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Nita Ahuja

MD, MBA, FACS

William H. Carmalt Professor of Surgery; Chair, Surgery; Associate Cancer Center Director, Surgical Services

Research & Publications
Biography
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Coauthors

Selected Publications

The Promise of Epigenetics Research in the Treatment of Appendiceal NeoplasmsLadel L, Tan W, Jeyakanthan T, Sailo B, Sharma A, Ahuja N. The Promise of Epigenetics Research in the Treatment of Appendiceal Neoplasms. Cells 2023, 12: 1962. PMID: 37566041, PMCID: PMC10417136, DOI: 10.3390/cells12151962.
Impact of COVID-19 on the gastrointestinal surgical oncology patient populationBakkila B, Marks V, Kerekes D, Kunstman J, Salem R, Billingsley K, Ahuja N, Laurans M, Olino K, Khan S. Impact of COVID-19 on the gastrointestinal surgical oncology patient population. Heliyon 2023, 9: e18459. PMID: 37534012, PMCID: PMC10391949, DOI: 10.1016/j.heliyon.2023.e18459.
76 ROLE OF COLECTOMY FOR APPENDICEAL TUMORSMarks V, Kerekes D, Ahuja N, Turaga K, Khan S. 76 ROLE OF COLECTOMY FOR APPENDICEAL TUMORS. Gastroenterology 2023, 164: s-1442. DOI: 10.1016/s0016-5085(23)04363-9.
A study of using epigenetic modulators to enhance response to pembrolizumab (MK-3475) in microsatellite stable advanced colorectal cancerBaretti M, Murphy A, Zahurak M, Gianino N, Parkinson R, Walker R, Lopez-Vidal T, Zheng L, Rosner G, Ahuja N, Kurt S, Azad N. A study of using epigenetic modulators to enhance response to pembrolizumab (MK-3475) in microsatellite stable advanced colorectal cancer. Clinical Epigenetics 2023, 15: 74. PMID: 37120591, PMCID: PMC10149019, DOI: 10.1186/s13148-023-01485-x.
Early Detection of Cancers in the Era of Precision OncologyTan W, Sharma A, Das P, Ahuja N. Early Detection of Cancers in the Era of Precision Oncology. Current Opinion In Oncology 2023, 35: 115-124. PMID: 36721896, DOI: 10.1097/cco.0000000000000931.
Utility of promoter hypermethylation in malignant risk stratification of intraductal papillary mucinous neoplasmsChhoda A, Sharma A, Sailo B, Tang H, Ruzgar N, Tan W, Ying L, Khatri R, Narayanan A, Mane S, De Kumar B, Wood L, Iacobuzio-Donahue C, Wolfgang C, Kunstman J, Salem R, Farrell J, Ahuja N. Utility of promoter hypermethylation in malignant risk stratification of intraductal papillary mucinous neoplasms. Clinical Epigenetics 2023, 15: 28. PMID: 36803844, PMCID: PMC9942382, DOI: 10.1186/s13148-023-01429-5.
Comparison of Male and Female Surgeons’ Experiences With Gender Across 5 Qualitative/Quantitative DomainsZogg C, Kandi L, Thomas H, Siki M, Choi A, Guetter C, Smith C, Maduakolam E, Kondle S, Stein S, Shaughnessy E, Ahuja N. Comparison of Male and Female Surgeons’ Experiences With Gender Across 5 Qualitative/Quantitative Domains. JAMA Surgery 2023, 158: e226431. PMID: 36477515, PMCID: PMC9857060, DOI: 10.1001/jamasurg.2022.6431.
Use of distinct molecular signatures of appendiceal cancer subtypes to assess biomarker development.Tan W, Tian M, Ruzgar N, Hengartner A, Sailo B, Ang-Olson O, Ubas A, John N, Yaghoobi V, Tang H, Sharma A, Nalbantoglu I, Ahuja N. Use of distinct molecular signatures of appendiceal cancer subtypes to assess biomarker development. Journal Of Clinical Oncology 2023, 41: 189-189. DOI: 10.1200/jco.2023.41.4_suppl.189.
A randomized, phase II trial of oral azacitidine (CC-486) in patients with resected pancreatic adenocarcinoma at high risk for recurrenceHeumann T, Baretti M, Sugar E, Durham J, Linden S, Lopez-Vidal T, Leatherman J, Cope L, Sharma A, Weekes C, O’Dwyer P, Reiss K, Monga D, Ahuja N, Azad N. A randomized, phase II trial of oral azacitidine (CC-486) in patients with resected pancreatic adenocarcinoma at high risk for recurrence. Clinical Epigenetics 2022, 14: 166. PMID: 36463226, PMCID: PMC9719150, DOI: 10.1186/s13148-022-01367-8.
Bile acid distributions, sex-specificity, and prognosis in colorectal cancerCai Y, Shen X, Lu L, Yan H, Huang H, Gaule P, Muca E, Theriot CM, Rattray Z, Rattray NJW, Lu J, Ahuja N, Zhang Y, Paty PB, Khan SA, Johnson CH. Bile acid distributions, sex-specificity, and prognosis in colorectal cancer. Biology Of Sex Differences 2022, 13: 61. PMID: 36274154, PMCID: PMC9590160, DOI: 10.1186/s13293-022-00473-9.
How Male and Female Surgeons’ Experiences with Gender in Surgery Compare: National Concurrent Mixed-Methods Survey of Fellows of the American College of SurgeonsZogg C, Kandi L, Thomas H, Siki M, Ahuja N. How Male and Female Surgeons’ Experiences with Gender in Surgery Compare: National Concurrent Mixed-Methods Survey of Fellows of the American College of Surgeons. Journal Of The American College Of Surgeons 2022, 235: s221-s222. DOI: 10.1097/01.xcs.0000894740.81658.e5.
Benefit of Extended Surveillance of Low-Risk Pancreatic Cysts After 5-Year Stability: A Systematic Review and Meta-AnalysisChhoda A, Singh S, Sheth AH, Grimshaw AA, Gunderson C, Sharma P, Kunstman JW, Sharma A, Ahuja N, Gonda TA, Farrell JJ. Benefit of Extended Surveillance of Low-Risk Pancreatic Cysts After 5-Year Stability: A Systematic Review and Meta-Analysis. Clinical Gastroenterology And Hepatology 2022, 21: 1430-1446. PMID: 35568304, DOI: 10.1016/j.cgh.2022.04.025.
1147: DISPARITIES IN TIME TO TREATMENT INITIATION IN COLORECTAL CANCER IN THE US FROM 2004-2018: ANALYSIS OF THE NATIONAL CANCER DATABASEKhatri R, Chhoda A, Sharma A, Farrell J, Ahuja N, Ehrlich A, Friedenberg F. 1147: DISPARITIES IN TIME TO TREATMENT INITIATION IN COLORECTAL CANCER IN THE US FROM 2004-2018: ANALYSIS OF THE NATIONAL CANCER DATABASE. Gastroenterology 2022, 162: s-270-s-271. DOI: 10.1016/s0016-5085(22)60641-3.
Tu1185: DOES CURRENT EVIDENCE SUPPORT CYST GROWTH RATE AS A WORRISOME FEATURE? A SYSTEMATIC REVIEW AND META-ANALYSISSingh S, Chhoda A, Vodusek Z, Khatri R, Gunderson C, McCarty T, Sharma P, Grimshaw A, Kunstman J, Sharma A, Ahuja N, Gonda T, Farrell J. Tu1185: DOES CURRENT EVIDENCE SUPPORT CYST GROWTH RATE AS A WORRISOME FEATURE? A SYSTEMATIC REVIEW AND META-ANALYSIS. Gastroenterology 2022, 162: s-907. DOI: 10.1016/s0016-5085(22)62148-6.
Mo1131: HIGHLY SPECIFIC PROMOTER METHYLATION MARKERS FOR MALIGANT STRATIFICATION OF INTRADUCTAL PAPILLARY MUCINOUS NEOPLASMSChhoda A, Sharma A, Tang H, Tan W, Sailo B, Peters N, Ying L, Ruzgar N, Kunstman J, Salem R, Farrell J, Ahuja N. Mo1131: HIGHLY SPECIFIC PROMOTER METHYLATION MARKERS FOR MALIGANT STRATIFICATION OF INTRADUCTAL PAPILLARY MUCINOUS NEOPLASMS. Gastroenterology 2022, 162: s-708. DOI: 10.1016/s0016-5085(22)61664-0.
Evaluation of Racial Disparities in Quality of Care for Patients With Gastrointestinal Tract Cancer Treated With SurgeryBakkila BF, Kerekes D, Nunez-Smith M, Billingsley KG, Ahuja N, Wang K, Oladele C, Johnson CH, Khan SA. Evaluation of Racial Disparities in Quality of Care for Patients With Gastrointestinal Tract Cancer Treated With Surgery. JAMA Network Open 2022, 5: e225664. PMID: 35377425, PMCID: PMC8980937, DOI: 10.1001/jamanetworkopen.2022.5664.
Correction to: Analysis of Differentiation Changes and Outcomes at Time of First Recurrence of Retroperitoneal Liposarcoma by Transatlantic Australasian Retroperitoneal Sarcoma Working Group (TARPSWG)Nessim C, Raut CP, Callegaro D, Barretta F, Miceli R, Fairweather M, Blay JY, Strauss D, Rutkowski P, Ahuja N, Gonzalez R, Grignani G, Quagliuolo V, Stoeckle E, Lahat G, De Paoli A, Pillarisetty VG, Canter RJ, Mullen JT, Pennacchioli E, van Houdt W, Swallow CJ, Schrage Y, Cardona K, Fiore M, Gronchi A, Bagaria SP. Correction to: Analysis of Differentiation Changes and Outcomes at Time of First Recurrence of Retroperitoneal Liposarcoma by Transatlantic Australasian Retroperitoneal Sarcoma Working Group (TARPSWG). Annals Of Surgical Oncology 2022, 29: 4390-4390. PMID: 35307808, DOI: 10.1245/s10434-022-11600-6.
Correction: ASO Visual Abstract: An Analysis of Differentiation Changes and Outcomes at the First Recurrence of Retroperitoneal Liposarcoma by the Transatlantic Australasian Retroperitoneal Sarcoma Working Group (TARPSWG)Nessim C, Raut C, Callegaro D, Barretta F, Miceli R, Fairweather M, Blay J, Strauss D, Rutkowski P, Ahuja N, Gonzalez R, Grignani G, Quagliuolo V, Stoeckle E, Lahat G, De Paoli A, Pillarisetty V, Canter R, Mullen J, Pennacchioli E, van Houdt W, Swallow C, Schrage Y, Cardona K, Fiore M, Gronchi A, Bagaria S. Correction: ASO Visual Abstract: An Analysis of Differentiation Changes and Outcomes at the First Recurrence of Retroperitoneal Liposarcoma by the Transatlantic Australasian Retroperitoneal Sarcoma Working Group (TARPSWG). Annals Of Surgical Oncology 2022, 29: 4391-4391. DOI: 10.1245/s10434-022-11601-5.
Abstract PO-155: Racial heterogeneity in the molecular landscape of pancreatic adenocarcinoma: A call for actionLarson H, Chhoda A, Hengartner A, Hasan N, Ruzgar N, Yalamanchi S, Kunstman J, Farrell J, Sharma A, Ahuja N. Abstract PO-155: Racial heterogeneity in the molecular landscape of pancreatic adenocarcinoma: A call for action. Cancer Epidemiology Biomarkers & Prevention 2022, 31: po-155-po-155. DOI: 10.1158/1538-7755.disp21-po-155.
1470P Oral azacitidine (CC-486) in patients with resected pancreatic adenocarcinoma at high risk for recurrenceHeumann T, Baretti M, Sugar E, Durhman J, Liden S, Miles T, Lopez-Vidal T, Leatherman J, Sharma A, Ahuja N, Weekes C, O'Dwyer P, Monga D, Binder K, Azad N. 1470P Oral azacitidine (CC-486) in patients with resected pancreatic adenocarcinoma at high risk for recurrence. Annals Of Oncology 2021, 32: s1087-s1088. DOI: 10.1016/j.annonc.2021.08.797.
Abstract 898: Survival for patients with early-onset colorectal cancer - An overall survival analysis from the National Cancer Database, 2004-2015Cheng E, Blackburn H, Ng K, Spiegelman D, Irwin M, Ma X, Gross C, Tabung F, Giovannucci E, Kunz P, Llor X, Billingsley K, Meyerhardt J, Ahuja N, Fuchs C. Abstract 898: Survival for patients with early-onset colorectal cancer - An overall survival analysis from the National Cancer Database, 2004-2015. Cancer Research 2021, 81: 898-898. DOI: 10.1158/1538-7445.am2021-898.
ASO Visual Abstract: An Analysis of Differentiation Changes and Outcomes at the First Recurrence of Retroperitoneal Liposarcoma by the Transatlantic Australasian Retroperitoneal Sarcoma Working Group (TARPSWG)Nessim C, Raut C, Callegaro D, Barretta F, Miceli R, Fairweather M, Blay J, Strauss D, Rutkowski P, Ahuja N, Gonzalez R, Grignani G, Quagliuolo V, Stoeckle E, Lahat G, De Paoli A, Pillarisetty V, Canter R, Mullen J, Pennacchioli E, van Houdt W, Swallow C, Schrage Y, Cardona K, Fiore M, Gronchi A, Bagaria S. ASO Visual Abstract: An Analysis of Differentiation Changes and Outcomes at the First Recurrence of Retroperitoneal Liposarcoma by the Transatlantic Australasian Retroperitoneal Sarcoma Working Group (TARPSWG). Annals Of Surgical Oncology 2021, 28: 490-491. DOI: 10.1245/s10434-021-10095-x.
Sa302 IS MULTIFOCALITY IN INTRADUCTAL PAPILLARY MUCINOUS NEOPLASMS A RISK FACTOR FOR PANCREATIC MALIGNANCY?: A SYSTEMATIC REVIEW AND META-ANALYSISChhoda A, Singh S, Grimshaw A, Sheth A, Sharma A, Kunstman J, Ahuja N, Farrell J. Sa302 IS MULTIFOCALITY IN INTRADUCTAL PAPILLARY MUCINOUS NEOPLASMS A RISK FACTOR FOR PANCREATIC MALIGNANCY?: A SYSTEMATIC REVIEW AND META-ANALYSIS. Gastroenterology 2021, 160: s-477. DOI: 10.1016/s0016-5085(21)01845-x.
Sa298 IS IT SAFE TO STOP SURVEILLANCE OF PANCREATIC CYSTS AFTER 5 YEARS OF STABILITY?: A SYSTEMATIC REVIEW AND META-ANALYSIS OF CURRENT EVIDENCE.Chhoda A, Singh S, Sheth A, Sharma P, Sharma A, Kunstman J, Grimshaw A, Ahuja N, Farrell J. Sa298 IS IT SAFE TO STOP SURVEILLANCE OF PANCREATIC CYSTS AFTER 5 YEARS OF STABILITY?: A SYSTEMATIC REVIEW AND META-ANALYSIS OF CURRENT EVIDENCE. Gastroenterology 2021, 160: s-475. DOI: 10.1016/s0016-5085(21)01841-2.
Abstract PO-015: Hypermethylated genes in leiomyosarcoma can be targeted through guadecitabine treatmentHasan N, De Carvalho Fischer C, Sharma A, Ahuja N. Abstract PO-015: Hypermethylated genes in leiomyosarcoma can be targeted through guadecitabine treatment. Cancer Research 2020, 80: po-015-po-015. DOI: 10.1158/1538-7445.epimetab20-po-015.
Patterns of recurrence and survival probability after second recurrence of retroperitoneal sarcoma: A study from TARPSWG.van Houdt WJ, Fiore M, Barretta F, Rutkowski P, Blay JY, Lahat G, Strauss D, Gonzalez RJ, Ahuja N, Grignani G, Quagliuolo V, Stoeckle E, De Paoli A, Schrage Y, Cardona K, Pennacchioli E, Pillarisetty VG, Nessim C, Swallow CJ, Bagaria SP, Canter R, Mullen JT, Callegaro D, Fairweather M, Miceli R, Raut CP, Gronchi A, Gladdy RA. Patterns of recurrence and survival probability after second recurrence of retroperitoneal sarcoma: A study from TARPSWG. Cancer 2020, 126: 4917-4925. PMID: 32797703, DOI: 10.1002/cncr.33139.
Variations in recommended surveillance in colorectal cancer survivorship care plans.Chodoff A, Smith K, Shukla A, Blackford A, Ahuja N, Johnston F, Peairs K, Ngaiza J, Warczynski T, Nettles B, Stotsky-Himelfarb E, Murphy A, Mayonado N, DeSanto J, Snyder C, Choi Y. Variations in recommended surveillance in colorectal cancer survivorship care plans. Journal Of Clinical Oncology 2020, 38: 13-13. DOI: 10.1200/jco.2020.38.29_suppl.13.
S0101 Clinical and Demographic Predictors of Rapidly Progressive Disease in Patients Undergoing Surgery for Pancreatic Ductal Adenocarcinoma: Risk Profiling From the National Cancer DatabaseIlagan-Ying Y, Ying L, Ferrucci L, Peters N, Blackburn H, Kunstman J, Ahuja N. S0101 Clinical and Demographic Predictors of Rapidly Progressive Disease in Patients Undergoing Surgery for Pancreatic Ductal Adenocarcinoma: Risk Profiling From the National Cancer Database. The American Journal Of Gastroenterology 2020, 115: s48-s49. DOI: 10.14309/01.ajg.0000702452.53969.ae.
22 Poster Discussion A phase II study of Guadecitabine (G) with Irinotecan (IRI) vs regorafenib or TAS-102 in metastatic colorectal cancer (mCRC) patients (pts)Lee V, Zahurak M, Cercek A, Verheul H, Lenz H, Jones P, Baylin S, Parkinson R, Rami V, Lilly E, Miles T, Brown T, Ahuja N, Khoueiry A, Azad N. 22 Poster Discussion A phase II study of Guadecitabine (G) with Irinotecan (IRI) vs regorafenib or TAS-102 in metastatic colorectal cancer (mCRC) patients (pts). European Journal Of Cancer 2020, 138: s12. DOI: 10.1016/s0959-8049(20)31096-0.
