Mario Skarica, MD
Associate Research Scientist
Research & Publications
Biography
News
Coauthors
Selected Publications
- Single Cell Genomic Analysis Reveals Cell Type-Specific Molecular Signatures in the Human PTSD Prefrontal CortexGirgenti M, Zhang J, Skarica M, Hwang A, Xu K, Young K, Zhao H, Sestan N, Krystal J. Single Cell Genomic Analysis Reveals Cell Type-Specific Molecular Signatures in the Human PTSD Prefrontal Cortex. Biological Psychiatry 2023, 93: s11-s12. DOI: 10.1016/j.biopsych.2023.02.049.
- AgRP neurons control structure and function of the medial prefrontal cortexStutz B, Waterson MJ, Šestan-Peša M, Dietrich MO, Škarica M, Sestan N, Racz B, Magyar A, Sotonyi P, Liu ZW, Gao XB, Matyas F, Stoiljkovic M, Horvath TL. AgRP neurons control structure and function of the medial prefrontal cortex. Molecular Psychiatry 2022, 27: 3951-3960. PMID: 35906488, PMCID: PMC9891653, DOI: 10.1038/s41380-022-01691-8.
- Integrative Functional Genomic Analysis of Human PTSD Molecular Pathology and RiskGirgenti M, Skarica M, Zhang J, Wang J, Friedman M, Zhao H, Krystal J. Integrative Functional Genomic Analysis of Human PTSD Molecular Pathology and Risk. Biological Psychiatry 2021, 89: s12. DOI: 10.1016/j.biopsych.2021.02.050.
- Revealing the brain's molecular architectureAshley-Koch A, Crawford G, Garrett M, Song L, Safi A, Johnson G, Wray G, Reddy T, Goes F, Zandi P, Bryois J, Jaffe A, Price A, Ivanov N, Collado-Torres L, Hyde T, Burke E, Kleiman J, Tao R, Shin J, Akbarian S, Girdhar K, Jiang Y, Kundakovic M, Brown L, Kassim B, Park R, Wiseman J, Zharovsky E, Jacobov R, Devillers O, Flatow E, Hoffman G, Lipska B, Lewis D, Haroutunian V, Hahn C, Charney A, Dracheva S, Kozlenkov A, Belmont J, DelValle D, Francoeur N, Hadjimichael E, Pinto D, van Bakel H, Roussos P, Fullard J, Bendl J, Hauberg M, Mangravite L, Peters M, Chae Y, Peng J, Niu M, Wang X, Webster M, Beach T, Chen C, Jiang Y, Dai R, Shieh A, Liu C, Grennan K, Xia Y, Vadukapuram R, Wang Y, Fitzgerald D, Cheng L, Brown M, Brown M, Brunetti T, Goodman T, Alsayed M, Gandal M, Geschwind D, Won H, Polioudakis D, Wamsley B, Yin J, Hadzic T, De La Torre Ubieta L, Swarup V, Sanders S, State M, Werling D, An J, Sheppard B, Willsey A, White K, Ray M, Giase G, Kefi A, Mattei E, Purcaro M, Weng Z, Moore J, Pratt H, Huey J, Borrman T, Sullivan P, Giusti-Rodriguez P, Kim Y, Sullivan P, Szatkiewicz J, Rhie S, Armoskus C, Camarena A, Farnham P, Spitsyna V, Witt H, Schreiner S, Evgrafov O, Knowles J, Gerstein M, Liu S, Wang D, Navarro F, Warrell J, Clarke D, Emani P, Gu M, Shi X, Xu M, Yang Y, Kitchen R, Gürsoy G, Zhang J, Carlyle B, Nairn A, Li M, Pochareddy S, Sestan N, Skarica M, Li Z, Sousa A, Santpere G, Choi J, Zhu Y, Gao T, Miller D, Cherskov A, Yang M, Amiri A, Coppola G, Mariani J, Scuderi S, Szekely A, Vaccarino F, Wu F, Weissman S, Roychowdhury T, Abyzov A. Revealing the brain's molecular architecture. Science 2018, 362: 1262-1263. PMID: 30545881, DOI: 10.1126/science.362.6420.1262.
