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Terrence E. Murphy, PhD

Associate Professor Adjunct

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Terrence E. Murphy, PhD
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Research Summary

Dr. Murphy is a member of the biostatistics staff of the Program on Aging. With twelve years experience in the design and manufacture of clinical instrumentation and advanced training in engineering statistics, he is interested in the application of engineering tools to research on aging. Current areas of investigation include multivariate statistics for characterization of multiple co–morbidity, robust design techniques for assessing the tradeoffs of multiple medication use, and the use of hierarchical models, propensity scores, and Bayesian techniques to enhance the analysis of non-randomized interventional designs such as the fall–related utilization of healthcare services by older persons in the state of Connecticut.

Specialized Terms: Aging; Bayesian methods; Spatial modeling; Non-randomized interventional designs; Multistate modeling

Extensive Research Description

YCCI-T3 Murphy (PI) 5/01/2011 - 4/30/13
Yale Center for Clinical Investigation
Enhancing Non-Randomized Studies in Public Health: A Novel Statistical Technique to Strengthen Causality of an Obesity Prevention Intervention for Children
The goal of this project is to integrate propensity scores into a spatial modeling framework to provide greater evidence of causality in this observational study.
Role: Principal Investigator

1R21AG033130 Murphy (PI) 9/30/2010 - 8/31/2012 NIH/NIA
Enhanced Evaluation of Second Stage Translational Research

Coauthors

Research Interests

Aging; Bayes Theorem; Geriatrics; Comorbidity; Statistics; Biostatistics; Propensity Score

