Research & Publications
My research is focused on studying and understanding the multi-omic (genomic/transcriptomic/epigenomic) profiles of various tumors through computational methods. I am specifically interested in the genomic profiles of primary brain tumors with a focus on inter and intra tumor heterogeneity. Having a background in computer science and computational biology; I use bioinformatics approaches to study large datasets to reveal the molecular mechanisms both in tumor formation, progression and also in clinical outlier subgroups such as treatment resistant/responsive or long/short term survivors. I am also interested in application of genomic techniques to precision medicine for brain tumors. I have been leading the computational arm of the precision medicine efforts at the Department of Neurosurgery at Yale since 2016. My lab is also building collaborations across the Medical school to translate our expertise to other CNS pathologies, such as traumatic brain injury.
Glioblastoma; Meningioma; Pituitary Diseases; Central Nervous System Neoplasms; Computational Biology; Genomics; Precision Medicine; Epigenomics; Transcriptome
Public Health Interests
Bioinformatics; Cancer; Genetics, Genomics, Epigenetics