Jason Greenberg, MD, MHS
Associate Professor of Pediatrics (Nephrology)Cards
Appointments
Contact Info
Pediatric Nephrology
333 Cedar St, 3086 LMP
New Haven, CT 06520
United States
About
Titles
Associate Professor of Pediatrics (Nephrology)
Biography
Dr. Greenberg grew up in New York, before attending Cornell University to study Biological Engineering. He then attended medical school at the State University of New York at Brooklyn. He completed his residency in Pediatrics at New York University Medical Center. Dr. Greenberg completed his fellowship in Pediatric Nephrology at the Yale University School of Medicine. He also obtained a Masters degree from Yale in Health Sciences Research . Dr. Greenberg is now an Assistant Professor of Pediatrics in the Section of Nephrology at Yale University and a clinical investigator in the Clinical and Translational Research Accelerator (CTRA). His research focuses on improving risk prediction to assist with clinical decision making and inform clinical trials in children with kidney disease.
Appointments
Pediatric Nephrology
Associate Professor on TermPrimary
Other Departments & Organizations
Education & Training
- MHS
- Yale University School of Medicine (2015)
- Resident
- NYU Medical Center (2011)
- MD
- SUNY Downstate College of Medicine (2008)
- BS
- Cornell University College of Engineering, Biological Engineering (2003)
- Fellow
- Yale University School of Medicine
Research
Overview
Medical Subject Headings (MeSH)
ORCID
0000-0001-5874-1109
Research at a Glance
Yale Co-Authors
Publications Timeline
Research Interests
F. Perry Wilson, MD, MSCE
Christine Bakhoum, MD, MAS
James Nugent, MD, MPH
Dennis G Moledina, MD, PhD, FASN
Abinet Aklilu, MD, MPH
Fan Li, PhD
Renal Insufficiency, Chronic
Acute Kidney Injury
Publications
2024
Long-Term Kidney Outcomes after Pediatric Acute Kidney Injury.
Robinson C, Jeyakumar N, Luo B, Askenazi D, Deep A, Garg A, Goldstein S, Greenberg J, Mammen C, Nash D, Parekh R, Silver S, Thabane L, Wald R, Zappitelli M, Chanchlani R. Long-Term Kidney Outcomes after Pediatric Acute Kidney Injury. Journal Of The American Society Of Nephrology 2024 PMID: 39018120, DOI: 10.1681/asn.0000000000000445.Peer-Reviewed Original ResearchAltmetricConceptsAcute kidney replacement therapyAcute kidney injuryKidney replacement therapyLong-term kidney replacement therapyChronic kidney diseasePediatric acute kidney injuryHospital CompareAcute kidney injury survivorsKidney injuryProvincial administrative health databasesLong-term chronic kidney diseaseLong-term risk of chronic kidney diseaseLong-term kidney outcomesMajor Adverse Kidney EventsHospitalized childrenAdministrative health databasesRisk of chronic kidney diseaseIntensive care unit admissionIncident chronic kidney diseaseAdverse kidney eventsRetrospective cohort studyPediatric AKI survivorsLong-term riskNeonatal statusPropensity score matchingUrine Biomarkers of Kidney Tubule Health and Risk of Incident CKD in Persons Without Diabetes: The ARIC, MESA, and REGARDS Studies
Amatruda J, Katz R, Rebholz C, Sarnak M, Gutierrez O, Schrauben S, Greenberg J, Coresh J, Cushman M, Waikar S, Parikh C, Schelling J, Jogalekar M, Bonventre J, Vasan R, Kimmel P, Ix J, Shlipak M, Consortium C. Urine Biomarkers of Kidney Tubule Health and Risk of Incident CKD in Persons Without Diabetes: The ARIC, MESA, and REGARDS Studies. Kidney Medicine 2024, 6: 100834. PMID: 38826568, PMCID: PMC11141432, DOI: 10.1016/j.xkme.2024.100834.Peer-Reviewed Original ResearchConceptsAssociated with incident chronic kidney diseaseIncident chronic kidney diseaseChronic kidney diseaseUrine MCP-1Meta-analysisUrine biomarkersMCP-1A1M concentrationsMultivariable Cox proportional hazards regressionRisk of chronic kidney diseaseRisk of incident chronic kidney diseaseCox proportional hazards regressionIndependent of eGFRPrevalent chronic kidney diseaseCohort of adultsMeta-analysis of resultsA1MLong follow-up periodEarly chronic kidney diseaseFollow-up periodProportional hazards regressionUrine A1MARIC participantsREGARDS studyHealth markersIs mild dehydration a risk for progression of childhood chronic kidney disease?