Selected Publications

  • Association of Sociodemographic Characteristics With 1-Year Hospital Readmission Among Adults Aged 18 to 55 Years With Acute Myocardial InfarctionOkafor C, Zhu C, Raparelli V, Murphy T, Arakaki A, D’Onofrio G, Tsang S, Smith M, Lichtman J, Spertus J, Pilote L, Dreyer R. Association of Sociodemographic Characteristics With 1-Year Hospital Readmission Among Adults Aged 18 to 55 Years With Acute Myocardial Infarction JAMA Network Open 2023, 6: e2255843. PMID: 36787140, PMCID: PMC9929697, DOI: 10.1001/jamanetworkopen.2022.55843.
  • A risk model for decline in health status after acute myocardial infarction among older adultsHajduk A, Dodson J, Murphy T, Chaudhry S. A risk model for decline in health status after acute myocardial infarction among older adults Journal Of The American Geriatrics Society 2022 PMID: 36519774, DOI: 10.1111/jgs.18162.
  • Young Women with Acute Myocardial Infarction: Risk Prediction Model for 1-Year ReadmissionDreyer R, Arakaki A, Raparelli V, Murphy T, Tsang S, D’Onofrio G, Wood M, Wright C, Pilote L. Young Women with Acute Myocardial Infarction: Risk Prediction Model for 1-Year Readmission CJC Open 2022 DOI: 10.1016/j.cjco.2022.12.004.
  • Abstract 9234: Evaluating the Association Between Perceived Discrimination and Health Status Outcomes Among Young Adults Hospitalized for Acute Myocardial InfarctionArakaki A, Dreyer R, Murphy T, Wang K, Krumholz H, Lu Y, Adejumo P, Mori M, DONOFRIO G, Spertus J, Lichtman J. Abstract 9234: Evaluating the Association Between Perceived Discrimination and Health Status Outcomes Among Young Adults Hospitalized for Acute Myocardial Infarction Circulation 2022, 146: a9234-a9234. DOI: 10.1161/circ.146.suppl_1.9234.
  • Longitudinal Patterns of Specialist Palliative Care Provision in the HEART-PAL Cohort (GP716)Feder S, Murphy T, Abel E, Ersek M, Gandhi P, Fried T, Redeker N, Akgün K. Longitudinal Patterns of Specialist Palliative Care Provision in the HEART-PAL Cohort (GP716) Journal Of Pain And Symptom Management 2022, 63: 1120-1121. DOI: 10.1016/j.jpainsymman.2022.04.107.
  • Distressing Symptoms Before and After Critical Illness Among Community-Living Older AdultsJain S, Murphy T, Gahbauer E, Leo-Summers L, Ferrante L, Gill T. Distressing Symptoms Before and After Critical Illness Among Community-Living Older Adults 2022, a2289-a2289. DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a2289.
  • Factors Associated with Disability Over the 6 Months After a COVID Hospitalization Among Older Adults: The VALIANT (CO V ID-19 in Older A dults: A L ong i tudinal A ssessme nt ) StudyFerrante L, Hajduk A, Cohen A, McAvay G, Geda M, Chattopadhyay S, Lee S, Acampora D, Gill T, Murphy T. Factors Associated with Disability Over the 6 Months After a COVID Hospitalization Among Older Adults: The VALIANT (CO V ID-19 in Older A dults: A L ong i tudinal A ssessme nt ) Study 2022, a3696-a3696. DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a3696.
  • Abstract 13264: Gender-Based Risk Prediction for 1-year Readmission Among Younger Women Hospitalized for Acute Myocardial InfarctionArakaki A, Raparelli V, Murphy T, Tsang S, DONOFRIO G, Wood M, Xie C, Pilote L, Dreyer R. Abstract 13264: Gender-Based Risk Prediction for 1-year Readmission Among Younger Women Hospitalized for Acute Myocardial Infarction Circulation 2021, 144: a13264-a13264. DOI: 10.1161/circ.144.suppl_1.13264.
  • The Impact of Social Isolation on Disability and Mortality Among Older Survivors of Critical IllnessFalvey J, Murphy T, Leo-Summers L, O'Leary J, Cohen A, Ferrante L. The Impact of Social Isolation on Disability and Mortality Among Older Survivors of Critical Illness 2021, a1213-a1213. DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a1213.
