Yujun Cai, PhD
Assistant Professor of Surgery (Vascular)
Research & Publications
Biography
Locations
Coauthors
Selected Publications
- Perfluorooctanesulfonic Acid and Perfluorooctanoic Acid Promote Migration of Three-Dimensional Colorectal Cancer SpheroidsZheng J, Sun B, Berardi D, Lu L, Yan H, Zheng S, Aladelokun O, Xie Y, Cai Y, Pollitt K, Khan S, Johnson C. Perfluorooctanesulfonic Acid and Perfluorooctanoic Acid Promote Migration of Three-Dimensional Colorectal Cancer Spheroids. Environmental Science And Technology 2023, 57: 21016-21028. PMID: 38064429, DOI: 10.1021/acs.est.3c04844.
- Sex hormones impact early maturation and immune response in the arteriovenous fistula mouse modelSatam K, Ohashi Y, Thaxton C, Gonzalez L, Setia O, Bai H, Aoyagi Y, Xie Y, Zhang W, Yatsula B, Martin K, Cai Y, Dardik A. Sex hormones impact early maturation and immune response in the arteriovenous fistula mouse model. AJP Heart And Circulatory Physiology 2023, 325: h77-h88. PMID: 37145957, PMCID: PMC10243550, DOI: 10.1152/ajpheart.00049.2023.
- Role of PDE10A in vascular smooth muscle cell hyperplasia and pathological vascular remodelling.Luo L, Cai Y, Zhang Y, Hsu CG, Korshunov VA, Long X, Knight PA, Berk BC, Yan C. Role of PDE10A in vascular smooth muscle cell hyperplasia and pathological vascular remodelling. Cardiovasc Res 2022, 118: 2703-2717. PMID: 34550322, DOI: 10.1093/cvr/cvab304.
- Recovery of limb perfusion and function after hindlimb ischemia is impaired by arterial calcificationZettervall SL, Wang X, Monk S, Lin T, Cai Y, Guzman RJ. Recovery of limb perfusion and function after hindlimb ischemia is impaired by arterial calcification. Physiological Reports 2021, 9: e15008. PMID: 34405571, PMCID: PMC8371346, DOI: 10.14814/phy2.15008.
- Cyclic nucleotide phosphodiesterase 1C contributes to abdominal aortic aneurysm.Zhang C, Zhao H, Cai Y, Xiong J, Mohan A, Lou D, Shi H, Zhang Y, Long X, Wang J, Yan C. Cyclic nucleotide phosphodiesterase 1C contributes to abdominal aortic aneurysm. Proc Natl Acad Sci U S A 2021, 118 PMID: 34312235, DOI: 10.1073/pnas.2107898118.
- Salt-Inducible Kinase 3 Promotes Vascular Smooth Muscle Cell Proliferation and Arterial Restenosis by Regulating AKT and PKA-CREB SignalingCai Y, Wang XL, Lu J, Lin X, Dong J, Guzman RJ. Salt-Inducible Kinase 3 Promotes Vascular Smooth Muscle Cell Proliferation and Arterial Restenosis by Regulating AKT and PKA-CREB Signaling. Arteriosclerosis Thrombosis And Vascular Biology 2021, 41: 2431-2451. PMID: 34196217, PMCID: PMC8411910, DOI: 10.1161/atvbaha.121.316219.
- Medial artery calcification increases neointimal hyperplasia after balloon injuryMarshall AP, Luo W, Wang XL, Lin T, Cai Y, Guzman RJ. Medial artery calcification increases neointimal hyperplasia after balloon injury. Scientific Reports 2019, 9: 8193. PMID: 31160618, PMCID: PMC6547750, DOI: 10.1038/s41598-019-44668-4.
- Inhibition of endo-lysosomal function exacerbates vascular calcificationCai Y, Wang XL, Flores AM, Lin T, Guzman RJ. Inhibition of endo-lysosomal function exacerbates vascular calcification. Scientific Reports 2018, 8: 3377. PMID: 29467541, PMCID: PMC5821871, DOI: 10.1038/s41598-017-17540-6.
- PDE1C deficiency antagonizes pathological cardiac remodeling and dysfunction.Knight WE, Chen S, Zhang Y, Oikawa M, Wu M, Zhou Q, Miller CL, Cai Y, Mickelsen DM, Moravec C, Small EM, Abe J, Yan C. PDE1C deficiency antagonizes pathological cardiac remodeling and dysfunction. Proc Natl Acad Sci U S A 2016, 113: E7116-E7125. PMID: 27791092, DOI: 10.1073/pnas.1607728113.
