Kathleen Martin, PhD
Research & Publications
Biography
News
Research Summary
Our goal is to understand how vascular smooth muscle cells contribute to normal vessel function and to cardiovascular disease. Hyperproliferation or dysfunction in vascular smooth muscle cells contributes to atherosclerosis, organ transplant failure, and failure of revascularization therapies such as balloon angioplasty or bypass surgery. By understanding the regulatory mechanisms of vascular smooth muscle, we aim to develop new therapies for treatment and prevention of cardiovascular diseases.
Specialized Terms: Vascular smooth muscle; Differentiation; Signal transduction; Transcription; Epigenetics
Extensive Research Description
Brief Research Summary
Our studies are aimed at understanding the molecular mechanisms that regulate vascular smooth muscle cell (SMC) phenotype. Mature SMC retain the ability to de-differentiate and re-enter the cell cycle. This is essential for such processes as angiogenesis, but also contributes to the pathogenesis of atherosclerosis, intimal hyperplasia, and restenosis.
Regulation of Vascular Smooth Muscle Phenotype: Rapamycin-eluting stents have revolutionized treatment of coronary artery disease, dramatically reducing restenosis. While highly efficacious in this localized drug delivery setting, systemic high dose rapamycin is not a viable strategy for other vascular diseases due to adverse effects. Our goal is to understand the molecular mechanisms by which rapamycin beneficially affects SMC phenotype, in order to develop novel therapeutics. Identifying the smooth muscle-specific targets of the mTOR pathway may generate new therapeutic strategies for treatment and prevention of atherosclerosis and intimal hyperplasia.
Epigenetic regulation: We have discovered that the mTOR pathway promotes VSMC differentiation through regulation of the DNA modifying enzyme TET2. We have identified TET2 as a novel master epigenetic regulator of VSMC phenotype. Notably, TET2 promotes changes in chromatin that lead to expression of prodifferentiation genes including SRF and myocardin and contractile genes such as SM-MHC and SM-alpha actin, while concomitantly downregulating expression of de-differentiation-associated genes including KFL4. We are currently employing genome-wide epigenetic methods to investigate mechanisms by which TET2, histone acetyltransferases, and other epigenetic regulators coordinately remodel chromatin to allow for VSMC plasticity.
Coauthors
Research Interests
Cardiology; Cardiovascular Diseases; Pharmacology; Vascular Diseases; Signal Transduction
Research Image
12
Selected Publications
- The age of bone marrow dictates the clonality of smooth muscle-derived cells in atherosclerotic plaquesKabir I, Zhang X, Dave J, Chakraborty R, Qu R, Chandran R, Ntokou A, Gallardo-Vara E, Aryal B, Rotllan N, Garcia-Milian R, Hwa J, Kluger Y, Martin K, Fernández-Hernando C, Greif D. The age of bone marrow dictates the clonality of smooth muscle-derived cells in atherosclerotic plaques. Nature Aging 2023, 1-18. DOI: 10.1038/s43587-022-00342-5.
- The age of bone marrow dictates the clonality of smooth muscle-derived cells in atherosclerotic plaquesKabir I, Zhang X, Dave J, Chakraborty R, Qu R, Chandran R, Ntokou A, Gallardo-Vara E, Aryal B, Rotllan N, Garcia-Milian R, Hwa J, Kluger Y, Martin K, Fernández-Hernando C, Greif D. The age of bone marrow dictates the clonality of smooth muscle-derived cells in atherosclerotic plaques. Nature Aging 2023, 3: 64-81. PMID: 36743663, PMCID: PMC9894379, DOI: 10.1038/s43587-022-00342-5.
- “Cre”ating New Tools for Smooth Muscle AnalysisO’Brien B, Martin K, Offermanns S. “Cre”ating New Tools for Smooth Muscle Analysis. Arteriosclerosis Thrombosis And Vascular Biology 2023, 43: 212-214. PMID: 36601960, PMCID: PMC10112502, DOI: 10.1161/atvbaha.122.318855.