  • The Effect of Socioeconomic Disadvantage on Development of Functional Decline Following Critical Illness Among Older AdultsJain S, Murphy T, O'Leary J, Leo-Summers L, Ferrante L. The Effect of Socioeconomic Disadvantage on Development of Functional Decline Following Critical Illness Among Older Adults 2021, a1214-a1214. DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a1214.
  • PREDICTORS OF RESIDUAL ANGINA 6 MONTHS AFTER HOSPITALIZATION FOR ACUTE MYOCARDIAL INFARCTION: FINDINGS FROM THE SILVER-AMI STUDYDodson J, Hajduk A, Arnold S, Spertus J, Dreyer R, Murphy T, Krumholz H, Chaudhry S. PREDICTORS OF RESIDUAL ANGINA 6 MONTHS AFTER HOSPITALIZATION FOR ACUTE MYOCARDIAL INFARCTION: FINDINGS FROM THE SILVER-AMI STUDY Journal Of The American College Of Cardiology 2021, 77: 37. DOI: 10.1016/s0735-1097(21)01396-6.
  • A SAS Macro for Cosinor Analysis of Automated Heart Rate Data in the ICUDoyle M, Murphy T, Knauert M. A SAS Macro for Cosinor Analysis of Automated Heart Rate Data in the ICU Innovation In Aging 2020, 4: 210-210. PMCID: PMC7740472, DOI: 10.1093/geroni/igaa057.679.
  • Abstract 14508: Development of a Risk Prediction Model for 1-year Readmission Among Younger Adults Hospitalized for Acute Myocardial InfarctionDreyer R, Murphy T, Raparelli V, Tsang S, Onofrio G, Lorenze N, Pilote L. Abstract 14508: Development of a Risk Prediction Model for 1-year Readmission Among Younger Adults Hospitalized for Acute Myocardial Infarction Circulation 2020, 142 DOI: 10.1161/circ.142.suppl_3.14508.
  • 380-P: Hypoglycemia among Nursing Home Residents with Diabetes Detected by Continuous Glucose Monitoring (CGM)LIPSKA K, DOYLE M, CENGIZ E, DROZDOWICZ B, GILL T, MURPHY T, INZUCCHI S. 380-P: Hypoglycemia among Nursing Home Residents with Diabetes Detected by Continuous Glucose Monitoring (CGM) Diabetes 2020, 69 DOI: 10.2337/db20-380-p.
  • Association Between Cumulative Dose of Physical Therapy and Incidence of Hospital-Acquired and Ventilator-Associated Pneumonias Among Critically Ill PatientsQi W, Murphy T, Doyle M, Ferrante L. Association Between Cumulative Dose of Physical Therapy and Incidence of Hospital-Acquired and Ventilator-Associated Pneumonias Among Critically Ill Patients 2020, a3577-a3577. DOI: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a3577.
  • BLEEDING READMISSIONS AFTER ACUTE MYOCARDIAL INFARCTION IN OLDER ADULTS: THE SILVER-AMI STUDYDodson J, Hajduk A, Curtis J, Murphy T, Krumholz H, Alexander K, Clardy D, Tsang S, Geda M, Blaum C, Chaudhry S. BLEEDING READMISSIONS AFTER ACUTE MYOCARDIAL INFARCTION IN OLDER ADULTS: THE SILVER-AMI STUDY Journal Of The American College Of Cardiology 2020, 75: 51. DOI: 10.1016/s0735-1097(20)30678-1.
  • 55: FACTORS ASSOCIATED WITH HOME HEALTH REHABILITATION UTILIZATION AMONG OLDER ICU SURVIVORSFalvey J, Murphy T, Gill T, Stevens-Lapsley J, Ferrante L. 55: FACTORS ASSOCIATED WITH HOME HEALTH REHABILITATION UTILIZATION AMONG OLDER ICU SURVIVORS Critical Care Medicine 2020, 48: 28-28. DOI: 10.1097/01.ccm.0000618720.61285.a5.
  • SPOUSAL ASSOCIATIONS IN MONTHLY REPORTS OF DISABILITY IN THE PRECIPITATING EVENTS PROJECTMonin J, Laws H, Gahbauer E, Murphy T, Gill T. SPOUSAL ASSOCIATIONS IN MONTHLY REPORTS OF DISABILITY IN THE PRECIPITATING EVENTS PROJECT Innovation In Aging 2019, 3: s672-s672. PMCID: PMC6845752, DOI: 10.1093/geroni/igz038.2484.
