Yingjun Cui, PhD
Associate Research Scientist (Infectious Diseases)
Research & Publications
Biography
News
Research Summary
His research focus on vector biology and vector-borne diseases including mosquito, tick and their transmitted diseases such as Lyme disease, Zika, Chikungunya fever, malaria, aim to understand vector-pathogen-host interactions by means of entomology, molecular biology, microbiology, omics, and develop anti-vector strategy to control these emerging and reemerging vector-borne diseases.
Coauthors
Selected Publications
- mosGILT controls innate immunity and germ cell development in Anopheles gambiaeArora G, Tang X, Cui Y, Yang J, Chuang Y, Joshi J, Sajid A, Dong Y, Cresswell P, Dimopoulos G, Fikrig E. mosGILT controls innate immunity and germ cell development in Anopheles gambiae. BMC Genomics 2024, 25: 42. PMID: 38191283, PMCID: PMC10775533, DOI: 10.1186/s12864-023-09887-0.
- mRNA vaccination of rabbits alters the fecundity, but not the attachment, of adult Ixodes scapularisMatias J, Cui Y, Lynn G, DePonte K, Mesquita E, Muramatsu H, Alameh M, Dwivedi G, Tam Y, Pardi N, Weissman D, Fikrig E. mRNA vaccination of rabbits alters the fecundity, but not the attachment, of adult Ixodes scapularis. Scientific Reports 2024, 14: 496. PMID: 38177212, PMCID: PMC10766947, DOI: 10.1038/s41598-023-50389-6.
- Metabolomic changes associated with acquired resistance to Ixodes scapularisCui Y, Matias J, Tang X, Cibichakravarthy B, DePonte K, Wu M, Fikrig E. Metabolomic changes associated with acquired resistance to Ixodes scapularis. Ticks And Tick-borne Diseases 2023, 15: 102279. PMID: 37972499, DOI: 10.1016/j.ttbdis.2023.102279.
- Adiponectin in the mammalian host influences ticks’ acquisition of the Lyme disease pathogen BorreliaTang X, Cao Y, Booth C, Arora G, Cui Y, Matias J, Fikrig E. Adiponectin in the mammalian host influences ticks’ acquisition of the Lyme disease pathogen Borrelia. PLOS Biology 2023, 21: e3002331. PMID: 37862360, PMCID: PMC10619873, DOI: 10.1371/journal.pbio.3002331.
- Bulk and single-nucleus RNA sequencing highlight immune pathways induced in individuals during an Ixodes scapularis tick biteTang X, Lynn G, Cui Y, Cerny J, Arora G, Tomayko M, Craft J, Fikrig E. Bulk and single-nucleus RNA sequencing highlight immune pathways induced in individuals during an Ixodes scapularis tick bite. Infection And Immunity 2023, 91: e00282-23. PMID: 37846980, PMCID: PMC10652856, DOI: 10.1128/iai.00282-23.
- Specific mRNA lipid nanoparticles and acquired resistance to ticksMatias J, Cui Y, Tang X, Sajid A, Arora G, Wu M, DePonte K, Muramatsu H, Tam Y, Narasimhan S, Pardi N, Weissman D, Fikrig E. Specific mRNA lipid nanoparticles and acquired resistance to ticks. Vaccine 2023, 41: 4996-5002. PMID: 37407406, PMCID: PMC10530371, DOI: 10.1016/j.vaccine.2023.06.081.
- A tick C1q protein alters infectivity of the Lyme disease agent by modulating interferon γTang X, Arora G, Matias J, Hart T, Cui Y, Fikrig E. A tick C1q protein alters infectivity of the Lyme disease agent by modulating interferon γ. Cell Reports 2022, 41: 111673. PMID: 36417869, PMCID: PMC9909562, DOI: 10.1016/j.celrep.2022.111673.