- Abstract 269: The Histone Methyl Transferase (SUV39H1) Promotes Smooth Muscle Cell DedifferentiationChatterjee P, Chakraborty R, Xie Y, Sizer A, Hwa J, Martin K. Abstract 269: The Histone Methyl Transferase (SUV39H1) Promotes Smooth Muscle Cell Dedifferentiation. Arteriosclerosis Thrombosis And Vascular Biology 2022, 42: a269-a269. DOI: 10.1161/atvb.42.suppl_1.269.
- Abstract 467: The Histone Acetyltransferases P300 And Cbp Coordinate Distinct Chromatin Remodeling Programs In Vascular Smooth Muscle PlasticityChakraborty R, Ostriker A, Xie Y, Dave J, Chatterjee P, Gallagher P, Sessa W, Hwa J, Martin K. Abstract 467: The Histone Acetyltransferases P300 And Cbp Coordinate Distinct Chromatin Remodeling Programs In Vascular Smooth Muscle Plasticity. Arteriosclerosis Thrombosis And Vascular Biology 2022, 42: a467-a467. DOI: 10.1161/atvb.42.suppl_1.467.
- A guide to molecular and functional investigations of platelets to bridge basic and clinical sciencesTyagi T, Jain K, Gu S, Qiu M, Gu V, Melchinger H, Rinder H, Martin K, Gardiner E, Lee A, Tang W, Hwa J. A guide to molecular and functional investigations of platelets to bridge basic and clinical sciences. Nature Cardiovascular Research 2022, 1: 223-237. PMID: 37502132, PMCID: PMC10373053, DOI: 10.1038/s44161-022-00021-z.
- A guide to molecular and functional investigations of platelets to bridge basic and clinical sciencesTyagi T, Jain K, Gu S, Qiu M, Gu V, Melchinger H, Rinder H, Martin K, Gardiner E, Lee A, Tang W, Hwa J. A guide to molecular and functional investigations of platelets to bridge basic and clinical sciences. Nature Cardiovascular Research 2022, 1: 223-237. DOI: 10.1038/s44161-022-00021-z.
- The Histone Methyl Transferase (SUV39H1) Promotes Smooth Muscle Cell DedifferentiationChatterjee P, Chakraborty R, Xie Y, Sizer A, Hwa J, Martin K. The Histone Methyl Transferase (SUV39H1) Promotes Smooth Muscle Cell Dedifferentiation. JVS Vascular Science 2022, 3: 403. DOI: 10.1016/j.jvssci.2022.05.003.
- Abstract MP11: Histone Methyl Transferase (suv39h1): Function In Smooth Muscle Cell Phenotypic PlasticityChatterjee P, Chakraborty R, Xie Y, Sizer A, Hwa J, Martin K. Abstract MP11: Histone Methyl Transferase (suv39h1): Function In Smooth Muscle Cell Phenotypic Plasticity. Arteriosclerosis Thrombosis And Vascular Biology 2021, 41 DOI: 10.1161/atvb.41.suppl_1.mp11.
- TET2 Protects Against Vascular Smooth Muscle Cell Apoptosis and Intimal Thickening in Transplant VasculopathyOstriker AC, Xie Y, Chakraborty R, Sizer AJ, Bai Y, Ding M, Song WL, Huttner A, Hwa J, Martin KA. TET2 Protects Against Vascular Smooth Muscle Cell Apoptosis and Intimal Thickening in Transplant Vasculopathy. Circulation 2021, 144: 455-470. PMID: 34111946, PMCID: PMC8643133, DOI: 10.1161/circulationaha.120.050553.
- Targeting smooth muscle cell phenotypic switching in vascular diseaseJVS-Vascular Science 2021;2:79-94.
- Thrombocytopathy and endotheliopathy: crucial contributors to COVID-19 thromboinflammationGu SX, Tyagi T, Jain K, Gu VW, Lee SH, Hwa JM, Kwan JM, Krause DS, Lee AI, Halene S, Martin KA, Chun HJ, Hwa J. Thrombocytopathy and endotheliopathy: crucial contributors to COVID-19 thromboinflammation. Nature Reviews Cardiology 2020, 18: 194-209. PMID: 33214651, PMCID: PMC7675396, DOI: 10.1038/s41569-020-00469-1.