Pandemic Recovery Using a COVID-Minimal Cancer Surgery PathwayBoffa DJ, Judson BL, Billingsley KG, Galetta D, Fontanez P, Odermatt C, Lindner K, Mitchell MR, Henderson CM, Carafeno T, Pinto J, Wagner J, Ancuta M, Beley P, Turner AL, Banack T, Laurans MS, Johnson DC, Yoo P, Morton JM, Zurich H, Davis K, Ahuja N. Pandemic Recovery Using a COVID-Minimal Cancer Surgery Pathway. The Annals Of Thoracic Surgery 2020, 110: 718-724. PMID: 32417195, PMCID: PMC7227551, DOI: 10.1016/j.athoracsur.2020.05.003.
Neoantigen-based EpiGVAX vaccine initiates antitumor immunity in colorectal cancerKim VM, Pan X, Soares KC, Azad NS, Ahuja N, Gamper CJ, Blair AB, Muth S, Ding D, Ladle BH, Zheng L. Neoantigen-based EpiGVAX vaccine initiates antitumor immunity in colorectal cancer. JCI Insight 2020, 5: e136368. PMID: 32376802, PMCID: PMC7253020, DOI: 10.1172/jci.insight.136368.
Understanding the Barriers to Reporting Sexual Harassment in Surgical TrainingFreedman-Weiss MR, Chiu AS, Heller DR, Cutler AS, Longo WE, Ahuja N, Yoo PS. Understanding the Barriers to Reporting Sexual Harassment in Surgical Training. Annals Of Surgery 2020, Publish Ahead of Print: &na;. PMID: 30946072, DOI: 10.1097/sla.0000000000003295.
Association of Treatment Inequity and Ancestry With Pancreatic Ductal Adenocarcinoma SurvivalHeller DR, Nicolson NG, Ahuja N, Khan S, Kunstman JW. Association of Treatment Inequity and Ancestry With Pancreatic Ductal Adenocarcinoma Survival. JAMA Surgery 2020, 155: e195047. PMID: 31800002, PMCID: PMC6902102, DOI: 10.1001/jamasurg.2019.5047.
Exposing Hidden Targets: Combining epigenetic and immunotherapy to overcome cancer resistanceOlino K, Park T, Ahuja N. Exposing Hidden Targets: Combining epigenetic and immunotherapy to overcome cancer resistance. Seminars In Cancer Biology 2020, 65: 114-122. PMID: 31911188, DOI: 10.1016/j.semcancer.2020.01.001.
Abstract B23: Bioadhesive nanoparticles as a delivery vehicle in pancreatic cancer epithelial cells and pancreatic fibroblastsHasan N, Suh H, Saltzman M, Ahuja N. Abstract B23: Bioadhesive nanoparticles as a delivery vehicle in pancreatic cancer epithelial cells and pancreatic fibroblasts. Cancer Research 2019, 79: b23-b23. DOI: 10.1158/1538-7445.panca19-b23.
The Emerging Roles of ATP-Dependent Chromatin Remodeling Complexes in Pancreatic CancerHasan N, Ahuja N. The Emerging Roles of ATP-Dependent Chromatin Remodeling Complexes in Pancreatic Cancer. Cancers 2019, 11: 1859. PMID: 31769422, PMCID: PMC6966483, DOI: 10.3390/cancers11121859.
Targeting the epigenome of pancreatic cancer for therapy: challenges and opportunitiesBaretti M, Ahuja N, Azad N. Targeting the epigenome of pancreatic cancer for therapy: challenges and opportunities. Annals Of Pancreatic Cancer 2019, 2: 18-18. DOI: 10.21037/apc.2019.10.01.
MAPT promoter CpG island hypermethylation is associated with poor prognosis in patients with stage II colorectal cancerWang C, Liu Y, Guo W, Zhu X, Ahuja N, Fu T. MAPT promoter CpG island hypermethylation is associated with poor prognosis in patients with stage II colorectal cancer. Cancer Management And Research 2019, 11: 7337-7343. PMID: 31496795, PMCID: PMC6689138, DOI: 10.2147/cmar.s206731.
A phase 1 trial of the oral DNA methyltransferase inhibitor CC‐486 and the histone deacetylase inhibitor romidepsin in advanced solid tumorsGaillard SL, Zahurak M, Sharma A, Durham J, Reiss K, Sartorius‐Mergenthaler S, Downs M, Anders N, Ahuja N, Rudek M, Azad N. A phase 1 trial of the oral DNA methyltransferase inhibitor CC‐486 and the histone deacetylase inhibitor romidepsin in advanced solid tumors. Cancer 2019, 125: 2837-2845. PMID: 31012962, PMCID: PMC6663621, DOI: 10.1002/cncr.32138.
Predicting Survival in Patients Undergoing Resection for Locally Recurrent Retroperitoneal Sarcoma: A Study and Novel Nomogram from TARPSWG.Raut CP, Callegaro D, Miceli R, Barretta F, Rutkowski P, Blay JY, Lahat G, Strauss DC, Gonzalez R, Ahuja N, Grignani G, Quagliuolo V, Stoeckle E, De Paoli A, Pillarisetty VG, Nessim C, Swallow C, Bagaria SP, Canter RJ, Mullen JT, Gelderblom H, Pennacchioli E, van Coevorden F, Cardona K, Fiore M, Fairweather M, Gronchi A. Predicting Survival in Patients Undergoing Resection for Locally Recurrent Retroperitoneal Sarcoma: A Study and Novel Nomogram from TARPSWG. Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research 2019, 25: 2664-2671. PMID: 30723141, DOI: 10.1158/1078-0432.CCR-18-2700.
Promoter methylation of ADAMTS1 and BNC1 as potential biomarkers for early detection of pancreatic cancer in bloodEissa MAL, Lerner L, Abdelfatah E, Shankar N, Canner JK, Hasan NM, Yaghoobi V, Huang B, Kerner Z, Takaesu F, Wolfgang C, Kwak R, Ruiz M, Tam M, Pisanic TR, Iacobuzio-Donahue CA, Hruban RH, He J, Wang TH, Wood LD, Sharma A, Ahuja N. Promoter methylation of ADAMTS1 and BNC1 as potential biomarkers for early detection of pancreatic cancer in blood. Clinical Epigenetics 2019, 11: 59. PMID: 30953539, PMCID: PMC6451253, DOI: 10.1186/s13148-019-0650-0.
Sarcomas in the United States: Recent trends and a call for improved stagingGage MM, Nagarajan N, Ruck JM, Canner JK, Khan S, Giuliano K, Gani F, Wolfgang C, Johnston FM, Ahuja N. Sarcomas in the United States: Recent trends and a call for improved staging. Oncotarget 2019, 10: 2462-2474. PMID: 31069009, PMCID: PMC6497437, DOI: 10.18632/oncotarget.26809.
Next-generation Sequencing in the Management of Gastric and Esophageal CancersRubinstein JC, Nicolson NG, Ahuja N. Next-generation Sequencing in the Management of Gastric and Esophageal Cancers. Surgical Clinics Of North America 2019, 99: 511-527. PMID: 31047039, DOI: 10.1016/j.suc.2019.02.005.
Aging-like Spontaneous Epigenetic Silencing Facilitates Wnt Activation, Stemness, and Braf V600E-Induced TumorigenesisTao Y, Kang B, Petkovich DA, Bhandari YR, In J, Stein-O'Brien G, Kong X, Xie W, Zachos N, Maegawa S, Vaidya H, Brown S, Yen R, Shao X, Thakor J, Lu Z, Cai Y, Zhang Y, Mallona I, Peinado MA, Zahnow CA, Ahuja N, Fertig E, Issa JP, Baylin SB, Easwaran H. Aging-like Spontaneous Epigenetic Silencing Facilitates Wnt Activation, Stemness, and Braf V600E-Induced Tumorigenesis. Cancer Cell 2019, 35: 315-328.e6. PMID: 30753828, PMCID: PMC6636642, DOI: 10.1016/j.ccell.2019.01.005.
Epigenetic priming prior to pembrolizumab in mismatch repair-proficient advanced colorectal cancer.Murphy A, Walker R, Lutz E, Parkinson R, Ahuja N, Zheng L, Jaffee E, Azad N. Epigenetic priming prior to pembrolizumab in mismatch repair-proficient advanced colorectal cancer. Journal Of Clinical Oncology 2019, 37: 591-591. DOI: 10.1200/jco.2019.37.4_suppl.591.
Operative Mortality Prediction for Primary Rectal Cancer: Age MattersLi Z, Coleman J, D'Adamo CR, Wolf J, Katlic M, Ahuja N, Blumberg D, Ahuja V. Operative Mortality Prediction for Primary Rectal Cancer: Age Matters. Journal Of The American College Of Surgeons 2019, 228: 627-633. PMID: 30630082, DOI: 10.1016/j.jamcollsurg.2018.12.014.
A Roadmap for Aspiring Surgeon-Scientists in Today's Healthcare EnvironmentGoldstein AM, Blair AB, Keswani SG, Gosain A, Morowitz M, Kuo J, Levine M, Ahuja N, Hackam DJ. A Roadmap for Aspiring Surgeon-Scientists in Today's Healthcare Environment. Annals Of Surgery 2019, 269: 66-72. PMID: 29958227, PMCID: PMC6298819, DOI: 10.1097/sla.0000000000002840.
A Phase I Trial of a Guadecitabine (SGI-110) and Irinotecan in Metastatic Colorectal Cancer Patients Previously Exposed to IrinotecanLee V, Wang J, Zahurak M, Gootjes E, Verheul H, Parkinson R, Kerner Z, Sharma A, Rosner G, De Jesus-Acosta A, Laheru D, Le DT, Oganesian A, Lilly E, Brown T, Jones P, Baylin S, Ahuja N, Azad N. A Phase I Trial of a Guadecitabine (SGI-110) and Irinotecan in Metastatic Colorectal Cancer Patients Previously Exposed to Irinotecan. Clinical Cancer Research 2018, 24: 6160-6167. PMID: 30097434, DOI: 10.1158/1078-0432.ccr-18-0421.
Low Frequency of Lymph Node Metastases in Patients in the United States With Early-stage Gastric Cancers That Fulfill Japanese Endoscopic Resection CriteriaHanada Y, Choi AY, Hwang JH, Draganov PV, Khanna L, Sethi A, Bartel MJ, Goel N, Abe S, De Latour RA, Park K, Melis M, Newman E, Hatzaras I, Reddy SS, Farma JM, Liu X, Schlachterman A, Kresak J, Trapp G, Ansari N, Schrope B, Lee JY, Dhall D, Lo S, Jamil LH, Burch M, Gaddam S, Gong Y, Del Portillo A, Tomizawa Y, Truong CD, Brewer Gutierrez OI, Montgomery E, Johnston FM, Duncan M, Canto M, Ahuja N, Lennon AM, Ngamruengphong S. Low Frequency of Lymph Node Metastases in Patients in the United States With Early-stage Gastric Cancers That Fulfill Japanese Endoscopic Resection Criteria. Clinical Gastroenterology And Hepatology 2018, 17: 1763-1769. PMID: 30471457, DOI: 10.1016/j.cgh.2018.11.031.
Trends in Outcomes After Cytoreductive Surgery with Hyperthermic Intraperitoneal ChemotherapyGani F, Conca-Cheng AM, Nettles B, Ahuja N, Johnston FM. Trends in Outcomes After Cytoreductive Surgery with Hyperthermic Intraperitoneal Chemotherapy. Journal Of Surgical Research 2018, 234: 240-248. PMID: 30527480, DOI: 10.1016/j.jss.2018.09.032.
High-Dose Rate Brachytherapy Increases Disease-Free Survival for Retroperitoneal SarcomasSingh J, Gani F, Shankar N, Canner J, Overton H, Blair A, Lerner L, Narang A, Johnston F, Ahuja N. High-Dose Rate Brachytherapy Increases Disease-Free Survival for Retroperitoneal Sarcomas. Journal Of The American College Of Surgeons 2018, 227: s239-s240. DOI: 10.1016/j.jamcollsurg.2018.07.629.
Ensuring Equity, Diversity, and Inclusion in Academic SurgeryWest MA, Hwang S, Maier RV, Ahuja N, Angelos P, Bass BL, Brasel KJ, Chen H, Davis KA, Eberlein TJ, Fong Y, Greenberg CC, Lillemoe KD, McCarthy MC, Michelassi F, Numann PJ, Parangi S, Reyes JD, Sanfey HA, Stain SC, Weigel RJ, Wren SM. Ensuring Equity, Diversity, and Inclusion in Academic Surgery. Annals Of Surgery 2018, 268: 403-407. PMID: 30004923, DOI: 10.1097/sla.0000000000002937.
Comparing the long‐term outcomes among patients with stomach and small intestine gastrointestinal stromal tumors: An analysis of the National Cancer DatabaseGiuliano K, Ejaz A, Reames BN, Choi W, Sham J, Gage M, Johnston FM, Ahuja N. Comparing the long‐term outcomes among patients with stomach and small intestine gastrointestinal stromal tumors: An analysis of the National Cancer Database. Journal Of Surgical Oncology 2018, 118: 486-492. PMID: 30129672, DOI: 10.1002/jso.25172.
Genomics of Peritoneal MalignanciesKarunasena E, Sham J, McMahon KW, Ahuja N. Genomics of Peritoneal Malignancies. Surgical Oncology Clinics Of North America 2018, 27: 463-475. PMID: 29935683, DOI: 10.1016/j.soc.2018.02.004.
A novel epigenetic modulating agent sensitizes pancreatic cells to a chemotherapy agentThakar M, Hu Y, Morreale M, Lerner L, Lin W, Sen R, Cai Y, Karunasena E, Thakar M, Saggi S, Keer H, Ahuja N. A novel epigenetic modulating agent sensitizes pancreatic cells to a chemotherapy agent. PLOS ONE 2018, 13: e0199130. PMID: 29927979, PMCID: PMC6013229, DOI: 10.1371/journal.pone.0199130.
Resection of retroperitoneal sarcoma en‐bloc with inferior vena cava: 20 year outcomes of a single institutionBlair AB, Reames BN, Singh J, Gani F, Overton HN, Beaulieu RJ, Lum YW, Black JH, Johnston FM, Ahuja N. Resection of retroperitoneal sarcoma en‐bloc with inferior vena cava: 20 year outcomes of a single institution. Journal Of Surgical Oncology 2018, 118: 127-137. PMID: 29878363, PMCID: PMC6220674, DOI: 10.1002/jso.25096.
Minimally Invasive Versus Open Primary Resection for Retroperitoneal Soft Tissue Sarcoma: A Propensity-Matched Study From the National Cancer DatabaseGani F, Goel U, Blair AB, Singh J, Overton HN, Meyer CF, Canner JK, Pawlik TM, Ahuja N, Johnston FM. Minimally Invasive Versus Open Primary Resection for Retroperitoneal Soft Tissue Sarcoma: A Propensity-Matched Study From the National Cancer Database. Annals Of Surgical Oncology 2018, 25: 2209-2217. PMID: 29855832, PMCID: PMC8383095, DOI: 10.1245/s10434-018-6538-y.
Extraskeletal versus Skeletal Ewing Sarcoma in the adult population: Controversies in careLynch AD, Gani F, Meyer CF, Morris CD, Ahuja N, Johnston FM. Extraskeletal versus Skeletal Ewing Sarcoma in the adult population: Controversies in care. Surgical Oncology 2018, 27: 373-379. PMID: 30217290, DOI: 10.1016/j.suronc.2018.05.016.
Epigenetic PharmacologyBurkhart R, Sharma A, Ahuja N. Epigenetic Pharmacology. 2018, 1551-1575. DOI: 10.1007/978-1-4939-7193-0_69.
Treatment with epigenetic agents profoundly inhibits tumor growth in leiomyosarcomaDe Carvalho Fischer C, Hu Y, Morreale M, Lin WY, Wali A, Thakar M, Karunasena E, Sen R, Cai Y, Murphy L, Zahnow CA, Keer H, Thakar M, Ahuja N. Treatment with epigenetic agents profoundly inhibits tumor growth in leiomyosarcoma. Oncotarget 2018, 9: 19379-19395. PMID: 29721210, PMCID: PMC5922404, DOI: 10.18632/oncotarget.25056.
Epigenetics of gastrointestinal diseases: notes from a workshopMarks DL, Olson RL, Urrutia R, Billadeau DD, Roy N, Calin GA, Fabbri M, Koutsioumpa M, Iliopoulos D, Ordog T, Huebert R, Sarmento O, Bamidele AO, Faubion W, Lomberk GL, Siveke J, Ahuja N, Iovanna J, Hlady RA, Robertson K, Kisiel J, Pin CL, Fernandez-Zapico ME. Epigenetics of gastrointestinal diseases: notes from a workshop. Epigenetics 2018, 13: 449-457. PMID: 30056798, PMCID: PMC6140811, DOI: 10.1080/15592294.2018.1464351.
Automated diagnosis of colon cancer using hyperspectral sensingBeaulieu RJ, Goldstein SD, Singh J, Safar B, Banerjee A, Ahuja N. Automated diagnosis of colon cancer using hyperspectral sensing. International Journal Of Medical Robotics And Computer Assisted Surgery 2018, 14: e1897. PMID: 29479794, DOI: 10.1002/rcs.1897.
DNA Methylation Patterns Separate Senescence from Transformation Potential and Indicate Cancer RiskXie W, Kagiampakis I, Pan L, Zhang YW, Murphy L, Tao Y, Kong X, Kang B, Xia L, Carvalho FLF, Sen S, Yen R, Zahnow CA, Ahuja N, Baylin SB, Easwaran H. DNA Methylation Patterns Separate Senescence from Transformation Potential and Indicate Cancer Risk. Cancer Cell 2018, 33: 309-321.e5. PMID: 29438699, PMCID: PMC5813821, DOI: 10.1016/j.ccell.2018.01.008.
