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Sajid A Khan

MD, FACS, FSSO

Associate Professor of Surgery (Oncology); Section Chief, Hepato-Pancreato-Biliary (HPB) and Mixed Tumors; Co-Director of Team Science, Yale Center for Clinical Investigation (YCCI)

Contact Information

Sajid A Khan, MD, FACS, FSSO

Lab Location

Khan Lab
Brady Memorial Laboratory
310 Cedar Street, Ste Suite 212
New Haven, CT 06510
Business Office:203.337.8507

Office Location

Yale Surgical Oncology
Farnam Memorial Building
310 Cedar Street, Ste 130
New Haven, CT 06510
Business Office:203.337.8507
Business Office Fax:203.330.7461

Mailing Address

Surgical Oncology
PO BOX 208062
New Haven, CT 06520-8062
United States

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Patient Care

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Research & Publications
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Research Summary

Dr. Khan is an NIH-funded, well published, surgeon-scientist who seeks to use modern molecular biology to improve our understanding and treatment of patients with gastrointestinal cancers. The Khan lab performs basic scientific investigation and translational research in close collaboration with other experts at the Yale Cancer Center in order to advance the field of oncology. Our lab is currently studying the genetic basis underlying the mechanism of metastasis, in addition to the relationship between sex hormones, metabolite and RNA expression on colon cancer patient outcomes. Furthermore, we perform clinical outcomes research in surgery for cancers which arise from the stomach, liver, pancreas, bile duct, small intestine, colon, appendix, and skin. Dr. Khan is also the Principal Investigator at Yale for a national clinical trial sponsored by the Southwest Oncology Group (SWOG) studying colorectal cancer chemoprevention.

Extensive Research Description

Coauthors

Research Interests

Liver; Molecular Biology; Neoplasm Metastasis; Stomach Neoplasms; Colorectal Neoplasms; Cholangiocarcinoma; Carcinoma, Pancreatic Ductal; Gastrointestinal Stromal Tumors; Translational Research, Biomedical; Metastasectomy

