Dr Abrahams' research focuses on understanding the role of innate immune Toll-like receptor and Nod-like receptor family members in placental and maternal-fetal immune responses, and their role in regulating pregnancy outcome, including those complicated by infections and by autoimmune diseases. Studies from the Abrahams laboratory characterizes the mechanisms by which Toll-like receptors, Nod-like receptors, and the inflammasome function in the placental trophoblast and fetal membranes in response to both infectious and non-infectious stimuli.
Autoimmune Diseases; Fetal Membranes, Premature Rupture; Immunity, Innate; Placenta; Pregnancy Complications; Pregnancy Complications, Infectious; Pregnancy in Diabetics; Antiphospholipid Syndrome; Antibodies, Antiphospholipid; MicroRNAs; Toll-Like Receptors; Nod Signaling Adaptor Proteins; Exosomes; Inflammasomes