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INFORMATION FOR

Zubin Bhagwagar

MBBS, MD, FRCPsych, DPhil

Contact Information

Zubin Bhagwagar, MBBS, MD, FRCPsych, DPhil

Research Summary

My main area of interest is to understand vulnerability to mood disorders. A conceptual difficulty with studies of patients who are in an acute episode of mood disturbance is that any neurobiological changes seen may be epiphenomena of the acute illness and its treatment, rather than of true pathophysiological significance. I have therefore tried to develop a complementary strategy, namely to study fully recovered, medication-free euthymic subjects with a history of recurrent depression. The identification of biological dysfunction in these subjects could help identify biological markers which are responsible for trait vulnerability to recurrent illness. Identification in previously depressed patients of trait biological markers which exist independently of the illness state and medication will be an important step in understanding neurobiological vulnerability to the disorder. This could lead to better methods of identifying those at risk and thus to appropriate intervention strategies.

The development of novel therapeutic modalities in the field of mood disorders is the thrust of my clinical work. I have started a Bipolar Research Clinic based at the Ribicoff Facilities and we are currently involved in clinical trials of existing and novel compounds in the treatment of bipolar disorder. The combination of clinical and research interests as above will provide residents/fellows with an all round experience in clinical and academic psychiatry.

Specialized Terms: Affective Disorders; Magnetic Resonance; Neurobiology; Neuroimaging; Neuropsychiatry; Neuroscience; Psychiatry; Psychopharmacology; Resonance Spectroscopy

Coauthors

Research Interests

Affective Disorders, Psychotic; Magnetic Resonance Imaging; Neurobiology; Neurosciences; Magnetic Resonance Spectroscopy; Psychiatry; Psychopharmacology; Neuropsychiatry; Neuroimaging