- Dorsomorphin homologue 1, a highly selective small-molecule bone morphogenetic protein inhibitor, suppresses medial artery calcificationLin T, Wang XL, Zettervall SL, Cai Y, Guzman RJ. Dorsomorphin homologue 1, a highly selective small-molecule bone morphogenetic protein inhibitor, suppresses medial artery calcification. Journal Of Vascular Surgery 2016, 66: 586-593. PMID: 27374065, PMCID: PMC5201454, DOI: 10.1016/j.jvs.2016.03.462.
- Role of cAMP-phosphodiesterase 1C signaling in regulating growth factor receptor stability, vascular smooth muscle cell growth, migration, and neointimal hyperplasia.Cai Y, Nagel DJ, Zhou Q, Cygnar KD, Zhao H, Li F, Pi X, Knight PA, Yan C. Role of cAMP-phosphodiesterase 1C signaling in regulating growth factor receptor stability, vascular smooth muscle cell growth, migration, and neointimal hyperplasia. Circ Res 2015, 116: 1120-32. PMID: 25608528, DOI: 10.1161/CIRCRESAHA.116.304408.
- Cyclic nucleotide phosphodiesterase 3A1 protects the heart against ischemia-reperfusion injury.Oikawa M, Wu M, Lim S, Knight WE, Miller CL, Cai Y, Lu Y, Blaxall BC, Takeishi Y, Abe J, Yan C. Cyclic nucleotide phosphodiesterase 3A1 protects the heart against ischemia-reperfusion injury. J Mol Cell Cardiol 2013, 64: 11-9. PMID: 23988739, DOI: 10.1016/j.yjmcc.2013.08.003.
- Vinpocetine attenuates lipid accumulation and atherosclerosis formation.Cai Y, Li JD, Yan C. Vinpocetine attenuates lipid accumulation and atherosclerosis formation. Biochem Biophys Res Commun 2013, 434: 439-43. PMID: 23583194, DOI: 10.1016/j.bbrc.2013.03.092.
- Vinpocetine suppresses pathological vascular remodeling by inhibiting vascular smooth muscle cell proliferation and migration.Cai Y, Knight WE, Guo S, Li JD, Knight PA, Yan C. Vinpocetine suppresses pathological vascular remodeling by inhibiting vascular smooth muscle cell proliferation and migration. J Pharmacol Exp Ther 2012, 343: 479-88. PMID: 22915768, DOI: 10.1124/jpet.112.195446.
- The short-time treatment with curcumin sufficiently decreases cell viability, induces apoptosis and copper enhances these effects in multidrug-resistant K562/A02 cells.Lu JJ, Cai YJ, Ding J. The short-time treatment with curcumin sufficiently decreases cell viability, induces apoptosis and copper enhances these effects in multidrug-resistant K562/A02 cells. Mol Cell Biochem 2012, 360: 253-60. PMID: 21938404, DOI: 10.1007/s11010-011-1064-2.
- Cyclic nucleotide phosphodiesterase 1 regulates lysosome-dependent type I collagen protein degradation in vascular smooth muscle cells.Cai Y, Miller CL, Nagel DJ, Jeon KI, Lim S, Gao P, Knight PA, Yan C. Cyclic nucleotide phosphodiesterase 1 regulates lysosome-dependent type I collagen protein degradation in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 2011, 31: 616-23. PMID: 21148428, DOI: 10.1161/ATVBAHA.110.212621.
- Ca2+/calmodulin-stimulated PDE1 regulates the beta-catenin/TCF signaling through PP2A B56 gamma subunit in proliferating vascular smooth muscle cells.Jeon KI, Jono H, Miller CL, Cai Y, Lim S, Liu X, Gao P, Abe J, Li JD, Yan C. Ca2+/calmodulin-stimulated PDE1 regulates the beta-catenin/TCF signaling through PP2A B56 gamma subunit in proliferating vascular smooth muscle cells. FEBS J 2010, 277: 5026-39. PMID: 21078118, DOI: 10.1111/j.1742-4658.2010.07908.x.
- Role of Ca2+/calmodulin-stimulated cyclic nucleotide phosphodiesterase 1 in mediating cardiomyocyte hypertrophy.Miller CL, Oikawa M, Cai Y, Wojtovich AP, Nagel DJ, Xu X, Xu H, Florio V, Rybalkin SD, Beavo JA, Chen YF, Li JD, Blaxall BC, Abe J, Yan C. Role of Ca2+/calmodulin-stimulated cyclic nucleotide phosphodiesterase 1 in mediating cardiomyocyte hypertrophy. Circ Res 2009, 105: 956-64. PMID: 19797176, DOI: 10.1161/CIRCRESAHA.109.198515.
