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INFORMATION FOR

Sacit Bulent Omay, MD, FAANS

Associate Professor of Neurosurgery and Otolaryngology; Surgical Director of Yale Pituitary Program, Neurosurgery; Section Chief, NeuroTrauma, Neurosurgery; Associate Professor, Comprehensive Otolaryngology

Research Summary

I have a background in translational neurooncology research. I am particularly interested in developing personalized therapies based on genomic and molecular profiles of individual tumors especially skull base tumors like pituitary adenomas. Additionally, I perform clinical research especially in the field of endoscopic skull base surgery in an effort to answer challenging questions that come across as the field progresses.

I am also conducting clinical and translational TBI research focusing on prognostication and outcomes as well colloborations for therapeutic opportunities.

Coauthors

Research Interests

Brain Neoplasms; Cerebrospinal Fluid Rhinorrhea; Craniocerebral Trauma; Hypothalamo-Hypophyseal System; Pituitary Apoplexy; Pituitary Diseases; Pituitary Gland; Cerebrospinal Fluid Pressure; Receptors, Oxytocin; Skull Base; Skull Base Neoplasms; Cerebrospinal Fluid Leak

Selected Publications

  • NIMG-105. DEUTERIUM METABOLIC IMAGING (DMI) DETECTS A LARGER WARBURG EFFECT IN HIGH-GRADE BRAIN TUMORS AND IN IDH WILD TYPE GLIOMASKim L, De Feyter H, de Graaf R, Fulbright R, Liu Y, Rothman D, Baehring J, Blondin N, Kim P, Omuro A, Chiang V, Moliterno J, Omay S, Piepmeier J, Corbin Z. NIMG-105. DEUTERIUM METABOLIC IMAGING (DMI) DETECTS A LARGER WARBURG EFFECT IN HIGH-GRADE BRAIN TUMORS AND IN IDH WILD TYPE GLIOMAS Neuro-Oncology 2022, 24: vii189-vii189. PMCID: PMC9660955, DOI: 10.1093/neuonc/noac209.723.
  • TRAF7 Mutated Subgroups Differ in Sphenoid Wing Meningiomas with HyperostosisJin L, Vetsa S, Vasandani S, Nadar A, Youngblood M, Gupte T, Barak T, Yalcin K, Aguilera S, Mishra-Gorur K, Blondin N, Gorelick E, Omay S, Pointdujour-Lim R, Judson B, Alperovich M, Aboian M, Marianayagam N, McGuone D, Gunel M, Erson-Omay Z, Fulbright R, Moliterno J. TRAF7 Mutated Subgroups Differ in Sphenoid Wing Meningiomas with Hyperostosis Journal Of Neurological Surgery Part B Skull Base 2022, 83: s1-s270. DOI: 10.1055/s-0042-1743640.
  • Utility of Intraoperative MRI Assessing Nasoseptal Flap Vascularity in Predicting Postoperative CSF Leak After Endoscopic Endonasal Approaches to Anterior Skull Base LesionsHong C, Manes R, Vining E, Omay S. Utility of Intraoperative MRI Assessing Nasoseptal Flap Vascularity in Predicting Postoperative CSF Leak After Endoscopic Endonasal Approaches to Anterior Skull Base Lesions Journal Of Neurological Surgery Part B Skull Base 2022, 83: s1-s270. DOI: 10.1055/s-0042-1743720.
  • Chapter 55 Non-neoplastic mass lesions of the central nervous systemKarschnia P, Omay S, Fulbright R, Baehring J. Chapter 55 Non-neoplastic mass lesions of the central nervous system 2022, 795-808. DOI: 10.1016/b978-0-12-822835-7.00043-3.