- Circular RNA CircMAP3K5 Acts as a MicroRNA-22-3p Sponge to Promote Resolution of Intimal Hyperplasia Via TET2-Mediated Smooth Muscle Cell DifferentiationZeng Z, Xia L, Fan S, Zheng J, Qin J, Fan X, Liu Y, Tao J, Liu Y, Li K, Ling Z, Bu Y, Martin KA, Hwa J, Liu R, Tang WH. Circular RNA CircMAP3K5 Acts as a MicroRNA-22-3p Sponge to Promote Resolution of Intimal Hyperplasia Via TET2-Mediated Smooth Muscle Cell Differentiation. Circulation 2020, 143: 354-371. PMID: 33207953, DOI: 10.1161/circulationaha.120.049715.
- TCF21Xie Y, Martin KA. TCF21. Circulation Research 2020, 126: 530-532. PMID: 32078454, PMCID: PMC7041869, DOI: 10.1161/circresaha.120.316533.
- Promoters to Study Vascular Smooth MuscleChakraborty R, Saddouk FZ, Carrao AC, Krause DS, Greif DM, Martin KA. Promoters to Study Vascular Smooth Muscle. Arteriosclerosis Thrombosis And Vascular Biology 2019, 39: 603-612. PMID: 30727757, PMCID: PMC6527360, DOI: 10.1161/atvbaha.119.312449.
- LMO7 Is a Negative Feedback Regulator of Transforming Growth Factor β Signaling and FibrosisXie Y, Ostriker AC, Jin Y, Hu H, Sizer AJ, Peng G, Morris AH, Ryu C, Herzog EL, Kyriakides T, Zhao H, Dardik A, Yu J, Hwa J, Martin KA. LMO7 Is a Negative Feedback Regulator of Transforming Growth Factor β Signaling and Fibrosis. Circulation 2019, 139: 679-693. PMID: 30586711, PMCID: PMC6371979, DOI: 10.1161/circulationaha.118.034615.
- TCF7L2 (Transcription Factor 7-Like 2) Regulation of GATA6 (GATA-Binding Protein 6)-Dependent and -Independent Vascular Smooth Muscle Cell Plasticity and Intimal HyperplasiaSrivastava R, Rolyan H, Xie Y, Li N, Bhat N, Hong L, Esteghamat F, Adeniran A, Geirsson A, Zhang J, Ge G, Nobrega M, Martin KA, Mani A. TCF7L2 (Transcription Factor 7-Like 2) Regulation of GATA6 (GATA-Binding Protein 6)-Dependent and -Independent Vascular Smooth Muscle Cell Plasticity and Intimal Hyperplasia. Arteriosclerosis Thrombosis And Vascular Biology 2018, 39: 250-262. PMID: 30567484, PMCID: PMC6365015, DOI: 10.1161/atvbaha.118.311830.
- Technical Feasibility of a Murine Model of Sleeve Gastrectomy with Ileal TranspositionYing LD, Breuer GA, Hubbard MO, Nadzam GS, Hwa J, Martin KA. Technical Feasibility of a Murine Model of Sleeve Gastrectomy with Ileal Transposition. Obesity Surgery 2018, 29: 593-600. PMID: 30353248, PMCID: PMC6365182, DOI: 10.1007/s11695-018-3555-7.
- Opposing Actions of AKT (Protein Kinase B) Isoforms in Vascular Smooth Muscle Injury and Therapeutic ResponseJin Y, Xie Y, Ostriker AC, Zhang X, Liu R, Lee MY, Leslie KL, Tang W, Du J, Lee SH, Wang Y, Sessa WC, Hwa J, Yu J, Martin KA. Opposing Actions of AKT (Protein Kinase B) Isoforms in Vascular Smooth Muscle Injury and Therapeutic Response. Arteriosclerosis Thrombosis And Vascular Biology 2017, 37: 2311-2321. PMID: 29025710, PMCID: PMC5699966, DOI: 10.1161/atvbaha.117.310053.