Introduction to the Special Edition of Annals of SurgeryWolfgang CL, Efron DT, Ahuja N, Lillemoe KD. Introduction to the Special Edition of Annals of Surgery. Annals Of Surgery 2018, 267: s1. PMID: 29401138, DOI: 10.1097/sla.0000000000002674.
Abstract A35: Treatment with demethylating drugs inhibits tumor growth in leiomyosarcoma cell lines and xenograft modelsFischer C, Hu Y, Singh J, Thakar M, Thakar M, Ahuja N. Abstract A35: Treatment with demethylating drugs inhibits tumor growth in leiomyosarcoma cell lines and xenograft models. Clinical Cancer Research 2018, 24: a35-a35. DOI: 10.1158/1557-3265.sarcomas17-a35.
Can echogenic appearance of neuroendocrine liver metastases on intraoperative ultrasonography predict tumor biology and prognosis?Dogeas E, Chong CCN, Weiss MJ, Ahuja N, Choti MA. Can echogenic appearance of neuroendocrine liver metastases on intraoperative ultrasonography predict tumor biology and prognosis? Hepato Pancreato Biliary 2017, 20: 237-243. PMID: 29103839, DOI: 10.1016/j.hpb.2017.08.029.
Combined circulating tumor DNA and protein biomarker-based liquid biopsy for the earlier detection of pancreatic cancers.Cohen JD, Javed AA, Thoburn C, Wong F, Tie J, Gibbs P, Schmidt CM, Yip-Schneider MT, Allen PJ, Schattner M, Brand RE, Singhi AD, Petersen GM, Hong SM, Kim SC, Falconi M, Doglioni C, Weiss MJ, Ahuja N, He J, Makary MA, Maitra A, Hanash SM, Dal Molin M, Wang Y, Li L, Ptak J, Dobbyn L, Schaefer J, Silliman N, Popoli M, Goggins MG, Hruban RH, Wolfgang CL, Klein AP, Tomasetti C, Papadopoulos N, Kinzler KW, Vogelstein B, Lennon AM. Combined circulating tumor DNA and protein biomarker-based liquid biopsy for the earlier detection of pancreatic cancers. Proceedings Of The National Academy Of Sciences Of The United States Of America 2017, 114: 10202-10207. PMID: 28874546, PMCID: PMC5617273, DOI: 10.1073/pnas.1704961114.
The independent effect of cancer on outcomes: a potential limitation of surgical risk predictionLeeds IL, Canner JK, Efron JE, Ahuja N, Haut ER, Wick EC, Johnston FM. The independent effect of cancer on outcomes: a potential limitation of surgical risk prediction. Journal Of Surgical Research 2017, 220: 402-409.e6. PMID: 28923559, PMCID: PMC5712450, DOI: 10.1016/j.jss.2017.08.039.
The Roles of DNA Methylation in the Stages of CancerMcMahon KW, Karunasena E, Ahuja N. The Roles of DNA Methylation in the Stages of Cancer. The Cancer Journal 2017, 23: 257-261. PMID: 28926425, PMCID: PMC5657558, DOI: 10.1097/ppo.0000000000000279.
Neutrophil-to-lymphocyte Ratio is a Predictive Marker for Invasive Malignancy in Intraductal Papillary Mucinous Neoplasms of the PancreasGemenetzis G, Bagante F, Griffin JF, Rezaee N, Javed AA, Manos LL, Lennon AM, Wood LD, Hruban RH, Zheng L, Zaheer A, Fishman EK, Ahuja N, Cameron JL, Weiss MJ, He J, Wolfgang CL. Neutrophil-to-lymphocyte Ratio is a Predictive Marker for Invasive Malignancy in Intraductal Papillary Mucinous Neoplasms of the Pancreas. Annals Of Surgery 2017, 266: 339-345. PMID: 27631774, DOI: 10.1097/sla.0000000000001988.
Circulating Epithelial Cells in Intraductal Papillary Mucinous Neoplasms and Cystic Pancreatic LesionsPoruk KE, Valero V, He J, Ahuja N, Cameron JL, Weiss MJ, Lennon AM, Goggins M, Wood LD, Wolfgang CL. Circulating Epithelial Cells in Intraductal Papillary Mucinous Neoplasms and Cystic Pancreatic Lesions. Pancreas 2017, 46: 943-947. PMID: 28697136, DOI: 10.1097/mpa.0000000000000869.
High dose-rate Intra-Operative Radiation Therapy During High Risk Genitourinary Surgery: Initial Observations and a Proposal for its Study in Bladder CancerKates M, Chappidi MR, Brant A, Milbar N, Sopko NA, Meyer C, Terezakis SA, Herman JM, Efron JE, Safar B, Tran PT, Ahuja N, Pierorazio PM, Bivalacqua TJ. High dose-rate Intra-Operative Radiation Therapy During High Risk Genitourinary Surgery: Initial Observations and a Proposal for its Study in Bladder Cancer. Bladder Cancer 2017, 3: 191-199. PMID: 28824947, PMCID: PMC5545919, DOI: 10.3233/blc-170104.
Genomics of peritoneal surface malignanciesSingh J, Sharma A, Ahuja N. Genomics of peritoneal surface malignancies. Journal Of Peritoneum (and Other Serosal Surfaces) 2017, 2 DOI: 10.4081/joper.2017.62.
Long‐term survival benefit of upfront chemotherapy in patients with newly diagnosed borderline resectable pancreatic cancerShrestha B, Sun Y, Faisal F, Kim V, Soares K, Blair A, Herman JM, Narang A, Dholakia AS, Rosati L, Hacker‐Prietz A, Chen L, Laheru DA, De Jesus‐Acosta A, Le DT, Donehower R, Azad N, Diaz LA, Murphy A, Lee V, Fishman EK, Hruban RH, Liang T, Cameron JL, Makary M, Weiss MJ, Ahuja N, He J, Wolfgang CL, Huang C, Zheng L. Long‐term survival benefit of upfront chemotherapy in patients with newly diagnosed borderline resectable pancreatic cancer. Cancer Medicine 2017, 6: 1552-1562. PMID: 28639410, PMCID: PMC5504321, DOI: 10.1002/cam4.1104.
Inhibiting DNA methylation activates cancer testis antigens and expression of the antigen processing and presentation machinery in colon and ovarian cancer cellsSiebenkäs C, Chiappinelli KB, Guzzetta AA, Sharma A, Jeschke J, Vatapalli R, Baylin SB, Ahuja N. Inhibiting DNA methylation activates cancer testis antigens and expression of the antigen processing and presentation machinery in colon and ovarian cancer cells. PLOS ONE 2017, 12: e0179501. PMID: 28622390, PMCID: PMC5473589, DOI: 10.1371/journal.pone.0179501.
The Future of Basic Science in Academic SurgeryKeswani SG, Moles CM, Morowitz M, Zeh H, Kuo JS, Levine MH, Cheng LS, Hackam DJ, Ahuja N, Goldstein AM. The Future of Basic Science in Academic Surgery. Annals Of Surgery 2017, 265: 1053-1059. PMID: 27643928, PMCID: PMC5450912, DOI: 10.1097/sla.0000000000002009.
Combination Epigenetic Therapy in Advanced Breast Cancer with 5-Azacitidine and Entinostat: A Phase II National Cancer Institute/Stand Up to Cancer StudyConnolly RM, Li H, Jankowitz RC, Zhang Z, Rudek MA, Jeter SC, Slater SA, Powers P, Wolff AC, Fetting JH, Brufsky A, Piekarz R, Ahuja N, Laird PW, Shen H, Weisenberger DJ, Cope L, Herman JG, Somlo G, Garcia AA, Jones PA, Baylin SB, Davidson NE, Zahnow CA, Stearns V. Combination Epigenetic Therapy in Advanced Breast Cancer with 5-Azacitidine and Entinostat: A Phase II National Cancer Institute/Stand Up to Cancer Study. Clinical Cancer Research 2017, 23: 2691-2701. PMID: 27979916, PMCID: PMC5457329, DOI: 10.1158/1078-0432.ccr-16-1729.
Mo1163 A Multicenter Study Evaluating Risk Factors of Lymph Node Metastasis in Early Gastric Cancer in the United StatesGutierrez O, Choi A, Draganov P, Khanna L, Sethi A, Bartel M, Abe S, Ali R, Park K, Melis M, Newman E, Hatzaras I, Hwang J, Reddy S, Farma J, Liu X, Schlachterman A, Kresak J, Gaddam S, Hanada Y, Montgomery E, Johnston F, Duncan M, Canto M, Ahuja N, Lennon A, Ngamruengphong S. Mo1163 A Multicenter Study Evaluating Risk Factors of Lymph Node Metastasis in Early Gastric Cancer in the United States. Gastrointestinal Endoscopy 2017, 85: ab444. DOI: 10.1016/j.gie.2017.03.1034.
Hypomethylating agents synergize with irinotecan to improve response to chemotherapy in colorectal cancer cellsSharma A, Vatapalli R, Abdelfatah E, McMahon K, Kerner Z, Guzzetta A, Singh J, Zahnow C, Baylin S, Yerram S, Hu Y, Azad N, Ahuja N. Hypomethylating agents synergize with irinotecan to improve response to chemotherapy in colorectal cancer cells. PLOS ONE 2017, 12: e0176139. PMID: 28445481, PMCID: PMC5405959, DOI: 10.1371/journal.pone.0176139.
A Four-Gene Promoter Methylation Marker Panel Consisting of GREM1, NEURL, LAD1, and NEFH Predicts Survival of Clear Cell Renal Cell Cancer Patientsvan Vlodrop IJH, Joosten SC, De Meyer T, Smits KM, Van Neste L, Melotte V, Baldewijns MMLL, Schouten LJ, van den Brandt PA, Jeschke J, Yi JM, Schuebel KE, Ahuja N, Herman JG, Aarts MJ, Bosman FT, Van Criekinge W, van Engeland M. A Four-Gene Promoter Methylation Marker Panel Consisting of GREM1, NEURL, LAD1, and NEFH Predicts Survival of Clear Cell Renal Cell Cancer Patients. Clinical Cancer Research 2017, 23: 2006-2018. PMID: 27756787, DOI: 10.1158/1078-0432.ccr-16-1236.
Epigenetic therapy and chemosensitization in solid malignancyRonnekleiv-Kelly SM, Sharma A, Ahuja N. Epigenetic therapy and chemosensitization in solid malignancy. Cancer Treatment Reviews 2017, 55: 200-208. PMID: 28431263, DOI: 10.1016/j.ctrv.2017.03.008.
MP65-20 EPIGENETIC PRIMING WITH 5-AZACITIDINE INCREASES SENSITIVITY OF BLADDER CANCER CELLS TO CHEMOTHERAPEUTIC AGENTSYoshida T, Sharma A, Kates M, Sopko N, Liu X, Hahn N, McConkey D, Ahuja N, Bivalacqua T. MP65-20 EPIGENETIC PRIMING WITH 5-AZACITIDINE INCREASES SENSITIVITY OF BLADDER CANCER CELLS TO CHEMOTHERAPEUTIC AGENTS. Journal Of Urology 2017, 197: e861. DOI: 10.1016/j.juro.2017.02.2014.
Postoperative complications following intraoperative radiotherapy in abdominopelvic malignancy: A single institution analysis of 113 consecutive patientsAbdelfatah E, Page A, Sacks J, Pierorazio P, Bivalacqua T, Efron J, Terezakis S, Gearhart S, Fang S, Safar B, Pawlik TM, Armour E, Hacker‐Prietz A, Herman J, Ahuja N. Postoperative complications following intraoperative radiotherapy in abdominopelvic malignancy: A single institution analysis of 113 consecutive patients. Journal Of Surgical Oncology 2017, 115: 883-890. PMID: 28252805, PMCID: PMC5572190, DOI: 10.1002/jso.24597.
Epigenetically altered miR-1247 functions as a tumor suppressor in pancreatic cancerYi JM, Kang EJ, Kwon HM, Bae JH, Kang K, Ahuja N, Yang K. Epigenetically altered miR-1247 functions as a tumor suppressor in pancreatic cancer. Oncotarget 2017, 5: 26600-26612. PMID: 28460450, PMCID: PMC5432282, DOI: 10.18632/oncotarget.15722.
Combination epigenetic therapy in metastatic colorectal cancer (mCRC) with subcutaneous 5-azacitidine and entinostat; a phase 2 consortium/stand Up 2 cancer studyAzad NS, el-Khoueiry A, Yin J, Oberg AL, Flynn P, Adkins D, Sharma A, Weisenberger DJ, Brown T, Medvari P, Jones PA, Easwaran H, Kamel I, Bahary N, Kim G, Picus J, Pitot HC, Erlichman C, Donehower R, Shen H, Laird PW, Piekarz R, Baylin S, Ahuja N. Combination epigenetic therapy in metastatic colorectal cancer (mCRC) with subcutaneous 5-azacitidine and entinostat; a phase 2 consortium/stand Up 2 cancer study. Oncotarget 2017, 5: 35326-35338. PMID: 28186961, PMCID: PMC5471058, DOI: 10.18632/oncotarget.15108.
Differential expression of hENT1 and hENT2 in colon cancer cell linesLiu Y, Zuo T, Zhu X, Ahuja N, Fu T. Differential expression of hENT1 and hENT2 in colon cancer cell lines. Genetics And Molecular Research 2017, 16 PMID: 28218790, DOI: 10.4238/gmr16019549.
A novel approach for selecting combination clinical markers of pathology applied to a large retrospective cohort of surgically resected pancreatic cysts.Masica DL, Dal Molin M, Wolfgang CL, Tomita T, Ostovaneh MR, Blackford A, Moran RA, Law JK, Barkley T, Goggins M, Irene Canto M, Pittman M, Eshleman JR, Ali SZ, Fishman EK, Kamel IR, Raman SP, Zaheer A, Ahuja N, Makary MA, Weiss MJ, Hirose K, Cameron JL, Rezaee N, He J, Joon Ahn Y, Wu W, Wang Y, Springer S, Diaz LL, Papadopoulos N, Hruban RH, Kinzler KW, Vogelstein B, Karchin R, Lennon AM. A novel approach for selecting combination clinical markers of pathology applied to a large retrospective cohort of surgically resected pancreatic cysts. Journal Of The American Medical Informatics Association : JAMIA 2017, 24: 145-152. PMID: 27330075, PMCID: PMC5201184, DOI: 10.1093/jamia/ocw069.
Locally advanced primary recto-sigmoid cancers: Improved survival with multivisceral resectionLaurence G, Ahuja V, Bell T, Grim R, Ahuja N. Locally advanced primary recto-sigmoid cancers: Improved survival with multivisceral resection. The American Journal Of Surgery 2016, 214: 432-436. PMID: 28082009, DOI: 10.1016/j.amjsurg.2016.12.018.
Circulating Tumor Cell Phenotype Predicts Recurrence and Survival in Pancreatic AdenocarcinomaPoruk KE, Valero V, Saunders T, Blackford AL, Griffin JF, Poling J, Hruban RH, Anders RA, Herman J, Zheng L, Rasheed ZA, Laheru DA, Ahuja N, Weiss MJ, Cameron JL, Goggins M, Iacobuzio-Donahue CA, Wood LD, Wolfgang CL. Circulating Tumor Cell Phenotype Predicts Recurrence and Survival in Pancreatic Adenocarcinoma. Annals Of Surgery 2016, 264: 1073-1081. PMID: 26756760, PMCID: PMC4936958, DOI: 10.1097/sla.0000000000001600.
Gastric and small intestine gastrointestinal stromal tumors: Do outcomes differ?Giuliano K, Nagarajan N, Canner J, Najafian A, Wolfgang C, Schneider E, Meyer C, Lennon AM, Johnston FM, Ahuja N. Gastric and small intestine gastrointestinal stromal tumors: Do outcomes differ? Journal Of Surgical Oncology 2016, 115: 351-357. PMID: 27885685, DOI: 10.1002/jso.24514.
Tumors with unmethylated MLH1 and the CpG island methylator phenotype are associated with a poor prognosis in stage II colorectal cancer patientsFu T, Liu Y, Li K, Wan W, Pappou EP, Iacobuzio-Donahue CA, Kerner Z, Baylin SB, Wolfgang CL, Ahuja N. Tumors with unmethylated MLH1 and the CpG island methylator phenotype are associated with a poor prognosis in stage II colorectal cancer patients. Oncotarget 2016, 5: 86480-86489. PMID: 27880934, PMCID: PMC5349928, DOI: 10.18632/oncotarget.13441.
O1-10-3 Associations of IGFBP3 SNPs, methylation and recurrence risk in patients with stage II colorectal cancerFu T, Li F, Ye J, Liu Z, Wolfgang C, Iacobuzio-Donahue C, Tong W, Liu B, Ahuja N. O1-10-3 Associations of IGFBP3 SNPs, methylation and recurrence risk in patients with stage II colorectal cancer. Annals Of Oncology 2016, 27: vii78. DOI: 10.1093/annonc/mdw521.016.
Innovative Two-Stage Process to Standardize Best Practices to Improve Patient MortalityAhuja V, Sheikh S, Castronuovo J, Ahuja N. Innovative Two-Stage Process to Standardize Best Practices to Improve Patient Mortality. Journal Of The American College Of Surgeons 2016, 223: e170. DOI: 10.1016/j.jamcollsurg.2016.08.432.
Passive Hyperspectral Sensing Reliably Identifies Colorectal Cancer in Intraoperative Colon SpecimensBeaulieu R, Goldstein S, Banerjee A, Safar B, Ahuja N. Passive Hyperspectral Sensing Reliably Identifies Colorectal Cancer in Intraoperative Colon Specimens. Journal Of The American College Of Surgeons 2016, 223: s34. DOI: 10.1016/j.jamcollsurg.2016.06.087.
Methylation of MGMT Is Associated with Poor Prognosis in Patients with Stage III Duodenal AdenocarcinomaFu T, Sharmab A, Xie F, Liu Y, Li K, Wan W, Baylin SB, Wolfgang CL, Ahuja N. Methylation of MGMT Is Associated with Poor Prognosis in Patients with Stage III Duodenal Adenocarcinoma. PLOS ONE 2016, 11: e0162929. PMID: 27643594, PMCID: PMC5028050, DOI: 10.1371/journal.pone.0162929.