Research Images

mRNA expression correlates with clinical outcome for liver metastases

Selected Publications

Bile acid distributions, sex-specificity, and prognosis in colorectal cancerCai Y, Shen X, Lu L, Yan H, Huang H, Gaule P, Muca E, Theriot CM, Rattray Z, Rattray NJW, Lu J, Ahuja N, Zhang Y, Paty PB, Khan SA, Johnson CH. Bile acid distributions, sex-specificity, and prognosis in colorectal cancer Biology Of Sex Differences 2022, 13: 61. PMID: 36274154, PMCID: PMC9590160, DOI: 10.1186/s13293-022-00473-9.
Hemoglobin normalization outperforms other methods for standardizing dried blood spot metabolomics: A comparative studyJain A, Morris M, Lin EZ, Khan SA, Ma X, Deziel NC, Godri Pollitt KJ, Johnson CH. Hemoglobin normalization outperforms other methods for standardizing dried blood spot metabolomics: A comparative study The Science Of The Total Environment 2022, 854: 158716. PMID: 36113793, DOI: 10.1016/j.scitotenv.2022.158716.
Asparagine, colorectal cancer, and the role of sex, genes, microbes, and diet: A narrative reviewShen X, Jain A, Aladelokun O, Yan H, Gilbride A, Ferrucci LM, Lu L, Khan SA, Johnson CH. Asparagine, colorectal cancer, and the role of sex, genes, microbes, and diet: A narrative review Frontiers In Molecular Biosciences 2022, 9: 958666. PMID: 36090030, PMCID: PMC9453556, DOI: 10.3389/fmolb.2022.958666.
Evaluation of Racial Disparities in Quality of Care for Patients With Gastrointestinal Tract Cancer Treated With SurgeryBakkila BF, Kerekes D, Nunez-Smith M, Billingsley KG, Ahuja N, Wang K, Oladele C, Johnson CH, Khan SA. Evaluation of Racial Disparities in Quality of Care for Patients With Gastrointestinal Tract Cancer Treated With Surgery JAMA Network Open 2022, 5: e225664. PMID: 35377425, PMCID: PMC8980937, DOI: 10.1001/jamanetworkopen.2022.5664.
HSR22-125: Quality of Gastrointestinal Surgical Oncology Care According to Insurance StatusBakkila B, Kerekes D, Johnson C, Khan S. HSR22-125: Quality of Gastrointestinal Surgical Oncology Care According to Insurance Status Journal Of The National Comprehensive Cancer Network 2022, 20: hsr22-125. DOI: 10.6004/jnccn.2021.7261.
Lipid Metabolism in Biliary Tract Cancer: A New Therapeutic Target?Kerekes DM, Khan SA. Lipid Metabolism in Biliary Tract Cancer: A New Therapeutic Target? Annals Of Surgical Oncology 2022, 29: 2750-2751. PMID: 35243594, DOI: 10.1245/s10434-022-11383-w.
Asparagine Metabolism in Tumors Is Linked to Poor Survival in Females with Colorectal Cancer: A Cohort StudyShen X, Cai Y, Lu L, Huang H, Yan H, Paty PB, Muca E, Ahuja N, Zhang Y, Johnson CH, Khan SA. Asparagine Metabolism in Tumors Is Linked to Poor Survival in Females with Colorectal Cancer: A Cohort Study Metabolites 2022, 12: 164. PMID: 35208238, PMCID: PMC8875032, DOI: 10.3390/metabo12020164.
Epigenetic signatures differentiate uterine and soft tissue leiomyosarcomaHasan NM, Sharma A, Ruzgar NM, Deshpande H, Olino K, Khan S, Ahuja N. Epigenetic signatures differentiate uterine and soft tissue leiomyosarcoma Oncotarget 2021, 12: 1566-1579. PMID: 34381562, PMCID: PMC8351604, DOI: 10.18632/oncotarget.28032.
Neuroendocrine and Adrenal Tumors, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology.Shah MH, Goldner WS, Benson AB, Bergsland E, Blaszkowsky LS, Brock P, Chan J, Das S, Dickson PV, Fanta P, Giordano T, Halfdanarson TR, Halperin D, He J, Heaney A, Heslin MJ, Kandeel F, Kardan A, Khan SA, Kuvshinoff BW, Lieu C, Miller K, Pillarisetty VG, Reidy D, Salgado SA, Shaheen S, Soares HP, Soulen MC, Strosberg JR, Sussman CR, Trikalinos NA, Uboha NA, Vijayvergia N, Wong T, Lynn B, Hochstetler C. Neuroendocrine and Adrenal Tumors, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology. Journal Of The National Comprehensive Cancer Network : JNCCN 2021, 19: 839-868. PMID: 34340212, DOI: 10.6004/jnccn.2021.0032.
Kynurenic acid may underlie sex-specific immune responses to COVID-19Cai Y, Kim DJ, Takahashi T, Broadhurst DI, Yan H, Ma S, Rattray NJW, Casanovas-Massana A, Israelow B, Klein J, Lucas C, Mao T, Moore AJ, Muenker MC, Oh JE, Silva J, Wong P, team Y, Ko AI, Khan SA, Iwasaki A, Johnson CH. Kynurenic acid may underlie sex-specific immune responses to COVID-19 Science Signaling 2021, 14: eabf8483. PMID: 34230210, PMCID: PMC8432948, DOI: 10.1126/scisignal.abf8483.
Intratumour microbiome associated with the infiltration of cytotoxic CD8+ T cells and patient survival in cutaneous melanomaZhu G, Su H, Johnson CH, Khan SA, Kluger H, Lu L. Intratumour microbiome associated with the infiltration of cytotoxic CD8+ T cells and patient survival in cutaneous melanoma European Journal Of Cancer 2021, 151: 25-34. PMID: 33962358, PMCID: PMC8184628, DOI: 10.1016/j.ejca.2021.03.053.