  • Predictors of Functional Decline Among Older Intensive Care Unit (ICU) SurvivorsFerrante L, Murphy T, Vander Wyk B, Leo-Summers L, Pisani M, Gill T. Predictors of Functional Decline Among Older Intensive Care Unit (ICU) Survivors 2019, a5674-a5674. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5674.
  • MORTALITY PREDICTION FOR OLDER ADULTS WITH AMI: THE SILVER-AMI STUDYDodson J, Hajduk A, Geda M, Krumholz H, Murphy T, Tsang S, Tinetti M, Nanna M, McNamara R, Gill T, Chaudhry S. MORTALITY PREDICTION FOR OLDER ADULTS WITH AMI: THE SILVER-AMI STUDY Journal Of The American College Of Cardiology 2019, 73: 102. DOI: 10.1016/s0735-1097(19)30710-7.
  • MULTIMORBIDITY BURDEN AND ADVERSE OUTCOMES IN OLDER ADULTS WITH HEART FAILURETisminetzky M, Gurwitz J, Fan D, Reynolds K, Smith D, Sung S, Murphy T, Go A. MULTIMORBIDITY BURDEN AND ADVERSE OUTCOMES IN OLDER ADULTS WITH HEART FAILURE Innovation In Aging 2018, 2: 703-704. PMCID: PMC6229076, DOI: 10.1093/geroni/igy023.2611.
  • Predictors of Discharge Home Among MICU Patients Receiving Early MobilizationKim R, Pisani M, Connors G, Murphy T, Tsang S, Wicker D, Gill T, Ferrante L. Predictors of Discharge Home Among MICU Patients Receiving Early Mobilization CHEST Journal 2017, 152: a337. DOI: 10.1016/j.chest.2017.08.363.
  • ASSOCIATIONS WITH POST-DISCHARGE FUNCTION OF OLDER ICU SURVIVORS: SENSITIVITY TO DEATHMurphy T, Pisani M, Ferrante L, Gill T. ASSOCIATIONS WITH POST-DISCHARGE FUNCTION OF OLDER ICU SURVIVORS: SENSITIVITY TO DEATH Innovation In Aging 2017, 1: 19-19. PMCID: PMC6241429, DOI: 10.1093/geroni/igx004.070.
  • DEALING WITH TRUNCATION BY DEATH IN LONGITUDINAL ANALYSES OF GERONTOLOGIC OUTCOMESMurphy T, Barry L, Van Ness P. DEALING WITH TRUNCATION BY DEATH IN LONGITUDINAL ANALYSES OF GERONTOLOGIC OUTCOMES Innovation In Aging 2017, 1: 18-19. PMCID: PMC6241470, DOI: 10.1093/geroni/igx004.069.
  • INDIVIDUALISED ABSOLUTE RISK CALCULATOR FOR PERSONS WITH MULTIPLE CHRONIC CONDITIONSAllore H, McAvay G, Murphy T, Agogo G, Fragoso C. INDIVIDUALISED ABSOLUTE RISK CALCULATOR FOR PERSONS WITH MULTIPLE CHRONIC CONDITIONS Innovation In Aging 2017, 1: 739-739. PMCID: PMC6248692, DOI: 10.1093/geroni/igx004.2664.
  • 44Ferrante L, Pisani M, Murphy T, Gahbauer E, Leo-Summers L, Gill T. 44 Critical Care Medicine 2016, 44: 97. DOI: 10.1097/01.ccm.0000508762.61546.56.
  • PRESENTATION AND TREATMENT OF THE “OLDEST-OLD” HOSPITALIZED WITH ACUTE MYOCARDIAL INFARCTION: THE SILVER AMI STUDYGupta A, Geda M, Murphy T, Tsang S, Gill T, McNamara R, Dodson J, Chaudhry S. PRESENTATION AND TREATMENT OF THE “OLDEST-OLD” HOSPITALIZED WITH ACUTE MYOCARDIAL INFARCTION: THE SILVER AMI STUDY Journal Of The American College Of Cardiology 2016, 67: 557. DOI: 10.1016/s0735-1097(16)30558-7.
  • SEX DIFFERENCES IN GERIATRIC IMPAIRMENTS AND IN-HOSPITAL MANAGEMENT STRATEGIES AMONG OLDER ADULTS HOSPITALIZED FOR AMI: THE SILVER AMI STUDYNanna M, Geda M, Murphy T, Tsang S, Dreyer R, Lakshminarayan D, Welty F, Chaudhry S, Dodson J. SEX DIFFERENCES IN GERIATRIC IMPAIRMENTS AND IN-HOSPITAL MANAGEMENT STRATEGIES AMONG OLDER ADULTS HOSPITALIZED FOR AMI: THE SILVER AMI STUDY Journal Of The American College Of Cardiology 2016, 67: 462. DOI: 10.1016/s0735-1097(16)30463-6.
  • Abstract 383: Quality of Weight Measurement Practices Among Heart Failure InpatientsNanna M, Murphy T, Wong R, Bazylevska V, Bellumkonda L, McNamara R. Abstract 383: Quality of Weight Measurement Practices Among Heart Failure Inpatients Circulation Cardiovascular Quality And Outcomes 2015, 8 DOI: 10.1161/circoutcomes.8.suppl_2.383.