Le Page A, Johnson E, Greenberg J. Is mild dehydration a risk for progression of childhood chronic kidney disease? Pediatric Nephrology 2024, 1-15. PMID: 38632124, DOI: 10.1007/s00467-024-06332-6.Peer-Reviewed Original ResearchAltmetricConceptsChronic kidney diseaseChronic kidney disease aetiologyKidney diseaseGraphical abstractA higher resolution versionMild dehydrationRisk of CKD progressionConcentrating capacityChronic kidney disease populationFrequency of dehydrationChildhood chronic kidney diseaseImpact renal functionRisk of complicationsLow fluid intakeAssessment of dehydrationChronic kidney disease outcomesHyperfiltration injuryRandomised controlled trialsArginine vasopressinRenal functionCKD progressionFluid intakeTreatment planningAdequate hydrationRisk factorsControlled trialsCOVID-19−Associated Acute Kidney Injury and Longitudinal Kidney Outcomes
Aklilu A, Kumar S, Nugent J, Yamamoto Y, Coronel-Moreno C, Kadhim B, Faulkner S, O’Connor K, Yasmin F, Greenberg J, Moledina D, Testani J, Wilson F. COVID-19−Associated Acute Kidney Injury and Longitudinal Kidney Outcomes. JAMA Internal Medicine 2024, 184: 414-423. PMID: 38407862, PMCID: PMC10897825, DOI: 10.1001/jamainternmed.2023.8225.Peer-Reviewed Original ResearchCitationsAltmetricConceptsCOVID-19-associated acute kidney injuryCOVID-19-associated AKIAcute kidney injuryMulticenter cohort studyKidney function declineKidney functionKidney injuryCohort studyKidney outcomes of patientsIncidence of acute kidney injuryLong-term kidney outcomesHistorical cohort of patientsMultivariate time-to-event analysesPositive influenza ALongitudinal multicenter cohort studyWorsening kidney functionOutcomes of patientsAdverse kidney eventsCohort of patientsComposite of mortalityMarkers of illness severityAdult hospitalized patientsBaseline comorbidity scoreTime-to-event analysisFunctional decline
2023
Long-Term Outcomes After Pediatric Non-Dialysis-Treated AKI: A Population-Based Cohort Study
Robinson C, Jeyakumar N, Askenazi D, Deep A, Garg A, Goldstein S, Greenberg J, Mammen C, Nash D, Parekh R, Silver S, Wald R, Zappitelli M, Chanchlani R. Long-Term Outcomes After Pediatric Non-Dialysis-Treated AKI: A Population-Based Cohort Study. Journal Of The American Society Of Nephrology 2023, 34: 232-232. DOI: 10.1681/asn.20233411s1232a.Peer-Reviewed Original ResearchRecent ambient temperature and fine particulate matter (PM2.5) exposure is associated with urinary kidney injury biomarkers in children
Politis M, Gutiérrez-Avila I, Just A, Pizano-Zárate M, Tamayo-Ortiz M, Greenberg J, Téllez-Rojo M, Sanders A, Rosa M. Recent ambient temperature and fine particulate matter (PM2.5) exposure is associated with urinary kidney injury biomarkers in children. The Science Of The Total Environment 2023, 907: 168119. PMID: 37884142, PMCID: PMC10842020, DOI: 10.1016/j.scitotenv.2023.168119.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsDistributed lag nonlinear modelParticulate matterAverage PM<sub>2.5</sub>Satellite-based spatio-temporal modelUrinary kidney injury biomarkersFine particulate matterExposure to ambient temperatureAir pollutionAerodynamic diameterBirth cohort studySpatio-temporal modelParticipating residentsCohort studyLimited researchEnvironmental exposuresMean temperatureDaily mean temperatureVisitsDaily temperatureAmbient temperatureMatterExposurePM2.5Linear regressionPollutionAssociations of Exposure to Urinary Metals with Kidney Injury Biomarkers among Pre-adolescent Children: A Cross-Sectional Study
Politis M, Yao M, Gennings C, Ortiz M, Amarasiriwardena C, Pantic I, Tolentino M, Gutierrez G, Greenberg J, Rojo M, Sanders A, Rosa M. Associations of Exposure to Urinary Metals with Kidney Injury Biomarkers among Pre-adolescent Children: A Cross-Sectional Study. ISEE Conference Abstracts 2023, 2023 DOI: 10.1289/isee.2023.vo-032.Peer-Reviewed Original ResearchEffect Measure Modification by Birth Weight on the Association Between Overweight or Obesity and Hypertension in Children and Adolescents
Nugent J, Lu Y, Deng Y, Sharifi M, Greenberg J. Effect Measure Modification by Birth Weight on the Association Between Overweight or Obesity and Hypertension in Children and Adolescents. JAMA Pediatrics 2023, 177: 735-737. PMID: 37155182, PMCID: PMC10167596, DOI: 10.1001/jamapediatrics.2023.0799.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsAssociations of Biomarkers of Kidney Tubule Health, Injury, and Inflammation with Left Ventricular Hypertrophy in Children with CKD