- Abstract 459: O-Linked N-Acetylglucosamine Promotes Vascular Smooth Muscle Cell Dedifferentiation and Intimal HyperplasiaBauer A, Leslie K, Ostriker A, Martin K. Abstract 459: O-Linked N-Acetylglucosamine Promotes Vascular Smooth Muscle Cell Dedifferentiation and Intimal Hyperplasia. Arteriosclerosis Thrombosis And Vascular Biology 2017, 37 DOI: 10.1161/atvb.37.suppl_1.459.
- Coordinating Regulation of Gene Expression in Cardiovascular Disease: Interactions between Chromatin Modifiers and Transcription FactorsBauer AJ, Martin KA. Coordinating Regulation of Gene Expression in Cardiovascular Disease: Interactions between Chromatin Modifiers and Transcription Factors. Frontiers In Cardiovascular Medicine 2017, 4: 19. PMID: 28428957, PMCID: PMC5382160, DOI: 10.3389/fcvm.2017.00019.
- Clonal hematopoiesis associated with TET2 deficiency accelerates atherosclerosis development in miceFuster JJ, MacLauchlan S, Zuriaga MA, Polackal MN, Ostriker AC, Chakraborty R, Wu CL, Sano S, Muralidharan S, Rius C, Vuong J, Jacob S, Muralidhar V, Robertson AA, Cooper MA, Andrés V, Hirschi KK, Martin KA, Walsh K. Clonal hematopoiesis associated with TET2 deficiency accelerates atherosclerosis development in mice. Science 2017, 355: 842-847. PMID: 28104796, PMCID: PMC5542057, DOI: 10.1126/science.aag1381.
- Abstract 176: O-GlcNAc Transferase Promotes Vascular Smooth Muscle Cell De-differentiationLeslie K, Xie Y, Ostriker A, Martin K. Abstract 176: O-GlcNAc Transferase Promotes Vascular Smooth Muscle Cell De-differentiation. Arteriosclerosis Thrombosis And Vascular Biology 2016, 36 DOI: 10.1161/atvb.36.suppl_1.176.
- Phosphorylation of GATA-6 is required for vascular smooth muscle cell differentiation after mTORC1 inhibitionXie Y, Jin Y, Merenick BL, Ding M, Fetalvero KM, Wagner RJ, Mai A, Gleim S, Tucker DF, Birnbaum MJ, Ballif BA, Luciano AK, Sessa WC, Rzucidlo EM, Powell RJ, Hou L, Zhao H, Hwa J, Yu J, Martin KA. Phosphorylation of GATA-6 is required for vascular smooth muscle cell differentiation after mTORC1 inhibition. Science Signaling 2015, 8: ra44. PMID: 25969542, PMCID: PMC4560350, DOI: 10.1126/scisignal.2005482.
- Epigenetic regulation of smooth muscle cell plasticityLiu R, Leslie KL, Martin KA. Epigenetic regulation of smooth muscle cell plasticity. Biochimica Et Biophysica Acta 2014, 1849: 448-453. PMID: 24937434, PMCID: PMC4552189, DOI: 10.1016/j.bbagrm.2014.06.004.
- Ten-Eleven Translocation-2 (TET2) Is a Master Regulator of Smooth Muscle Cell PlasticityLiu R, Jin Y, Tang WH, Qin L, Zhang X, Tellides G, Hwa J, Yu J, Martin KA. Ten-Eleven Translocation-2 (TET2) Is a Master Regulator of Smooth Muscle Cell Plasticity. Circulation 2013, 128: 2047-2057. PMID: 24077167, PMCID: PMC3899790, DOI: 10.1161/circulationaha.113.002887.
- Thioglitazones Improve SFA Stenting Primary Patency Rates in DiabeticsWalker K, Martin K, Glaser J, Goodney P, Walsh D, Stone D, Powell R, Rzucidlo E. Thioglitazones Improve SFA Stenting Primary Patency Rates in Diabetics. Journal Of Vascular Surgery 2013, 58: 853. DOI: 10.1016/j.jvs.2013.06.040.
