Marcelo Rigon Zimmer, PhD, BS
Research & Publications
Biography
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Research Summary
I am interested in understanding the neurobiological underpinning of infant-to-mother attachment using animal models.
Extensive Research Description
In my Ph.D. studies, I questioned the role of hypothalamic hunger-promoting Agrp neurons beyond its canonic role. In these studies, we found that Agrp neurons play a role in stereotypical behavior using transgenic mouse models. These findings provide new insights into metabolic disorders and psychiatric diseases that exhibit dysregulation of energy balance and stereotypical behaviors. We also identified a new role of Agrp neurons in contributing to the infant's bonding to the mother in neonatal mice. These findings revealed a hidden neuronal mechanism of the ontogeny of social relationships in mammals. Currently, I am interested in understanding how the infant develops a unique bond with the mother. I am studying infant behavior in different rodent species (mouse, rat, and guinea pig). I am conducting behavioral studies and using state-of-the-art neuroscience techniques to identify the underlying mechanisms mediating the infant's bonding to the mother.
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Selected Publications
- Functional Ontogeny of Hypothalamic Agrp Neurons in Neonatal Mouse BehaviorsZimmer MR, Fonseca AHO, Iyilikci O, Pra RD, Dietrich MO. Functional Ontogeny of Hypothalamic Agrp Neurons in Neonatal Mouse Behaviors. Cell 2019, 178: 44-59.e7. PMID: 31104844, PMCID: PMC6688755, DOI: 10.1016/j.cell.2019.04.026.
- Regulation of substrate utilization and adiposity by Agrp neuronsCavalcanti-de-Albuquerque JP, Bober J, Zimmer MR, Dietrich MO. Regulation of substrate utilization and adiposity by Agrp neurons. Nature Communications 2019, 10: 311. PMID: 30659173, PMCID: PMC6338802, DOI: 10.1038/s41467-018-08239-x.
- Activation of Agrp neurons modulates memory-related cognitive processes in miceZimmer MR, Schmitz AE, Dietrich MO. Activation of Agrp neurons modulates memory-related cognitive processes in mice. Pharmacological Research 2019, 141: 303-309. PMID: 30610962, PMCID: PMC6400640, DOI: 10.1016/j.phrs.2018.12.024.
- Hypothalamic Agrp Neurons Drive Stereotypic Behaviors beyond FeedingDietrich MO, Zimmer MR, Bober J, Horvath TL. Hypothalamic Agrp Neurons Drive Stereotypic Behaviors beyond Feeding. Cell 2015, 160: 1222-1232. PMID: 25748653, PMCID: PMC4484787, DOI: 10.1016/j.cell.2015.02.024.
- O-GlcNAc Transferase Enables AgRP Neurons to Suppress Browning of White FatRuan HB, Dietrich MO, Liu ZW, Zimmer MR, Li MD, Singh JP, Zhang K, Yin R, Wu J, Horvath TL, Yang X. O-GlcNAc Transferase Enables AgRP Neurons to Suppress Browning of White Fat. Cell 2014, 159: 306-317. PMID: 25303527, PMCID: PMC4509746, DOI: 10.1016/j.cell.2014.09.010.
- Leptin signaling in astrocytes regulates hypothalamic neuronal circuits and feedingKim JG, Suyama S, Koch M, Jin S, Argente-Arizon P, Argente J, Liu ZW, Zimmer MR, Jeong JK, Szigeti-Buck K, Gao Y, Garcia-Caceres C, Yi CX, Salmaso N, Vaccarino FM, Chowen J, Diano S, Dietrich MO, Tschöp MH, Horvath TL. Leptin signaling in astrocytes regulates hypothalamic neuronal circuits and feeding. Nature Neuroscience 2014, 17: 908-910. PMID: 24880214, PMCID: PMC4113214, DOI: 10.1038/nn.3725.