  • NIMG-64. TYPE OF BONY INVOLVEMENT PREDICTS GENOMIC SUBGROUP IN SPHENOID WING MENINGIOMASJin L, Youngblood M, Gupte T, Vetsa S, Nadar A, Barak T, Yalcin K, Aguilera S, Mishra-Gorur K, Blondin N, Omay S, Pointdujour-Lim R, Judson B, Alperovich M, Aboian M, McGuone D, Gunel M, Erson-Omay Z, Fulbright R, Moliterno J. NIMG-64. TYPE OF BONY INVOLVEMENT PREDICTS GENOMIC SUBGROUP IN SPHENOID WING MENINGIOMAS Neuro-Oncology 2021, 23: vi144-vi144. PMCID: PMC8598770, DOI: 10.1093/neuonc/noab196.562.
  • PATH-38. APC MUTATION AS A DRIVER ONCOGENE IN NON-CTNNB1 MUTANT ADAMANTINOMATOUS CRANIOPHARYNGIOMASHong C, Erson-Omay Z, Omay S. PATH-38. APC MUTATION AS A DRIVER ONCOGENE IN NON-CTNNB1 MUTANT ADAMANTINOMATOUS CRANIOPHARYNGIOMAS Neuro-Oncology 2021, 23: vi123-vi123. PMCID: PMC8598823, DOI: 10.1093/neuonc/noab196.490.
  • Endoscopic and Minimally Invasive Meningioma SurgeryOmay S, Schwartz T. Endoscopic and Minimally Invasive Meningioma Surgery 2020, 97-108. DOI: 10.1007/978-3-030-59558-6_7.
  • 26. GENETIC CHARACTERIZATION OF SELLAR METASTASIS FROM PRIMARY BRONCHIAL CARCINOID TUMOR OF NEUROENDOCRINE PATHOLOGYHong C, McGuone D, Erson-Omay E, Bulent Omay S. 26. GENETIC CHARACTERIZATION OF SELLAR METASTASIS FROM PRIMARY BRONCHIAL CARCINOID TUMOR OF NEUROENDOCRINE PATHOLOGY Neuro-Oncology Advances 2020, 2: ii4-ii5. PMCID: PMC7401391, DOI: 10.1093/noajnl/vdaa073.016.
  • A Case of the Use of Genomic Signatures in the Diagnosis of Cushing DiseaseMurari K, Gossman M, Mahajan A, Erson Z, Inzucchi S, Omay S. A Case of the Use of Genomic Signatures in the Diagnosis of Cushing Disease Journal Of Neurological Surgery Part B Skull Base 2020, 81: s1-s272. DOI: 10.1055/s-0040-1702681.
  • Micro-RNA Mutations Across Multiple Resections of a Giant Nonfunctional Pituitary AdenomaGummadavelli A, McCarthy L, Erson Z, Vining E, Gunel M, Omay S. Micro-RNA Mutations Across Multiple Resections of a Giant Nonfunctional Pituitary Adenoma Journal Of Neurological Surgery Part B Skull Base 2020, 81: s1-s272. DOI: 10.1055/s-0040-1702680.
  • Idiopathic Intracranial Hypertension Presenting as Spontaneous CSF LeakHong C, Vining E, Manes R, Omay S. Idiopathic Intracranial Hypertension Presenting as Spontaneous CSF Leak Journal Of Neurological Surgery Part B Skull Base 2020, 81: s1-s272. DOI: 10.1055/s-0040-1702591.
  • MNGI-09. MENINGIOMA WITH MULTIPLE DRIVERS: GENOMIC LANDSCAPE AND CLINICAL CORRELATIONSLi C, Tyrtova E, Youngblood M, Miyagishima D, Duran D, Montejo J, Özduman K, Sheth A, Zhao A, Fomchenko E, Clark V, Sohrabi S, Koljaka S, Li X, Necmettiin Pamir M, Avşar T, Kilic T, Zhu H, Gong Y, Bayri Y, Amankulor N, Bilgüvar K, Omay S, Huttner A, Simon M, Krischek B, Kalamarides M, Moliterno J, Zeynep Erson-Omay E, Günel M. MNGI-09. MENINGIOMA WITH MULTIPLE DRIVERS: GENOMIC LANDSCAPE AND CLINICAL CORRELATIONS Neuro-Oncology 2019, 21: vi141-vi141. PMCID: PMC6847476, DOI: 10.1093/neuonc/noz175.591.
  • GENE-56. MENINGIOMA GENOMIC SUBGROUP AS A PREDICTOR OF POST-OPERATIVE PATIENT OUTCOMES: IMPLICATIONS FOR TREATMENT AND FOLLOW-UPYoungblood M, Sheth A, Zhao A, Montejo J, Duran D, Li C, Tyrtova E, Özduman K, Peyre M, Boetto J, Omay S, Kalamarides M, Zeynep Erson-Omay E, Günel M, Moliterno J. GENE-56. MENINGIOMA GENOMIC SUBGROUP AS A PREDICTOR OF POST-OPERATIVE PATIENT OUTCOMES: IMPLICATIONS FOR TREATMENT AND FOLLOW-UP Neuro-Oncology 2019, 21: vi109-vi110. PMCID: PMC6846980, DOI: 10.1093/neuonc/noz175.458.
