Nadya Dimitrova, PhD
Associate Professor on Term of Molecular, Cellular and Developmental Biology
Research & Publications
Biography
News
Research Summary
The Dimitrova lab focuses on long non-coding RNAs (lncRNAs) and their roles in the regulation of critical cellular pathways during tumor development. Using advanced genomic, genetic and molecular biology tools, we study the contribution of lncRNAs to cancer-relevant processes at the cellular and organismal level. Our aim is to dissect the complex biology of this novel class of RNAs and to gain a deeper understanding of the contribution of lncRNAs in health and disease.
Research Interests
Genetics; Molecular Biology; RNA, Untranslated; Genomics
Selected Publications
- The p53 transcriptional response across tumor types reveals core and senescence-specific signatures modulated by long noncoding RNAsTesfaye E, Martinez-Terroba E, Bendor J, Winkler L, Olivero C, Chen K, Feldser DM, Zamudio JR, Dimitrova N. The p53 transcriptional response across tumor types reveals core and senescence-specific signatures modulated by long noncoding RNAs. Proceedings Of The National Academy Of Sciences Of The United States Of America 2021, 118: e2025539118. PMID: 34326251, PMCID: PMC8346867, DOI: 10.1073/pnas.2025539118.
- Identification and characterization of functional long noncoding RNAs in cancerOlivero CE, Dimitrova N. Identification and characterization of functional long noncoding RNAs in cancer. The FASEB Journal 2020, 34: 15630-15646. PMID: 33058262, PMCID: PMC7756267, DOI: 10.1096/fj.202001951r.
- p53 Activates the Long Noncoding RNA Pvt1b to Inhibit Myc and Suppress TumorigenesisOlivero CE, MartÃnez-Terroba E, Zimmer J, Liao C, Tesfaye E, Hooshdaran N, Schofield JA, Bendor J, Fang D, Simon MD, Zamudio JR, Dimitrova N. p53 Activates the Long Noncoding RNA Pvt1b to Inhibit Myc and Suppress Tumorigenesis. Molecular Cell 2020, 77: 761-774.e8. PMID: 31973890, PMCID: PMC7184554, DOI: 10.1016/j.molcel.2019.12.014.
- Chapter 16 Genetic Variations of Long Noncoding RNAs in CancerDimitrova N. Chapter 16 Genetic Variations of Long Noncoding RNAs in Cancer. 2018, 289-308. DOI: 10.1016/b978-0-12-811022-5.00016-4.
- Stromal Expression of miR-143/145 Promotes Neoangiogenesis in Lung Cancer DevelopmentDimitrova N, Gocheva V, Bhutkar A, Resnick R, Jong RM, Miller KM, Bendor J, Jacks T. Stromal Expression of miR-143/145 Promotes Neoangiogenesis in Lung Cancer Development. Cancer Discovery 2016, 6: 188-201. PMID: 26586766, PMCID: PMC4744583, DOI: 10.1158/2159-8290.cd-15-0854.
- LincRNA-p21 Activates p21 In cis to Promote Polycomb Target Gene Expression and to Enforce the G1/S CheckpointDimitrova N, Zamudio JR, Jong RM, Soukup D, Resnick R, Sarma K, Ward AJ, Raj A, Lee JT, Sharp PA, Jacks T. LincRNA-p21 Activates p21 In cis to Promote Polycomb Target Gene Expression and to Enforce the G1/S Checkpoint. Molecular Cell 2014, 54: 777-790. PMID: 24857549, PMCID: PMC4103188, DOI: 10.1016/j.molcel.2014.04.025.