Predictors of improved survival for patients with retroperitoneal sarcomaGiuliano K, Nagarajan N, Canner JK, Wolfgang CL, Bivalacqua T, Terezakis S, Herman J, Schneider EB, Ahuja N. Predictors of improved survival for patients with retroperitoneal sarcoma. Surgery 2016, 160: 1628-1635. PMID: 27495850, DOI: 10.1016/j.surg.2016.05.041.
Abstract CT017: A phase I study of guadecitabine (GUA) combined with irinotecan (IRI) in previously treated metastatic colorectal cancer (mCRC) patientsLee V, Wang J, El Khoueiry A, Verheul H, Gootjes E, Sharma A, Kerner Z, Jones P, Baylin S, Lilly E, Ahuja N, Brown T, Azad N. Abstract CT017: A phase I study of guadecitabine (GUA) combined with irinotecan (IRI) in previously treated metastatic colorectal cancer (mCRC) patients. Cancer Research 2016, 76: ct017-ct017. DOI: 10.1158/1538-7445.am2016-ct017.
Epigenetic therapy in gastrointestinal cancer: the right combinationAbdelfatah E, Kerner Z, Nanda N, Ahuja N. Epigenetic therapy in gastrointestinal cancer: the right combination. Therapeutic Advances In Gastroenterology 2016, 9: 560-579. PMID: 27366224, PMCID: PMC4913338, DOI: 10.1177/1756283x16644247.
Epigenetic priming prior to pembrolizumab in microsatellite-stable (MSS) advanced colorectal cancer.Murphy A, White S, Walker R, Lutz E, Ahuja N, Zheng L, Jaffee E, Azad N. Epigenetic priming prior to pembrolizumab in microsatellite-stable (MSS) advanced colorectal cancer. Journal Of Clinical Oncology 2016, 34: tps3626-tps3626. DOI: 10.1200/jco.2016.34.15_suppl.tps3626.
Passive hyperspectral sensing to identify colorectal cancer in intraoperative colon specimens.Beaulieu R, Goldstein S, Banerjee A, Safar B, Ahuja N. Passive hyperspectral sensing to identify colorectal cancer in intraoperative colon specimens. Journal Of Clinical Oncology 2016, 34: e15161-e15161. DOI: 10.1200/jco.2016.34.15_suppl.e15161.
A Contemporary Evaluation of the Cause of Death and Long‐Term Quality of Life After Total PancreatectomyWu W, Dodson R, Makary MA, Weiss MJ, Hirose K, Cameron JL, Ahuja N, Pawlik TM, Wolfgang CL, He J. A Contemporary Evaluation of the Cause of Death and Long‐Term Quality of Life After Total Pancreatectomy. World Journal Of Surgery 2016, 40: 2513-2518. PMID: 27177647, DOI: 10.1007/s00268-016-3552-8.
Understanding the Barriers to Hiring and Promoting Women in Surgical SubspecialtiesValsangkar N, Fecher AM, Rozycki GS, Blanton C, Bell TM, Freischlag J, Ahuja N, Zimmers TA, Koniaris LG. Understanding the Barriers to Hiring and Promoting Women in Surgical Subspecialties. Journal Of The American College Of Surgeons 2016, 223: 387-398.e2. PMID: 27109779, DOI: 10.1016/j.jamcollsurg.2016.03.042.
Long‐term outcomes in treatment of retroperitoneal sarcomas: A 15 year single‐institution evaluation of prognostic featuresAbdelfatah E, Guzzetta AA, Nagarajan N, Wolfgang CL, Pawlik TM, Choti MA, Schulick R, Montgomery EA, Meyer C, Thornton K, Herman J, Terezakis S, Frassica D, Ahuja N. Long‐term outcomes in treatment of retroperitoneal sarcomas: A 15 year single‐institution evaluation of prognostic features. Journal Of Surgical Oncology 2016, 114: 56-64. PMID: 27076350, PMCID: PMC4917421, DOI: 10.1002/jso.24256.
MP23-12 INTRAOPERATIVE RADIATION THERAPY DURING GENITOURINARY SURGERY: THE IMPORTANCE OF SPECIMEN MARGIN STATUS IN IMPROVING SURVIVALChappidi M, Kates M, Schwen Z, Sopko N, Tran P, Ahuja N, Terezakis S, Pierorazio P, Bivalacqua T. MP23-12 INTRAOPERATIVE RADIATION THERAPY DURING GENITOURINARY SURGERY: THE IMPORTANCE OF SPECIMEN MARGIN STATUS IN IMPROVING SURVIVAL. Journal Of Urology 2016, 195: e266. DOI: 10.1016/j.juro.2016.02.734.
Cystic lesions of the pancreas: Why we get it wrongManos L, Moran R, Rezaee N, Hruban R, Fishman E, Ahuja N, Cameron J, He J, Weiss M, Lennon A, Wolfgang C. Cystic lesions of the pancreas: Why we get it wrong. Hepato Pancreato Biliary 2016, 18: e337. DOI: 10.1016/j.hpb.2016.02.873.
DNA methylation changes in extracellular remodeling pathway genes during the transformation of human mesenchymal stem cellsKim T, Park S, Kim H, Ahuja N, Yi J. DNA methylation changes in extracellular remodeling pathway genes during the transformation of human mesenchymal stem cells. Genes & Genomics 2016, 38: 611-617. DOI: 10.1007/s13258-016-0402-x.
Combining Epigenetic and Immunotherapy to Combat CancerChiappinelli KB, Zahnow CA, Ahuja N, Baylin SB. Combining Epigenetic and Immunotherapy to Combat Cancer. Cancer Research 2016, 76: 1683-1689. PMID: 26988985, PMCID: PMC4873370, DOI: 10.1158/0008-5472.can-15-2125.
IGFBP-3 Gene Methylation in Primary Tumor Predicts Recurrence of Stage II Colorectal CancersFu T, Pappou EP, Guzzetta AA, de Freitas Calmon M, Sun L, Herrera A, Li F, Wolfgang CL, Baylin SB, Iacobuzio-Donahue CA, Tong W, Ahuja N. IGFBP-3 Gene Methylation in Primary Tumor Predicts Recurrence of Stage II Colorectal Cancers. Annals Of Surgery 2016, 263: 337-344. PMID: 25822686, PMCID: PMC4648704, DOI: 10.1097/sla.0000000000001204.
Patterns of PD-L1 expression and CD8 T cell infiltration in gastric adenocarcinomas and associated immune stromaThompson ED, Zahurak M, Murphy A, Cornish T, Cuka N, Abdelfatah E, Yang S, Duncan M, Ahuja N, Taube JM, Anders RA, Kelly RJ. Patterns of PD-L1 expression and CD8 T cell infiltration in gastric adenocarcinomas and associated immune stroma. Gut 2016, 66: 794. PMID: 26801886, PMCID: PMC4958028, DOI: 10.1136/gutjnl-2015-310839.
Epigenetic Therapeutics: A New Weapon in the War Against CancerAhuja N, Sharma AR, Baylin SB. Epigenetic Therapeutics: A New Weapon in the War Against Cancer. Annual Review Of Medicine 2016, 67: 73-89. PMID: 26768237, PMCID: PMC4937439, DOI: 10.1146/annurev-med-111314-035900.
Chapter 11 Prognostic EpigeneticsSharma A, Abdelfatah E, Eissa M, Ahuja N. Chapter 11 Prognostic Epigenetics. 2016, 177-195. DOI: 10.1016/b978-0-12-803239-8.00011-9.
Epigenetic PharmacologyBurkhart R, Sharma A, Ahuja N. Epigenetic Pharmacology. 2016, 1-25. DOI: 10.1007/978-1-4939-6631-8_69-1.
Intraductal papillary mucinous neoplasm (IPMN) with high-grade dysplasia is a risk factor for the subsequent development of pancreatic ductal adenocarcinomaRezaee N, Barbon C, Zaki A, He J, Salman B, Hruban RH, Cameron JL, Herman JM, Ahuja N, Lennon AM, Weiss MJ, Wood LD, Wolfgang CL. Intraductal papillary mucinous neoplasm (IPMN) with high-grade dysplasia is a risk factor for the subsequent development of pancreatic ductal adenocarcinoma. Hepato Pancreato Biliary 2015, 18: 236-246. PMID: 27017163, PMCID: PMC4814593, DOI: 10.1016/j.hpb.2015.10.010.
Standard Fractionation External Beam Radiation Therapy With and Without Intraoperative Radiation Therapy for Patients With Locally Recurrent Rectal CancerKishan A, Moningi S, Kumar R, Ancukiewicz M, Ahuja N, Gearhart S, Efron J, Herman J, Hong T. Standard Fractionation External Beam Radiation Therapy With and Without Intraoperative Radiation Therapy for Patients With Locally Recurrent Rectal Cancer. International Journal Of Radiation Oncology • Biology • Physics 2015, 93: e145. DOI: 10.1016/j.ijrobp.2015.07.918.
Epidemiology and treatment outcome among patients with desmoplastic small round cell tumorsJuo Y, Meyer C, Thornton K, Herman J, Terezakis S, Ahuja N. Epidemiology and treatment outcome among patients with desmoplastic small round cell tumors. Journal Of The American College Of Surgeons 2015, 221: e128. DOI: 10.1016/j.jamcollsurg.2015.08.243.
Early outcomes after elective colorectal surgery in end stage renal disease (ESRD) vs non-ESRD PatientsArhuidese I, Malas M, Obeid T, Qazi U, Ahuja N, Efron J. Early outcomes after elective colorectal surgery in end stage renal disease (ESRD) vs non-ESRD Patients. Journal Of The American College Of Surgeons 2015, 221: e59. DOI: 10.1016/j.jamcollsurg.2015.08.052.
Survival Following Lung Metastasectomy in Soft Tissue SarcomasGiuliano K, Sachs T, Montgomery E, Guzzetta A, Brock M, Pawlik TM, Yang SC, Ahuja N. Survival Following Lung Metastasectomy in Soft Tissue Sarcomas. The Thoracic And Cardiovascular Surgeon 2015, 64: 150-158. PMID: 26339728, DOI: 10.1055/s-0035-1563538.
Time to Chemotherapy After Abdominoperineal Resection: Comparison Between Primary Closure and Perineal Flap ReconstructionAlthumairi AA, Canner JK, Ahuja N, Sacks JM, Safar B, Efron JE. Time to Chemotherapy After Abdominoperineal Resection: Comparison Between Primary Closure and Perineal Flap Reconstruction. World Journal Of Surgery 2015, 40: 225-230. PMID: 26336877, DOI: 10.1007/s00268-015-3224-0.
A Combination of Molecular Markers and Clinical Features Improve the Classification of Pancreatic CystsSpringer S, Wang Y, Dal Molin M, Masica DL, Jiao Y, Kinde I, Blackford A, Raman SP, Wolfgang CL, Tomita T, Niknafs N, Douville C, Ptak J, Dobbyn L, Allen PJ, Klimstra DS, Schattner MA, Schmidt CM, Yip-Schneider M, Cummings OW, Brand RE, Zeh HJ, Singhi AD, Scarpa A, Salvia R, Malleo G, Zamboni G, Falconi M, Jang JY, Kim SW, Kwon W, Hong SM, Song KB, Kim SC, Swan N, Murphy J, Geoghegan J, Brugge W, Castillo C, Mino-Kenudson M, Schulick R, Edil BH, Adsay V, Paulino J, van Hooft J, Yachida S, Nara S, Hiraoka N, Yamao K, Hijioka S, van der Merwe S, Goggins M, Canto MI, Ahuja N, Hirose K, Makary M, Weiss MJ, Cameron J, Pittman M, Eshleman JR, Diaz LA, Papadopoulos N, Kinzler KW, Karchin R, Hruban RH, Vogelstein B, Lennon AM. A Combination of Molecular Markers and Clinical Features Improve the Classification of Pancreatic Cysts. Gastroenterology 2015, 149: 1501-1510. PMID: 26253305, PMCID: PMC4782782, DOI: 10.1053/j.gastro.2015.07.041.
Early detection of pancreatic cancer.Kim VM, Ahuja N. Early detection of pancreatic cancer. Chinese Journal Of Cancer Research 2015, 27: 321-31. PMID: 26361402, PMCID: PMC4560741, DOI: 10.3978/j.issn.1000-9604.2015.07.03.
Promoter Methylation of CDO1 Identifies Clear-Cell Renal Cell Cancer Patients with Poor Survival OutcomeDeckers IA, Schouten LJ, Van Neste L, van Vlodrop IJ, Soetekouw PM, Baldewijns MM, Jeschke J, Ahuja N, Herman JG, van den Brandt PA, van Engeland M. Promoter Methylation of CDO1 Identifies Clear-Cell Renal Cell Cancer Patients with Poor Survival Outcome. Clinical Cancer Research 2015, 21: 3492-3500. PMID: 25904753, PMCID: PMC4612631, DOI: 10.1158/1078-0432.ccr-14-2049.
AGA Guidelines for the Management of Pancreatic CystsLennon AM, Ahuja N, Wolfgang CL. AGA Guidelines for the Management of Pancreatic Cysts. Gastroenterology 2015, 149: 825. PMID: 26231607, DOI: 10.1053/j.gastro.2015.05.062.
Early hospital readmission for gastrointestinal-related complications predicts long-term mortality after pancreatectomyHicks CW, Tosoian JJ, Craig-Schapiro R, Valero V, Cameron JL, Eckhauser FE, Hirose K, Makary MA, Pawlik TM, Ahuja N, Weiss MJ, Wolfgang CL. Early hospital readmission for gastrointestinal-related complications predicts long-term mortality after pancreatectomy. The American Journal Of Surgery 2015, 210: 636-642.e1. PMID: 26384793, PMCID: PMC4634566, DOI: 10.1016/j.amjsurg.2015.05.009.
Personalized Approaches to Gastrointestinal Cancers Importance of Integrating Genomic Information to Guide TherapyHe J, Ahuja N. Personalized Approaches to Gastrointestinal Cancers Importance of Integrating Genomic Information to Guide Therapy. Surgical Clinics Of North America 2015, 95: 1081-1094. PMID: 26315525, DOI: 10.1016/j.suc.2015.05.002.
A randomized phase II trial of epigenetic therapy following adjuvant treatment in patients with resected pancreatic cancer and high risk for recurrence.Reiss K, Ahuja N, Baylin S, Mauro L, Linden S, White S, Laheru D, Herman J, Wolfgang C, Weiss M, Cameron J, Makary M, Azad N. A randomized phase II trial of epigenetic therapy following adjuvant treatment in patients with resected pancreatic cancer and high risk for recurrence. Journal Of Clinical Oncology 2015, 33: tps4144-tps4144. DOI: 10.1200/jco.2015.33.15_suppl.tps4144.
A phase I trial of oral 5-azacitidine in combination with romidepsin in advanced solid tumors with an expansion cohort in virally mediated cancers and liposarcoma.Reiss K, Rudek M, Sartorius-Mergenthaler S, Downs M, Cosgrove D, Gaillard S, Baylin S, Ahuja N, Azad N. A phase I trial of oral 5-azacitidine in combination with romidepsin in advanced solid tumors with an expansion cohort in virally mediated cancers and liposarcoma. Journal Of Clinical Oncology 2015, 33: tps2619-tps2619. DOI: 10.1200/jco.2015.33.15_suppl.tps2619.
Adaptive immune resistance in gastro-esophageal cancer: Correlating tumoral/stromal PDL1 expression with CD8 + cell count.Kelly R, Thompson E, Zahurak M, Cornish T, Cuka N, Abdelfatah E, Taube J, Yang S, Duncan M, Ahuja N, Murphy A, Anders R. Adaptive immune resistance in gastro-esophageal cancer: Correlating tumoral/stromal PDL1 expression with CD8 + cell count. Journal Of Clinical Oncology 2015, 33: 4031-4031. DOI: 10.1200/jco.2015.33.15_suppl.4031.
Epigenetic silencing of neurofilament genes promotes an aggressive phenotype in breast cancerCalmon MF, Jeschke J, Zhang W, Dhir M, Siebenkäs C, Herrera A, Tsai HC, O'Hagan HM, Pappou EP, Hooker CM, Fu T, Schuebel KE, Gabrielson E, Rahal P, Herman JG, Baylin SB, Ahuja N. Epigenetic silencing of neurofilament genes promotes an aggressive phenotype in breast cancer. Epigenetics 2015, 10: 622-632. PMID: 25985363, PMCID: PMC4622480, DOI: 10.1080/15592294.2015.1050173.
Multimodal Therapy in the Treatment of Prostate Sarcoma: The Johns Hopkins ExperienceBall MW, Sundi D, Reese AC, Meyer CF, Terezakis SA, Efron JE, Schoenberg MP, Epstein JI, Ahuja N, Bivalacqua TJ. Multimodal Therapy in the Treatment of Prostate Sarcoma: The Johns Hopkins Experience. Clinical Genitourinary Cancer 2015, 13: 435-440. PMID: 26003268, DOI: 10.1016/j.clgc.2015.04.011.
Epigenetic therapy for solid tumors: from bench science to clinical trialsJuo YY, Gong XJ, Mishra A, Cui X, Baylin SB, Azad NS, Ahuja N. Epigenetic therapy for solid tumors: from bench science to clinical trials. Epigenomics 2015, 7: 215-235. PMID: 25942532, DOI: 10.2217/epi.14.73.
Tracking Early Readmission After Pancreatectomy to Index and Nonindex Institutions: A More Accurate Assessment of ReadmissionTosoian JJ, Hicks CW, Cameron JL, Valero V, Eckhauser FE, Hirose K, Makary MA, Pawlik TM, Ahuja N, Weiss MJ, Wolfgang CL. Tracking Early Readmission After Pancreatectomy to Index and Nonindex Institutions: A More Accurate Assessment of Readmission. JAMA Surgery 2015, 150: 152-158. PMID: 25535811, PMCID: PMC4461067, DOI: 10.1001/jamasurg.2014.2346.