  • Upfront Stereotactic Radiosurgery in the Treatment of Brain Metastasis from Small Cell Lung CancerMiccio J, Miccio J, Johnson S, Johnson S, Jairam V, Yu J, Yu J, Hansen J, Aneja S, An Y, Decker R, Omay S, Chiang V, Park H, Park H. Upfront Stereotactic Radiosurgery in the Treatment of Brain Metastasis from Small Cell Lung Cancer International Journal Of Radiation Oncology • Biology • Physics 2019, 105: e81-e82. DOI: 10.1016/j.ijrobp.2019.06.2348.
  • Outcome Analysis Among Meningioma Genomic Subgroups Identifies Decreased Recurrence Free Survival in PI3K Activated TumorsYoungblood M, Sheth A, Zhao A, Montejo J, Duran D, Li C, Tyrtova E, Ozduman K, Miyagishima D, Boetto J, Peyre M, Omay S, Kalamarides M, Omay Z, Gunel M, Moliterno J. Outcome Analysis Among Meningioma Genomic Subgroups Identifies Decreased Recurrence Free Survival in PI3K Activated Tumors Neurosurgery 2019, 66: 310-646. DOI: 10.1093/neuros/nyz310_646.
  • SAT-475 PRL Secreting Macroadenoma and Development CSF Leak Secondary to Cabergoline UseUlrich J, Omay S, Manes P, Majumdar S. SAT-475 PRL Secreting Macroadenoma and Development CSF Leak Secondary to Cabergoline Use Journal Of The Endocrine Society 2019, 3: sat-475. PMCID: PMC6552443, DOI: 10.1210/js.2019-sat-475.
  • 5 Suprasellar PathologyOmay S, Anand V, Schwartz T. 5 Suprasellar Pathology 2019, 61-69. DOI: 10.1007/978-3-319-64379-3_5.
  • Two-Hit Germline and Somatic AIP Mutations in a Pediatric Growth Hormone-Secreting Pituitary AdenomaFreedman I, Gummadavelli A, Mccarthy L, Spencer D, Fisayo A, Dinauer C, Vining E, Erson-Omay E, Omay S. Two-Hit Germline and Somatic AIP Mutations in a Pediatric Growth Hormone-Secreting Pituitary Adenoma Journal Of Neurological Surgery Part B Skull Base 2019, 80: s1-s244. DOI: 10.1055/s-0039-1679833.
  • Skull Base Complications after Medical Treatment of Skull Base Tumors: Case IllustrationsAbdel-Aty A, Abdel-Aty A, Spock T, Spock T, Manes R, Tomak P, Tomak P, Omay S, Vining E. Skull Base Complications after Medical Treatment of Skull Base Tumors: Case Illustrations Journal Of Neurological Surgery Part B Skull Base 2019, 80: s1-s244. DOI: 10.1055/s-0039-1679722.
  • Results of a pilot/phase II study of gamma knife radiosurgery for brain metastases and implications for future prospective clinical trialsYu J, Singh C, Bindra R, Contessa J, Husain Z, Hansen J, Park H, Roberts K, Bond J, Tien C, Guo F, Colaco R, Housri N, Magnuson W, Mahajan A, Omay S, Chiang V. Results of a pilot/phase II study of gamma knife radiosurgery for brain metastases and implications for future prospective clinical trials Journal Of Radiation Oncology 2019, 8: 39-46. DOI: 10.1007/s13566-018-0370-7.
  • Operative Cranial Neurosurgical AnatomyAbdulrauf S, Abolfotoh M, Acerno S, Aldahak N, Allevi F, Almeida J, Al-Mahfoudh R, Arnaout M, Ashour A, Autelitano L, Aziz K, Bailo M, Beretta L, Biglioli F, Boari N, Bonney P, Borba L, da Silva H, Buchfelder M, Buohliqah L, Burks J, Bussi M, Carrau R, Castellano A, Cavalcanti D, Cherian N, Ciporen J, Colombo E, Conner A, Cornejo V, De La Rosa S, de Oliveira E, de Oliveira J, Donofrio C, El-Bahy K, Elbabaa S, Elhefnawi F, Eloy J, Erickson N, Esposito I, Falini A, Fernandez-Miranda J, Garcia-Lopez V, Garcia-Martinez V, Germanwala A, Glenn C, González-López P, Hattar E, Huynh K, Johnson J, Kadri P, Kang