My research is focused on studying and understanding the multi-omic (genomic/transcriptomic/epigenomic) profiles of various tumors through computational methods. I am specifically interested in the genomic profiles of primary brain tumors with a focus on inter and intra tumor heterogeneity. Having a background in computer science and computational biology; I develop bioinformatics approaches to study large datasets to reveal the molecular mechanisms both in tumor formation, progression and also in clinical outlier subgroups such as treatment resistant/responsive or long/short term survivors. I am also interested in application of genomic techniques to precision medicine for brain tumors. I have been leading the computational arm of the precision medicine efforts at the Department of Neurosurgery at Yale since 2016.
We are looking for highly motivated individuals with an interest in computational biology (with or without wet-lab experience) to study on very exciting projects. Send an email if you are interested!
Glioblastoma; Meningioma; Pituitary Diseases; Central Nervous System Neoplasms; Computational Biology; Genomics; Precision Medicine; Epigenomics; Transcriptome