Jean-Leon Thomas, PhD

Associate Professor of Neurology

Research Departments & Organizations


Vascular Biology and Therapeutics Program

Office of Cooperative Research

Research Interests

Cell Differentiation; Cell Proliferation; Neurogenesis; Stem Cells

Research Summary

Our first axis of research aims at understanding the development of glial cells in the central nervous system. Studies are focusing onto the specification and migration of oligodendrocyte precursor cells (OPCs) in the avian and murine embryonic brain. Research programs are currently developed to investigate the role of Hox Homeoproteins in OPC development and myelin repair.

Our second axis of studies concerns neurovascular interactions, especially the neurobiology of vascular growth factors and receptors. In collaboration with A. EICHMANN (Dpt of CardioVascular Medicine, Yale School of Medicine), we are exploring the role of VEGFRs (Vascular Endothelial Growth Factor Receptors) in neural stem cells and neurovascular niches of the adult brain. As VEGF receptors are targeted by anti-angiogenic anti-tumor therapies, investigations of possible effects of these treatments in the CNS are clinically highly relevant.

Specialized Terms: stem cells; Glial cells; Neurovascular niches; Cell proliferation and differentiation; Cell migration; Vascular growth factors and receptors; Axonal guidance molecules

Extensive Research Description

Projet 1: Hox paralog group 2 genes in oligodendrocyte development and myelin repair

(funded by ARSEP, 2010)

Projet 2: Neurogenesis through VEGF-C/VEGFR-3 signaling

(funded by ANR 2010)

Selected Publications

See list of PubMed publications

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Anne Eichmann

Contact Info

Jean-Leon Thomas, PhD
Mailing Address
Neurology300 George Street
New Haven, CT 06405

Curriculum Vitae