5‐Fluorouracil efficacy requires anti‐tumor immunity triggered by cancer‐cell‐intrinsic STINGTian J, Zhang D, Kurbatov V, Wang Q, Wang Y, Fang D, Wu L, Bosenberg M, Muzumdar MD, Khan S, Lu Q, Yan Q, Lu J. 5‐Fluorouracil efficacy requires anti‐tumor immunity triggered by cancer‐cell‐intrinsic STING The EMBO Journal 2021, 40: e106065. PMID: 33615517, PMCID: PMC8013832, DOI: 10.15252/embj.2020106065.
Gene Alterations of N6-Methyladenosine (m6A) Regulators in Colorectal Cancer: A TCGA Database StudyZhang Q, Cai Y, Kurbatov V, Khan SA, Lu L, Zhang Y, Johnson CH. Gene Alterations of N6-Methyladenosine (m6A) Regulators in Colorectal Cancer: A TCGA Database Study BioMed Research International 2020, 2020: 8826456. PMID: 33415160, PMCID: PMC7769650, DOI: 10.1155/2020/8826456.
Margin negative resection and pathologic downstaging with multiagent chemotherapy with or without radiotherapy in patients with localized pancreas cancer: A national cancer database analysisMiccio JA, Talcott WJ, Patel T, Park HS, Cecchini M, Salem RR, Khan SA, Stein S, Kortmansky JS, Lacy J, Narang A, Herman J, Jabbour SK, Hallemeier CL, Johung K, Jethwa KR. Margin negative resection and pathologic downstaging with multiagent chemotherapy with or without radiotherapy in patients with localized pancreas cancer: A national cancer database analysis Clinical And Translational Radiation Oncology 2020, 27: 15-23. PMID: 33392398, PMCID: PMC7772693, DOI: 10.1016/j.ctro.2020.12.003.
Treatment Selection and Survival Outcomes in Locally Advanced Proximal Gastric Cancer: A National Cancer Data Base AnalysisTang S, Liu F, Li Y, Zhao L, Wang X, Khan SA, Chen Y, Zhang Y. Treatment Selection and Survival Outcomes in Locally Advanced Proximal Gastric Cancer: A National Cancer Data Base Analysis Frontiers In Oncology 2020, 10: 537051. PMID: 33102212, PMCID: PMC7546198, DOI: 10.3389/fonc.2020.537051.
Kynurenic acid underlies sex-specific immune responses to COVID-19.Cai Y, Kim DJ, Takahashi T, Broadhurst DI, Ma S, Rattray NJW, Casanovas-Massana A, Israelow B, Klein J, Lucas C, Mao T, Moore AJ, Muenker MC, Oh J, Silva J, Wong P, Ko AJ, Khan SA, Iwasaki A, Johnson CH. Kynurenic acid underlies sex-specific immune responses to COVID-19. MedRxiv : The Preprint Server For Health Sciences 2020 PMID: 32935119, PMCID: PMC7491534, DOI: 10.1101/2020.09.06.20189159.
Tumor Tissue-Specific Biomarkers of Colorectal Cancer by Anatomic Location and StageCai Y, Rattray NJW, Zhang Q, Mironova V, Santos-Neto A, Muca E, Vollmar AKR, Hsu KS, Rattray Z, Cross JR, Zhang Y, Paty PB, Khan SA, Johnson CH. Tumor Tissue-Specific Biomarkers of Colorectal Cancer by Anatomic Location and Stage Metabolites 2020, 10: 257. PMID: 32575361, PMCID: PMC7345993, DOI: 10.3390/metabo10060257.
Sex Differences in Colon Cancer Metabolism Reveal A Novel SubphenotypeCai Y, Rattray NJW, Zhang Q, Mironova V, Santos-Neto A, Hsu KS, Rattray Z, Cross JR, Zhang Y, Paty PB, Khan SA, Johnson CH. Sex Differences in Colon Cancer Metabolism Reveal A Novel Subphenotype Scientific Reports 2020, 10: 4905. PMID: 32184446, PMCID: PMC7078199, DOI: 10.1038/s41598-020-61851-0.
Palliative care is underutilized and affects healthcare costs in ruptured abdominal aortic aneurysmsLiu S, Heller DR, Jean RA, Chiu AS, Khan SA, Dardik A. Palliative care is underutilized and affects healthcare costs in ruptured abdominal aortic aneurysms Surgery 2020, 168: 234-236. PMID: 32139140, PMCID: PMC7748368, DOI: 10.1016/j.surg.2020.01.017.
Association of Treatment Inequity and Ancestry With Pancreatic Ductal Adenocarcinoma SurvivalHeller DR, Nicolson NG, Ahuja N, Khan S, Kunstman JW. Association of Treatment Inequity and Ancestry With Pancreatic Ductal Adenocarcinoma Survival JAMA Surgery 2020, 155: e195047. PMID: 31800002, PMCID: PMC6902102, DOI: 10.1001/jamasurg.2019.5047.
Liver-first approach to stage IV colon cancer with synchronous isolated liver metastasesKurbatov V, Resio BJ, Cama CA, Heller DR, Cha C, Zhang Y, Lu J, Khan SA. Liver-first approach to stage IV colon cancer with synchronous isolated liver metastases Journal Of Gastrointestinal Oncology 2020, 11: 76-83. PMID: 32175108, PMCID: PMC7052756, DOI: 10.21037/jgo.2020.01.03.
Exploring Microsatellite Instability (MSI) in Colorectal Cancer at Elevated Microsatellite Alterations at Selected Tetranucleotides (EMAST)Kurbatov V, Khan SA. Exploring Microsatellite Instability (MSI) in Colorectal Cancer at Elevated Microsatellite Alterations at Selected Tetranucleotides (EMAST) Annals Of Surgical Oncology 2019, 27: 973-974. PMID: 31788754, DOI: 10.1245/s10434-019-08051-x.
Molecular Pathway Analysis Indicates a Distinct Metabolic Phenotype in Women With Right-Sided Colon CancerSun Y, Mironova V, Chen Y, Lundh EPF, Zhang Q, Cai Y, Vasiliou V, Zhang Y, Garcia-Milian R, Khan SA, Johnson CH. Molecular Pathway Analysis Indicates a Distinct Metabolic Phenotype in Women With Right-Sided Colon Cancer Translational Oncology 2019, 13: 42-56. PMID: 31760268, PMCID: PMC6883319, DOI: 10.1016/j.tranon.2019.09.004.
