Mancy Tong, PhD
Assistant Professor
Research & Publications
Biography
News
Coauthors
Selected Publications
- Impact of preimplantation exposure to viral double-stranded RNA on decidualization, placental development and pregnancy outcomeTong M. Impact of preimplantation exposure to viral double-stranded RNA on decidualization, placental development and pregnancy outcome. Placenta 2023, 140: e21. DOI: 10.1016/j.placenta.2023.07.083.
- Decidualization dampens toll-like receptor mediated inflammatory responses in human endometrial stromal cells by upregulating IκBαTong M, Scott J, Whirledge S, Abrahams V. Decidualization dampens toll-like receptor mediated inflammatory responses in human endometrial stromal cells by upregulating IκBα. Journal Of Reproductive Immunology 2023, 159: 103988. PMID: 37451159, PMCID: PMC10530124, DOI: 10.1016/j.jri.2023.103988.
- Endometrial responses to bacterial and viral infection: a scoping review.Lindsay C, Potter J, Grimshaw A, Abrahams V, Tong M. Endometrial responses to bacterial and viral infection: a scoping review. Human Reproduction Update 2023, 29: 675-693. PMID: 37290428, PMCID: PMC10477945, DOI: 10.1093/humupd/dmad013.
- Viral infection dampens human fetal membrane type I interferon responses triggered by bacterial LPSPotter JA, Tong M, Aldo P, Kwon JY, Pitruzzello M, Mor G, Abrahams VM. Viral infection dampens human fetal membrane type I interferon responses triggered by bacterial LPS. Journal Of Reproductive Immunology 2020, 140: 103126. PMID: 32289593, PMCID: PMC7299810, DOI: 10.1016/j.jri.2020.103126.
- Immunology of the PlacentaTong M, Abrahams VM. Immunology of the Placenta. Obstetrics And Gynecology Clinics Of North America 2020, 47: 49-63. PMID: 32008671, DOI: 10.1016/j.ogc.2019.10.006.
- Neutrophil Activation and Extracellular Trap Formation at the Fetal Membranes: Relevance for Preterm BirthTong M. Neutrophil Activation and Extracellular Trap Formation at the Fetal Membranes: Relevance for Preterm Birth. Placenta 2019, 83: e6-e7. DOI: 10.1016/j.placenta.2019.06.024.
- Lipopolysaccharide-Stimulated Human Fetal Membranes Induce Neutrophil Activation and Release of Vital Neutrophil Extracellular Traps.Tong M, Potter JA, Mor G, Abrahams VM. Lipopolysaccharide-Stimulated Human Fetal Membranes Induce Neutrophil Activation and Release of Vital Neutrophil Extracellular Traps. The Journal Of Immunology 2019, 203: 500-510. PMID: 31167775, PMCID: PMC6616008, DOI: 10.4049/jimmunol.1900262.
- Immunological effects of placental extracellular vesiclesTong M, Abrahams VM, Chamley LW. Immunological effects of placental extracellular vesicles. Immunology And Cell Biology 2018, 96: 714-722. PMID: 29604098, DOI: 10.1111/imcb.12049.
- Antiphospholipid antibodies increase the levels of mitochondrial DNA in placental extracellular vesicles: Alarmin-g for preeclampsiaTong M, Johansson C, Xiao F, Stone PR, James JL, Chen Q, Cree LM, Chamley LW. Antiphospholipid antibodies increase the levels of mitochondrial DNA in placental extracellular vesicles: Alarmin-g for preeclampsia. Scientific Reports 2017, 7: 16556. PMID: 29185455, PMCID: PMC5707355, DOI: 10.1038/s41598-017-16448-5.
- Low molecular weight heparin and aspirin exacerbate human endometrial endothelial cell responses to antiphospholipid antibodiesQuao ZC, Tong M, Bryce E, Guller S, Chamley LW, Abrahams VM. Low molecular weight heparin and aspirin exacerbate human endometrial endothelial cell responses to antiphospholipid antibodies. American Journal Of Reproductive Immunology 2017, 79 PMID: 29135051, PMCID: PMC5728699, DOI: 10.1111/aji.12785.