Spectrin Repeat Containing Nuclear Envelope 1 and Forkhead Box Protein E1 Are Promising Markers for the Detection of Colorectal Cancer in BloodMelotte V, Yi JM, Lentjes MH, Smits KM, Van Neste L, Niessen HE, Wouters KA, Louwagie J, Schuebel KE, Herman JG, Baylin SB, van Criekinge W, Meijer GA, Ahuja N, van Engeland M. Spectrin Repeat Containing Nuclear Envelope 1 and Forkhead Box Protein E1 Are Promising Markers for the Detection of Colorectal Cancer in Blood. Cancer Prevention Research 2015, 8: 157-164. PMID: 25538088, PMCID: PMC4316751, DOI: 10.1158/1940-6207.capr-14-0198.
A phase I study of investigational agent SGI-110 combined with irinotecan in previously treated metastatic colorectal cancer patients.Wang J, Gootjes E, Uram J, Zahurak M, El-Khoueiry A, Verheul H, Ahuja N, Azad N. A phase I study of investigational agent SGI-110 combined with irinotecan in previously treated metastatic colorectal cancer patients. Journal Of Clinical Oncology 2015, 33: tps797-tps797. DOI: 10.1200/jco.2015.33.3_suppl.tps797.
Hospital Volume and Patient Outcomes in Hepato-Pancreatico-Biliary Surgery: Is Assessing Differences in Mortality Enough?Schneider EB, Ejaz A, Spolverato G, Hirose K, Makary MA, Wolfgang CL, Ahuja N, Weiss M, Pawlik TM. Hospital Volume and Patient Outcomes in Hepato-Pancreatico-Biliary Surgery: Is Assessing Differences in Mortality Enough? Journal Of Gastrointestinal Surgery 2014, 18: 2105-2115. PMID: 25297443, DOI: 10.1007/s11605-014-2619-9.
Portal/superior mesenteric vein resection during pancreatic surgery: evolution of technique and lessons learnedWesson R, Leng J, Schulick R, Weiss M, Wolfgang C, Ahuja N, Pawlik T, Hirose K, Cameron J, Cameron A. Portal/superior mesenteric vein resection during pancreatic surgery: evolution of technique and lessons learned. Journal Of The American College Of Surgeons 2014, 219: e114. DOI: 10.1016/j.jamcollsurg.2014.07.691.
Firm Flank Mass Decreasing in Size After PregnancyDafrawy M, Baras A, Ahuja N. Firm Flank Mass Decreasing in Size After Pregnancy. JAMA Surgery 2014, 149: 1089-1090. PMID: 25162611, DOI: 10.1001/jamasurg.2014.1632.
The promise of methylation on beads for cancer detection and treatmentGuzzetta AA, Pisanic T, Sharma P, Yi JM, Stark A, Wang TH, Ahuja N. The promise of methylation on beads for cancer detection and treatment. Expert Review Of Molecular Diagnostics 2014, 14: 845-852. PMID: 25136840, PMCID: PMC4427839, DOI: 10.1586/14737159.2014.943665.
Liver transplant patients have a risk of progression similar to that of sporadic patients with branch duct intraductal papillary mucinous neoplasmsLennon AM, Victor D, Zaheer A, Ostovaneh MR, Jeh J, Law JK, Rezaee N, Dal Molin M, Ahn YJ, Wu W, Khashab MA, Girotra M, Ahuja N, Makary MA, Weiss MJ, Hirose K, Goggins M, Hruban RH, Cameron A, Wolfgang CL, Singh VK, Gurakar A. Liver transplant patients have a risk of progression similar to that of sporadic patients with branch duct intraductal papillary mucinous neoplasms. Liver Transplantation 2014, 20: 1462-1467. PMID: 25155689, PMCID: PMC4322915, DOI: 10.1002/lt.23983.
Overcoming immune system evasion by personalized immunotherapySoares KC, Zheng L, Ahuja N. Overcoming immune system evasion by personalized immunotherapy. Personalized Medicine 2014, 11: 561-564. PMID: 29758801, DOI: 10.2217/pme.14.45.
A comparison of open and minimally invasive surgery for hepatic and pancreatic resections using the nationwide inpatient sampleEjaz A, Sachs T, He J, Spolverato G, Hirose K, Ahuja N, Wolfgang CL, Makary MA, Weiss M, Pawlik TM. A comparison of open and minimally invasive surgery for hepatic and pancreatic resections using the nationwide inpatient sample. Surgery 2014, 156: 538-547. PMID: 25017135, PMCID: PMC4316739, DOI: 10.1016/j.surg.2014.03.046.
Race-based differences in length of stay among patients undergoing pancreatoduodenectomySchneider EB, Calkins KL, Weiss MJ, Herman JM, Wolfgang CL, Makary MA, Ahuja N, Haider AH, Pawlik TM. Race-based differences in length of stay among patients undergoing pancreatoduodenectomy. Surgery 2014, 156: 528-537. PMID: 24973128, DOI: 10.1016/j.surg.2014.04.004.
Clinicopathologic Presentation and Natural History of Anorectal Melanoma: A Case Series of 18 PatientsHicks CW, Pappou EP, Magruder JT, Gazer B, Fang S, Wick EC, Gearhart SL, Ahuja N, Efron JE. Clinicopathologic Presentation and Natural History of Anorectal Melanoma: A Case Series of 18 Patients. JAMA Surgery 2014, 149: 608-611. PMID: 24848283, DOI: 10.1001/jamasurg.2013.4643.
Prognostic factors after pancreaticoduodenectomy for duodenal adenocarcinoma: Results from a dual center analysis.He J, Kwon W, Wu W, Cameron J, Hruban R, Weiss M, Ahuja N, Pawlik T, Jang J, Wolfgang C. Prognostic factors after pancreaticoduodenectomy for duodenal adenocarcinoma: Results from a dual center analysis. Journal Of Clinical Oncology 2014, 32: e15181-e15181. DOI: 10.1200/jco.2014.32.15_suppl.e15181.
Phase 2 study investigating the safety, efficacy, and surrogate biomarkers of response to 5-azacitidine (5-AZA) and entinostat in advanced breast cancer.Connolly R, Jankowitz R, Zahnow C, Zhang Z, Rudek M, Slater S, Powers P, Jeter S, Brufsky A, Piekarz R, Herman J, Ahuja N, Somlo G, Garcia A, Baylin S, Davidson N, Stearns V. Phase 2 study investigating the safety, efficacy, and surrogate biomarkers of response to 5-azacitidine (5-AZA) and entinostat in advanced breast cancer. Journal Of Clinical Oncology 2014, 32: 569-569. DOI: 10.1200/jco.2014.32.15_suppl.569.
Association of recurrence patterns following resection of pancreatic adenocarcinoma with overall survival.He J, Rezaee N, Wu W, Cameron J, Ahuja N, Pawlik T, Herman J, Hruban R, Weiss M, Zheng L, Wolfgang C. Association of recurrence patterns following resection of pancreatic adenocarcinoma with overall survival. Journal Of Clinical Oncology 2014, 32: 4127-4127. DOI: 10.1200/jco.2014.32.15_suppl.4127.
Role of a Multidisciplinary Clinic in the Management of Patients with Pancreatic Cysts: A Single-Center Cohort StudyLennon AM, Manos LL, Hruban RH, Ali SZ, Fishman EK, Kamel IR, Raman SP, Zaheer A, Hutfless S, Salamone A, Kiswani V, Ahuja N, Makary MA, Weiss MJ, Hirose K, Goggins M, Wolfgang CL. Role of a Multidisciplinary Clinic in the Management of Patients with Pancreatic Cysts: A Single-Center Cohort Study. Annals Of Surgical Oncology 2014, 21: 3668-3674. PMID: 24806116, PMCID: PMC4332823, DOI: 10.1245/s10434-014-3739-x.
The Impact of Postoperative Complications on the Administration of Adjuvant Therapy Following Pancreaticoduodenectomy for AdenocarcinomaWu W, He J, Cameron JL, Makary M, Soares K, Ahuja N, Rezaee N, Herman J, Zheng L, Laheru D, Choti MA, Hruban RH, Pawlik TM, Wolfgang CL, Weiss MJ. The Impact of Postoperative Complications on the Administration of Adjuvant Therapy Following Pancreaticoduodenectomy for Adenocarcinoma. Annals Of Surgical Oncology 2014, 21: 2873-2881. PMID: 24770680, PMCID: PMC4454347, DOI: 10.1245/s10434-014-3722-6.
Prognostic value of CpG island methylator phenotype among colorectal cancer patients: a systematic review and meta-analysisJuo YY, Johnston FM, Zhang DY, Juo HH, Wang H, Pappou EP, Yu T, Easwaran H, Baylin S, van Engeland M, Ahuja N. Prognostic value of CpG island methylator phenotype among colorectal cancer patients: a systematic review and meta-analysis. Annals Of Oncology 2014, 25: 2314-2327. PMID: 24718889, PMCID: PMC4239805, DOI: 10.1093/annonc/mdu149.
High-dose-rate intraoperative radiation therapy: the nuts and bolts of starting a programMoningi S, Armour EP, Terezakis SA, Efron JE, Gearhart SL, Bivalacqua TJ, Kumar R, Le Y, Ng S, Wolfgang CL, Zellars RC, Ellsworth SG, Ahuja N, Herman JM. High-dose-rate intraoperative radiation therapy: the nuts and bolts of starting a program. Journal Of Contemporary Brachytherapy 2014, 6: 99-105. PMID: 24790628, PMCID: PMC4003434, DOI: 10.5114/jcb.2014.42027.
A Systematic Review of Solid-Pseudopapillary NeoplasmsLaw JK, Ahmed A, Singh VK, Akshintala VS, Olson MT, Raman SP, Ali SZ, Fishman EK, Kamel I, Canto MI, Dal Molin M, Moran RA, Khashab MA, Ahuja N, Goggins M, Hruban RH, Wolfgang CL, Lennon AM. A Systematic Review of Solid-Pseudopapillary Neoplasms. Pancreas 2014, 43: 331-337. PMID: 24622060, PMCID: PMC4888067, DOI: 10.1097/mpa.0000000000000061.
Functional Identification of Cancer-Specific Methylation of CDO1, HOXA9, and TAC1 for the Diagnosis of Lung CancerWrangle J, Machida EO, Danilova L, Hulbert A, Franco N, Zhang W, Glöckner SC, Tessema M, Van Neste L, Easwaran H, Schuebel KE, Licchesi J, Hooker CM, Ahuja N, Amano J, Belinsky SA, Baylin SB, Herman JG, Brock MV. Functional Identification of Cancer-Specific Methylation of CDO1, HOXA9, and TAC1 for the Diagnosis of Lung Cancer. Clinical Cancer Research 2014, 20: 1856-1864. PMID: 24486589, PMCID: PMC4019442, DOI: 10.1158/1078-0432.ccr-13-2109.
Assessing the experience in complex hepatopancreatobiliary surgery among graduating chief residents: Is the operative experience enough?Sachs TE, Ejaz A, Weiss M, Spolverato G, Ahuja N, Makary MA, Wolfgang CL, Hirose K, Pawlik TM. Assessing the experience in complex hepatopancreatobiliary surgery among graduating chief residents: Is the operative experience enough? Surgery 2014, 156: 385-393. PMID: 24953270, PMCID: PMC4316664, DOI: 10.1016/j.surg.2014.03.006.
Inpatient survival after gastrectomy for gastric cancer in the 21st centuryWang H, Pawlik TM, Duncan MD, Hui X, Selvarajah S, Canner JK, Haider AH, Ahuja N, Schneider EB. Inpatient survival after gastrectomy for gastric cancer in the 21st century. Journal Of Surgical Research 2014, 190: 72-78. PMID: 24725677, DOI: 10.1016/j.jss.2014.03.015.
Immune regulation by low doses of the DNA methyltransferase inhibitor 5-azacitidine in common human epithelial cancersLi H, Chiappinelli KB, Guzzetta AA, Easwaran H, Yen RW, Vatapalli R, Topper MJ, Luo J, Connolly RM, Azad NS, Stearns V, Pardoll DM, Davidson N, Jones PA, Slamon DJ, Baylin SB, Zahnow CA, Ahuja N. Immune regulation by low doses of the DNA methyltransferase inhibitor 5-azacitidine in common human epithelial cancers. Oncotarget 2014, 5: 587-598. PMID: 24583822, PMCID: PMC3996658, DOI: 10.18632/oncotarget.1782.
CpG island methylator phenotype and its association with malignancy in sporadic duodenal adenomasSun L, Guzzetta AA, Fu T, Chen J, Jeschke J, Kwak R, Vatapalli R, Baylin SB, Iacobuzio-Donahue CA, Wolfgang CL, Ahuja N. CpG island methylator phenotype and its association with malignancy in sporadic duodenal adenomas. Epigenetics 2014, 9: 738-746. PMID: 24518818, PMCID: PMC4063833, DOI: 10.4161/epi.28082.
Inpatient Survival after Gastrectomy for Gastric Cancer in the 21st Century: Are We Making Progress?Wang H, Pawlik T, Duncan M, Hui X, Selvarajah S, Canner J, Haider A, Ahuja N, Schneider E. Inpatient Survival after Gastrectomy for Gastric Cancer in the 21st Century: Are We Making Progress? Journal Of Surgical Research 2014, 186: 683. DOI: 10.1016/j.jss.2013.11.946.
Black and Hispanic Pancreaticoduodenectomy Patients Are Treated by Lower Volume Providers and Have Longer Hospital Stays Compared with White PatientsSchneider E, Calkins K, Weiss M, Wolfgang C, Makary M, Ahuja N, Haider A, Pawlik T. Black and Hispanic Pancreaticoduodenectomy Patients Are Treated by Lower Volume Providers and Have Longer Hospital Stays Compared with White Patients. Journal Of Surgical Research 2014, 186: 607-608. DOI: 10.1016/j.jss.2013.11.584.
Hospital Volume and Patient Outcomes in Hepato-Pancreato-Biliary Surgery: is Assessing Differences in Mortality Enough?Schneider E, Ejaz A, Spolverato G, Haider A, Makary M, Wolfgang C, Ahuja N, Weiss M, Pawlik T. Hospital Volume and Patient Outcomes in Hepato-Pancreato-Biliary Surgery: is Assessing Differences in Mortality Enough? Journal Of Surgical Research 2014, 186: 520. DOI: 10.1016/j.jss.2013.11.355.
Assessing the Experience in Complex Hepatopancreatobiliary Surgery Among Graduating Chief Residents: Is the Operative Caseload Enough?Sachs T, Ejaz A, Weiss M, Spolverato G, Ahuja N, Makary M, Wolfgang C, Hirose K, Pawlik T. Assessing the Experience in Complex Hepatopancreatobiliary Surgery Among Graduating Chief Residents: Is the Operative Caseload Enough? Journal Of Surgical Research 2014, 186: 546. DOI: 10.1016/j.jss.2013.11.439.
A Comparison of Open and Minimally Invasive Surgery for Hepatic & Pancreatic Resections Using the Nationwide Inpatient Sample (NIS)Ejaz A, Sachs T, Spolverato G, Ahuja N, Makary M, Wolfgang C, Hirose K, Weiss M, Pawlik T. A Comparison of Open and Minimally Invasive Surgery for Hepatic & Pancreatic Resections Using the Nationwide Inpatient Sample (NIS). Journal Of Surgical Research 2014, 186: 641-642. DOI: 10.1016/j.jss.2013.11.665.
Is Minimally Invasive Colon Resection Better Than Traditional Approaches?: First Comprehensive National Examination With Propensity Score MatchingJuo YY, Hyder O, Haider AH, Camp M, Lidor A, Ahuja N. Is Minimally Invasive Colon Resection Better Than Traditional Approaches?: First Comprehensive National Examination With Propensity Score Matching. JAMA Surgery 2014, 149: 177-184. PMID: 24352653, PMCID: PMC4036435, DOI: 10.1001/jamasurg.2013.3660.
Harnessing the potential of epigenetic therapy to target solid tumorsAhuja N, Easwaran H, Baylin SB. Harnessing the potential of epigenetic therapy to target solid tumors. Journal Of Clinical Investigation 2014, 124: 56-63. PMID: 24382390, PMCID: PMC3871229, DOI: 10.1172/jci69736.
Trends and Risk Factors for Transfusion in Hepatopancreatobiliary SurgeryLucas DJ, Schexneider KI, Weiss M, Wolfgang CL, Frank SM, Hirose K, Ahuja N, Makary M, Cameron JL, Pawlik TM. Trends and Risk Factors for Transfusion in Hepatopancreatobiliary Surgery. Journal Of Gastrointestinal Surgery 2013, 18: 719-728. PMID: 24323432, DOI: 10.1007/s11605-013-2417-9.
Novel Methylation Biomarker Panel for the Early Detection of Pancreatic CancerYi JM, Guzzetta AA, Bailey VJ, Downing SR, Van Neste L, Chiappinelli KB, Keeley BP, Stark A, Herrera A, Wolfgang C, Pappou EP, Iacobuzio-Donahue CA, Goggins MG, Herman JG, Wang TH, Baylin SB, Ahuja N. Novel Methylation Biomarker Panel for the Early Detection of Pancreatic Cancer. Clinical Cancer Research 2013, 19: 6544-6555. PMID: 24088737, PMCID: PMC4310572, DOI: 10.1158/1078-0432.ccr-12-3224.
CHFR silencing or microsatellite instability is associated with increased antitumor activity of docetaxel or gemcitabine in colorectal cancerPelosof L, Yerram SR, Ahuja N, Delmas A, Danilova L, Herman JG, Azad NS. CHFR silencing or microsatellite instability is associated with increased antitumor activity of docetaxel or gemcitabine in colorectal cancer. International Journal Of Cancer 2013, 134: 596-605. PMID: 23873170, PMCID: PMC3830586, DOI: 10.1002/ijc.28390.
MC13-0076 CHFR silencing and microsatellite instability as predictors of sensitivity to docetaxel and gemcitabine in colorectal cancerPelosof L, Yerram S, Ahuja N, Delmas A, Danilova L, Herman J, Azad N. MC13-0076 CHFR silencing and microsatellite instability as predictors of sensitivity to docetaxel and gemcitabine in colorectal cancer. European Journal Of Cancer 2013, 49: s33. DOI: 10.1016/s0959-8049(13)70182-5.