Lymph Node Status In Reply to CarrHeller DR, Jean RA, Khan SA. Lymph Node Status In Reply to Carr Journal Of The American College Of Surgeons 2019, 229: 516-517. PMID: 31655706, DOI: 10.1016/j.jamcollsurg.2019.07.007.
Appendiceal Carcinoid Tumors In Reply to SugarbakerHeller DR, Jean RA, Khan SA. Appendiceal Carcinoid Tumors In Reply to Sugarbaker Journal Of The American College Of Surgeons 2019, 229: 519. PMID: 31655709, DOI: 10.1016/j.jamcollsurg.2019.07.005.
Predictors of Lymph Node Involvement by Soft Tissue Sarcoma of the Trunk and Extremity: An Analysis of the National Cancer DatabaseMiccio JA, Jairam V, Gao S, Augustyn A, Oladeru OT, Onderdonk BE, Chowdhary M, Han D, Khan S, Friedlaender G, Lindskog DM, Desphande HA, Osborn H, Roberts KB, Patel KR. Predictors of Lymph Node Involvement by Soft Tissue Sarcoma of the Trunk and Extremity: An Analysis of the National Cancer Database Cureus 2019, 11: e6038. PMID: 31824805, PMCID: PMC6886621, DOI: 10.7759/cureus.6038.
Hepatocellular carcinoma: Impact of academic setting and hospital volume on patient survivalUhlig J, Sellers CM, Khan SA, Cha C, Kim HS. Hepatocellular carcinoma: Impact of academic setting and hospital volume on patient survival Surgical Oncology 2019, 31: 111-118. PMID: 31654956, DOI: 10.1016/j.suronc.2019.10.009.
Digital Inference of Immune Microenvironment Reveals Low-Risk Subtype of Early Lung AdenocarcinomaKurbatov V, Balayev A, Saffarzadeh A, Heller DR, Boffa DJ, Blasberg JD, Lu J, Khan SA. Digital Inference of Immune Microenvironment Reveals Low-Risk Subtype of Early Lung Adenocarcinoma The Annals Of Thoracic Surgery 2019, 109: 343-349. PMID: 31568747, DOI: 10.1016/j.athoracsur.2019.08.050.
APC mutational patterns in gastric adenocarcinoma are enriched for missense variants with associated decreased survivalRubinstein JC, Khan SA, Christison‐Lagay E, Cha C. APC mutational patterns in gastric adenocarcinoma are enriched for missense variants with associated decreased survival Genes Chromosomes And Cancer 2019, 59: 64-68. PMID: 31353684, DOI: 10.1002/gcc.22792.
Joint effect of pre-operative anemia and perioperative blood transfusion on outcomes of colon-cancer patients undergoing colectomyLiu Z, Luo JJ, Pei KY, Khan SA, Wang XX, Zhao ZX, Yang M, Johnson CH, Wang XS, Zhang Y. Joint effect of pre-operative anemia and perioperative blood transfusion on outcomes of colon-cancer patients undergoing colectomy Gastroenterology Report 2019, 8: 151-157. PMID: 32280475, PMCID: PMC7136710, DOI: 10.1093/gastro/goz033.
Patterns of failure after immunotherapy with checkpoint inhibitors predict durable progression-free survival after local therapy for metastatic melanomaKlemen ND, Wang M, Feingold PL, Cooper K, Pavri SN, Han D, Detterbeck FC, Boffa DJ, Khan SA, Olino K, Clune J, Ariyan S, Salem RR, Weiss SA, Kluger HM, Sznol M, Cha C. Patterns of failure after immunotherapy with checkpoint inhibitors predict durable progression-free survival after local therapy for metastatic melanoma Journal For ImmunoTherapy Of Cancer 2019, 7: 196. PMID: 31340861, PMCID: PMC6657062, DOI: 10.1186/s40425-019-0672-3.
Comparison on Clinicopathological Features, Treatments and Prognosis between Proximal Gastric Cancer and Distal Gastric Cancer: A National Cancer Data Base AnalysisWang X, Liu F, Li Y, Tang S, Zhang Y, Chen Y, Khan SA. Comparison on Clinicopathological Features, Treatments and Prognosis between Proximal Gastric Cancer and Distal Gastric Cancer: A National Cancer Data Base Analysis Journal Of Cancer 2019, 10: 3145-3153. PMID: 31289585, PMCID: PMC6603385, DOI: 10.7150/jca.30371.
The Role of Bowel Preparation in Open, Minimally Invasive, and Converted-to-Open ColectomyLuo J, Liu Z, Pei KY, Khan SA, Wang X, Yang M, Wang X, Zhang Y. The Role of Bowel Preparation in Open, Minimally Invasive, and Converted-to-Open Colectomy Journal Of Surgical Research 2019, 242: 183-192. PMID: 31085366, DOI: 10.1016/j.jss.2019.02.039.
Practice Patterns and Guideline Non-Adherence in Surgical Management of Appendiceal Carcinoid TumorsHeller DR, Jean RA, Luo J, Kurbatov V, Grisotti G, Jacobs D, Chiu AS, Zhang Y, Khan SA. Practice Patterns and Guideline Non-Adherence in Surgical Management of Appendiceal Carcinoid Tumors Journal Of The American College Of Surgeons 2019, 228: 839-851. PMID: 30898583, PMCID: PMC6751559, DOI: 10.1016/j.jamcollsurg.2019.02.050.
Does sentinel lymph node status have prognostic significance in patients with acral lentiginous melanoma?Pavri SN, Han G, Khan S, Han D. Does sentinel lymph node status have prognostic significance in patients with acral lentiginous melanoma? Journal Of Surgical Oncology 2019, 119: 1060-1069. PMID: 30883783, DOI: 10.1002/jso.25445.