- Viral Infection Sensitizes Human Fetal Membranes to Bacterial Lipopolysaccharide by MERTK Inhibition and Inflammasome Activation.Cross SN, Potter JA, Aldo P, Kwon JY, Pitruzzello M, Tong M, Guller S, Rothlin CV, Mor G, Abrahams VM. Viral Infection Sensitizes Human Fetal Membranes to Bacterial Lipopolysaccharide by MERTK Inhibition and Inflammasome Activation. The Journal Of Immunology 2017, 199: 2885-2895. PMID: 28916522, PMCID: PMC5659726, DOI: 10.4049/jimmunol.1700870.
- Aggregated transthyretin is specifically packaged into placental nano-vesicles in preeclampsiaTong M, Cheng SB, Chen Q, DeSousa J, Stone PR, James JL, Chamley LW, Sharma S. Aggregated transthyretin is specifically packaged into placental nano-vesicles in preeclampsia. Scientific Reports 2017, 7: 6694. PMID: 28751735, PMCID: PMC5532246, DOI: 10.1038/s41598-017-07017-x.
- Nifedipine prevents endothelial cell activation in response to placental micro- and nano- vesicles released from 1st trimester placental explants that had been treated with preeclamptic seraChen Q, Xiao X, Xiao M, Tong M, Wise M, Stone P, Chamley L. Nifedipine prevents endothelial cell activation in response to placental micro- and nano- vesicles released from 1st trimester placental explants that had been treated with preeclamptic sera. Placenta 2016, 45: 120. DOI: 10.1016/j.placenta.2016.06.203.
- In vivo localisation and vascular effects of nano-vesicles derived from normal first trimester human placentaeTong M, Stanley J, Chen Q, James J, Stone P, Chamley L. In vivo localisation and vascular effects of nano-vesicles derived from normal first trimester human placentae. Placenta 2016, 45: 67. DOI: 10.1016/j.placenta.2016.06.024.
- The target organs of human placental micro- and nano-vesiclesChamley L, Tong M, Stanley J, Chen Q, Wise M, James J, Stone P. The target organs of human placental micro- and nano-vesicles. Reproduction Abstracts 2016 DOI: 10.1530/repabs.3.o032.
- 7 The antihypertensives, nifedipine and labetalol prevent endothelial cell activation in response to placental extracellular vesicles released from 1st trimester placental explants that had been treated with preeclamptic sera Endothelial dysfunction, anti-angiogenic factorsChen Q, Xiao X, Zhao M, Tong M, Wise M, Stone P, Chamley L. 7 The antihypertensives, nifedipine and labetalol prevent endothelial cell activation in response to placental extracellular vesicles released from 1st trimester placental explants that had been treated with preeclamptic sera Endothelial dysfunction, anti-angiogenic factors. Pregnancy Hypertension 2016, 6: 140. DOI: 10.1016/j.preghy.2016.08.008.
- 61 Melatonin supplementation prevents endothelial cell activation, possible relevance to preeclampsia Endothelial dysfunction, anti-angiogenic factorsChen Q, Zhao M, Tong M, Xu L, Groom K, Stone P, Chamley L. 61 Melatonin supplementation prevents endothelial cell activation, possible relevance to preeclampsia Endothelial dysfunction, anti-angiogenic factors. Pregnancy Hypertension 2016, 6: 207-208. DOI: 10.1016/j.preghy.2016.08.143.
- Body Mass Index Is Positively Associated with Endometrial Cancer in Chinese Women, Especially Prior to MenopauseGao Y, Dai X, Chen L, Lee A, Tong M, Wise M, Chen Q. Body Mass Index Is Positively Associated with Endometrial Cancer in Chinese Women, Especially Prior to Menopause. Journal Of Cancer 2016, 7: 1169-1173. PMID: 27326261, PMCID: PMC4911885, DOI: 10.7150/jca.15037.
- The reduction in circulating levels of melatonin may be associated with the development of preeclampsiaZeng K, Gao Y, Wan J, Tong M, Lee A, Zhao M, Chen Q. The reduction in circulating levels of melatonin may be associated with the development of preeclampsia. Journal Of Human Hypertension 2016, 30: 666-671. PMID: 27251079, DOI: 10.1038/jhh.2016.37.