- Naphthalimides induce G(2) arrest through the ATM-activated Chk2-executed pathway in HCT116 cells.Zhu H, Miao ZH, Huang M, Feng JM, Zhang ZX, Lu JJ, Cai YJ, Tong LJ, Xu YF, Qian XH, Ding J. Naphthalimides induce G(2) arrest through the ATM-activated Chk2-executed pathway in HCT116 cells. Neoplasia 2009, 11: 1226-34. PMID: 19881958, DOI: 10.1593/neo.09986.
- Salvicine triggers DNA double-strand breaks and apoptosis by GSH-depletion-driven H2O2 generation and topoisomerase II inhibition.Cai YJ, Lu JJ, Zhu H, Xie H, Huang M, Lin LP, Zhang XW, Ding J. Salvicine triggers DNA double-strand breaks and apoptosis by GSH-depletion-driven H2O2 generation and topoisomerase II inhibition. Free Radic Biol Med 2008, 45: 627-35. PMID: 18582559, DOI: 10.1016/j.freeradbiomed.2008.05.017.
- Dihydroartemisinin induces apoptosis in HL-60 leukemia cells dependent of iron and p38 mitogen-activated protein kinase activation but independent of reactive oxygen species.Lu JJ, Meng LH, Cai YJ, Chen Q, Tong LJ, Lin LP, Ding J. Dihydroartemisinin induces apoptosis in HL-60 leukemia cells dependent of iron and p38 mitogen-activated protein kinase activation but independent of reactive oxygen species. Cancer Biol Ther 2008, 7: 1017-23. PMID: 18414062, DOI: 10.4161/cbt.7.7.6035.
- Chk1 and Chk2 are differentially involved in homologous recombination repair and cell cycle arrest in response to DNA double-strand breaks induced by camptothecins.Huang M, Miao ZH, Zhu H, Cai YJ, Lu W, Ding J. Chk1 and Chk2 are differentially involved in homologous recombination repair and cell cycle arrest in response to DNA double-strand breaks induced by camptothecins. Mol Cancer Ther 2008, 7: 1440-9. PMID: 18566216, DOI: 10.1158/1535-7163.MCT-07-2116.
- Structural modification of an angiogenesis inhibitor discovered from traditional Chinese medicine and a structure-activity relationship study.Yang SP, Cai YJ, Zhang BL, Tong LJ, Xie H, Wu Y, Lin LP, Ding J, Yue JM. Structural modification of an angiogenesis inhibitor discovered from traditional Chinese medicine and a structure-activity relationship study. J Med Chem 2008, 51: 77-85. PMID: 18078313, DOI: 10.1021/jm070906g.
- Reactive oxygen species contribute to cell killing and P-glycoprotein downregulation by salvicine in multidrug resistant K562/A02 cells.Cai Y, Lu J, Miao Z, Lin L, Ding J. Reactive oxygen species contribute to cell killing and P-glycoprotein downregulation by salvicine in multidrug resistant K562/A02 cells. Cancer Biol Ther 2007, 6: 1794-9. PMID: 18032928, DOI: 10.4161/cbt.6.11.4860.
- MFTZ-1, an actinomycetes subspecies derived antitumor macrolide, functions as a novel topoisomerase II poison.Xie CY, Zhu H, Lin LP, Miao ZH, Geng MY, Cai YJ, Chen Y, Zhao HJ, Luo HB, Zhang XW, Fan LM, Shen YM, Ding J. MFTZ-1, an actinomycetes subspecies derived antitumor macrolide, functions as a novel topoisomerase II poison. Mol Cancer Ther 2007, 6: 3059-70. PMID: 18025289, DOI: 10.1158/1535-7163.MCT-07-0014.
- Chimmitecan, a novel 9-substituted camptothecin, with improved anticancer pharmacologic profiles in vitro and in vivo.Huang M, Gao H, Chen Y, Zhu H, Cai Y, Zhang X, Miao Z, Jiang H, Zhang J, Shen H, Lin L, Lu W, Ding J. Chimmitecan, a novel 9-substituted camptothecin, with improved anticancer pharmacologic profiles in vitro and in vivo. Clin Cancer Res 2007, 13: 1298-307. PMID: 17287296, DOI: 10.1158/1078-0432.CCR-06-1277.
- R16, a novel amonafide analogue, induces apoptosis and G2-M arrest via poisoning topoisomerase II.Zhu H, Huang M, Yang F, Chen Y, Miao ZH, Qian XH, Xu YF, Qin YX, Luo HB, Shen X, Geng MY, Cai YJ, Ding J. R16, a novel amonafide analogue, induces apoptosis and G2-M arrest via poisoning topoisomerase II. Mol Cancer Ther 2007, 6: 484-95. PMID: 17308047, DOI: 10.1158/1535-7163.MCT-06-0584.