- Expression and immunolocalization of metallothioneins MT1, MT2 and MT3 in rat nephronSabolić I, Škarica M, Ljubojević M, Breljak D, Herak-Kramberger C, Crljen V, Ljubešić N. Expression and immunolocalization of metallothioneins MT1, MT2 and MT3 in rat nephron. Journal Of Trace Elements In Medicine And Biology 2017, 46: 62-75. PMID: 29413112, DOI: 10.1016/j.jtemb.2017.11.011.
- Intersection of diverse neuronal genomes and neuropsychiatric disease: The Brain Somatic Mosaicism NetworkMcConnell MJ, Moran JV, Abyzov A, Akbarian S, Bae T, Cortes-Ciriano I, Erwin JA, Fasching L, Flasch DA, Freed D, Ganz J, Jaffe AE, Kwan KY, Kwon M, Lodato MA, Mills RE, Paquola ACM, Rodin RE, Rosenbluh C, Sestan N, Sherman MA, Shin JH, Song S, Straub RE, Thorpe J, Weinberger DR, Urban AE, Zhou B, Gage FH, Lehner T, Senthil G, Walsh CA, Chess A, Courchesne E, Gleeson JG, Kidd JM, Park PJ, Pevsner J, Vaccarino FM, Barton A, Bekiranov S, Bohrson C, Burbulis I, Chronister W, Coppola G, Daily K, D’Gama A, Emery S, Frisbie T, Gao T, Gulyás-Kovács A, Haakenson M, Keil J, Kopera H, Lam M, Lee E, Marques-Bonet T, Mathern G, Moldovan J, Oetjens M, Omberg L, Peters M, Pochareddy S, Pramparo T, Ratan A, Sanavia T, Shi L, Skarica M, Wang J, Wang M, Wang Y, Wierman M, Wolpert M, Woodworth M, Zhao X, Zhou W. Intersection of diverse neuronal genomes and neuropsychiatric disease: The Brain Somatic Mosaicism Network. Science 2017, 356 PMID: 28450582, PMCID: PMC5558435, DOI: 10.1126/science.aal1641.
- Immunoregulatory NeuropeptidesGanea D, Skarica M. Immunoregulatory Neuropeptides. 2013, 144-160. DOI: 10.1002/9781118314814.ch7.
- Modulation of Inflammatory Responses by a Cannabinoid-2–Selective Agonist after Spinal Cord InjuryAdhikary S, Li H, Heller J, Skarica M, Zhang M, Ganea D, Tuma R. Modulation of Inflammatory Responses by a Cannabinoid-2–Selective Agonist after Spinal Cord Injury. Journal Of Neurotrauma 2011, 28: 2417-2427. PMID: 21970496, PMCID: PMC3235339, DOI: 10.1089/neu.2011.1853.
- Novel mechanisms of immune modulation of natalizumab in multiple sclerosis patientsSkarica M, Eckstein C, Whartenby K, Calabresi P. Novel mechanisms of immune modulation of natalizumab in multiple sclerosis patients. Journal Of Neuroimmunology 2011, 235: 70-76. PMID: 21550672, DOI: 10.1016/j.jneuroim.2011.02.010.
- Role of metallothionein in cadmium traffic and toxicity in kidneys and other mammalian organsSabolić I, Breljak D, Škarica M, Herak-Kramberger C. Role of metallothionein in cadmium traffic and toxicity in kidneys and other mammalian organs. BioMetals 2010, 23: 897-926. PMID: 20549307, DOI: 10.1007/s10534-010-9351-z.
- Dendritic Cells Transduced With Lentiviral Vectors Expressing VIP Differentiate Into VIP-secreting Tolerogenic-like DCsToscano M, Delgado M, Kong W, Martin F, Skarica M, Ganea D. Dendritic Cells Transduced With Lentiviral Vectors Expressing VIP Differentiate Into VIP-secreting Tolerogenic-like DCs. Molecular Therapy 2010, 18: 1035-1045. PMID: 20068554, PMCID: PMC2890107, DOI: 10.1038/mt.2009.293.
- Cyclophosphamide resets dendritic cell homeostasis and enhances antitumor immunity through effects that extend beyond regulatory T cell eliminationRadojcic V, Bezak K, Skarica M, Pletneva M, Yoshimura K, Schulick R, Luznik L. Cyclophosphamide resets dendritic cell homeostasis and enhances antitumor immunity through effects that extend beyond regulatory T cell elimination. Cancer Immunology, Immunotherapy 2009, 59: 137-148. PMID: 19590872, PMCID: PMC3103867, DOI: 10.1007/s00262-009-0734-3.