- Increased levels of High Mobility Group Box 1 (HMGB1) in trophoblastic debris may contribute to endothelial cell activation: A potential player in the pathogenesis of preeclampsiaShao J, Tong M, Wei J, Wise M, Stone P, Chamley L, Chen Q. Increased levels of High Mobility Group Box 1 (HMGB1) in trophoblastic debris may contribute to endothelial cell activation: A potential player in the pathogenesis of preeclampsia. Journal Of Reproductive Immunology 2016, 115: 41. DOI: 10.1016/j.jri.2016.04.124.
- An analysis of the differences between early and late preeclampsia with severe hypertensionLi X, Guo P, Xue Y, Gou W, Tong M, Chen Q. An analysis of the differences between early and late preeclampsia with severe hypertension. Pregnancy Hypertension 2015, 6: 47-52. PMID: 26955772, DOI: 10.1016/j.preghy.2015.12.003.
- The reduction of circulating levels of melatonin contribute to the development of preeclampsiaGao Y, Zeng K, Wan J, Tong M, Zhao J, Zhao M, Chen Q. The reduction of circulating levels of melatonin contribute to the development of preeclampsia. Placenta 2015, 36: a50. DOI: 10.1016/j.placenta.2015.07.337.
- Antiphospholipid antibodies affect mitochondrial DNA levels in placental extracellular vesicles: Alarmin(g) for preeclampsiaTong M, Chen Q, Viall C, Desousa J, Wise M, Stone P, James J, Cree L, Chamley L. Antiphospholipid antibodies affect mitochondrial DNA levels in placental extracellular vesicles: Alarmin(g) for preeclampsia. Placenta 2015, 36: a52. DOI: 10.1016/j.placenta.2015.07.343.
- Associations between body mass index and maternal weight gain on the delivery of LGA infants in Chinese women with gestational diabetes mellitusChen Q, Wei J, Tong M, Yu L, Lee A, Gao Y, Zhao M. Associations between body mass index and maternal weight gain on the delivery of LGA infants in Chinese women with gestational diabetes mellitus. Journal Of Diabetes And Its Complications 2015, 29: 1037-1041. PMID: 26376766, DOI: 10.1016/j.jdiacomp.2015.08.017.
- Serum uric acid may not be involved in the development of preeclampsiaChen Q, Lau S, Tong M, Wei J, Shen F, Zhao J, Zhao M. Serum uric acid may not be involved in the development of preeclampsia. Journal Of Human Hypertension 2015, 30: 136-140. PMID: 25994995, DOI: 10.1038/jhh.2015.47.
- The expression of high mobility group box 1 (HMGB1) correlates with the severity and onset of preeclampsia and associates with the levels of uric acidYin Y, Wei J, Tong M, Shen F, Zhao M, Chen Q. The expression of high mobility group box 1 (HMGB1) correlates with the severity and onset of preeclampsia and associates with the levels of uric acid. Placenta 2014, 35: a82. DOI: 10.1016/j.placenta.2014.06.264.
- Microvesicles from preeclamptic placentae activate endothelial cells through a Flt-1 mediated mechanismTong M, Chen Q, James J, de Sousa J, Stone P, Chamley L. Microvesicles from preeclamptic placentae activate endothelial cells through a Flt-1 mediated mechanism. Placenta 2014, 35: a82. DOI: 10.1016/j.placenta.2014.06.265.
- Melatonin prevents trophoblastic debris extruded from placenta in an apoptosis formChen Q, Li Y, Tong M, Stone P, Chamley L. Melatonin prevents trophoblastic debris extruded from placenta in an apoptosis form. Placenta 2014, 35: a80. DOI: 10.1016/j.placenta.2014.06.258.
- PP168. The role of calcium supplementation in prevention endothelial cell activation, and possible relevance to preeclampsiaChen Q, Tong M, Wu M, Stone P, Snowise S, Chamley L. PP168. The role of calcium supplementation in prevention endothelial cell activation, and possible relevance to preeclampsia. Pregnancy Hypertension 2012, 2: 330. PMID: 26105489, DOI: 10.1016/j.preghy.2012.04.279.