Nikolay Peter Gresko, MD, PhD
Associate Research Scientist of Cellular and Molecular Physiology
Research & Publications
Biography
Locations
Coauthors
Selected Publications
- Metabolic effects of polycystin-1 C-terminal tail (CTT) expression in Pkd1-KO miceOnuchic L, Padovano V, Schena G, Shi X, Dong K, Rajendran V, Rai V, Pandya R, Gresko N, Shen H, Somlo S, Caplan M. Metabolic effects of polycystin-1 C-terminal tail (CTT) expression in Pkd1-KO mice. Physiology 2023, 38: 5731616. DOI: 10.1152/physiol.2023.38.s1.5731616.
- Polycystin 1 ciliary localization is controlled by mechanosensitive signaling that involves secretion of ATPGresko N, Caplan M. Polycystin 1 ciliary localization is controlled by mechanosensitive signaling that involves secretion of ATP. Physiology 2023, 38: 5731529. DOI: 10.1152/physiol.2023.38.s1.5731529.
- The C-terminal tail of polycystin-1 suppresses cystic disease in a mitochondrial enzyme-dependent fashionOnuchic L, Padovano V, Schena G, Rajendran V, Dong K, Shi X, Pandya R, Rai V, Gresko N, Ahmed O, Lam T, Wang W, Shen H, Somlo S, Caplan M. The C-terminal tail of polycystin-1 suppresses cystic disease in a mitochondrial enzyme-dependent fashion. Nature Communications 2023, 14: 1790. PMID: 36997516, PMCID: PMC10063565, DOI: 10.1038/s41467-023-37449-1.
- Polycystin 1 Ciliary Localization Is Controlled by Chemo- and Mechanosensitive Signaling Processes That Involve the Machinery of GPCR DesensitizationGresko N, Caplan M. Polycystin 1 Ciliary Localization Is Controlled by Chemo- and Mechanosensitive Signaling Processes That Involve the Machinery of GPCR Desensitization. Journal Of The American Society Of Nephrology 2022, 33: 407-407. DOI: 10.1681/asn.20223311s1407a.
- The Polycystin-1 C-Terminal Tail (CTT) Suppresses Cystic Disease: Elucidating the Underlying MechanismsOnuchic L, Padovano V, Schena G, Rajendran V, Shi X, Dong K, Gresko N, Shen H, Somlo S, Caplan M. The Polycystin-1 C-Terminal Tail (CTT) Suppresses Cystic Disease: Elucidating the Underlying Mechanisms. Journal Of The American Society Of Nephrology 2022, 33: 398-399. DOI: 10.1681/asn.20223311s1398d.
- Polycystin 1 ciliary localization is regulated by its aGPCR activityGresko N, Caplan M. Polycystin 1 ciliary localization is regulated by its aGPCR activity. The FASEB Journal 2022, 36 DOI: 10.1096/fasebj.2022.36.s1.r4689.
- The C-Terminal Tail of Polycystin 1 Rescues Cystic Phenotype in a Mitochondrial Enzyme-Dependent FashionOnuchic L, Padovano V, Schena G, Rajendran V, Gresko N, Dong K, Shi X, Shen H, Somlo S, Caplan M. The C-Terminal Tail of Polycystin 1 Rescues Cystic Phenotype in a Mitochondrial Enzyme-Dependent Fashion. Journal Of The American Society Of Nephrology 2021, 32: 11-11. DOI: 10.1681/asn.20213210s111b.
- Polycystin 1 Ciliary Localization Is Regulated by Its aGPCR ActivityGresko N, Caplan M. Polycystin 1 Ciliary Localization Is Regulated by Its aGPCR Activity. Journal Of The American Society Of Nephrology 2021, 32: 397-397. DOI: 10.1681/asn.20213210s1397b.
- Defective NAD+ Homeostasis in ADPKD and the Effects of PC1CTT on Redox Modulation and Disease ProgressionOnuchic L, Padovano V, Gresko N, Schena G, Rajendran V, Caplan M. Defective NAD+ Homeostasis in ADPKD and the Effects of PC1CTT on Redox Modulation and Disease Progression. Journal Of The American Society Of Nephrology 2020, 31: 483-483. DOI: 10.1681/asn.20203110s1483b.
- Novel protein trafficking and signaling pathways in kidney physiology and pathophysiologyCaplan M, Padovano V, Gresko N, Olesen C, Schena G, Mistry K, Bateson R. Novel protein trafficking and signaling pathways in kidney physiology and pathophysiology. The FASEB Journal 2019, 33: 20.2-20.2. DOI: 10.1096/fasebj.2019.33.1_supplement.20.2.
- Polycystin 1 is an atypical adhesion GPCR that responds to non‐canonical WNT signals and inhibits GSK3βGresko N, Merrick D, Mistry K, Caplan M. Polycystin 1 is an atypical adhesion GPCR that responds to non‐canonical WNT signals and inhibits GSK3β. The FASEB Journal 2019, 33: 863.10-863.10. DOI: 10.1096/fasebj.2019.33.1_supplement.863.10.
- Rapid dephosphorylation of the renal sodium chloride cotransporter in response to oral potassium intake in miceSorensen M, Grossmann S, Roesinger M, Gresko N, Todkar A, Barmettler G, Ziegler U, Odermatt A, Loffing-Cueni D, Loffing J. Rapid dephosphorylation of the renal sodium chloride cotransporter in response to oral potassium intake in mice. Kidney International 2013, 83: 811-824. PMID: 23447069, DOI: 10.1038/ki.2013.14.
- Immunofluorescent localization of the Rab-GAP protein TBC1D4 (AS160) in mouse kidneyLier N, Gresko N, Di Chiara M, Loffing-Cueni D, Loffing J. Immunofluorescent localization of the Rab-GAP protein TBC1D4 (AS160) in mouse kidney. Histochemistry And Cell Biology 2012, 138: 101-112. PMID: 22466139, DOI: 10.1007/s00418-012-0944-1.
- In vivo nuclear translocation of mineralocorticoid and glucocorticoid receptors in rat kidney: differential effect of corticosteroids along the distal tubuleAckermann D, Gresko N, Carrel M, Loffing-Cueni D, Habermehl D, Gomez-Sanchez C, Rossier B, Loffing J. In vivo nuclear translocation of mineralocorticoid and glucocorticoid receptors in rat kidney: differential effect of corticosteroids along the distal tubule. American Journal Of Physiology. Renal Physiology 2010, 299: f1473-f1485. PMID: 20861076, DOI: 10.1152/ajprenal.00437.2010.
- Role of Golgi apparatus and microtubules for aldosterone and vasopressin–dependent regulation of ENaC activityGresko N, Rossier B, Loffing J. Role of Golgi apparatus and microtubules for aldosterone and vasopressin–dependent regulation of ENaC activity. The FASEB Journal 2008, 22: 1201.22-1201.22. DOI: 10.1096/fasebj.22.1_supplement.1201.22.