Arya Mani

My laboratory’s major focus is the identification of genetic causes of major cardiovascular disorders and the elucidation of their pathophysiology. Through collaborative efforts with physicians and scientist across the world we have recruited large populations of patients and families with early onset coronary artery disease and metabolic syndrome and have successfully mapped and identified number of genes for these diseases. An ongoing effort in the laboratory is to understand the function of these genes and how the mutations affect the phenotype, using mouse and zebrafish models.

Having unique access to the genetic study population, we have had the opportunity to carry out clinical studies to investigate the disease mechanisms and have made numerous novel discoveries. We are actively investigating pathways that regulate insulin signaling, glucose metabolism, VLDL and LDL syntheis and clearance and atherosclerosis.

In addition, my laboratory studies the genetic causes of adult congenital heart disease, such as bicuspid aortic valve, atrial fibrillation and patent ductus arteriosus.