03:27 PM Abstract No. 319 Multidisciplinary center experience and academic setting for HCC treatment: impact on outcomes for interventional oncologyUhlig J, Sellers C, Khan S, Cha C, Kim H. 03:27 PM Abstract No. 319 Multidisciplinary center experience and academic setting for HCC treatment: impact on outcomes for interventional oncology Journal Of Vascular And Interventional Radiology 2019, 30: s141. DOI: 10.1016/j.jvir.2018.12.387.
Impact of hospital volume and type on survival in hepatocellular carcinoma: Results from the National Cancer Database.Uhlig J, Sellers C, Khan S, Cha C, Kim H. Impact of hospital volume and type on survival in hepatocellular carcinoma: Results from the National Cancer Database. Journal Of Clinical Oncology 2019, 37: 417-417. DOI: 10.1200/jco.2019.37.4_suppl.417.
Intrahepatic Cholangiocarcinoma: Socioeconomic Discrepancies, Contemporary Treatment Approaches and Survival Trends from the National Cancer DatabaseUhlig J, Sellers CM, Cha C, Khan SA, Lacy J, Stein SM, Kim HS. Intrahepatic Cholangiocarcinoma: Socioeconomic Discrepancies, Contemporary Treatment Approaches and Survival Trends from the National Cancer Database Annals Of Surgical Oncology 2019, 26: 1993-2000. PMID: 30693451, DOI: 10.1245/s10434-019-07175-4.
How I Treat Gastric and Esophageal Cancer, Surgery.Khan SA, Kurbatov V, Posner MC. Handbook of Gastrointestinal Cancers: Evidence-Based Treatment and Multidisciplinary Patient Care 2019.
Review and current state of radiation therapy for locally advanced pancreatic adenocarcinomaBlakaj A, Stein SM, Khan SA, Johung KL. Review and current state of radiation therapy for locally advanced pancreatic adenocarcinoma Journal Of Gastrointestinal Oncology 2018, 9: 1027-1036. PMID: 30603121, PMCID: PMC6286948, DOI: 10.21037/jgo.2018.03.07.
Author Correction: Integrated molecular subtyping defines a curable oligometastatic state in colorectal liver metastasisPitroda SP, Khodarev NN, Huang L, Uppal A, Wightman SC, Ganai S, Joseph N, Pitt J, Brown M, Forde M, Mangold K, Xue L, Weber C, Segal JP, Kadri S, Stack ME, Khan S, Paty P, Kaul K, Andrade J, White KP, Talamonti M, Posner MC, Hellman S, Weichselbaum RR. Author Correction: Integrated molecular subtyping defines a curable oligometastatic state in colorectal liver metastasis Nature Communications 2018, 9: 4827. PMID: 30425251, PMCID: PMC6233186, DOI: 10.1038/s41467-018-07303-w.
Defining Early-Onset Colon and Rectal CancersJacobs D, Zhu R, Luo J, Grisotti G, Heller DR, Kurbatov V, Johnson CH, Zhang Y, Khan SA. Defining Early-Onset Colon and Rectal Cancers Frontiers In Oncology 2018, 8: 504. PMID: 30460196, PMCID: PMC6232522, DOI: 10.3389/fonc.2018.00504.
Predictors of Lymph Node Involvement by Soft Tissue Sarcoma: An Analysis of the National Cancer Database (NCDB)Miccio J, Jairam V, Gao S, Augustyn A, Oladeru O, Onderdonk B, Costa J, Han D, Khan S, Friedlaender G, Lindskog D, Deshpande H, Tara H, Osborn H, Roberts K, Patel K. Predictors of Lymph Node Involvement by Soft Tissue Sarcoma: An Analysis of the National Cancer Database (NCDB) International Journal Of Radiation Oncology • Biology • Physics 2018, 102: e335. DOI: 10.1016/j.ijrobp.2018.07.1028.
Integrated Molecular Subtyping of Clinical Metastasis: Implications for Defining a Curable Oligometastatic StatePitroda S, Khodarev N, Huang L, Uppal A, Wightman S, Ganai S, Joseph N, Xue L, Weber C, Segal J, Stack M, Khan S, Paty P, Kaul K, Andrade J, White K, Talamonti M, Posner M, Hellman S, Weichselbaum R. Integrated Molecular Subtyping of Clinical Metastasis: Implications for Defining a Curable Oligometastatic State International Journal Of Radiation Oncology • Biology • Physics 2018, 102: s12. DOI: 10.1016/j.ijrobp.2018.06.122.
Impact of Hepatectomy-First in Management of Stage IV Colon Cancer with Synchronous Liver MetastasesKurbatov V, Heller D, Lu J, Khan S. Impact of Hepatectomy-First in Management of Stage IV Colon Cancer with Synchronous Liver Metastases Journal Of The American College Of Surgeons 2018, 227: s66. DOI: 10.1016/j.jamcollsurg.2018.07.139.
Long Noncoding RNA HOTTIP Is Biomarker for Recurrence after Hepatic Metastasectomy for Colorectal CancerKurbatov V, Heller D, Zeng Z, Paty P, Lu J, Khan S. Long Noncoding RNA HOTTIP Is Biomarker for Recurrence after Hepatic Metastasectomy for Colorectal Cancer Journal Of The American College Of Surgeons 2018, 227: s67. DOI: 10.1016/j.jamcollsurg.2018.07.141.
Practice Patterns and Guideline Non-Adherence in Surgical Management of Appendiceal Carcinoid TumorsHeller D, Jean R, Kurbatov V, Chiu A, Khan S. Practice Patterns and Guideline Non-Adherence in Surgical Management of Appendiceal Carcinoid Tumors Journal Of The American College Of Surgeons 2018, 227: e218. DOI: 10.1016/j.jamcollsurg.2018.08.590.