Jiang K, Greenberg J, Abraham A, Xu Y, Schelling J, Feldman H, Schrauben S, Waikar S, Shlipak M, Wettersten N, Coca S, Vasan R, Gutierrez O, Ix J, Warady B, Kimmel P, Bonventre J, Parikh C, Mitsnefes M, Denburg M, Furth S, Ramachandran V, Schelling J, Denburg M, Furth S, Warady B, Bonventre J, Waikar S, Sabbisetti V, Coresh J, Grams M, Rebholz C, Abraham A, Parikh C, Coca S, Rhee E, Kimmel P, Kusek J, Rovin B, Shlipak M, Sarnak M, Gutiérrez O, Ix J, Dubin R, Hostetter T, Deo R, Feldman H, Xie D, Shou H, Ballard S, Whitehead K, Collins H, Greenberg J, Ganz P. Associations of Biomarkers of Kidney Tubule Health, Injury, and Inflammation with Left Ventricular Hypertrophy in Children with CKD. Kidney360 2023, 4: 1039-1047. PMID: 37303083, PMCID: PMC10476681, DOI: 10.34067/kid.0000000000000183.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsKidney injury molecule-1Left ventricular hypertrophyUrine KIM-1Injury molecule-1Chemoattractant protein-1Ventricular hypertrophyAlpha-1-microglobulinHigher plasmaLVH prevalenceHigh prevalenceMolecule-1Urine kidney injury molecule-1Urine monocyte chemoattractant protein-1Soluble urokinase-type plasminogen activator receptorTumor necrosis factor receptor 2Monocyte chemoattractant protein-1Kidney tubule healthNecrosis factor receptor 2Pathophysiology of LVHUrine MCP-1Multivariable-adjusted modelsMCP-1 concentrationsBody mass indexProtein 1Child Cohort StudyA randomized clinical trial assessing the effect of automated medication-targeted alerts on acute kidney injury outcomes
Wilson F, Yamamoto Y, Martin M, Coronel-Moreno C, Li F, Cheng C, Aklilu A, Ghazi L, Greenberg J, Latham S, Melchinger H, Mansour S, Moledina D, Parikh C, Partridge C, Testani J, Ugwuowo U. A randomized clinical trial assessing the effect of automated medication-targeted alerts on acute kidney injury outcomes. Nature Communications 2023, 14: 2826. PMID: 37198160, PMCID: PMC10192367, DOI: 10.1038/s41467-023-38532-3.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsAcute kidney injuryUsual care groupKidney injuryCare groupAcute Kidney Injury OutcomesAlert groupNon-steroidal anti-inflammatory drugsComposite of progressionHours of randomizationMedications of interestAldosterone system inhibitorsClasses of medicationsProton pump inhibitorsRandomized clinical trialsAnti-inflammatory drugsClinical decision support systemNephrotoxic medicationsHospitalized adultsDiscontinuation ratesCertain medicationsPrimary outcomeSubstantial morbiditySystem inhibitorsPump inhibitorsParallel group
Clinical Care
Overview
Jason Greenberg, MD, MHS, is a pediatric nephrologist who treats a wide variety of kidney problems, including acute kidney injury, chronic kidney disease, glomerular disease, high blood pressure, kidney stones, and other kidney disorders.
“I enjoy being able to work with and support patients and families to improve their medical problem and their quality of life,” says Dr. Greenberg, adding that families are pleased to learn that there are many approaches and therapies for treating kidney disease in children. “I like the continuity of care as I am able to treat patients throughout their childhood.”
Dr. Greenberg is also a clinical investigator in the Yale Clinical and Translational Research Accelerator, which is dedicated to applying discoveries generated in the laboratory and in preclinical experiments to the development of clinical studies, and to the design of clinical trials. He is focused on improving risk prediction to assist with clinical decision-making and informing clinical trials targeting children with kidney disease. “Ultimately, my goal is to improve clinical decision-making and outcomes for these patients,” he says.
Clinical Specialties
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Pediatric Nephrology
333 Cedar St, 3086 LMP
New Haven, CT 06520
United States
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Are You a Patient? View this doctor's clinical profile on the Yale Medicine website for information about the services we offer and making an appointment.