Kanika Jain, PhD
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About
Titles
Associate Research Scientist
Biography
Dr. Jain obtained her PhD in Life Sciences (Cardiovascular Biology) from India. Her PhD work focused on identifying the effect of high altitude hypoxia on rodent heart and further investigating the role of the Proteostasis network in the cardiovascular system. Her work has contributed to understanding the mechanism behind the differential hypoxic tolerance and has published several research articles during her PhD.
Currently her projects at the Hwa lab at Yale, involve the study of platelets, the anucleate cells in the blood stream. Dr. Jain is doing extensive work on exploring the role of stress induced signaling cascades in the platelets, more specifically in context of protein misfolding and ER Stress. Using a combination of basic and advanced techniques, involving both human and rodent samples, her studies involve a wide range of pathophysiological conditions including Diabetes Mellitus, Aging and Neurodegenerative diseases.
Appointments
Cardiovascular Medicine
Associate Research ScientistPrimary
Other Departments & Organizations
Education & Training
- PhD
- DIPAS, DRDO, Life Sciences (2015)
- MSc
- Jamia Hamdard University, Biochemistry (2009)
Research
Overview
Medical Subject Headings (MeSH)
Academic Achievements and Community Involvement
Links & Media
Media
Unfolded Protein Response in the Diabetic Platelet
Confocal microscopy image of platelets (green) from patients with Type II Diabetes Mellitus stained for UPR markers , GRP78 (red) and IRE (blue). Image from Jain et al. 2022, Circ Res (10.1161/CIRCRESAHA.121.320530 )Unfolded Protein Response as a differential modulator of Platelet Phenotype
Figure from Jain et al. Circ Res 2022 (10.1161/CIRCRESAHA.121.320530 )Figure from Jain et al. 2019, eBiomedicine (https://doi.org/10.1016/j.ebiom.2019.05.022)
Platelet phenotype differs distinctly with age and is likely due to the age associated adaptive changes in platelet antioxidant levels.
News
- January 09, 2024
Recap & Reflections: Vascular Biology & Therapeutics Program & Cardiovascular Research Center 2023 Retreat
- December 07, 2023
Decoding Female-Specific Mechanisms in Cardiovascular Disease: A Captivating Conversation with Dr. Lauren Biwer
- October 26, 2023
Unraveling the Mysteries of type 1 Diabetes and Cardiovascular Disease: A Conversation with Dr. David Alagpulinsa.
- October 16, 2023
Recap & Reflections: the Chalk Talk event