Regional Differences in Palliative Care Utilization Among Geriatric Colorectal Cancer Patients Needing Emergent SurgeryHeller DR, Jean RA, Chiu AS, Feder SI, Kurbatov V, Cha C, Khan SA. Regional Differences in Palliative Care Utilization Among Geriatric Colorectal Cancer Patients Needing Emergent Surgery Journal Of Gastrointestinal Surgery 2018, 23: 153-162. PMID: 30328071, PMCID: PMC6751557, DOI: 10.1007/s11605-018-3929-0.
NCCN Guidelines Insights: Neuroendocrine and Adrenal Tumors, Version 2.2018.Shah MH, Goldner WS, Halfdanarson TR, Bergsland E, Berlin JD, Halperin D, Chan J, Kulke MH, Benson AB, Blaszkowsky LS, Eads J, Engstrom PF, Fanta P, Giordano T, He J, Heslin MJ, Kalemkerian GP, Kandeel F, Khan SA, Kidwai WZ, Kunz PL, Kuvshinoff BW, Lieu C, Pillarisetty VG, Saltz L, Sosa JA, Strosberg JR, Sussman CA, Trikalinos NA, Uboha NA, Whisenant J, Wong T, Yao JC, Burns JL, Ogba N, Zuccarino-Catania G. NCCN Guidelines Insights: Neuroendocrine and Adrenal Tumors, Version 2.2018. Journal Of The National Comprehensive Cancer Network 2018, 16: 693-702. PMID: 29891520, DOI: 10.6004/jnccn.2018.0056.
Clinical impact of underutilization of adjuvant therapy in node positive gastric adenocarcinomaZhu R, Liu F, Grisotti G, Perez-Irizarry J, Salem RR, Cha CH, Johung KL, Boffa DJ, Zhang Y, Khan SA. Clinical impact of underutilization of adjuvant therapy in node positive gastric adenocarcinoma Journal Of Gastrointestinal Oncology 2018, 9: 517-526. PMID: 29998017, PMCID: PMC6006033, DOI: 10.21037/jgo.2018.03.05.
Integrated molecular subtyping defines a curable oligometastatic state in colorectal liver metastasisPitroda SP, Khodarev NN, Huang L, Uppal A, Wightman SC, Ganai S, Joseph N, Pitt J, Brown M, Forde M, Mangold K, Xue L, Weber C, Segal JP, Kadri S, Stack ME, Khan S, Paty P, Kaul K, Andrade J, White KP, Talamonti M, Posner MC, Hellman S, Weichselbaum RR. Integrated molecular subtyping defines a curable oligometastatic state in colorectal liver metastasis Nature Communications 2018, 9: 1793. PMID: 29728604, PMCID: PMC5935683, DOI: 10.1038/s41467-018-04278-6.
420 - Regional Differences in the Utilization of Palliative Care in Geriatric Colorectal Cancer Patients Requiring Emergent SurgeryHeller D, Jean R, Chiu A, Feder S, Kurbatov V, Cha C, Khan S. 420 - Regional Differences in the Utilization of Palliative Care in Geriatric Colorectal Cancer Patients Requiring Emergent Surgery Gastroenterology 2018, 154: s-1269. DOI: 10.1016/s0016-5085(18)34158-1.
Distinctive features of gastrointestinal stromal tumors arising from the colon and rectumZhu R, Liu F, Grisotti G, Pérez-Irizarry J, Cha CH, Johnson CH, Boffa DJ, Han D, Johung KL, Zhang Y, Khan SA. Distinctive features of gastrointestinal stromal tumors arising from the colon and rectum Journal Of Gastrointestinal Oncology 2018, 9: 231-240. PMID: 29755761, PMCID: PMC5934147, DOI: 10.21037/jgo.2017.11.12.
Beyond genomics: understanding exposotypes through metabolomicsRattray NJW, Deziel NC, Wallach JD, Khan SA, Vasiliou V, Ioannidis JPA, Johnson CH. Beyond genomics: understanding exposotypes through metabolomics Human Genomics 2018, 12: 4. PMID: 29373992, PMCID: PMC5787293, DOI: 10.1186/s40246-018-0134-x.
Post-operative radiotherapy is associated with improved survival in esophageal cancer with positive surgical marginsGao SJ, Park HS, Corso CD, Rutter CE, Khan SA, Johung KL. Post-operative radiotherapy is associated with improved survival in esophageal cancer with positive surgical margins Journal Of Gastrointestinal Oncology 2017, 8: 953-961. PMID: 29299354, PMCID: PMC5750177, DOI: 10.21037/jgo.2017.08.12.
The DNA Methylcytosine Dioxygenase Tet2 Sustains Immunosuppressive Function of Tumor-Infiltrating Myeloid Cells to Promote Melanoma ProgressionPan W, Zhu S, Qu K, Meeth K, Cheng J, He K, Ma H, Liao Y, Wen X, Roden C, Tobiasova Z, Wei Z, Zhao J, Liu J, Zheng J, Guo B, Khan SA, Bosenberg M, Flavell RA, Lu J. The DNA Methylcytosine Dioxygenase Tet2 Sustains Immunosuppressive Function of Tumor-Infiltrating Myeloid Cells to Promote Melanoma Progression Immunity 2017, 47: 284-297.e5. PMID: 28813659, PMCID: PMC5710009, DOI: 10.1016/j.immuni.2017.07.020.
Hyperparathyroidism-Jaw Tumor Syndrome Associated With Large-Scale 1q31 DeletionRubinstein JC, Majumdar SK, Laskin W, Lazaga F, Prasad ML, Carling T, Khan SA. Hyperparathyroidism-Jaw Tumor Syndrome Associated With Large-Scale 1q31 Deletion Journal Of The Endocrine Society 2017, 1: 926-930. PMID: 29264543, PMCID: PMC5686645, DOI: 10.1210/js.2016-1089.
Prognostic signatures of oligometastasis in colorectal cancer liver metastasis.Khan S, Paty P, Zeng Z, Lu J. Prognostic signatures of oligometastasis in colorectal cancer liver metastasis. Journal Of Clinical Oncology 2017, 35: 3588-3588. DOI: 10.1200/jco.2017.35.15_suppl.3588.
Predictors of Nonadherence to NCCN Guideline Recommendations for the Management of Stage I Anal Canal Cancer.Kole AJ, Stahl JM, Park HS, Khan SA, Johung KL. Predictors of Nonadherence to NCCN Guideline Recommendations for the Management of Stage I Anal Canal Cancer. Journal Of The National Comprehensive Cancer Network 2017, 15: 355-362. PMID: 28275036, DOI: 10.6004/jnccn.2017.0035.