- Signal Transduction Inhibition of APCs Diminishes Th17 and Th1 Responses in Experimental Autoimmune EncephalomyelitisSkarica M, Wang T, McCadden E, Kardian D, Calabresi P, Small D, Whartenby K. Signal Transduction Inhibition of APCs Diminishes Th17 and Th1 Responses in Experimental Autoimmune Encephalomyelitis. The Journal Of Immunology 2009, 182: 4192-4199. PMID: 19299717, PMCID: PMC3727416, DOI: 10.4049/jimmunol.0803631.
- 320: In vivo activation of APCs with TLR ligands and tissue damage rather than amount of host APCs are critical factors that determine DLI-mediated GVL reactivity and GVHD in MHC-matched minor histocompatibility antigen (mHAg)-mismatched chimerasRadojcic V, Skarica M, Murphy G, Luznik L. 320: In vivo activation of APCs with TLR ligands and tissue damage rather than amount of host APCs are critical factors that determine DLI-mediated GVL reactivity and GVHD in MHC-matched minor histocompatibility antigen (mHAg)-mismatched chimeras. Transplantation And Cellular Therapy 2007, 13: 116-117. DOI: 10.1016/j.bbmt.2006.12.325.
- Factors governing the activation of adoptively transferred donor T cells infused after allogeneic bone marrow transplantation in the mouseDurakovic N, Radojcic V, Skarica M, Bezak K, Powell J, Fuchs E, Luznik L. Factors governing the activation of adoptively transferred donor T cells infused after allogeneic bone marrow transplantation in the mouse. Blood 2007, 109: 4564-4574. PMID: 17227829, PMCID: PMC1885486, DOI: 10.1182/blood-2006-09-048124.
- Host-Derived Langerhans Cells Persist after MHC-Matched Allografting Independent of Donor T Cells and Critically Influence the Alloresponses Mediated by Donor Lymphocyte InfusionsDurakovic N, Bezak K, Skarica M, Radojcic V, Fuchs E, Murphy G, Luznik L. Host-Derived Langerhans Cells Persist after MHC-Matched Allografting Independent of Donor T Cells and Critically Influence the Alloresponses Mediated by Donor Lymphocyte Infusions. The Journal Of Immunology 2006, 177: 4414-4425. PMID: 16982876, DOI: 10.4049/jimmunol.177.7.4414.
- Host Langerhans cells (LCs) can be therapeutically manipulated In vivo with imiquimod (TLR7 agonist) to augment DLI-mediated GVH and GVL reactivitySkarica M, Radojcic V, Luznik L. Host Langerhans cells (LCs) can be therapeutically manipulated In vivo with imiquimod (TLR7 agonist) to augment DLI-mediated GVH and GVL reactivity. Transplantation And Cellular Therapy 2006, 12: 52. DOI: 10.1016/j.bbmt.2005.11.164.
- Interferon-producing killer dendritic cells provide a link between innate and adaptive immunityChan C, Crafton E, Fan H, Flook J, Yoshimura K, Skarica M, Brockstedt D, Dubensky T, Stins M, Lanier L, Pardoll D, Housseau F. Interferon-producing killer dendritic cells provide a link between innate and adaptive immunity. Nature Medicine 2006, 12: 207-213. PMID: 16444266, DOI: 10.1038/nm1352.
- Rat renal glucose transporter SGLT1 exhibits zonal distribution and androgen-dependent gender differencesSabolić I, Škarica M, Gorboulev V, Ljubojević M, Balen D, Herak-Kramberger C, Koepsell H. Rat renal glucose transporter SGLT1 exhibits zonal distribution and androgen-dependent gender differences. American Journal Of Physiology. Renal Physiology 2005, 290: f913-f926. PMID: 16204409, DOI: 10.1152/ajprenal.00270.2005.
- After MHC-matched allografting, host-derived langerhans cells (LCs) persist in skin and cutaneous lymph nodes in the steady-state and are the targets of DLI-mediated alloresponseDurakovic N, Bezak K, Skarica M, Fuchs E, Luznik L. After MHC-matched allografting, host-derived langerhans cells (LCs) persist in skin and cutaneous lymph nodes in the steady-state and are the targets of DLI-mediated alloresponse. Transplantation And Cellular Therapy 2005, 11: 12. DOI: 10.1016/j.bbmt.2004.12.033.