- DNA damage induced by resveratrol and its synthetic analogues in the presence of Cu (II) ions: mechanism and structure-activity relationship.Zheng LF, Wei QY, Cai YJ, Fang JG, Zhou B, Yang L, Liu ZL. DNA damage induced by resveratrol and its synthetic analogues in the presence of Cu (II) ions: mechanism and structure-activity relationship. Free Radic Biol Med 2006, 41: 1807-16. PMID: 17157183, DOI: 10.1016/j.freeradbiomed.2006.09.007.
- Cytotoxic and apoptotic activities of diarylheptanoids and gingerol-related compounds from the rhizome of Chinese ginger.Wei QY, Ma JP, Cai YJ, Yang L, Liu ZL. Cytotoxic and apoptotic activities of diarylheptanoids and gingerol-related compounds from the rhizome of Chinese ginger. J Ethnopharmacol 2005, 102: 177-84. PMID: 16024193, DOI: 10.1016/j.jep.2005.05.043.
- Reactive oxygen species elicit apoptosis by concurrently disrupting topoisomerase II and DNA-dependent protein kinase.Lu HR, Zhu H, Huang M, Chen Y, Cai YJ, Miao ZH, Zhang JS, Ding J. Reactive oxygen species elicit apoptosis by concurrently disrupting topoisomerase II and DNA-dependent protein kinase. Mol Pharmacol 2005, 68: 983-94. PMID: 16024664, DOI: 10.1124/mol.105.011544.
- Diterpenoids from the Chinese herb Caryopteris terniflora and their antibacterial and antitumor activity.Zhang YH, Wang YL, Wei QY, Cai YJ, Wang Q, Liu ZL. Diterpenoids from the Chinese herb Caryopteris terniflora and their antibacterial and antitumor activity. Pharmazie 2005, 60: 551-3. PMID: 16076086.
- The 3,4-dihydroxyl groups are important for trans-resveratrol analogs to exhibit enhanced antioxidant and apoptotic activities.Cai YJ, Wei QY, Fang JG, Yang L, Liu ZL, Wyche JH, Han Z. The 3,4-dihydroxyl groups are important for trans-resveratrol analogs to exhibit enhanced antioxidant and apoptotic activities. Anticancer Res 2004, 24: 999-1002. PMID: 15161055.
- Structure determination, apoptosis induction, and telomerase inhibition of CFP-2, a novel lichenin from Cladonia furcata.Lin X, Cai YJ, Li ZX, Chen Q, Liu ZL, Wang R. Structure determination, apoptosis induction, and telomerase inhibition of CFP-2, a novel lichenin from Cladonia furcata. Biochim Biophys Acta 2003, 1622: 99-108. PMID: 12880947, DOI: 10.1016/s0304-4165(03)00131-4.
- Inhibition of free radical-induced peroxidation of rat liver microsomes by resveratrol and its analogues.Cai YJ, Fang JG, Ma LP, Yang L, Liu ZL. Inhibition of free radical-induced peroxidation of rat liver microsomes by resveratrol and its analogues. Biochim Biophys Acta 2003, 1637: 31-8. PMID: 12527404, DOI: 10.1016/s0925-4439(02)00174-6.
- Antioxidant effects of green tea polyphenols on free radical initiated peroxidation of rat liver microsomes.Cai YJ, Ma LP, Hou LF, Zhou B, Yang L, Liu ZL. Antioxidant effects of green tea polyphenols on free radical initiated peroxidation of rat liver microsomes. Chem Phys Lipids 2002, 120: 109-17. PMID: 12426080, DOI: 10.1016/s0009-3084(02)00110-x.
- Antioxidative and free radical scavenging effects of ecdysteroids from Serratula strangulata.Cai YJ, Dai JQ, Fang JG, Ma LP, Hou LF, Yang L, Liu ZL. Antioxidative and free radical scavenging effects of ecdysteroids from Serratula strangulata. Can J Physiol Pharmacol 2002, 80: 1187-94. PMID: 12564645, DOI: 10.1139/y02-152.
- Efficiency and structure-activity relationship of the antioxidant action of resveratrol and its analogs.Lu M, Cai YJ, Fang JG, Zhou YL, Liu ZL, Wu LM. Efficiency and structure-activity relationship of the antioxidant action of resveratrol and its analogs. Pharmazie 2002, 57: 474-8. PMID: 12168529.
- Cladonia furcata polysaccharide induced apoptosis in human leukemia K562 cells.Lin X, Cai YJ, Li ZX, Liu ZL, Yin SF, Zhao JC. Cladonia furcata polysaccharide induced apoptosis in human leukemia K562 cells. Acta Pharmacol Sin 2001, 22: 716-20. PMID: 11749844.