Arya Mani, MD, FACC, FAHA

Professor of Medicine (Cardiology) and of Genetics; Director, Cardiovascular Genetics Program; Director, Cardiovascular Module

Departments & Organizations

Internal Medicine: Cardiovascular Medicine: Cardiac Advanced Imaging Program; Cardiomyopathy & Inherited Cardiovascular Disease Program; Cardiovascular Genetics Program | Diabetes Research Center | Liver Center


Vascular Biology and Therapeutics Program

Yale Combined Program in the Biological and Biomedical Sciences (BBS): Molecular Cell Biology, Genetics and Development

Yale Medicine

Office of Cooperative Research


My laboratory’s major focus is the identification of genetic causes of major cardiovascular disorders and the elucidation of their pathophysiology. Through collaborative efforts with physicians and scientist across the world we have recruited large populations of patients and families with early onset coronary artery disease and metabolic syndrome and have successfully mapped and identified number of genes for these diseases. An ongoing effort in the laboratory is to understand the function of these genes and how the mutations affect the phenotype, using mouse and zebrafish models.

Having unique access to the genetic study population, we have had the opportunity to carry out clinical studies to investigate the disease mechanisms and have made numerous novel discoveries. We are actively investigating pathways that regulate insulin signaling, glucose metabolism, VLDL and LDL syntheis and clearance and atherosclerosis.

In addition, my laboratory studies the genetic causes of adult congenital heart disease, such as bicuspid aortic valve, atrial fibrillation and patent ductus arteriosus.

Education & Training

MD Johannes-Gutenberg-University of Mainz (1991)
Fellow Yale University School of Medicine
Resident Yale-New Haven Hospital
Fellow University of Erlangen-Nuernberg
Board Certification The Certification Board of Nuclear Cardiology, Nuclear Cardiology (2000)
Board Certification AB of Internal Medicine, Cardiovascular Disease (2001, recertified: 2012)


  • The genetic etiology of coronary artery disease Mumbai, India (2001)

    Identification of genetic causes of premature coronary artery disease in South Asians

  • Genetics of Cardiovascular Diseases Isfahan, Iran; Shiraz, Iran; Tehran, Iran (1998)

    Study of genetic causes of coronary artery disease and congenital heart defect

Edit this profile

Contact Info

Arya Mani, MD, FACC, FAHA
Patient Care Locations
Yale Nuclear CardiologyYale New Haven Hospital
20 York Street

New Haven, CT 06510
View on map...
Yale CardiologyYale Physicians Building
800 Howard Avenue, Ste 2nd floor

New Haven, CT 06519
View on map...
Lab Location
Mani's Lab300 George Street, Ste 759
New Haven, CT 06511
View on map...
Mailing Address
Cardiovascular MedicinePO Box 208056
333 Cedar Street

New Haven, CT 06520-8056