B, Kemp J, Kerr E, Koduru S, König S, Lee J, Litvack Z, Liu J, Lopez-Sanchez C, Lucke-Wold B, Maghami S, McCormack E, McKenna G, Medone M, Melot A, Messelberger V, Monfared A, Morgan M, Nader R, Nakaji P, Neto M, Olivas J, Omay S, Patel C, Pilolli F, Piloni M, Porras-Estrada L, Prevedello D, Rassi M, Roche P, Ruggieri F, Sabetrasekh P, Samandouras G, Santoreneos S, Sven-Martin S, Schwartz T, Scott S, Sekhar L, Singh A, Singh H, Siu A, Sivakanthan S, Sorrilha C, Spetzger U, Spina A, Spinazzi E, Steinberg G, Sughrue M, Swong K, Teo M, Toma S, Trimarchi M, Troude L, Tsimpas A, Vaughan K, Verdú-Martínez I, Wang W, Wormald P, Zaidi H, Zeinalizadeh M, Zhao Y, Zoerle T. Operative Cranial Neurosurgical Anatomy 2019 DOI: 10.1055/b-005-143339.
  • Transnasal Endoscopic Skull Base and Brain SurgeryAbdelmeguid A, Abucham J, de Alencastro L, de Alencastro L, Almeida J, Alves-Belo J, Anand V, Lozano P, Balsalobre L, Banks C, Bassagaisteguy L, Battaglia P, Beer-Furlan A, Bernat A, Bleier B, Bouazza S, Bresson D, Briner H, Brock R, Bronstein M, Torrero R, Campero A, Cardoso A, Cappabianca P, Barreiro G, Carrau R, Castelnuovo P, Cavallo L, Chakravarthi S, Méndez M, Choby G, Cohen S, Dassi C, de Notaris M, Deshmukh O, Dhepnorrarat C, Dunn I, Eloy J, Refaee E, Esposito F, Esposito I, de Barros Faria M, Fernandez-Miranda J, Frank G, Froelich S, Fukui M, Gardner P, Talamas L, Gentil A, Ghalib L, Goel G, de Queiroz Teles Gomes M, Gonen L, Hadad G, Haetinger R, Hanakita S, Hanna E, Hardesty D, Harvey R, Herman P, Vivas A, Hoshide R, Howard D, Hsueh W, Hwang P, Inoue K, Casanova E, Janakiram N, Jennings J, Karligkiotis A, Kassam A, Kelly D, Kennedy D, Kenning T, Khoueir N, Kilic S, Kirschner L, Klatt-Cromwell C, Kowalski L, Kshettry V, Labidi M, Lambertoni A, Lancini D, Laws E, Lieber S, Lira R, Liu J, Lobo B, Locatelli D, Lodetti A, Silveira P, Lubbe D, Lund V, Macías-Valle L, Marconato F, Martins C, Mattavelli D, Mazzatenta D, Mizumoto N, Moe K, Monroy-Sosa A, Montaser A, Müller S, Mural M, Najera E, Nakanishi M, Nakayama T, Narayanan P, Natori Y, Nicolai P, Nuñez M, Oakley G, de Oliveira M, Omay S, Osawa S, Ospina J, Otori N, Paes T, Palmer J, Parasher A, Pasquini E, Peris-Celda M, Pfisterer M, Pietrobon G, Pinheiro-Neto C, Pozzi F, Prevedello D, Rampinelli V, Recinos P, Rhoton A, Riley C, Rodriguez J, Rovin R, Sacks R, Salas-Galicia J, Schroeder H, Schuman T, Schwartz T, Scopel T, Sekhsaria V, Senior B, Sethi D, Sharma S, Simmen D, Sindwani R, Sivasubramaniam R, Snyderman C, Solari D, Soneru C, Tabaee A, Tang I, Tedeschi H, Teo C, Thorp B, Todeschini A, Toledo R, Truong H, Tschabitscher M, Turri-Zanoni M, Valentine R, de Arnaldo S. Vellutini E, Verillaud B, Wang E, Wang J, Wang W, Watanabe K, Woodard T, Workman A, Wormald P, Wuesthoff C, Yanagi K, Yasuda A, Zanation A, Zocchi J, Zoli M. Transnasal Endoscopic Skull Base and Brain Surgery 2019 DOI: 10.1055/b-006-164723.
  • Evolving National Practice Patterns of Hypofractionated Stereotactic Radiation Therapy Versus Single-Fraction Radiosurgery for Brain MetastasesJairam V, Kann B, Patel K, Yu J, Hansen J, Husain Z, Bindra R, Contessa J, Omay S, Chiang V, Park H. Evolving National Practice Patterns of Hypofractionated Stereotactic Radiation Therapy Versus Single-Fraction Radiosurgery for Brain Metastases International Journal Of Radiation Oncology • Biology • Physics 2018, 102: e227. DOI: 10.1016/j.ijrobp.2018.07.775.