- Identification of the extracellular metallo-endopeptidases ADAM and ADAMTS in the yellow fever mosquito Aedes aegyptiHerd C, Yu X, Cui Y, Franz A. Identification of the extracellular metallo-endopeptidases ADAM and ADAMTS in the yellow fever mosquito Aedes aegypti. Insect Biochemistry And Molecular Biology 2022, 148: 103815. PMID: 35932972, DOI: 10.1016/j.ibmb.2022.103815.
- Cellular diversity and gene expression profiles in the male and female brain of Aedes aegyptiCui Y, Behura SK, Franz AWE. Cellular diversity and gene expression profiles in the male and female brain of Aedes aegypti. BMC Genomics 2022, 23: 119. PMID: 35144549, PMCID: PMC8832747, DOI: 10.1186/s12864-022-08327-9.
- Heterogeneity of midgut cells and their differential responses to blood meal ingestion by the mosquito, Aedes aegyptiCui Y, Franz AWE. Heterogeneity of midgut cells and their differential responses to blood meal ingestion by the mosquito, Aedes aegypti. Insect Biochemistry And Molecular Biology 2020, 127: 103496. PMID: 33188922, PMCID: PMC7739889, DOI: 10.1016/j.ibmb.2020.103496.
- Analysis of blood-induced Anopheles gambiae midgut proteins and sexual stage Plasmodium falciparum interaction reveals mosquito genes important for malaria transmissionCui Y, Niu G, Li VL, Wang X, Li J. Analysis of blood-induced Anopheles gambiae midgut proteins and sexual stage Plasmodium falciparum interaction reveals mosquito genes important for malaria transmission. Scientific Reports 2020, 10: 14316. PMID: 32868841, PMCID: PMC7459308, DOI: 10.1038/s41598-020-71186-5.
- Quantitative Proteomic Analysis of Chikungunya Virus-Infected Aedes aegypti Reveals Proteome Modulations Indicative of Persistent InfectionCui Y, Liu P, Mooney BP, Franz AWE. Quantitative Proteomic Analysis of Chikungunya Virus-Infected Aedes aegypti Reveals Proteome Modulations Indicative of Persistent Infection. Journal Of Proteome Research 2020, 19: 2443-2456. PMID: 32375005, PMCID: PMC7419016, DOI: 10.1021/acs.jproteome.0c00173.
- Zika Virus Dissemination from the Midgut of Aedes aegypti is Facilitated by Bloodmeal-Mediated Structural Modification of the Midgut Basal LaminaCui Y, Grant DG, Lin J, Yu X, Franz AWE. Zika Virus Dissemination from the Midgut of Aedes aegypti is Facilitated by Bloodmeal-Mediated Structural Modification of the Midgut Basal Lamina. Viruses 2019, 11: 1056. PMID: 31739432, PMCID: PMC6893695, DOI: 10.3390/v11111056.
- Chitosan, Carbon Quantum Dot, and Silica Nanoparticle Mediated dsRNA Delivery for Gene Silencing in Aedes aegypti: A Comparative AnalysisDas S, Debnath N, Cui Y, Unrine J, Palli SR. Chitosan, Carbon Quantum Dot, and Silica Nanoparticle Mediated dsRNA Delivery for Gene Silencing in Aedes aegypti: A Comparative Analysis. ACS Applied Materials & Interfaces 2015, 7: 19530-19535. PMID: 26291176, DOI: 10.1021/acsami.5b05232.
- Juvenile hormone regulates Aedes aegypti Krüppel homolog 1 through a conserved E box motifCui Y, Sui Y, Xu J, Zhu F, Palli SR. Juvenile hormone regulates Aedes aegypti Krüppel homolog 1 through a conserved E box motif. Insect Biochemistry And Molecular Biology 2014, 52: 23-32. PMID: 24931431, PMCID: PMC4143451, DOI: 10.1016/j.ibmb.2014.05.009.
- Molecular characterization of DSC1 orthologs in invertebrate speciesCui YJ, Yu LL, Xu HJ, Dong K, Zhang CX. Molecular characterization of DSC1 orthologs in invertebrate species. Insect Biochemistry And Molecular Biology 2012, 42: 353-359. PMID: 22321571, DOI: 10.1016/j.ibmb.2012.01.005.