  • IN HOSPITAL WEIGHT CHANGE IS NOT ASSOCIATED WITH READMISSION RISK IN PATIENTS WITH HEART FAILURENanna M, Bazylevska V, Wong R, Murphy T, Bellumkonda L, McNamara R. IN HOSPITAL WEIGHT CHANGE IS NOT ASSOCIATED WITH READMISSION RISK IN PATIENTS WITH HEART FAILURE Journal Of The American College Of Cardiology 2015, 65: a812. DOI: 10.1016/s0735-1097(15)60812-9.
  • Signal‐to‐Noise Ratios for Robust DesignMurphy T, Tsui K, McShane‐Vaughn M. Signal‐to‐Noise Ratios for Robust Design 2014 DOI: 10.1002/9781118445112.stat04113.
  • Performance Measures for Robust DesignMurphy T, Tsui K. Performance Measures for Robust Design 2014 DOI: 10.1002/9781118445112.stat04109.
  • Pleural Effusions and 30-Day MortalityMurphy E, Pisani M, Murphy T, Araujo K, Kookoolis A, Argento A, Puchalski J. Pleural Effusions and 30-Day Mortality CHEST Journal 2013, 144: 507a-507b. DOI: 10.1378/chest.1703023.
  • Functional Status After Critical Illness: Agreement Between Patient and Proxy AssessmentsAhasic A, Murphy T, Araujo K, Pisani M. Functional Status After Critical Illness: Agreement Between Patient and Proxy Assessments CHEST Journal 2013, 144: 393a-393b. DOI: 10.1378/chest.1693988.
  • Sources of Overnight Patient Sleep Disruption in the Medical Intensive Care UnitKnauert M, Yaggi H, Redeker N, Murphy T, Araujo K, Pisani M. Sources of Overnight Patient Sleep Disruption in the Medical Intensive Care Unit CHEST Journal 2012, 142: 547a-547b. DOI: 10.1378/chest.1383037.
  • Impact of Thoracentesis on Dyspnea and Quality of LifeArgento A, Pisani M, Murphy T, Araujo K, Kookoolis A, Johnson K, Puchalski J. Impact of Thoracentesis on Dyspnea and Quality of Life CHEST Journal 2012, 142: 488a-488b. DOI: 10.1378/chest.1389760.
  • The Safety, Tolerability And Outcomes Of Performing Endobronchial Ultrasound (EBUS) In Obese PatientsErb C, Pisani M, Murphy T, Araujo K, Puchalski J. The Safety, Tolerability And Outcomes Of Performing Endobronchial Ultrasound (EBUS) In Obese Patients 2012, a3000-a3000. DOI: 10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a3000.
  • Feasibility Of Conducting 24-Hour Polysomnography Studies In The Medical Intensive Care UnitKnauert-Brown M, Yaggi H, Redeker N, Murphy T, Araujo K, Donlon T, Pisani M. Feasibility Of Conducting 24-Hour Polysomnography Studies In The Medical Intensive Care Unit 2012, a1617-a1617. DOI: 10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a1617.
  • Bayesian Time-Series Analysis of a Repeated-Measures Poisson Outcome With Excess ZeroesMurphy TE, Van Ness PH, Araujo KL, Pisani MA. Bayesian Time-Series Analysis of a Repeated-Measures Poisson Outcome With Excess Zeroes American Journal Of Epidemiology 2011, 174: 1230-1237. PMID: 22025357, PMCID: PMC3254157, DOI: 10.1093/aje/kwr252.
  • Identifying Feasible Design Concepts for Products with Competing Performance Requirements by Metamodeling of Loss-Scaled Principal ComponentsMurphy T, Lin Y, Tsui K, Chen V, Allen J. Identifying Feasible Design Concepts for Products with Competing Performance Requirements by Metamodeling of Loss-Scaled Principal Components Quality Engineering 2011, 23: 167-179. PMID: 23125480, PMCID: PMC3487716, DOI: 10.1080/08982112.2011.555438.
  • Bayesian hierarchical modeling for a non‐randomized, longitudinal fall prevention trial with spatially correlated observationsMurphy TE, Allore HG, Leo‐Summers L, Carlin BP. Bayesian hierarchical modeling for a non‐randomized, longitudinal fall prevention trial with spatially correlated observations Statistics In Medicine 2011, 30: 522-530. PMID: 21294148, PMCID: PMC3477673, DOI: 10.1002/sim.3912.