  • Reoperation for Growth-Hormone Secreting Pituitary Adenomas: Endonasal Endoscopic Series and Systematic Review of the LiteratureAlmeida J, Ruiz-Trevi?o A, Liang B, Shetty S, Chen Y, Omay S, Anand V, Schwartz T. Reoperation for Growth-Hormone Secreting Pituitary Adenomas: Endonasal Endoscopic Series and Systematic Review of the Literature Journal Of Neurological Surgery Part B Skull Base 2017, 78: s1-s156. DOI: 10.1055/s-0037-1600584.
  • Endoscopic Skull Base Surgeons. Profile of a New SubspecialtyAlmeida J, Omay S, Ruiz-Trevi?o A, Shetty S, Chen Y, Liang B, Anand V, Schwartz T. Endoscopic Skull Base Surgeons. Profile of a New Subspecialty Journal Of Neurological Surgery Part B Skull Base 2017, 78: s1-s156. DOI: 10.1055/s-0037-1600609.
  • Do Craniopharyngioma Molecular Signatures Correlate with Clinical Characteristics?Omay S, Chen Y, Almeida J, Ruiz-Trevi?o A, Boockvar J, Stieg P, Greenfield J, Souweidane M, Kacker A, Pisapia D, Anand V, Schwartz T. Do Craniopharyngioma Molecular Signatures Correlate with Clinical Characteristics? Journal Of Neurological Surgery Part B Skull Base 2017, 78: s1-s156. DOI: 10.1055/s-0037-1600617.
  • Olfactory Groove Meningioma Recurrence after Endonasal Endoscopic Surgery: Case Report and Updated Literature ReviewShetty S, Ruis-trevino A, Omay S, Almeida J, Liang B, Chen Y, Schwartz T. Olfactory Groove Meningioma Recurrence after Endonasal Endoscopic Surgery: Case Report and Updated Literature Review Journal Of Neurological Surgery Part B Skull Base 2017, 78: s1-s156. DOI: 10.1055/s-0037-1600625.
  • Is The Chiasm - pituitary Corridor Important for Achieving Gross Total Resection in Craniopharyngiomas?Omay S, Almeida J, Chen Y, Shetty S, Liang B, Ni S, Anand V, Schwartz T. Is The Chiasm - pituitary Corridor Important for Achieving Gross Total Resection in Craniopharyngiomas? Journal Of Neurological Surgery Part B Skull Base 2017, 78: s1-s156. DOI: 10.1055/s-0037-1600678.
  • Transorbital Endoscopic Eyelid Approach for Resection of Spheno-Orbital Meningiomas with Predominant Hyperostosis: Report of Two Cases and Review of the LiteratureAlmeida J, Omay S, Ruiz-Trevi?o A, Shetty S, Liang B, Chen Y, Levine B, Anand V, Schwartz T. Transorbital Endoscopic Eyelid Approach for Resection of Spheno-Orbital Meningiomas with Predominant Hyperostosis: Report of Two Cases and Review of the Literature Journal Of Neurological Surgery Part B Skull Base 2017, 78: s1-s156. DOI: 10.1055/s-0037-1600878.
  • Chapter 53 Nonneoplastic Mass Lesions of the Central Nervous SystemOmay S, Atsina K, Baehring J. Chapter 53 Nonneoplastic Mass Lesions of the Central Nervous System 2016, 653-665. DOI: 10.1016/b978-0-12-800945-1.00053-7.
  • GENO-15IDENTIFICATION AND GENOMIC ANALYSIS OF HYPER-MUTATED AND ULTRA-MUTATED GBMSErson-Omay E, Schultz N, Omay S, Ozduman K, Harmanci A, Clark V, Baranoski J, Gunel J, Pamir M, Bilguvar K, Yasuno K, Vortmeyer A, Huttner A, Sander C, Gunel M. GENO-15IDENTIFICATION AND GENOMIC ANALYSIS OF HYPER-MUTATED AND ULTRA-MUTATED GBMS Neuro-Oncology 2015, 17: v94-v94. PMCID: PMC4638807, DOI: 10.1093/neuonc/nov215.15.