- Correction: Human Thromboxane A2 Receptor Genetic Variants: In Silico, In Vitro and “In Platelet” AnalysisGleim S, Stitham J, Tang W, Li H, Douville K, Chelikani P, Rade J, Martin K, Hwa J. Correction: Human Thromboxane A2 Receptor Genetic Variants: In Silico, In Vitro and “In Platelet” Analysis. PLOS ONE 2013, 8: 10.1371/annotation/83ddfba7-3c48-4c96-8cd1-0f0b5f69a5d1. PMCID: PMC3734324, DOI: 10.1371/annotation/83ddfba7-3c48-4c96-8cd1-0f0b5f69a5d1.
- Mitochondria, the Cardiomyocyte “Power plant”: Sugar-Fueled Power Outages and Toxic WasteTang W, Martin K, Hwa J. Mitochondria, the Cardiomyocyte “Power plant”: Sugar-Fueled Power Outages and Toxic Waste. International Journal Of Cardiovascular Research 2012, 01 DOI: 10.4172/2324-8602.1000e109.
- Prostacyclin receptor regulation--from transcription to trafficking.Midgett C, Stitham J, Martin K, Hwa J. Prostacyclin receptor regulation--from transcription to trafficking. 2011, 11: 517-28. PMID: 21707517, PMCID: PMC3647249, DOI: 10.2174/156652411800615144.
- Adiponectin Is Secreted by Vascular Smooth Muscle Cells and Regulates Muscle Contractile PhenotypeDing M, Wagner R, Martin K. Adiponectin Is Secreted by Vascular Smooth Muscle Cells and Regulates Muscle Contractile Phenotype. The FASEB Journal 2010, 24: 957.5-957.5. DOI: 10.1096/fasebj.24.1_supplement.957.5.
- Activation of Hedgehog Signaling by the Environmental Toxicant Arsenic May Contribute to the Etiology of Arsenic-Induced TumorsFei D, Li H, Kozul C, Black K, Singh S, Gosse J, DiRenzo J, Martin K, Wang B, Hamilton J, Karagas M, Robbins D. Activation of Hedgehog Signaling by the Environmental Toxicant Arsenic May Contribute to the Etiology of Arsenic-Induced Tumors. Cancer Research 2010, 70: 1981-1988. PMID: 20179202, PMCID: PMC2831120, DOI: 10.1158/0008-5472.can-09-2898.
- 6.05 In Vitro Vascular Cell Culture Systems – Vascular Smooth MuscleMartin K, Rzucidlo E, Ding M, Merenick B, Kasza Z, Wagner R, Powell R. 6.05 In Vitro Vascular Cell Culture Systems – Vascular Smooth Muscle. 2010, 69-96. DOI: 10.1016/b978-0-08-046884-6.00705-3.
- Adiponectin Induces Vascular Smooth Muscle Cell Differentiation via AMPKDing M, Wagner R, Fetalvero K, Kasza Z, Powell R, Martin K. Adiponectin Induces Vascular Smooth Muscle Cell Differentiation via AMPK. The FASEB Journal 2009, 23: 577.10-577.10. DOI: 10.1096/fasebj.23.1_supplement.577.10.
- Prostacyclin primes pregnant human myometrium for an enhanced contractile response in parturitionFetalvero KM, Zhang P, Shyu M, Young BT, Hwa J, Young RC, Martin KA. Prostacyclin primes pregnant human myometrium for an enhanced contractile response in parturition. Journal Of Clinical Investigation 2008, 118: 3966-3979. PMID: 19033666, PMCID: PMC2582928, DOI: 10.1172/jci33800.
- Prostacyclin receptor regulates contraction‐associated proteins and contractile proteins in pregnant human myometrium via PKA/cAMP and the transcription factors GATA‐6 and myocardinFetalvero K, Zhang P, Shyu M, Young B, Hwa J, Young R, Martin K. Prostacyclin receptor regulates contraction‐associated proteins and contractile proteins in pregnant human myometrium via PKA/cAMP and the transcription factors GATA‐6 and myocardin. The FASEB Journal 2008, 22: 719.15-719.15. DOI: 10.1096/fasebj.22.1_supplement.719.15.