The CpG Island Methylator Phenotype: What's in a Name?Hughes LA, Melotte V, de Schrijver J, de Maat M, Smit VT, Bovée JV, French PJ, van den Brandt PA, Schouten LJ, de Meyer T, van Criekinge W, Ahuja N, Herman JG, Weijenberg MP, van Engeland M. The CpG Island Methylator Phenotype: What's in a Name? Cancer Research 2013, 73: 5858-5868. PMID: 23801749, DOI: 10.1158/0008-5472.can-12-4306.
Incidence and prognostic impact of KRAS and BRAF mutation in patients undergoing liver surgery for colorectal metastasesKaragkounis G, Torbenson MS, Daniel HD, Azad NS, Diaz LA, Donehower RC, Hirose K, Ahuja N, Pawlik TM, Choti MA. Incidence and prognostic impact of KRAS and BRAF mutation in patients undergoing liver surgery for colorectal metastases. Cancer 2013, 119: 4137-4144. PMID: 24104864, PMCID: PMC3967132, DOI: 10.1002/cncr.28347.
Extrathoracic Location and “Borderline” Histology are Associated with Recurrence of Solitary Fibrous Tumors After Surgical ResectionWilky BA, Montgomery EA, Guzzetta AA, Ahuja N, Meyer CF. Extrathoracic Location and “Borderline” Histology are Associated with Recurrence of Solitary Fibrous Tumors After Surgical Resection. Annals Of Surgical Oncology 2013, 20: 4080-4089. PMID: 24046107, PMCID: PMC4124630, DOI: 10.1245/s10434-013-3241-x.
Cost and outcomes analysis of robotic, laparoscopic, and open colon resection: a national studyJuo Y, Hyder O, Haider A, Camp M, Lidor A, Ahuja N. Cost and outcomes analysis of robotic, laparoscopic, and open colon resection: a national study. Journal Of The American College Of Surgeons 2013, 217: s112-s113. DOI: 10.1016/j.jamcollsurg.2013.07.260.
Assessing Readmission After General, Vascular, and Thoracic Surgery Using ACS-NSQIPLucas DJ, Haider A, Haut E, Dodson R, Wolfgang CL, Ahuja N, Sweeney J, Pawlik TM. Assessing Readmission After General, Vascular, and Thoracic Surgery Using ACS-NSQIP. Annals Of Surgery 2013, 258: 430-439. PMID: 24022435, PMCID: PMC4623433, DOI: 10.1097/sla.0b013e3182a18fcc.
Extraction and processing of circulating DNA from large sample volumes using methylation on beads for the detection of rare epigenetic eventsKeeley B, Stark A, Pisanic TR, Kwak R, Zhang Y, Wrangle J, Baylin S, Herman J, Ahuja N, Brock MV, Wang TH. Extraction and processing of circulating DNA from large sample volumes using methylation on beads for the detection of rare epigenetic events. Clinica Chimica Acta 2013, 425: 169-175. PMID: 23911908, PMCID: PMC3963364, DOI: 10.1016/j.cca.2013.07.023.
Frequent Inactivation of Cysteine Dioxygenase Type 1 Contributes to Survival of Breast Cancer Cells and Resistance to AnthracyclinesJeschke J, O'Hagan HM, Zhang W, Vatapalli R, Calmon MF, Danilova L, Nelkenbrecher C, Van Neste L, Bijsmans IT, Van Engeland M, Gabrielson E, Schuebel KE, Winterpacht A, Baylin SB, Herman JG, Ahuja N. Frequent Inactivation of Cysteine Dioxygenase Type 1 Contributes to Survival of Breast Cancer Cells and Resistance to Anthracyclines. Clinical Cancer Research 2013, 19: 3201-3211. PMID: 23630167, PMCID: PMC3985391, DOI: 10.1158/1078-0432.ccr-12-3751.
A phase II study of combination epigenetic therapy in metastatic colorectal cancer (mCRC): A phase II consortium (P2C)/Stand Up 2 Cancer (SU2C) study.Azad N, El-Khoueiry A, Mahoney M, Adkins D, Flynn P, Bahary N, Kim G, Pitot H, Erlichman C, Donehower R, Herman J, Baylin S, Ahuja N. A phase II study of combination epigenetic therapy in metastatic colorectal cancer (mCRC): A phase II consortium (P2C)/Stand Up 2 Cancer (SU2C) study. Journal Of Clinical Oncology 2013, 31: 3539-3539. DOI: 10.1200/jco.2013.31.15_suppl.3539.
Abstract 4666: A phase 2 study investigating the safety, efficacy and surrogate biomarkers of response of 5-azacitidine (5-AZA) andentinostat (MS-275) in patients with triple-negative advanced breast cancer.Connolly R, Jankowitz R, Zahnow C, Zhang Z, Rudek M, Jeter S, Slater S, Powers P, Wolff A, Fetting J, Brufsky A, Piekarz R, Ahuja N, Somlo G, Garcia A, Baylin S, Davidson N, Stearns V. Abstract 4666: A phase 2 study investigating the safety, efficacy and surrogate biomarkers of response of 5-azacitidine (5-AZA) andentinostat (MS-275) in patients with triple-negative advanced breast cancer. Cancer Research 2013, 73: 4666-4666. DOI: 10.1158/1538-7445.am2013-4666.
2564 resected periampullary adenocarcinomas at a single institution: trends over three decadesHe J, Ahuja N, Makary MA, Cameron JL, Eckhauser FE, Choti MA, Hruban RH, Pawlik TM, Wolfgang CL. 2564 resected periampullary adenocarcinomas at a single institution: trends over three decades. Hepato Pancreato Biliary 2013, 16: 83-90. PMID: 23472829, PMCID: PMC3892319, DOI: 10.1111/hpb.12078.
Discovery of early detection markers of pancreatic cancer and clinical application in blood-based screeningKwak R, Keeley B, Guzzetta A, Jeschke J, Wolfgang C, Wang T, Herman J, Iacobuzio-Donahue C, Ahuja N. Discovery of early detection markers of pancreatic cancer and clinical application in blood-based screening. Pancreatology 2013, 13: e46. DOI: 10.1016/j.pan.2012.12.216.
DNA Methylation Biomarkers of Stool and Blood for Early Detection of Colon CancerHong L, Ahuja N. DNA Methylation Biomarkers of Stool and Blood for Early Detection of Colon Cancer. Genetic Testing And Molecular Biomarkers 2013, 17: 401-406. PMID: 23406208, DOI: 10.1089/gtmb.2012.0478.
High Expression of Epidermal Growth Factor Receptor Might Predict Poor Survival in Patients with Colon Cancer: A Meta-AnalysisHong L, Han Y, Zhang H, Zhao Q, Yang J, Ahuja N. High Expression of Epidermal Growth Factor Receptor Might Predict Poor Survival in Patients with Colon Cancer: A Meta-Analysis. Genetic Testing And Molecular Biomarkers 2013, 17: 348-351. PMID: 23387315, DOI: 10.1089/gtmb.2012.0421.
Is It Necessary to Follow Patients after Resection of a Benign Pancreatic Intraductal Papillary Mucinous Neoplasm?He J, Cameron JL, Ahuja N, Makary MA, Hirose K, Choti MA, Schulick RD, Hruban RH, Pawlik TM, Wolfgang CL. Is It Necessary to Follow Patients after Resection of a Benign Pancreatic Intraductal Papillary Mucinous Neoplasm? Journal Of The American College Of Surgeons 2013, 216: 657-665. PMID: 23395158, PMCID: PMC3963007, DOI: 10.1016/j.jamcollsurg.2012.12.026.
140 Portal/Superior Mesenteric Vein Resections During Pancreaticoduodenectomy: Evolution of Technique and Lessons LearnedCameron A, Wesson R, Leng H, Cameron J, Wolfgang C, Edil B, Choti M, Pawlik T, Makary M, Eckhauser F, Hirose K, Ahuja N, Singer A, Dagher N, Schulick R. 140 Portal/Superior Mesenteric Vein Resections During Pancreaticoduodenectomy: Evolution of Technique and Lessons Learned. Journal Of Surgical Research 2013, 179: 241-242. DOI: 10.1016/j.jss.2012.10.451.
Epigenetic Upregulation of Beta-2 Microglobulin in Microsatellite Stable Colon Cancer Cell LinesGuzzetta A, Kwak R, Vatapalli R, Syed L, Koch A, Easwaran H, Baylin S, Ahuja N. Epigenetic Upregulation of Beta-2 Microglobulin in Microsatellite Stable Colon Cancer Cell Lines. Journal Of Surgical Research 2013, 179: 339. DOI: 10.1016/j.jss.2012.10.764.
Improving Sensitivity to Irinotecan Using 5-Azacytidine in Colon Cancer Cell LinesVatapalli R, Guzzetta A, Fu T, Syed L, Kwak R, Ahuja N. Improving Sensitivity to Irinotecan Using 5-Azacytidine in Colon Cancer Cell Lines. Journal Of Surgical Research 2013, 179: 251-252. DOI: 10.1016/j.jss.2012.10.474.
Blood-based screening for methylation changes in colorectal cancer patients using novel nanotechnologies.Ahuja N, Kwak R, Keeley B, Stark A, Guzzetta A, Wolfgang C, Herman J, Iacobuzio-Donahue C, Wang T. Blood-based screening for methylation changes in colorectal cancer patients using novel nanotechnologies. Journal Of Clinical Oncology 2013, 31: 384-384. DOI: 10.1200/jco.2013.31.4_suppl.384.
KRAS G>A mutation favors poor tumor differentiation but may not be associated with prognosis in patients with curatively resected duodenal adenocarcinomaFu T, Guzzetta AA, Jeschke J, Vatapalli R, Dave P, Hooker CM, Morgan R, Iacobuzio‐Donahue C, Liu B, Ahuja N. KRAS G>A mutation favors poor tumor differentiation but may not be associated with prognosis in patients with curatively resected duodenal adenocarcinoma. International Journal Of Cancer 2013, 132: 2502-2509. PMID: 23065691, PMCID: PMC3579006, DOI: 10.1002/ijc.27910.
Angiogenesis-related microRNAs in colon cancer.Hong L, Han Y, Zhou Y, Nita A. Angiogenesis-related microRNAs in colon cancer. Expert Opinion On Biological Therapy 2013, 13: 77-84. PMID: 23163807, DOI: 10.1517/14712598.2013.727391.
Young Patients Undergoing Resection of Pancreatic Cancer Fare Better than their Older CounterpartsHe J, Edil BH, Cameron JL, Schulick RD, Hruban RH, Herman JM, Zheng L, Iacobuzio-Donahue C, Ahuja N, Pawlik TM, Wolfgang CL. Young Patients Undergoing Resection of Pancreatic Cancer Fare Better than their Older Counterparts. Journal Of Gastrointestinal Surgery 2012, 17: 339-344. PMID: 23184271, PMCID: PMC3600849, DOI: 10.1007/s11605-012-2066-4.
Analysis of Cone BeamCT Shifts in Image Guided Radiation Therapy for Abdominopelvic Soft-tissue SarcomasSharabi A, Alcorn S, Tryggestad E, Ahuja N, Frassica D, McNutt T, Hales R, Terezakis S. Analysis of Cone BeamCT Shifts in Image Guided Radiation Therapy for Abdominopelvic Soft-tissue Sarcomas. International Journal Of Radiation Oncology • Biology • Physics 2012, 84: s659. DOI: 10.1016/j.ijrobp.2012.07.1760.
The Heat of the Matter: Comment on “Initial Experience With Hyperthermic Intraperitoneal Chemotherapy”Ahuja N. The Heat of the Matter: Comment on “Initial Experience With Hyperthermic Intraperitoneal Chemotherapy”. JAMA Surgery 2012, 147: 924-924. PMID: 23117831, DOI: 10.1001/archsurg.2012.1292.
Management and Recurrence Patterns of Desmoids Tumors: A Multi-institutional Analysis of 211 PatientsPeng PD, Hyder O, Mavros MN, Turley R, Groeschl R, Firoozmand A, Lidsky M, Herman JM, Choti M, Ahuja N, Anders R, Blazer DG, Gamblin TC, Pawlik TM. Management and Recurrence Patterns of Desmoids Tumors: A Multi-institutional Analysis of 211 Patients. Annals Of Surgical Oncology 2012, 19: 4036-4042. PMID: 22972507, PMCID: PMC3568525, DOI: 10.1245/s10434-012-2634-6.
CpG Island Methylator Phenotype–Positive Tumors in the Absence of MLH1 Methylation Constitute a Distinct Subset of Duodenal Adenocarcinomas and Are Associated with Poor PrognosisFu T, Pappou EP, Guzzetta AA, Jeschke J, Kwak R, Dave P, Hooker CM, Morgan R, Baylin SB, Iacobuzio-Donahue CA, Wolfgang CL, Ahuja N. CpG Island Methylator Phenotype–Positive Tumors in the Absence of MLH1 Methylation Constitute a Distinct Subset of Duodenal Adenocarcinomas and Are Associated with Poor Prognosis. Clinical Cancer Research 2012, 18: 4743-4752. PMID: 22825585, PMCID: PMC3482463, DOI: 10.1158/1078-0432.ccr-12-0707.
Biomarkers for detection and prognosis of breast cancer identified by a functional hypermethylome screenJeschke J, Van Neste L, Glöckner SC, Dhir M, Calmon MF, Deregowski V, Van Criekinge W, Vlassenbroeck I, Koch A, Chan TA, Cope L, Hooker CM, Schuebel KE, Gabrielson E, Winterpacht A, Baylin SB, Herman JG, Ahuja N. Biomarkers for detection and prognosis of breast cancer identified by a functional hypermethylome screen. Epigenetics 2012, 7: 701-709. PMID: 22647880, DOI: 10.4161/epi.20445.
Epithelioid sarcoma: one institution's experience with a rare sarcomaGuzzetta AA, Montgomery EA, Lyu H, Hooker CM, Meyer CF, Loeb DM, Frassica D, Weber KL, Ahuja N. Epithelioid sarcoma: one institution's experience with a rare sarcoma. Journal Of Surgical Research 2012, 177: 116-122. PMID: 22575361, PMCID: PMC3715113, DOI: 10.1016/j.jss.2012.04.030.
Abstract 995: Transient low doses of DNA demethylating agents exert durable antitumor effects on hematological and epithelial tumor cellsTsai H, Li H, Neste L, Cai Y, Robert C, Rassool F, Shin J, Harbom K, Beaty R, Pappou E, Harris J, Yen R, Ahuja N, Brock M, Stearns V, Feller-Kopman D, Lin Y, Welm A, Issa J, Minn I, Matsui W, Jang Y, Sharkis S, Baylin S, Zahnow C. Abstract 995: Transient low doses of DNA demethylating agents exert durable antitumor effects on hematological and epithelial tumor cells. Cancer Research 2012, 72: 995-995. DOI: 10.1158/1538-7445.am2012-995.
Abstract 94: Epigenetic silencing of CDO1 sustains viability of breast cancer cells via the reduction of cellular ROSJeschke J, O'Hagan H, Zhang W, Calmon M, Dhir M, van Neste L, Bijsmans I, Gabrielson E, Schuebel K, Baylin S, Winterpacht A, Herman J, Ahuja N. Abstract 94: Epigenetic silencing of CDO1 sustains viability of breast cancer cells via the reduction of cellular ROS. Cancer Research 2012, 72: 94-94. DOI: 10.1158/1538-7445.am2012-94.
A pressure cooking-based DNA extraction from archival formalin-fixed, paraffin-embedded tissueChung JY, Yi JM, Xie R, Brown V, Lee O, Ahuja N, Braunschweig T, Hewitt SM. A pressure cooking-based DNA extraction from archival formalin-fixed, paraffin-embedded tissue. Analytical Biochemistry 2012, 425: 128-134. PMID: 22449494, PMCID: PMC3358925, DOI: 10.1016/j.ab.2012.03.012.
A DNA hypermethylation module for the stem/progenitor cell signature of cancerEaswaran H, Johnstone SE, Van Neste L, Ohm J, Mosbruger T, Wang Q, Aryee MJ, Joyce P, Ahuja N, Weisenberger D, Collisson E, Zhu J, Yegnasubramanian S, Matsui W, Baylin SB. A DNA hypermethylation module for the stem/progenitor cell signature of cancer. Genome Research 2012, 22: 837-849. PMID: 22391556, PMCID: PMC3337430, DOI: 10.1101/gr.131169.111.
Transient Low Doses of DNA-Demethylating Agents Exert Durable Antitumor Effects on Hematological and Epithelial Tumor CellsTsai HC, Li H, Van Neste L, Cai Y, Robert C, Rassool FV, Shin JJ, Harbom KM, Beaty R, Pappou E, Harris J, Yen RW, Ahuja N, Brock MV, Stearns V, Feller-Kopman D, Yarmus LB, Lin YC, Welm AL, Issa JP, Minn I, Matsui W, Jang YY, Sharkis SJ, Baylin SB, Zahnow CA. Transient Low Doses of DNA-Demethylating Agents Exert Durable Antitumor Effects on Hematological and Epithelial Tumor Cells. Cancer Cell 2012, 21: 430-446. PMID: 22439938, PMCID: PMC3312044, DOI: 10.1016/j.ccr.2011.12.029.
Epithelial Sarcomas: Experience From a Single InstitutionGuzzetta A, Montgomery E, Emmanouil P, Fu T, Ahuja N. Epithelial Sarcomas: Experience From a Single Institution. Journal Of Surgical Research 2012, 172: 310. DOI: 10.1016/j.jss.2011.11.553.
Lymph Node Evaluation by Tumor Location in Colon Cancer Elderly Patients: A SEER-Medicare StudyTucker J, Yanagawa F, Ahuja N, Bell T, Grim R, Ahuja V. Lymph Node Evaluation by Tumor Location in Colon Cancer Elderly Patients: A SEER-Medicare Study. Journal Of Surgical Research 2012, 172: 191. DOI: 10.1016/j.jss.2011.11.095.