miR-125b promotes MLL-AF9–driven murine acute myeloid leukemia involving a VEGFA-mediated non–cell-intrinsic mechanismLiu J, Guo B, Chen Z, Wang N, Iacovino M, Cheng J, Roden C, Pan W, Khan S, Chen S, Kyba M, Fan R, Guo S, Lu J. miR-125b promotes MLL-AF9–driven murine acute myeloid leukemia involving a VEGFA-mediated non–cell-intrinsic mechanism Blood 2017, 129: 1491-1502. PMID: 28053194, PMCID: PMC5356452, DOI: 10.1182/blood-2016-06-721027.
Predictors of non-adherence to national comprehensive cancer network management guidelines for stage I anal canal cancerKole AJ, Stahl JM, Park HS, Khan SA, Johung KL. Predictors of non-adherence to national comprehensive cancer network management guidelines for stage I anal canal cancer. Journal of National Comprehensive Cancer Network 2017.
Gastric volvulus after laparoscopic distal pancreatectomy and splenectomy: a case report of a rare post-operative complicationAlkukhun A, Grisotti G, Salem RR, Cha C, Khan SA. Gastric volvulus after laparoscopic distal pancreatectomy and splenectomy: a case report of a rare post-operative complication. In press at American College of Surgeons Case Reviews in Surgery 2017.
EGFR Gene Amplification and KRAS Mutation Predict Response to Combination Targeted Therapy in Metastatic Colorectal CancerKhan SA, Zeng Z, Shia J, Paty PB. EGFR Gene Amplification and KRAS Mutation Predict Response to Combination Targeted Therapy in Metastatic Colorectal Cancer Pathology & Oncology Research 2016, 23: 673-677. PMID: 28025786, PMCID: PMC5451302, DOI: 10.1007/s12253-016-0166-2.
Colorectal cancer in the very young: a comparative study of tumor markers, pathology and survival in early onset and adult onset patientsKhan SA, Morris M, Idrees K, Gimbel MI, Rosenberg S, Zeng Z, Li F, Gan G, Shia J, LaQuaglia MP, Paty PB. Colorectal cancer in the very young: a comparative study of tumor markers, pathology and survival in early onset and adult onset patients Journal Of Pediatric Surgery 2016, 51: 1812-1817. PMID: 27558481, PMCID: PMC5312708, DOI: 10.1016/j.jpedsurg.2016.07.015.
Management of Small Nonfunctional Pancreatic Neuroendocrine TumorsGrisotti G, Khan S. Management of Small Nonfunctional Pancreatic Neuroendocrine Tumors 2016, 641-653. DOI: 10.1007/978-3-319-27365-5_56.
Pancreaticoduodenectomy for locally advanced colon cancer in hereditary nonpolyposis colorectal cancerZhu R, Grisotti G, Salem RR, Khan SA. Pancreaticoduodenectomy for locally advanced colon cancer in hereditary nonpolyposis colorectal cancer World Journal Of Surgical Oncology 2015, 14: 12. PMID: 26769110, PMCID: PMC4714509, DOI: 10.1186/s12957-015-0755-7.
Oncogenic CXCL10 signalling drives metastasis development and poor clinical outcomeWightman SC, Uppal A, Pitroda SP, Ganai S, Burnette B, Stack M, Oshima G, Khan S, Huang X, Posner MC, Weichselbaum RR, Khodarev NN. Oncogenic CXCL10 signalling drives metastasis development and poor clinical outcome British Journal Of Cancer 2015, 113: 327-335. PMID: 26042934, PMCID: PMC4506383, DOI: 10.1038/bjc.2015.193.
Management of Small Nonfunctional Pancreatic Neuroendocrine Tumor Molecular Cancer TherapeuticsGrisotti G, Khan SA. Management of Small Nonfunctional Pancreatic Neuroendocrine Tumor Molecular Cancer Therapeutics. Difficult Decisions in Hepatobiliary and Pancreatic Surgery – An Evidence Based Approach 2015
Skin and Subcutaneous TissueKhan SA, Bank J, Choi E, Song D. Skin and Subcutaneous Tissue. Schwartz's Principles of Surgery, Tenth Edition, 2014.
Correction: Oligo- and Polymetastatic Progression in Lung Metastasis(es) Patients Is Associated with Specific MicroRNAsLussier Y, Khodarev N, Regan K, Corbin K, Li H, Ganai S, Khan S, Gnerlich J, Darga T, Fan H, Karpenko O, Paty P, Posner M, Chmura S, Hellman S, Ferguson M, Weichselbaum R. Correction: Oligo- and Polymetastatic Progression in Lung Metastasis(es) Patients Is Associated with Specific MicroRNAs PLOS ONE 2013, 8: 10.1371/annotation/2489ae5e-3650-4897-8df6-3e974ca585c4. PMCID: PMC3676315, DOI: 10.1371/annotation/2489ae5e-3650-4897-8df6-3e974ca585c4.
Intraoperative margin re-resection for colorectal cancer liver metastases.Khan SA, Matthews JB. Intraoperative margin re-resection for colorectal cancer liver metastases. Hepatobiliary Surgery And Nutrition 2013, 2: 108-12. PMID: 24570924, PMCID: PMC3924657, DOI: 10.3978/j.issn.2304-3881.2012.10.16.
Oligo- and Polymetastatic Progression in Lung Metastasis(es) Patients Is Associated with Specific MicroRNAsLussier YA, Khodarev NN, Regan K, Corbin K, Li H, Ganai S, Khan SA, Gnerlich J, Darga TE, Fan H, Karpenko O, Paty PB, Posner MC, Chmura SJ, Hellman S, Ferguson MK, Weichselbaum RR. Oligo- and Polymetastatic Progression in Lung Metastasis(es) Patients Is Associated with Specific MicroRNAs PLOS ONE 2012, 7: e50141. PMID: 23251360, PMCID: PMC3518475, DOI: 10.1371/journal.pone.0050141.
