Biomedicine (PTB)
- Yale Cancer Center
- Yale Combined Program in the Biological and Biomedical Sciences (BBS)
- Yale Medicine
- Yale Stem Cell Center
- Yale Ventures
Education & Training
- Nephrology Fellow
- Beth Israel Hospital, Harvard Medical School (1990)
- Resident
- University of North Carolina (1984)
- MD
- West Virginia University (1981)
- BS
- West Virginia Wesleyan College (1977)
Research
Overview
The primary focus of our laboratory is to determine the mechanisms of renal tubule development, homeostasis and repair. When the kidney is injured following ischemia or toxin exposure, the remaining epithelial cells de-differentiate, spread over the denuded basement membrane, divide, and re-arrange themselves in a specific pattern to regenerate functional tubules. This process requires a complex array of events involving rearrangement of cell shape and regulation of cell-matrix and cell-cell interactions. By examining epithelial cell adhesion, migration, and branching tubulogenesis in response to growth factors such as Hepatocyte Growth Factor and chitin's 3-like 1, we are determining the intracellular signaling events critical for tubule formation during kidney development and following injury. We have focused these efforts on the role of activation of specific MAPK isoforms as well as the PI 3-kinase in the regulation of cell morphogenesis and cell-matrix interactions.
In addition, we are examining the role of the innate immune response to kidney injury and found that macrophages home to the injured kidney and initially promote apoptosis of sublethally injured tubular cells. Subsequent macrophage accumulation includes increasing numbers of alternatively activated macrophages that promote the survival and proliferation of the remaining tubular cells to effect tubule repair. We are currently expanding this work to study human acute kidney injury and have developed the use of Imaging Mass Cytometry in the human kidney.
Medical Research Interests
Research at a Glance
Yale Co-Authors
Publications Timeline
Research Interests
Dennis G Moledina, MD, PhD, FASN
Leyuan Xu, PhD
Gilbert Moeckel, MD, PhD, FASN
F. Perry Wilson, MD, MSCE
Vijayakumar Kakade, PhD
Jiankan Guo
Kidney
Macrophages
Epithelial Cells
Morphogenesis
Publications
2024
Adamts1 and Cyst Expansion in Polycystic Kidney Disease.
Kakade V, Akman Z, Motrapu M, Cassini M, Xu L, Moeckel G, Somlo S, Cantley L. Adamts1 and Cyst Expansion in Polycystic Kidney Disease. Journal Of The American Society Of Nephrology 2024 PMID: 39514301, DOI: 10.1681/asn.0000000557.Peer-Reviewed Original ResearchConceptsAutosomal dominant polycystic kidney diseasePolycystic kidney diseaseKidney diseaseLoss of Pkd1Cyst growthInterstitial macrophage accumulationDominant polycystic kidney diseaseInterstitial mononuclear cellsReduced cyst growthDetectable phenotypeMembrane remodelingMotif 1Progressive cyst growthIsoforms of versicanSimultaneous deletionPKD2 geneTubular basement membraneDisintegrin and metalloproteinaseRNA sequencingBasement membrane remodelingPKD1Thrombospondin motifs 1Cystic enlargementMacrophage accumulationCystic dilatationUsing Imaging Mass Cytometry to Define Cell Identities in AKI and CKD in Humans
Budiman T, Shelar A, Baker M, Weiss M, Cantley L, Kakade V. Using Imaging Mass Cytometry to Define Cell Identities in AKI and CKD in Humans. Journal Of The American Society Of Nephrology 2024, 35: 10.1681/asn.2024g4m5sdnf. DOI: 10.1681/asn.2024g4m5sdnf.Peer-Reviewed Original ResearchTubule-Specific Deletion of Adamts1 Slows Cyst Expansion in Polycystic Kidney Disease
Kakade V, Akman Z, Motrapu M, Cantley L. Tubule-Specific Deletion of Adamts1 Slows Cyst Expansion in Polycystic Kidney Disease. Journal Of The American Society Of Nephrology 2024, 35: 10.1681/asn.20246ecyxtfs. DOI: 10.1681/asn.20246ecyxtfs.Peer-Reviewed Original ResearchSegment-Specific Cyst Index (SSCI): A Quantitative Analysis of Segment-Specific Responses during Cystogenesis
Akman Z, Kakade V, Cantley L. Segment-Specific Cyst Index (SSCI): A Quantitative Analysis of Segment-Specific Responses during Cystogenesis. Journal Of The American Society Of Nephrology 2024, 35: 10.1681/asn.2024mpmapkd5. DOI: 10.1681/asn.2024mpmapkd5.Peer-Reviewed Original ResearchAnalysis of Kidney Biopsies from Patients with Glomerulonephritis Using Imaging Mass Cytometry Reveals Increase in Immune Cells with Associated Dedifferentiation and Injury of Tubular Cells
Weiss M, Kakade V, Baker M, Budiman T, Shelar A, Cantley L. Analysis of Kidney Biopsies from Patients with Glomerulonephritis Using Imaging Mass Cytometry Reveals Increase in Immune Cells with Associated Dedifferentiation and Injury of Tubular Cells. Journal Of The American Society Of Nephrology 2024, 35: 10.1681/asn.202490mzwbkc. DOI: 10.1681/asn.202490mzwbkc.Peer-Reviewed Original ResearchUnderstanding Pathophysiology of Acute Interstitial Nephritis through Spatial Characterization of Cell-Cell Interactions Using Imaging Mass Cytometry in a Human Biopsy Cohort