- Regulation of vascular smooth muscle cell differentiationRzucidlo E, Martin K, Powell R. Regulation of vascular smooth muscle cell differentiation. Journal Of Vascular Surgery 2007, 45: a25-a32. PMID: 17544021, DOI: 10.1016/j.jvs.2007.03.001.
- Rapamycin inhibits cell motility by suppression of mTOR-mediated S6K1 and 4E-BP1 pathwaysLiu L, Li F, Cardelli J, Martin K, Blenis J, Huang S. Rapamycin inhibits cell motility by suppression of mTOR-mediated S6K1 and 4E-BP1 pathways. Oncogene 2006, 25: 7029-7040. PMID: 16715128, DOI: 10.1038/sj.onc.1209691.
- The prostacyclin receptor induces human vascular smooth muscle cell differentiation via PKAFetalvero K, Shyu M, Nomikos A, Chiu Y, Wagner R, Powell R, Hwa J, Martin K. The prostacyclin receptor induces human vascular smooth muscle cell differentiation via PKA. The FASEB Journal 2006, 20: a665-a666. DOI: 10.1096/fasebj.20.4.a665-d.
- Endothelial cell activation of the smooth muscle cell phosphoinositide 3-kinase/Akt pathway promotes differentiationBrown D, Rzucidlo E, Merenick B, Wagner R, Martin K, Powell R. Endothelial cell activation of the smooth muscle cell phosphoinositide 3-kinase/Akt pathway promotes differentiation. Journal Of Vascular Surgery 2005, 41: 509-516. PMID: 15838487, DOI: 10.1016/j.jvs.2004.12.024.
- Deletion of Ribosomal S6 Kinases Does Not Attenuate Pathological, Physiological, or Insulin-Like Growth Factor 1 Receptor-Phosphoinositide 3-Kinase-Induced Cardiac HypertrophyMcMullen J, Shioi T, Zhang L, Tarnavski O, Sherwood M, Dorfman A, Longnus S, Pende M, Martin K, Blenis J, Thomas G, Izumo S. Deletion of Ribosomal S6 Kinases Does Not Attenuate Pathological, Physiological, or Insulin-Like Growth Factor 1 Receptor-Phosphoinositide 3-Kinase-Induced Cardiac Hypertrophy. Molecular And Cellular Biology 2004, 24: 6231-6240. PMID: 15226426, PMCID: PMC434247, DOI: 10.1128/mcb.24.14.6231-6240.2004.
- The mTOR/p70 S6K1 pathway regulates vascular smooth muscle cell differentiationMartin K, Rzucidlo E, Merenick B, Fingar D, Brown D, Wagner R, Powell R. The mTOR/p70 S6K1 pathway regulates vascular smooth muscle cell differentiation. American Journal Of Physiology - Cell Physiology 2003, 286: c507-c517. PMID: 14592809, DOI: 10.1152/ajpcell.00201.2003.
- The Critical Role of Transmembrane Prolines in Human Prostacyclin Receptor ActivationStitham J, Martin KA, Hwa J. The Critical Role of Transmembrane Prolines in Human Prostacyclin Receptor Activation. Molecular Pharmacology 2002, 61: 1202-1210. PMID: 11961139, DOI: 10.1124/mol.61.5.1202.
- Ribosomal S6 Kinase 2 Inhibition by a Potent C-terminal Repressor Domain Is Relieved by Mitogen-activated Protein-Extracellular Signal-regulated Kinase Kinase-regulated Phosphorylation*Martin K, Schalm S, Romanelli A, Keon K, Blenis J. Ribosomal S6 Kinase 2 Inhibition by a Potent C-terminal Repressor Domain Is Relieved by Mitogen-activated Protein-Extracellular Signal-regulated Kinase Kinase-regulated Phosphorylation*. Journal Of Biological Chemistry 2000, 276: 7892-7898. PMID: 11108720, DOI: 10.1074/jbc.m009972200.