Tumor Endothelial Inflammation Predicts Clinical Outcome in Diverse Human CancersPitroda SP, Zhou T, Sweis RF, Filippo M, Labay E, Beckett MA, Mauceri HJ, Liang H, Darga TE, Perakis S, Khan SA, Sutton HG, Zhang W, Khodarev NN, Garcia JG, Weichselbaum RR. Tumor Endothelial Inflammation Predicts Clinical Outcome in Diverse Human Cancers PLOS ONE 2012, 7: e46104. PMID: 23056240, PMCID: PMC3464251, DOI: 10.1371/journal.pone.0046104.
Abstract 1369: Mouse models of clinical oligo- and poly-metastatic progressionZhang Q, Yang X, Shen J, Salama J, Khodarev N, Hasselle M, Huang Y, Fan H, Khan S, Darga T, Hoffma R, Chmura S, Lussier1 Y, Weichselbaum R, Weichselbaum R, Xing R. Abstract 1369: Mouse models of clinical oligo- and poly-metastatic progression Cancer Research 2012, 72: 1369-1369. DOI: 10.1158/1538-7445.am2012-1369.
Abstract 3405: MicroRNA expression characterizes oligometastasis(es)Xing R, Lussier Y, Salama J, Khodarev N, Huang Y, Zhang Q, Khan S, Yang X, Hasselle M, Darga T, Malik R, Fan H, Perakis S, Filippo M, Corbin K, Lee Y, Posner M, Chmura S, Hellman S, Weichselbaum R. Abstract 3405: MicroRNA expression characterizes oligometastasis(es) Cancer Research 2012, 72: 3405-3405. DOI: 10.1158/1538-7445.am2012-3405.
MicroRNA Expression Characterizes Oligometastasis(es)Lussier YA, Xing HR, Salama JK, Khodarev NN, Huang Y, Zhang Q, Khan SA, Yang X, Hasselle MD, Darga TE, Malik R, Fan H, Perakis S, Filippo M, Corbin K, Lee Y, Posner MC, Chmura SJ, Hellman S, Weichselbaum RR. MicroRNA Expression Characterizes Oligometastasis(es) PLOS ONE 2011, 6: e28650. PMID: 22174856, PMCID: PMC3236765, DOI: 10.1371/journal.pone.0028650.
Radiofrequency ablation of advanced head and neck cancer.Owen RP, Khan SA, Negassa A, Beitler JJ, Bello JA, Brook A, Farinhas J, Garg MK, Haigentz M, Miller TS, Hsu MS, Ravikumar TS, Shifteh K, Smith RV, Silver CE. Radiofrequency ablation of advanced head and neck cancer. Archives Of Otolaryngology--head & Neck Surgery 2011, 137: 493-8. PMID: 21576561, DOI: 10.1001/archoto.2011.62.
Abstract 573: Ionizing radiation activates IFN signaling in tumor cellsKhodarev N, Pitroda S, Sood R, Khan S, Filippo M, Gutt R, Perakis S, Darga T, Malik R, Pederson A, Weichselbaum R. Abstract 573: Ionizing radiation activates IFN signaling in tumor cells Cancer Research 2011, 71: 573-573. DOI: 10.1158/1538-7445.am2011-573.
Improved Testing for Microsatellite Instability in Colorectal Cancer Using a Simplified 3-Marker AssayEsemuede I, Forslund A, Khan SA, Qin LX, Gimbel MI, Nash GM, Zeng Z, Rosenberg S, Shia J, Barany F, Paty PB. Improved Testing for Microsatellite Instability in Colorectal Cancer Using a Simplified 3-Marker Assay Annals Of Surgical Oncology 2010, 17: 3370-3378. PMID: 20703819, PMCID: PMC3269820, DOI: 10.1245/s10434-010-1147-4.
Loss of imprinting and marked gene elevation are 2 forms of aberrant IGF2 expression in colorectal cancerCheng Y, Idrees K, Shattock R, Khan SA, Zeng Z, Brennan CW, Paty P, Barany F. Loss of imprinting and marked gene elevation are 2 forms of aberrant IGF2 expression in colorectal cancer International Journal Of Cancer 2010, 127: 568-577. PMID: 19957330, PMCID: PMC3270092, DOI: 10.1002/ijc.25086.
CpG Island Methylator Phenotype Associates with Low-Degree Chromosomal Abnormalities in Colorectal CancerCheng YW, Pincas H, Bacolod MD, Schemmann G, Giardina SF, Huang J, Barral S, Idrees K, Khan SA, Zeng Z, Rosenberg S, Notterman DA, Ott J, Paty P, Barany F. CpG Island Methylator Phenotype Associates with Low-Degree Chromosomal Abnormalities in Colorectal Cancer Clinical Cancer Research 2008, 14: 6005-6013. PMID: 18829479, PMCID: PMC3268558, DOI: 10.1158/1078-0432.ccr-08-0216.
Genetic variants in germline TP53 and MDM2 SNP309 are not associated with early onset colorectal cancerKhan SA, Idrees K, Forslund A, Zeng Z, Rosenberg S, Pincas H, Barany F, Offit K, LaQuaglia MP, Paty PB. Genetic variants in germline TP53 and MDM2 SNP309 are not associated with early onset colorectal cancer Journal Of Surgical Oncology 2008, 97: 621-625. PMID: 18381604, PMCID: PMC4381874, DOI: 10.1002/jso.20996.
c-Met gene amplification is associated with advanced stage colorectal cancer and liver metastasesZeng ZS, Weiser MR, Kuntz E, Chen CT, Khan SA, Forslund A, Nash GM, Gimbel M, Yamaguchi Y, Culliford AT, D’Alessio M, Barany F, Paty PB. c-Met gene amplification is associated with advanced stage colorectal cancer and liver metastases Cancer Letters 2008, 265: 258-269. PMID: 18395971, PMCID: PMC4367187, DOI: 10.1016/j.canlet.2008.02.049.

Clinical Trials

Conditions	Study Title
Colon	S0820, Adenoma and Second Primary Prevention Trial (PACES)

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