Selected Publications

  • Lithium for acute maniaBhagwagar Z, Goodwin G, Geddes J. Lithium for acute mania 2019, 2019 PMCID: PMC6524414, DOI: 10.1002/14651858.cd004048.pub3.
  • P2‐412: A comparison of hippocampal atrophy algorithms to select outcome measures for clinical trials in mild‐to‐moderate Alzheimer's diseaseBurns L, Rueckert D, Bhagwagar Z, Donohue M, Wolz R, Tiller J, Soares H, l'Italien G, Coric V, Hayes W, Fox N, Berman R. P2‐412: A comparison of hippocampal atrophy algorithms to select outcome measures for clinical trials in mild‐to‐moderate Alzheimer's disease Alzheimer's & Dementia 2012, 8: p408-p408. DOI: 10.1016/j.jalz.2012.05.2037.
  • P2‐423: vMRI and whole‐brain volume in patients with mild‐to‐moderate Alzheimer's diseaseBudd D, Nalysnyk L, Fahrbach K, Bhagwagar Z, Berman R, Burns L, l'Italien G. P2‐423: vMRI and whole‐brain volume in patients with mild‐to‐moderate Alzheimer's disease Alzheimer's & Dementia 2012, 8: p411-p412. DOI: 10.1016/j.jalz.2012.05.2048.
  • P2‐422: vMRI and hippocampal volume in patients with suspected predementia Alzheimer's diseaseBudd D, Nalysnyk L, Fahrbach K, Bhagwagar Z, Berman R, Burns L, l'Italien G. P2‐422: vMRI and hippocampal volume in patients with suspected predementia Alzheimer's disease Alzheimer's & Dementia 2012, 8: p411-p411. DOI: 10.1016/j.jalz.2012.05.2047.
  • AntidepressantsBhagwagar Z, Heninger G. Antidepressants 2012, 1185-1198. DOI: 10.1093/med/9780199696758.003.0153.
  • The Relationship Between Mood, Stress, and Tobacco SmokingWalderhaug E, Cosgrove K, Bhagwagar Z, Neumeister A. The Relationship Between Mood, Stress, and Tobacco Smoking 2010, 147-161. DOI: 10.1007/978-1-4419-6373-4_10.
  • Neurotransmitter Systems in Bipolar DisorderNakic M, Krystal J, Bhagwagar Z. Neurotransmitter Systems in Bipolar Disorder 2010, 210-227. DOI: 10.1002/9780470661277.ch16.
  • Association between serotonin transporter binding, physiological and environmental factors in healthy male subjectsComley R, Miller S, Murthy V, Bhagwagar Z, Turner D, Peers P, Riedel W, Grasby P, Rabiner E. Association between serotonin transporter binding, physiological and environmental factors in healthy male subjects NeuroImage 2010, 52: s93-s94. DOI: 10.1016/j.neuroimage.2010.04.075.
  • P1‐387: Mild to moderate Alzheimer's disease (AD) clinical trials: The role of hippocampal atrophy as an inclusion criterionRisinger R, Berman R, Coric V, Han J, Kaplita S, Burns L, Bhagwagar Z, Hill D, Wolz R, Rueckert D, Feldman H. P1‐387: Mild to moderate Alzheimer's disease (AD) clinical trials: The role of hippocampal atrophy as an inclusion criterion Alzheimer's & Dementia 2010, 6: s285-s286. DOI: 10.1016/j.jalz.2010.05.941.
  • Diminished center-surround inhibition in patients with a history of depressionGolomb J, Ruf B, Beck J, Saricicek A, Hu J, Chun M, Bhagwagar Z. Diminished center-surround inhibition in patients with a history of depression Journal Of Vision 2010, 8: 1029-1029. DOI: 10.1167/8.6.1029.
  • P.1.025 Molecular imaging of beta-2 subunit containing nicotinic acetylcholine receptors in major depressive disorderSaricicek A, Esterlis I, Ruf B, Maloney K, Muralidharan A, Seibyl J, Tamagnan G, Bois F, Staley J, Bhagwagar Z. P.1.025 Molecular imaging of beta-2 subunit containing nicotinic acetylcholine receptors in major depressive disorder European Neuropsychopharmacology 2010, 20: s22. DOI: 10.1016/s0924-977x(10)70027-4.
  • P.2.e.029 Levetiracetam in the management of bipolar depression: a randomized, double-blind, placebo controlled trialSaricicek A, Maloney K, Lorberg B, Muralidharan A, Ruf B, Blumberg H, Hu J, Pittman B, Sanacora G, Bhagwagar Z. P.2.e.029 Levetiracetam in the management of bipolar depression: a randomized, double-blind, placebo controlled trial European Neuropsychopharmacology 2009, 19: s465. DOI: 10.1016/s0924-977x(09)70728-x.
  • A Novel Paradigm for Examining the Interfering Effects of Emotional Distracters During a Working Memory Task: A Functional Magnetic Resonance Imaging (fMRI) StudyKerestes R, Ladouceur C, Meda S, Blumberg H, Nathan P, Maloney K, Ruf B, Saricicek A, Hu J, Pearlson G, Bhagwagar Z, Phillips M. A Novel Paradigm for Examining the Interfering Effects of Emotional Distracters During a Working Memory Task: A Functional Magnetic Resonance Imaging (fMRI) Study NeuroImage 2009, 47: s191. DOI: 10.1016/s1053-8119(09)72145-7.
  • NMDA Receptor Antagonist Ketamine Produces Opposing Effects on Resting and Task-Related Brain Activation During Working Memory in HumansDriesen N, McCarthy G, Bhagwagar Z, Calhoun V, D'Souza D, Holub J, Morgan P, Krystal J. NMDA Receptor Antagonist Ketamine Produces Opposing Effects on Resting and Task-Related Brain Activation During Working Memory in Humans NeuroImage 2009, 47: s145. DOI: 10.1016/s1053-8119(09)71458-2.
  • Drs. Ghaznavi and Bhagwagar ReplyGHAZNAVI S, BHAGWAGAR Z. Drs. Ghaznavi and Bhagwagar Reply American Journal Of Psychiatry 2008, 165: 1611-1612. DOI: 10.1176/appi.ajp.2008.08071105r.
  • Lower brain serotonin transporter binding potential in unipolar acutely depressed patients — A preliminary [11C]DASB PET studySelvaraj S, Murthy V, Bhagwagar Z, Bose S, Cowen P, Grasby P. Lower brain serotonin transporter binding potential in unipolar acutely depressed patients — A preliminary [11C]DASB PET study NeuroImage 2008, 41: t167. DOI: 10.1016/j.neuroimage.2008.04.134.