DNA methylation biomarker candidates for early detection of colon cancerYi JM, Dhir M, Guzzetta AA, Iacobuzio-Donahue CA, Heo K, Yang KM, Suzuki H, Toyota M, Kim HM, Ahuja N. DNA methylation biomarker candidates for early detection of colon cancer. Tumor Biology 2012, 33: 363-372. PMID: 22238052, PMCID: PMC3593674, DOI: 10.1007/s13277-011-0302-2.
Colorectal Cancer Stem Cells—Hype or Real?: Comment on “Combined CD133+/CD44+ Expression as a Prognostic Indicator of Disease-Free Survival in Patients With Colorectal Cancer”Ahuja N. Colorectal Cancer Stem Cells—Hype or Real?: Comment on “Combined CD133+/CD44+ Expression as a Prognostic Indicator of Disease-Free Survival in Patients With Colorectal Cancer”. JAMA Surgery 2012, 147: 24-25. PMID: 22250107, DOI: 10.1001/archsurg.2011.1218.
OT3-01-06: A Phase 2 Study Investigating the Safety, Efficacy and Surrogate Biomarkers of Response of 5-Azacitidine (5-AZA) and Entinostat (MS-275) in Patients with Advanced Breast Cancer.Connolly R, Jankowitz R, Andreopoulou E, Allred J, Jeter S, Zorzi J, Adam B, Espinoza-Delgado I, Baylin S, Zahnow C, Ahuja N, Davidson N, Stearns V. OT3-01-06: A Phase 2 Study Investigating the Safety, Efficacy and Surrogate Biomarkers of Response of 5-Azacitidine (5-AZA) and Entinostat (MS-275) in Patients with Advanced Breast Cancer. Cancer Research 2011, 71: ot3-01-06-ot3-01-06. DOI: 10.1158/0008-5472.sabcs11-ot3-01-06.
Duodenal Adenocarcinoma: Clinicopathologic Analysis and Implications for TreatmentPoultsides GA, Huang LC, Cameron JL, Tuli R, Lan L, Hruban RH, Pawlik TM, Herman JM, Edil BH, Ahuja N, Choti MA, Wolfgang CL, Schulick RD. Duodenal Adenocarcinoma: Clinicopathologic Analysis and Implications for Treatment. Annals Of Surgical Oncology 2011, 19: 1928-1935. PMID: 22167476, PMCID: PMC3663711, DOI: 10.1245/s10434-011-2168-3.
Neoadjuvant chemoradiation followed by interstitial prostate brachytherapy for synchronous prostate and rectal cancerQiu H, Herman JM, Ahuja N, DeWeese TL, Song DY. Neoadjuvant chemoradiation followed by interstitial prostate brachytherapy for synchronous prostate and rectal cancer. Practical Radiation Oncology 2011, 2: e77-e84. PMID: 24674189, DOI: 10.1016/j.prro.2011.11.001.
Predicting the Risk of Perioperative Mortality in Patients Undergoing Pancreaticoduodenectomy: A Novel Scoring SystemVenkat R, Puhan MA, Schulick RD, Cameron JL, Eckhauser FE, Choti MA, Makary MA, Pawlik TM, Ahuja N, Edil BH, Wolfgang CL. Predicting the Risk of Perioperative Mortality in Patients Undergoing Pancreaticoduodenectomy: A Novel Scoring System. JAMA Surgery 2011, 146: 1277-1284. PMID: 22106320, DOI: 10.1001/archsurg.2011.294.
The CpG island methylator phenotype in colorectal cancer: Progress and problemsHughes LA, Bakker C, Smits KM, van den Brandt PA, Jonkers D, Ahuja N, Herman JG, Weijenberg MP, van Engeland M. The CpG island methylator phenotype in colorectal cancer: Progress and problems. Biochimica Et Biophysica Acta 2011, 1825: 77-85. PMID: 22056543, DOI: 10.1016/j.bbcan.2011.10.005.
Abstract B43: Early detection biomarker of pancreatic cancer using a nanoparticle-based methylation assayYi J, Bailey V, Downing S, Goggins M, Yang K, Wang T, Herman J, Baylin S, Ahuja N. Abstract B43: Early detection biomarker of pancreatic cancer using a nanoparticle-based methylation assay. Cancer Epidemiology Biomarkers & Prevention 2011, 20: b43-b43. DOI: 10.1158/1055-9965.disp-11-b43.
Early-Stage Gallbladder Cancer in the Surveillance, Epidemiology, and End Results Database: Effect of Extended Surgical ResectionDowning SR, Cadogan KA, Ortega G, Oyetunji TA, Siram SM, Chang DC, Ahuja N, Leffall LD, Frederick WA. Early-Stage Gallbladder Cancer in the Surveillance, Epidemiology, and End Results Database: Effect of Extended Surgical Resection. JAMA Surgery 2011, 146: 734-738. PMID: 21690451, DOI: 10.1001/archsurg.2011.128.
Abstract 2618: DNMT1 as a marker of differential sensitivities to epigenetic therapy of a Kras mutant and Kras wild type human non small cell lung cancer cell lineDu Z, Wrangle J, Pelosky K, Harris J, Shin J, Vendetti F, Hulbert A, Lee B, Zahnow C, Ahuja N, Herman J, Baylin S, Brock M. Abstract 2618: DNMT1 as a marker of differential sensitivities to epigenetic therapy of a Kras mutant and Kras wild type human non small cell lung cancer cell line. Cancer Research 2011, 71: 2618-2618. DOI: 10.1158/1538-7445.am2011-2618.
Breast Cancer Methylomes Establish an Epigenomic Foundation for MetastasisFang F, Turcan S, Rimner A, Kaufman A, Giri D, Morris LG, Shen R, Seshan V, Mo Q, Heguy A, Baylin SB, Ahuja N, Viale A, Massague J, Norton L, Vahdat LT, Moynahan ME, Chan TA. Breast Cancer Methylomes Establish an Epigenomic Foundation for Metastasis. Science Translational Medicine 2011, 3: 75ra25. PMID: 21430268, PMCID: PMC3146366, DOI: 10.1126/scitranslmed.3001875.
Genomic and Epigenomic Integration Identifies a Prognostic Signature in Colon CancerYi JM, Dhir M, Van Neste L, Downing SR, Jeschke J, Glöckner SC, de Freitas Calmon M, Hooker CM, Funes JM, Boshoff C, Smits KM, van Engeland M, Weijenberg MP, Iacobuzio-Donahue CA, Herman JG, Schuebel KE, Baylin SB, Ahuja N. Genomic and Epigenomic Integration Identifies a Prognostic Signature in Colon Cancer. Clinical Cancer Research 2011, 17: 1535-1545. PMID: 21278247, PMCID: PMC3077819, DOI: 10.1158/1078-0432.ccr-10-2509.
Sessile serrated adenomas and classical adenomas: An epigenetic perspective on premalignant neoplastic lesions of the gastrointestinal tractDhir M, Yachida S, Van Neste L, Glöckner SC, Jeschke J, Pappou EP, Montgomery EA, Herman JG, Baylin SB, Iacobuzio‐Donahue C, Ahuja N. Sessile serrated adenomas and classical adenomas: An epigenetic perspective on premalignant neoplastic lesions of the gastrointestinal tract. International Journal Of Cancer 2011, 129: 1889-1898. PMID: 21154739, PMCID: PMC3206997, DOI: 10.1002/ijc.25847.
Biomarkers to Tailor Chemoradiation TherapiesGuzzetta AA, Ahuja N. Biomarkers to Tailor Chemoradiation Therapies. Journal Of Surgical Research 2011, 173: 243-245. PMID: 21435667, DOI: 10.1016/j.jss.2011.01.045.
Use of [18F]-2-Fluoro-2-deoxy-D-glucose Positron Emission Tomography in the Management of Colorectal CancerTsai S, Jacene H, Ahuja N. Use of [18F]-2-Fluoro-2-deoxy-D-glucose Positron Emission Tomography in the Management of Colorectal Cancer. 2011, 200-204. DOI: 10.1016/b978-1-4377-0823-3.10049-9.
5 Behavior and Dietary Modification in the Prevention of Colon CancerDowning S, Pappou E, Ahuja N. 5 Behavior and Dietary Modification in the Prevention of Colon Cancer. 2011, 47-64. DOI: 10.1016/b978-1-4160-4686-8.50010-5.
PrefaceGearhart S, Ahuja N. Preface. 2011, ix. DOI: 10.1016/b978-1-4160-4686-8.50004-x.
20 Genetic Profiling in Colorectal CancerBose D, Ahuja N. 20 Genetic Profiling in Colorectal Cancer. 2011, 239-249. DOI: 10.1016/b978-1-4160-4686-8.50025-7.
9 Stool and Blood Sampling for Early Detection of Colorectal CancerSicklick J, Ahuja N. 9 Stool and Blood Sampling for Early Detection of Colorectal Cancer. 2011, 93-105. DOI: 10.1016/b978-1-4160-4686-8.50014-2.
Nurse-Perceived Barriers to Effective Communication Regarding Prognosis and Optimal End-of-Life Care for Surgical ICU Patients: A Qualitative Exploration (314-A)Aslakson R, Wyskiel R, Thornton I, Copley C, Shaffer D, Zyra M, Ahuja N, Nelson J, Pronovost P. Nurse-Perceived Barriers to Effective Communication Regarding Prognosis and Optimal End-of-Life Care for Surgical ICU Patients: A Qualitative Exploration (314-A). Journal Of Pain And Symptom Management 2011, 41: 193. DOI: 10.1016/j.jpainsymman.2010.10.051.
17 Surveillance and Follow-upHueman M, Ahuja N. 17 Surveillance and Follow-up. 2011, 201-217. DOI: 10.1016/b978-1-4160-4686-8.50022-1.
22 ConclusionGearhart S, Ahuja N. 22 Conclusion. 2011, 261. DOI: 10.1016/b978-1-4160-4686-8.50027-0.
Surgical intensive care unit clinician estimates of the adequacy of communication regarding patient prognosisAslakson RA, Wyskiel R, Shaeffer D, Zyra M, Ahuja N, Nelson JE, Pronovost PJ. Surgical intensive care unit clinician estimates of the adequacy of communication regarding patient prognosis. Critical Care 2010, 14: r218. PMID: 21114837, PMCID: PMC3220002, DOI: 10.1186/cc9346.
The role of oncogenes in gastrointestinal cancer.Pappou EP, Ahuja N. The role of oncogenes in gastrointestinal cancer. Gastrointestinal Cancer Research : GCR 2010, s2-s15. PMID: 21472044, PMCID: PMC3047044.
A Bioinformatics Pipeline for Cancer EpigeneticsVan Neste L, G. Herman J, E. Schuebel K, Cope L, B. Baylin S, Van Criekinge W, Ahuja N. A Bioinformatics Pipeline for Cancer Epigenetics. Current Bioinformatics 2010, 5: 153-163. DOI: 10.2174/157489310792006710.
Asian Race/Ethnicity as a Risk Factor for Bile Duct Injury During CholecystectomyDowning SR, Datoo G, Oyetunji TA, Fullum T, Chang DC, Ahuja N. Asian Race/Ethnicity as a Risk Factor for Bile Duct Injury During Cholecystectomy. JAMA Surgery 2010, 145: 785-787. PMID: 20713933, PMCID: PMC4086633, DOI: 10.1001/archsurg.2010.131.
M1629 Preoperative Biopsy Findings Correlate Poorly With Postoperative Findings in IBD-Associated NeoplasiaGearhart S, Wick E, Ahuja N, Montgomery E, Efron J. M1629 Preoperative Biopsy Findings Correlate Poorly With Postoperative Findings in IBD-Associated Neoplasia. Gastroenterology 2010, 138: s-870. DOI: 10.1016/s0016-5085(10)64018-8.
Abstract LB-88: Transient exposure to low-dose decitabine and azacytidine reprograms cancer cells to produce a prolonged antitumor responseTsai H, Van Neste L, Li H, Cai Y, Robert C, Shin J, Pappou E, Yen R, Minn I, Ahuja N, Brock M, Rassool F, Jang Y, Sharkis S, Matsui W, Zahnow C, Baylin S. Abstract LB-88: Transient exposure to low-dose decitabine and azacytidine reprograms cancer cells to produce a prolonged antitumor response. Cancer Research 2010, 70: lb-88-lb-88. DOI: 10.1158/1538-7445.am10-lb-88.
Teaching Hospital Status and Operative Mortality in the United States: Tipping Point in the Volume-Outcome Relationship Following Colon Resections?Hayanga AJ, Mukherjee D, Chang D, Kaiser H, Lee T, Gearhart S, Ahuja N, Freischlag J. Teaching Hospital Status and Operative Mortality in the United States: Tipping Point in the Volume-Outcome Relationship Following Colon Resections? JAMA Surgery 2010, 145: 346-350. PMID: 20404284, PMCID: PMC4036455, DOI: 10.1001/archsurg.2010.24.
Disparity in limb-salvage surgery among sarcoma patientsDowning S, Ahuja N, Oyetunji TA, Chang D, Frederick WA. Disparity in limb-salvage surgery among sarcoma patients. The American Journal Of Surgery 2010, 199: 549-553. PMID: 20359572, DOI: 10.1016/j.amjsurg.2009.12.003.
Intraabdominal Tissue Expanders to Prevent Radiation Enteritis: Preliminary ReportAngster K, Shridharani SM, Rad AN, Ahuja N, Rosson GD. Intraabdominal Tissue Expanders to Prevent Radiation Enteritis: Preliminary Report. Plastic & Reconstructive Surgery 2010, 125: 177e-179e. PMID: 20335853, DOI: 10.1097/prs.0b013e3181d45db2.
Histopathologic Basis for the Favorable Survival after Resection of Intraductal Papillary Mucinous Neoplasm-Associated Invasive Adenocarcinoma of the PancreasPoultsides GA, Reddy S, Cameron JL, Hruban RH, Pawlik TM, Ahuja N, Jain A, Edil BH, Iacobuzio-Donahue CA, Schulick RD, Wolfgang CL. Histopathologic Basis for the Favorable Survival after Resection of Intraductal Papillary Mucinous Neoplasm-Associated Invasive Adenocarcinoma of the Pancreas. Annals Of Surgery 2010, 251: 470-476. PMID: 20142731, PMCID: PMC3437748, DOI: 10.1097/sla.0b013e3181cf8a19.
Translational Research in Surgical DiseaseStojadinovic A, Ahuja N, Nazarian SM, Segev DL, Jacobs L, Wang Y, Eberhardt J, Zeiger MA. Translational Research in Surgical Disease. JAMA Surgery 2010, 145: 187-196. PMID: 20157088, DOI: 10.1001/archsurg.2009.280.
Is the Debate Finally Over?: Comment on “Survival Effects of Adjuvant Chemoradiation Following Chemoradiotherapy After Resection for Pancreatic Carcinoma”Ahuja N. Is the Debate Finally Over?: Comment on “Survival Effects of Adjuvant Chemoradiation Following Chemoradiotherapy After Resection for Pancreatic Carcinoma”. JAMA Surgery 2010, 145: 56-56. PMID: 20088100, DOI: 10.1001/archsurg.2009.241.
Prognostic Significance of Gremlin1 (GREM1) Promoter CpG Island Hypermethylation in Clear Cell Renal Cell Carcinomavan Vlodrop IJ, Baldewijns MM, Smits KM, Schouten LJ, van Neste L, van Criekinge W, van Poppel H, Lerut E, Schuebel KE, Ahuja N, Herman JG, de Bruïne AP, van Engeland M. Prognostic Significance of Gremlin1 (GREM1) Promoter CpG Island Hypermethylation in Clear Cell Renal Cell Carcinoma. American Journal Of Pathology 2009, 176: 575-584. PMID: 20042676, PMCID: PMC2808066, DOI: 10.2353/ajpath.2010.090442.
Variations in Referral Patterns to High-Volume Centers for Pancreatic CancerChang DC, Zhang Y, Mukherjee D, Wolfgang CL, Schulick RD, Cameron JL, Ahuja N. Variations in Referral Patterns to High-Volume Centers for Pancreatic Cancer. Journal Of The American College Of Surgeons 2009, 209: 720-726. PMID: 19959040, PMCID: PMC4036485, DOI: 10.1016/j.jamcollsurg.2009.09.011.
Predictors of Survival After Resection of Retroperitoneal SarcomaNathan H, Raut CP, Thornton K, Herman JM, Ahuja N, Schulick RD, Choti MA, Pawlik TM. Predictors of Survival After Resection of Retroperitoneal Sarcoma. Annals Of Surgery 2009, 250: 970-976. PMID: 19644351, PMCID: PMC3099434, DOI: 10.1097/sla.0b013e3181b25183.
Asian race as a risk factor for bile duct injury during cholecystectomyDatoo G, Downing S, Oyetunji T, Fullum T, Chang D, Ahuja N. Asian race as a risk factor for bile duct injury during cholecystectomy. Journal Of The American College Of Surgeons 2009, 209: s24. DOI: 10.1016/j.jamcollsurg.2009.06.046.
12LBA A Plasma-based colorectal cancer (CRC) screening assay using DNA methylation markers - first results of multicenter studiesLouwagie J, Pommerien W, Brichard G, Otto G, Van Criekinge W, Baylin S, Ahuja N, Adams H, Nürnberg D, Bierau K. 12LBA A Plasma-based colorectal cancer (CRC) screening assay using DNA methylation markers - first results of multicenter studies. European Journal Of Cancer Supplements 2009, 7: 9. DOI: 10.1016/s1359-6349(09)72047-6.
Methylation of TFPI2 in Stool DNA: A Potential Novel Biomarker for the Detection of Colorectal CancerGlöckner S, Dhir M, Yi JM, McGarvey KE, Van Neste L, Louwagie J, Chan TA, Kleeberger W, de Bruïne A, Smits KM, Bakker C, Jonkers DM, Stockbrügger R, Meijer GA, Oort FA, Iacobuzio-Donahue C, Bierau K, Herman JG, Baylin SB, Van Engeland M, Schuebel KE, Ahuja N. Methylation of TFPI2 in Stool DNA: A Potential Novel Biomarker for the Detection of Colorectal Cancer. Cancer Research 2009, 69: 4691-4699. PMID: 19435926, PMCID: PMC3062162, DOI: 10.1158/0008-5472.can-08-0142.
