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John Hwa, MD, PhD, FRACP

Professor of Medicine (Cardiology)
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Additional Titles

Co-Director Yale Cooperative Center of Excellence in Hematology, Cardiovascular Medicine

About

Titles

Professor of Medicine (Cardiology)

Co-Director Yale Cooperative Center of Excellence in Hematology, Cardiovascular Medicine

Biography

Dr. Hwa received his medical degree (First Class Honors) from the University of Sydney, Australia. He completed his Residency in Internal Medicine and Fellowship in Cardiology at the Royal Prince Alfred Hospital, Sydney, Australia. He then pursued further studies in the Department of Molecular Cardiology at the Cleveland Clinic Foundation during which time he completed his doctoral thesis through Case Western Reserve University. Dr. Hwa was then awarded a Howard Hughes Physician Postdoctoral Fellowship to continue studies at M.I.T in the laboratory of Nobel Laureate, H. Gobind Khorana. He joined the faculty At Dartmouth (Pharmacology and Toxicology and Medicine) in 2000, and moved to Yale (Section of Cardiovascular Medicine) in 2009.

Appointments

Education & Training

Howard Hughes Physician Postdoctoral Fellow
M.I.T. (2000)
PhD
Case Western Reserve Univ (1996)
Research Fellow
Cleveland Clinic Foundation (1996)
Resident/Fellow
Royal Prince Alfred Hospital, Sydney Australia (1992)
MD
University of Sydney (1986)

Research

Overview

The Hwa Laboratory research interests focuses on platelet metabolic reprogramming under stress conditions (e.g. hyperglycemia, oxidative stress) leading to thrombosis and critical intercellular communication with such cells as endothelial cells, vascular smooth muscle cells, and T-cells. Platelets play key roles in the regulation of vascular stress response, including hemostasis, immunoregulation, initiation of repair, and cessation of the repair process. Defective platelets thus contributes to vascular pathology including thromboinflammation, intimal hyperplasia, aneurysm formation, and immune dysregulation.

Our current studies can be broadly divided into the following major areas.

1) Platelet metabolic reprogramming in response to stress and aging

2) Platelet communication to other cells in health and disease

3) The Yale cardiovascular tissue repository collaborative effort

Medical Subject Headings (MeSH)

Blood Platelets; Carcinoma, Non-Small-Cell Lung; Cardiology; Diabetes Mellitus; Metabolism

Research at a Glance

Yale Co-Authors

Frequent collaborators of John Hwa's published research.

Publications

Featured Publications

2024

Academic Achievements & Community Involvement

  • honor

    Plenary Lecture Vascular Discovery 2022

  • honor

    Master of Arts (Privatim)

  • honor

    Elected Member Interurban Clinical Club

  • honor

    Recognition Award for Cardiovascular Research

  • honor

    American Heart Association Established Investigator Award

Get In Touch

Contacts

Academic Office Number
Office Fax Number
Mailing Address

Cardiovascular Medicine

PO Box 208017

New Haven, CT 06520-8017

United States

Locations