Baker M, Kakade V, Budiman T, Weiss M, Shelar A, Moledina D, Cantley L. Understanding Pathophysiology of Acute Interstitial Nephritis through Spatial Characterization of Cell-Cell Interactions Using Imaging Mass Cytometry in a Human Biopsy Cohort. Journal Of The American Society Of Nephrology 2024, 35: 10.1681/asn.2024n6j4nxq1. DOI: 10.1681/asn.2024n6j4nxq1.Peer-Reviewed Original ResearchMyofibroblast-Macrophage Cross-Talk Supports Proliferative Tubule Repair after Kidney Injury
Bharathan B, Xu L, Guo J, Cantley L. Myofibroblast-Macrophage Cross-Talk Supports Proliferative Tubule Repair after Kidney Injury. Journal Of The American Society Of Nephrology 2024, 35: 10.1681/asn.20249phzkecs. DOI: 10.1681/asn.20249phzkecs.Peer-Reviewed Original ResearchUrine Proteomic Signatures of Kidney Function Decline after Hospitalization
Wen Y, Menez S, Philbrook H, Moledina D, Bhatraju P, Coca S, Chinchilli V, Go A, Siew E, Kimmel P, Ikizler T, Hsu C, Himmelfarb J, Cantley L, Parikh C. Urine Proteomic Signatures of Kidney Function Decline after Hospitalization. Journal Of The American Society Of Nephrology 2024, 35: 10.1681/asn.20245v3jz4vr. DOI: 10.1681/asn.20245v3jz4vr.Peer-Reviewed Original ResearchAKI in the Kidney Precision Medicine Project: Acute Tubular Injury vs. Acute Interstitial Nephritis
Schaub J, Castro A, Menez S, Wen Y, Menon R, Bhatraju P, Wilson F, Coca S, Eadon M, Bomback A, Moledina D, Cantley L, Palevsky P, D'Agati V, Randhawa P, Murugan R, Alpers C, Kretzler M, Himmelfarb J, Parikh C. AKI in the Kidney Precision Medicine Project: Acute Tubular Injury vs. Acute Interstitial Nephritis. Journal Of The American Society Of Nephrology 2024, 35: 10.1681/asn.2024cxh8wvky. DOI: 10.1681/asn.2024cxh8wvky.Peer-Reviewed Original ResearchVCAM-1 mediates proximal tubule-immune cell cross talk in failed tubule recovery during AKI-to-CKD transition
Melchinger I, Guo K, Li X, Guo J, Cantley L, Xu L. VCAM-1 mediates proximal tubule-immune cell cross talk in failed tubule recovery during AKI-to-CKD transition. American Journal Of Physiology. Renal Physiology 2024, 327: f610-f622. PMID: 39116349, PMCID: PMC11483080, DOI: 10.1152/ajprenal.00076.2024.Peer-Reviewed Original ResearchAltmetricConceptsAcute kidney injuryChronic kidney diseaseVCAM-1 expressionProximal tubule cellsVCAM-1Tubule cellsKidney Precision Medicine ProjectProinflammatory cytokinesAcute kidney injury to chronic kidney diseaseModel of chronic kidney diseaseExpression of vascular cell adhesion protein 1Cell adhesion pathwaysInflammatory response to injuryInjured proximal tubule cellsVascular cell adhesion protein 1Mouse model of chronic kidney diseaseRisk of progressionChronic kidney disease transitionIncreased immune cell adhesionVCAM-1-positive cellsOverexpression of VCAM-1Inhibition of NF-kB signalingActivation of NF-kBImmune cell adhesionSingle-cell transcriptome analysis
Clinical Care
Overview
Lloyd G. Cantley, MD, is a nephrologist whose clinical practice focuses on kidney disorders such as acute kidney injury, kidney dysfunction, chronic kidney disease and electrolyte imbalances. He is the C. N. H. Long Professor of Medicine in nephrology, professor of cellular and molecular physiology, and co-director of education at the Yale Center for Clinical Investigation.
Dr. Cantley's research explores acute kidney injury, polycystic kidney disease, chronic kidney disease, and the immune system's involvement in kidney disease. His interests include the causes of acute injury and how repair can be optimized, progression of kidney diseases, and the link between kidney diseases and general health.
Dr. Cantley has received awards and support from organizations such as the National Center for Advancing Translational Sciences, the American Heart Association, the National Institute of Diabetes and Digestive and Kidney Diseases, and the Department of Defense.
Clinical Specialties
Board Certifications
Nephrology
- Certification Organization
- AB of Internal Medicine
- Original Certification Date
- 1988
Internal Medicine
- Certification Organization
- AB of Internal Medicine
- Original Certification Date
- 1984
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View this doctor's clinical profile on the Yale Medicine website for information about the services we offer and making an appointment.
View Doctor ProfileNews
News
- December 02, 2024
2025 YCCI Funding Opportunities Open for Applications
- March 20, 2024
The power of collaboration
- November 16, 2023
YCCI Funding Opportunities Open for Applications
- October 24, 2023
Yale Contributions Shape ASN Kidney Week 2023
Get In Touch
Contacts
Administrative Support
Locations
Yale Nephrology
Academic Office
The Anlyan Center
300 Cedar Street, Ste Room S261
New Haven, CT 06519
Patient Care Locations
Are You a Patient? View this doctor's clinical profile on the Yale Medicine website for information about the services we offer and making an appointment.