- Regulation of Ribosomal S6 Kinase 2 by Effectors of the Phosphoinositide 3-Kinase Pathway*Martin K, Schalm S, Richardson C, Romanelli A, Keon K, Blenis J. Regulation of Ribosomal S6 Kinase 2 by Effectors of the Phosphoinositide 3-Kinase Pathway*. Journal Of Biological Chemistry 2000, 276: 7884-7891. PMID: 11108711, DOI: 10.1074/jbc.m006969200.
- p70 S6 Kinase Is Regulated by Protein Kinase Cζ and Participates in a Phosphoinositide 3-Kinase-Regulated Signalling ComplexRomanelli A, Martin K, Toker A, Blenis J. p70 S6 Kinase Is Regulated by Protein Kinase Cζ and Participates in a Phosphoinositide 3-Kinase-Regulated Signalling Complex. Molecular And Cellular Biology 1999, 19: 2921-2928. PMID: 10082559, PMCID: PMC84086, DOI: 10.1128/mcb.19.4.2921.
- The orphan seven-transmembrane receptor apj supports the entry of primary T-cell-line-tropic and dualtropic human immunodeficiency virus type 1.Choe H, Farzan M, Konkel M, Martin K, Sun Y, Marcon L, Cayabyab M, Berman M, Dorf M, Gerard N, Gerard C, Sodroski J. The orphan seven-transmembrane receptor apj supports the entry of primary T-cell-line-tropic and dualtropic human immunodeficiency virus type 1. Journal Of Virology 1998, 72: 6113-8. PMID: 9621075, PMCID: PMC110417, DOI: 10.1128/jvi.72.7.6113-6118.1998.
- Structural interactions between chemokine receptors, gp120 Env and CD4Choe H, Martin K, Farzan M, Sodroski J, GERARD N, Gerard C. Structural interactions between chemokine receptors, gp120 Env and CD4. Seminars In Immunology 1998, 10: 249-257. PMID: 9653051, DOI: 10.1006/smim.1998.0127.
- A tyrosine-rich region in the N terminus of CCR5 is important for human immunodeficiency virus type 1 entry and mediates an association between gp120 and CCR5.Farzan M, Choe H, Vaca L, Martin K, Sun Y, Desjardins E, Ruffing N, Wu L, Wyatt R, Gerard N, Gerard C, Sodroski J. A tyrosine-rich region in the N terminus of CCR5 is important for human immunodeficiency virus type 1 entry and mediates an association between gp120 and CCR5. Journal Of Virology 1998, 72: 1160-4. PMID: 9445013, PMCID: PMC124591, DOI: 10.1128/jvi.72.2.1160-1164.1998.
- CD4-Independent Binding of SIV gp120 to Rhesus CCR5Martin K, Wyatt R, Farzan M, Choe H, Marcon L, Desjardins E, Robinson J, Sodroski J, Gerard C, Gerard N. CD4-Independent Binding of SIV gp120 to Rhesus CCR5. Science 1997, 278: 1470-1473. PMID: 9367961, DOI: 10.1126/science.278.5342.1470.
- Stage-specific expression of P2Y receptors, ecto-apyrase, and ecto-5'-nucleotidase in myeloid leukocytesClifford E, Martin K, Dalal P, Thomas R, Dubyak G. Stage-specific expression of P2Y receptors, ecto-apyrase, and ecto-5'-nucleotidase in myeloid leukocytes. American Journal Of Physiology 1997, 273: c973-c987. PMID: 9316419, DOI: 10.1152/ajpcell.1997.273.3.c973.
- Two Orphan Seven-Transmembrane Segment Receptors Which Are Expressed in CD4-positive Cells Support Simian Immunodeficiency Virus InfectionFarzan M, Choe H, Martin K, Marcon L, Hofmann W, Karlsson G, Sun Y, Barrett P, Marchand N, Sullivan N, Gerard N, Gerard C, Sodroski J. Two Orphan Seven-Transmembrane Segment Receptors Which Are Expressed in CD4-positive Cells Support Simian Immunodeficiency Virus Infection. Journal Of Experimental Medicine 1997, 186: 405-411. PMID: 9236192, PMCID: PMC2198994, DOI: 10.1084/jem.186.3.405.