  • Treatment of Death in the Analysis of Longitudinal Studies of Gerontological OutcomesMurphy TE, Han L, Allore HG, Peduzzi PN, Gill TM, Lin H. Treatment of Death in the Analysis of Longitudinal Studies of Gerontological Outcomes The Journals Of Gerontology Series A 2010, 66A: 109-114. PMID: 21030467, PMCID: PMC3011957, DOI: 10.1093/gerona/glq188.
  • Disability In Activities Of Daily Living And Quality Of Life Among Older Medical ICU SurvivorsVest M, Murphy T, Araujo K, Pisani M. Disability In Activities Of Daily Living And Quality Of Life Among Older Medical ICU Survivors 2010, a5358-a5358. DOI: 10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a5358.
  • Sedative, Narcotic And Delirium Drug Dosing By Nursing Shift In A Medical ICUBramley K, Vest M, Murphy T, Araujo K, Pisani M. Sedative, Narcotic And Delirium Drug Dosing By Nursing Shift In A Medical ICU 2010, a4549-a4549. DOI: 10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a4549.
  • Duration of ICU Delirium, Severity of the Underlying Disease, and MortalityPisani M, Murphy T, Araujo K, Van Ness P. Duration of ICU Delirium, Severity of the Underlying Disease, and Mortality American Journal Of Respiratory And Critical Care Medicine 2010, 181: 420-421. DOI: 10.1164/ajrccm.181.4.420.
  • Assessing Multiple Medication Use With Probabilities of Benefits and HarmsMurphy TE, Agostini JV, Van Ness PH, Peduzzi P, Tinetti ME, Allore HG. Assessing Multiple Medication Use With Probabilities of Benefits and Harms Journal Of Aging And Health 2008, 20: 694-709. PMID: 18625759, PMCID: PMC3477770, DOI: 10.1177/0898264308321006.
  • Effect of Dissemination of Evidence in Reducing Injuries from FallsTinetti ME, Baker DI, King M, Gottschalk M, Murphy TE, Acampora D, Carlin BP, Leo-Summers L, Allore HG. Effect of Dissemination of Evidence in Reducing Injuries from Falls New England Journal Of Medicine 2008, 359: 252-261. PMID: 18635430, PMCID: PMC3472807, DOI: 10.1056/nejmoa0801748.
  • Performance Measures for Robust DesignMurphy T, Tsui K. Performance Measures for Robust Design 2007 DOI: 10.1002/9780470061572.eqr038.
  • Signal‐to‐Noise Ratios for Robust DesignMurphy T, Tsui K, McShane‐Vaughn M. Signal‐to‐Noise Ratios for Robust Design 2007 DOI: 10.1002/9780470061572.eqr042.
  • Hierarchical models to evaluate translational research: Connecticut collaboration for fall preventionMurphy TE, Tinetti ME, Allore HG. Hierarchical models to evaluate translational research: Connecticut collaboration for fall prevention Contemporary Clinical Trials 2007, 29: 343-350. PMID: 18054289, PMCID: PMC2453244, DOI: 10.1016/j.cct.2007.10.004.
  • Mining and modeling for a metropolitan Atlanta ozone pollution decision-making frameworkYang Z, Chen V, Chang M, Murphy T, Tsai J. Mining and modeling for a metropolitan Atlanta ozone pollution decision-making framework IIE Transactions 2007, 39: 607-615. DOI: 10.1080/07408170600899508.
  • Statistical Methods for Quality and Productivity ImprovementJiang W, Murphy T, Tsui K. Statistical Methods for Quality and Productivity Improvement 2006, 173-192. DOI: 10.1007/978-1-84628-288-1_10.
  • A review of robust design methods for multiple responsesMurphy T, Tsui K, Allen J. A review of robust design methods for multiple responses Research In Engineering Design 2005, 16: 118-132. DOI: 10.1007/s00163-005-0004-0.
  • A review of robust design methods for multiple responsesMurphy T, Tsui K, Allen J. A review of robust design methods for multiple responses Research In Engineering Design 2004, 15: 201-215. DOI: 10.1007/s00163-004-0054-8.
  • Compromise Design Settings for Multiple ResponsesMurphy T, Tsui K, Allen J. Compromise Design Settings for Multiple Responses 2002 DOI: 10.2514/6.2002-5615.
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