  • Nicotinic receptor dysfunction in major depressive disorder: A trait vulnerability marker of depressionBhagwagar Z, Esterlis I, Ruf B, Muralidharan A, Lorberg B, Saricicek A, Bois F, Tamagnan G, Seibyl J, Staley J. Nicotinic receptor dysfunction in major depressive disorder: A trait vulnerability marker of depression NeuroImage 2008, 41: t176. DOI: 10.1016/j.neuroimage.2008.04.143.
  • Bipolar disorder: the neglected psychosisBhagwagar Z, Goodwin G. Bipolar disorder: the neglected psychosis Psychiatry 2007, 6: 389-392. DOI: 10.1016/j.mppsy.2007.06.005.
  • Lithium for bipolar depressionBhagwagar Z, Goodwin G, Geddes J. Lithium for bipolar depression 2007 DOI: 10.1002/14651858.cd004042.pub2.
  • Lithium for acute maniaBhagwagar Z, Goodwin G, Geddes J. Lithium for acute mania 2007 DOI: 10.1002/14651858.cd004048.pub2.
  • Changes of [11C]DASB binding in human brain after citalopram infusionHinz R, Murthy V, Selvaraj S, Taylor M, Cowen P, Bhagwagar Z, Grasby P. Changes of [11C]DASB binding in human brain after citalopram infusion NeuroImage 2006, 31: t26. DOI: 10.1016/j.neuroimage.2006.04.016.
  • 5-HT1A receptor density and defensive personality - interaction of neurochemistry, personality and depression explored with [11C]WAY 100635 PETRabiner E, Lawrence A, Bhagwagar Z, Murthy N, Bantick R, Cowen P, Grasby P. 5-HT1A receptor density and defensive personality - interaction of neurochemistry, personality and depression explored with [11C]WAY 100635 PET Cerebrovascular And Brain Metabolism Reviews 2005, 25: s376-s376. DOI: 10.1038/sj.jcbfm.9591524.0376.
  • P.2.01 The effects of altering dietary L-tryptophan on the performance of an iterated Prisoner's Dilemma (PD) game in healthy volunteersWood R, Rilling J, Sanfey A, Bhagwagar Z, Rogers R. P.2.01 The effects of altering dietary L-tryptophan on the performance of an iterated Prisoner's Dilemma (PD) game in healthy volunteers European Neuropsychopharmacology 2005, 15: s32. DOI: 10.1016/s0924-977x(05)80141-5.
  • P.1.028 Persistent reduction in brain 5-HT1A receptorbinding in recovered depressed men using positron emission tomography and [11C]WAY-100835Bhagwagar Z, Rabiner E, Sargente R, Grasby P, Cowen P. P.1.028 Persistent reduction in brain 5-HT1A receptorbinding in recovered depressed men using positron emission tomography and [11C]WAY-100835 European Neuropsychopharmacology 2004, 14: s185. DOI: 10.1016/s0924-977x(04)80117-2.
  • Bipolar disorder: the neglected psychosisBhagwagar Z, Goodwin G. Bipolar disorder: the neglected psychosis Psychiatry 2004, 3: 67-70. DOI: 10.1383/psyt.3.10.67.52406.
  • Bipolar-spectrum disorders: an epidemic unseen, invisible or unreal?Bhagwagar Z, Goodwin G. Bipolar-spectrum disorders: an epidemic unseen, invisible or unreal? Advances In Psychiatric Treatment 2004, 10: 1-3. DOI: 10.1192/apt.10.1.1.
  • Lithium for acute maniaBhagwagar Z, Goodwin G, Geddes J. Lithium for acute mania 2003 DOI: 10.1002/14651858.cd004048.
  • Lithium for bipolar depressionBhagwagar Z, Goodwin G, Geddes J. Lithium for bipolar depression 2003 DOI: 10.1002/14651858.cd004042.
  • The role of lithium in the treatment of bipolar depressionBhagwagar Z, Goodwin G. The role of lithium in the treatment of bipolar depression Clinical Neuroscience Research 2002, 2: 222-227. DOI: 10.1016/s1566-2772(02)00046-4.
  • Inositol for depressive disordersTaylor M, Wilder H, Bhagwagar Z, Geddes J. Inositol for depressive disorders 2002 DOI: 10.1002/14651858.cd004049.
  • State and Trait Abnormalities in Serotonin Function in Major DepressionBhagwagar Z, Whale R, Cowen P. State and Trait Abnormalities in Serotonin Function in Major Depression Clinical Science 2002, 103: 65p-65p. DOI: 10.1042/cs103065p.
  • PET Measurement of the Influence of Corticosteroids on Serotonin-1A Receptor NumberMontgomery A, Bench C, Young A, Hammers A, Bhagwagar Z, Grasby P. PET Measurement of the Influence of Corticosteroids on Serotonin-1A Receptor Number Clinical Science 2002, 103: 64p-64p. DOI: 10.1042/cs103064pa.
  • PET measurement of the influence of corticosteroids on serotonin-1A receptor numberMontgomery A, Bench C, Young A, Hammers A, Bhagwagar Z, Grasby P. PET measurement of the influence of corticosteroids on serotonin-1A receptor number NeuroImage 2001, 13: 1075. DOI: 10.1016/s1053-8119(01)92404-8.
  • Velo-cardio-facial (Shprintzen's) Syndrome, violence and schizophreniaBhagwagar Z, Mawson D. Velo-cardio-facial (Shprintzen's) Syndrome, violence and schizophrenia Journal Of Forensic Psychiatry And Psychology 2000, 11: 449-455. DOI: 10.1080/09585180050142642.
  • Working with offenders: psychological practice in offender rehabilitation. Edited by Clive R. Hollin. Wiley, Chichester PO19 1UD, March 1996, 288 pp. ISBN 0‐471‐95776‐3. ISBN 0‐471‐95349‐0Bhagwagar Z. Working with offenders: psychological practice in offender rehabilitation. Edited by Clive R. Hollin. Wiley, Chichester PO19 1UD, March 1996, 288 pp. ISBN 0‐471‐95776‐3. ISBN 0‐471‐95349‐0 Criminal Behaviour And Mental Health 1998, 8: 323-324. DOI: 10.1002/cbm.271.
  • Book Reviews : Fundamentals of Psychopharmacology— Second EditionBhagwagar Z. Book Reviews : Fundamentals of Psychopharmacology— Second Edition Journal Of Psychopharmacology 1998, 12: 109-110. DOI: 10.1177/026988119801200118.
  • Financial implications of Calman changes in psychiatryBhagwagar Z. Financial implications of Calman changes in psychiatry BJPsych Bulletin 1997, 21: 784-785. DOI: 10.1192/pb.21.12.784-b.