- Angiotensin II activates the beta 1 isoform of phospholipase C in vascular smooth muscle cellsSchelling J, Nkemere N, Konieczkowski M, Martin K, Dubyak G. Angiotensin II activates the beta 1 isoform of phospholipase C in vascular smooth muscle cells. American Journal Of Physiology 1997, 272: c1558-c1566. PMID: 9176147, DOI: 10.1152/ajpcell.1997.272.5.c1558.
- A Competitive Mechanism of CArG Element Regulation by YY1 and SRF: Implications for Assessment of Phox1/MHox Transcription Factor Interactions at CArG ElementsMartin K, Gualberto A, Kolman M, Lowry J, Walsh K. A Competitive Mechanism of CArG Element Regulation by YY1 and SRF: Implications for Assessment of Phox1/MHox Transcription Factor Interactions at CArG Elements. DNA And Cell Biology 1997, 16: 653-661. PMID: 9174170, DOI: 10.1089/dna.1997.16.653.
- HIV-1 Entry and Macrophage Inflammatory Protein-1β-mediated Signaling Are Independent Functions of the Chemokine Receptor CCR5*Farzan M, Choe H, Martin K, Sun Y, Sidelko M, Mackay C, Gerard N, Sodroski J, Gerard C. HIV-1 Entry and Macrophage Inflammatory Protein-1β-mediated Signaling Are Independent Functions of the Chemokine Receptor CCR5*. Journal Of Biological Chemistry 1997, 272: 6854-6857. PMID: 9054370, DOI: 10.1074/jbc.272.11.6854.
- Utilization of C-C chemokine receptor 5 by the envelope glycoproteins of a pathogenic simian immunodeficiency virus, SIVmac239.Marcon L, Choe H, Martin K, Farzan M, Ponath P, Wu L, Newman W, Gerard N, Gerard C, Sodroski J. Utilization of C-C chemokine receptor 5 by the envelope glycoproteins of a pathogenic simian immunodeficiency virus, SIVmac239. Journal Of Virology 1997, 71: 2522-7. PMID: 9032394, PMCID: PMC191367, DOI: 10.1128/jvi.71.3.2522-2527.1997.
- Down-Regulation of P2U-Purinergic Nucleotide Receptor Messenger RNA Expression During In Vitro Differentiation of Human Myeloid Leukocytes by Phorbol Esters or Inflammatory ActivatorsMartin K, Kertesy S, Dubyak G. Down-Regulation of P2U-Purinergic Nucleotide Receptor Messenger RNA Expression During In Vitro Differentiation of Human Myeloid Leukocytes by Phorbol Esters or Inflammatory Activators. Molecular Pharmacology 1997, 51: 97-108. PMID: 9016351, DOI: 10.1124/mol.51.1.97.
- Expression of multiple ATP receptor subtypes during the differentiation and inflammatory activation of myeloid leukocytesDubyak G, Clifford E, Humphreys B, Kertesy S, Martin K. Expression of multiple ATP receptor subtypes during the differentiation and inflammatory activation of myeloid leukocytes. Drug Development Research 1996, 39: 269-278. DOI: 10.1002/(sici)1098-2299(199611/12)39:3/4<269::aid-ddr6>3.0.co;2-p.
- Recruitment of purinergically stimulated Cl- channels from granule membrane to plasma membraneMerlin D, Guo X, Martin K, Laboisse C, Landis D, Dubyak G, Hopfer U. Recruitment of purinergically stimulated Cl- channels from granule membrane to plasma membrane. American Journal Of Physiology 1996, 271: c612-c619. PMID: 8770002, DOI: 10.1152/ajpcell.1996.271.2.c612.
- The mouse creatine kinase paired E-box element confers muscle-specific expression to a heterologous promoter embryonic chicken primary cell culture; CAT assay; luciferase assay; human growth hormone assayMartin K, Walsh K, Mader S. The mouse creatine kinase paired E-box element confers muscle-specific expression to a heterologous promoter embryonic chicken primary cell culture; CAT assay; luciferase assay; human growth hormone assay. Gene 1994, 142: 275-278. PMID: 8194764, DOI: 10.1016/0378-1119(94)90274-7.