W1755 Exploring Combination Epigenetic Therapy for the Treatment of Colorectal CancerDhir M, Calmon M, Jeschke J, Azad N, Herman J, Baylin S, Ahuja N. W1755 Exploring Combination Epigenetic Therapy for the Treatment of Colorectal Cancer. Gastroenterology 2009, 136: a-934. DOI: 10.1016/s0016-5085(09)64324-9.
M1592 Is There Any Role for Resection for Stage IV Gastric Cancers?Downing S, Dhir M, Frederick W, Oyetunji T, Wolfgang C, Schulick R, Chang D, Ahuja N. M1592 Is There Any Role for Resection for Stage IV Gastric Cancers? Gastroenterology 2009, 136: a-903. DOI: 10.1016/s0016-5085(09)64174-3.
Surgical Management of Solid-Pseudopapillary Neoplasms of the Pancreas (Franz or Hamoudi Tumors): A Large Single-Institutional SeriesReddy S, Cameron JL, Scudiere J, Hruban RH, Fishman EK, Ahuja N, Pawlik TM, Edil BH, Schulick RD, Wolfgang CL. Surgical Management of Solid-Pseudopapillary Neoplasms of the Pancreas (Franz or Hamoudi Tumors): A Large Single-Institutional Series. Journal Of The American College Of Surgeons 2009, 208: 950-957. PMID: 19476869, PMCID: PMC3109868, DOI: 10.1016/j.jamcollsurg.2009.01.044.
QS47. Age and Racial Disparities in Access to High Volume Centers for Colorectal Cancer. Who Makes the Cut?Hayanga A, Mukherjee D, Chang D, Kaiser H, Gearhart S, Ahuja N, Freischlag J. QS47. Age and Racial Disparities in Access to High Volume Centers for Colorectal Cancer. Who Makes the Cut? Journal Of Surgical Research 2009, 151: 284. DOI: 10.1016/j.jss.2008.11.340.
55: Early Methylation of SYNE1 in Colorectal Cancer: Implications for Stool-Based Colorectal Cancer ScreeningDhir M, Glockner S, Van Neste L, Schuebel K, Baylin S, Ahuja N. 55: Early Methylation of SYNE1 in Colorectal Cancer: Implications for Stool-Based Colorectal Cancer Screening. Journal Of Surgical Research 2009, 151: 195-196. DOI: 10.1016/j.jss.2008.11.065.
QS277. The Effect of Teaching Hospital Status on Operative Mortality and Outcomes Following Colorectal Cancer ResectionHayanga A, Mukherjee D, Chang D, Kaiser H, Gearhart S, Ahuja N, Freischlag J. QS277. The Effect of Teaching Hospital Status on Operative Mortality and Outcomes Following Colorectal Cancer Resection. Journal Of Surgical Research 2009, 151: 295. DOI: 10.1016/j.jss.2008.11.581.
Multilevel Analysis of the Impact of Community vs Patient Factors on Access to Immediate Breast Reconstruction Following Mastectomy in MarylandRosson GD, Singh NK, Ahuja N, Jacobs LK, Chang DC. Multilevel Analysis of the Impact of Community vs Patient Factors on Access to Immediate Breast Reconstruction Following Mastectomy in Maryland. JAMA Surgery 2008, 143: 1076-1081. PMID: 19015466, DOI: 10.1001/archsurg.143.11.1076.
Abnormal DNA Methylation of CD133 in Colorectal and Glioblastoma TumorsYi JM, Tsai HC, Glöckner S, Lin S, Ohm JE, Easwaran H, James CD, Costello JF, Riggins G, Eberhart CG, Laterra J, Vescovi AL, Ahuja N, Herman JG, Schuebel KE, Baylin SB. Abnormal DNA Methylation of CD133 in Colorectal and Glioblastoma Tumors. Cancer Research 2008, 68: 8094-8103. PMID: 18829568, PMCID: PMC2744404, DOI: 10.1158/0008-5472.can-07-6208.
Pancreatic Resection of Isolated Metastases from Nonpancreatic Primary CancersReddy S, Edil BH, Cameron JL, Pawlik TM, Herman JM, Gilson MM, Campbell KA, Schulick RD, Ahuja N, Wolfgang CL. Pancreatic Resection of Isolated Metastases from Nonpancreatic Primary Cancers. Annals Of Surgical Oncology 2008, 15: 3199-3206. PMID: 18784960, DOI: 10.1245/s10434-008-0140-7.
Syne1 Promoter Hypermethylation as a Predictor of Tumor Aggressiveness in Primary Breast CancerRimner A, Ho A, Ahuja N, Schuebel K, Baylin S, Gerald W, Chan T. Syne1 Promoter Hypermethylation as a Predictor of Tumor Aggressiveness in Primary Breast Cancer. International Journal Of Radiation Oncology • Biology • Physics 2008, 72: s681-s682. DOI: 10.1016/j.ijrobp.2008.06.563.
Epigenetic Regulation of WNT Signaling Pathway Genes in Inflammatory Bowel Disease (IBD) Associated NeoplasiaDhir M, Montgomery EA, Glöckner SC, Schuebel KE, Hooker CM, Herman JG, Baylin SB, Gearhart SL, Ahuja N. Epigenetic Regulation of WNT Signaling Pathway Genes in Inflammatory Bowel Disease (IBD) Associated Neoplasia. Journal Of Gastrointestinal Surgery 2008, 12: 1745-1753. PMID: 18716850, PMCID: PMC3976145, DOI: 10.1007/s11605-008-0633-5.
Is There a Difference in Survival Between Right- Versus Left-Sided Colon Cancers?Meguid RA, Slidell MB, Wolfgang CL, Chang DC, Ahuja N. Is There a Difference in Survival Between Right- Versus Left-Sided Colon Cancers? Annals Of Surgical Oncology 2008, 15: 2388. PMID: 18622647, PMCID: PMC3072702, DOI: 10.1245/s10434-008-0015-y.
Management of Retroperitoneal SarcomasHueman MT, Herman JM, Ahuja N. Management of Retroperitoneal Sarcomas. Surgical Clinics Of North America 2008, 88: 583-597. PMID: 18514700, DOI: 10.1016/j.suc.2008.03.002.
PrefaceHueman MT, Ahuja N. Preface. Surgical Clinics Of North America 2008, 88: xiii-xvii. PMID: 18514693, DOI: 10.1016/j.suc.2008.04.009.
Management of Extremity Soft Tissue SarcomasHueman MT, Thornton K, Herman JM, Ahuja N. Management of Extremity Soft Tissue Sarcomas. Surgical Clinics Of North America 2008, 88: 539-557. PMID: 18514697, DOI: 10.1016/j.suc.2008.04.003.
Convergence of Mutation and Epigenetic Alterations Identifies Common Genes in Cancer That Predict for Poor PrognosisChan TA, Glockner S, Yi JM, Chen W, Van Neste L, Cope L, Herman JG, Velculescu V, Schuebel KE, Ahuja N, Baylin SB. Convergence of Mutation and Epigenetic Alterations Identifies Common Genes in Cancer That Predict for Poor Prognosis. PLOS Medicine 2008, 5: e114. PMID: 18507500, PMCID: PMC2429944, DOI: 10.1371/journal.pmed.0050114.
Retroperitoneal masses with associated human chorionic gonadotropin production: Report of two casesDuffield AS, Jarrar P, Shum C, Ahuja N, Yeo CJ, Sokoll LJ. Retroperitoneal masses with associated human chorionic gonadotropin production: Report of two cases. Clinica Chimica Acta 2008, 395: 166-169. PMID: 18505680, DOI: 10.1016/j.cca.2008.04.030.
Epigenetic Inactivation of the Canonical Wnt Antagonist SRY-Box Containing Gene 17 in Colorectal CancerZhang W, Glöckner S, Guo M, Machida EO, Wang DH, Easwaran H, Van Neste L, Herman JG, Schuebel KE, Watkins DN, Ahuja N, Baylin SB. Epigenetic Inactivation of the Canonical Wnt Antagonist SRY-Box Containing Gene 17 in Colorectal Cancer. Cancer Research 2008, 68: 2764-2772. PMID: 18413743, PMCID: PMC2823123, DOI: 10.1158/0008-5472.can-07-6349.
557 Epigenetic Regulation of WNT Signaling Pathway Genes in Inflammatory Bowel Disease (IBD) NeoplasiaDhir M, Montgomery E, Schuebel K, Gearhart S, Ahuja N. 557 Epigenetic Regulation of WNT Signaling Pathway Genes in Inflammatory Bowel Disease (IBD) Neoplasia. Gastroenterology 2008, 134: a-848-a-849. DOI: 10.1016/s0016-5085(08)63975-x.
42. Utilization of Genomic Approaches to Identify the Hypermethylome of Colorectal Cancer - A Strategy for Biomarker DiscoveryAhuja N, Schuebel K, Glockner S, Dhir M, Van Neste L, Yi J, Herman J, Baylin S. 42. Utilization of Genomic Approaches to Identify the Hypermethylome of Colorectal Cancer - A Strategy for Biomarker Discovery. Journal Of Surgical Research 2008, 144: 194. DOI: 10.1016/j.jss.2007.12.049.
What Constitutes a “High-Volume” Hospital for Pancreatic Resection?Meguid RA, Ahuja N, Chang DC. What Constitutes a “High-Volume” Hospital for Pancreatic Resection? Journal Of The American College Of Surgeons 2008, 206: 622.e1-622.e9. PMID: 18387466, DOI: 10.1016/j.jamcollsurg.2007.11.011.
The Role of Ultrasound-Guided Fine-Needle Aspiration of Axillary Nodes in the Staging of Breast CancerJain A, Haisfield-Wolfe ME, Lange J, Ahuja N, Khouri N, Tsangaris T, Zhang Z, Balch C, Jacobs LK. The Role of Ultrasound-Guided Fine-Needle Aspiration of Axillary Nodes in the Staging of Breast Cancer. Annals Of Surgical Oncology 2007, 15: 462-471. PMID: 17985188, DOI: 10.1245/s10434-007-9623-1.
Methylation-induced silencing of ASC/TMS1, a pro-apoptotic gene, is a late-stage event in colorectal cancerRiojas MA, Guo M, Glöckner SC, Machida EO, Baylin SB, Ahuja N. Methylation-induced silencing of ASC/TMS1, a pro-apoptotic gene, is a late-stage event in colorectal cancer. Cancer Biology & Therapy 2007, 6: 1710-1716. PMID: 17986858, DOI: 10.4161/cbt.6.11.4829.
Subclassification of microsatellite-unstable tumors in colorectal cancerAhuja N, Baylin S. Subclassification of microsatellite-unstable tumors in colorectal cancer. Current Colorectal Cancer Reports 2007, 3: 212-219. DOI: 10.1007/s11888-007-0033-3.
Comparing the DNA Hypermethylome with Gene Mutations in Human Colorectal CancerSchuebel KE, Chen W, Cope L, Glöckner SC, Suzuki H, Yi JM, Chan TA, Van Neste L, Van Criekinge W, van den Bosch S, van Engeland M, Ting AH, Jair K, Yu W, Toyota M, Imai K, Ahuja N, Herman JG, Baylin SB. Comparing the DNA Hypermethylome with Gene Mutations in Human Colorectal Cancer. PLOS Genetics 2007, 3: e157. PMID: 17892325, PMCID: PMC1988850, DOI: 10.1371/journal.pgen.0030157.
Potential pitfalls associated with using a cut-point of 12 lymph nodes as a quality of care measure for patients with NO adenocarcinoma of the colonSlidell M, Ahuja N, Evangelista R, White J, Evans S, Kreishman P, Chang D. Potential pitfalls associated with using a cut-point of 12 lymph nodes as a quality of care measure for patients with NO adenocarcinoma of the colon. Journal Of The American College Of Surgeons 2007, 205: s72. DOI: 10.1016/j.jamcollsurg.2007.06.179.
The role of radiation in retroperitoneal sarcomas: a surgical perspectivePawlik TM, Ahuja N, Herman JM. The role of radiation in retroperitoneal sarcomas: a surgical perspective. Current Opinion In Oncology 2007, 19: 359-366. PMID: 17545800, DOI: 10.1097/cco.0b013e328122d757.
80 What constitutes a “high volume” hospital for pancreatic resection?Meguid R, Ahuja N, Chang D. 80 What constitutes a “high volume” hospital for pancreatic resection? Journal Of Surgical Research 2007, 137: 184-185. DOI: 10.1016/j.jss.2006.12.091.
Image of the Month—Quiz CaseSicklick JK, Weiss CR, Ahuja N. Image of the Month—Quiz Case. JAMA Surgery 2007, 142: 199-199. PMID: 17309972, DOI: 10.1001/archsurg.142.2.199.
Disparities in Colon Cancer Presentation and In-Hospital Mortality in Maryland: A Ten-Year ReviewAhuja N, Chang D, Gearhart SL. Disparities in Colon Cancer Presentation and In-Hospital Mortality in Maryland: A Ten-Year Review. Annals Of Surgical Oncology 2006, 14: 411-416. PMID: 17080235, DOI: 10.1245/s10434-006-9130-9.
Long‐Term Function After Restorative ProctocolectomyWheeler JM, Banerjee A, Ahuja N, Jewell DP, Mortensen NJ. Long‐Term Function After Restorative Proctocolectomy. Diseases Of The Colon & Rectum 2005, 48: 946-951. PMID: 15868242, DOI: 10.1007/s10350-004-0885-4.
Comparing the DNA Hypermethylome with Gene Mutations in Human Colorectal CancerSchuebel K, Chen W, Cope L, Glockner S, Suzuki H, Yi J, Chan T, Van Neste L, Van Criekinge W, van den Bosch S, van Engeland M, Ting A, Jair K, Yu W, Toyota M, Imai K, Ahuja N, Herman J, Baylin S. Comparing the DNA Hypermethylome with Gene Mutations in Human Colorectal Cancer. PLOS Genetics 2005, preprint: e157. DOI: 10.1371/journal.pgen.0030157.eor.
DNA Methylation and Environmental Exposures in Human Hepatocellular CarcinomaShen L, Ahuja N, Shen Y, Habib NA, Toyota M, Rashid A, Issa JP. DNA Methylation and Environmental Exposures in Human Hepatocellular Carcinoma. Journal Of The National Cancer Institute 2002, 94: 755-761. PMID: 12011226, DOI: 10.1093/jnci/94.10.755.
Accelerated age-related CpG island methylation in ulcerative colitis.Issa JP, Ahuja N, Toyota M, Bronner MP, Brentnall TA. Accelerated age-related CpG island methylation in ulcerative colitis. Cancer Research 2001, 61: 3573-7. PMID: 11325821.
Aging, methylation and cancer.Ahuja N, Issa JP. Aging, methylation and cancer. Cellular And Molecular Biology 2000, 15: 835-42. PMID: 10963127, DOI: 10.14670/hh-15.835.
Distinct genetic profiles in colorectal tumors with or without the CpG island methylator phenotypeToyota M, Ohe-Toyota M, Ahuja N, Issa J. Distinct genetic profiles in colorectal tumors with or without the CpG island methylator phenotype. Proceedings Of The National Academy Of Sciences Of The United States Of America 2000, 97: 710-715. PMID: 10639144, PMCID: PMC15395, DOI: 10.1073/pnas.97.2.710.
Aberrant methylation in gastric cancer associated with the CpG island methylator phenotype.Toyota M, Ahuja N, Suzuki H, Itoh F, Ohe-Toyota M, Imai K, Baylin SB, Issa JP. Aberrant methylation in gastric cancer associated with the CpG island methylator phenotype. Cancer Research 1999, 59: 5438-42. PMID: 10554013.
CpG island methylator phenotype in colorectal cancerToyota M, Ahuja N, Ohe-Toyota M, Herman J, Baylin S, Issa J. CpG island methylator phenotype in colorectal cancer. Proceedings Of The National Academy Of Sciences Of The United States Of America 1999, 96: 8681-8686. PMID: 10411935, PMCID: PMC17576, DOI: 10.1073/pnas.96.15.8681.
Methylation and silencing of the Thrombospondin-1 promoter in human cancerLi Q, Ahuja N, Burger P, Issa J. Methylation and silencing of the Thrombospondin-1 promoter in human cancer. Oncogene 1999, 18: 3284-3289. PMID: 10359534, DOI: 10.1038/sj.onc.1202663.
Identification of differentially methylated sequences in colorectal cancer by methylated CpG island amplification.Toyota M, Ho C, Ahuja N, Jair KW, Li Q, Ohe-Toyota M, Baylin SB, Issa JP. Identification of differentially methylated sequences in colorectal cancer by methylated CpG island amplification. Cancer Research 1999, 59: 2307-12. PMID: 10344734.
Aging and DNA methylation in colorectal mucosa and cancer.Ahuja N, Li Q, Mohan AL, Baylin SB, Issa JP. Aging and DNA methylation in colorectal mucosa and cancer. Cancer Research 1998, 58: 5489-94. PMID: 9850084.
Concordant methylation of the ER and N33 genes in glioblastoma multiformeLi Q, Jedlicka A, Ahuja N, Gibbons M, Baylin S, Burger P, Issa J. Concordant methylation of the ER and N33 genes in glioblastoma multiforme. Oncogene 1998, 16: 3197-3202. PMID: 9671399, DOI: 10.1038/sj.onc.1201831.
Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinomaHerman J, Umar A, Polyak K, Graff J, Ahuja N, Issa J, Markowitz S, Willson J, Hamilton S, Kinzler K, Kane M, Kolodner R, Vogelstein B, Kunkel T, Baylin S. Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma. Proceedings Of The National Academy Of Sciences Of The United States Of America 1998, 95: 6870-6875. PMID: 9618505, PMCID: PMC22665, DOI: 10.1073/pnas.95.12.6870.
Association between CpG island methylation and microsatellite instability in colorectal cancer.Ahuja N, Mohan AL, Li Q, Stolker JM, Herman JG, Hamilton SR, Baylin SB, Issa JP. Association between CpG island methylation and microsatellite instability in colorectal cancer. Cancer Research 1997, 57: 3370-4. PMID: 9269998.

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