Ke Xu, MD
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Psychiatry
Primary
Titles
Director of Stress Epigenetics, Yale Stress Center
Contact Info
Appointments
Psychiatry
Primary
Titles
Director of Stress Epigenetics, Yale Stress Center
Contact Info
Appointments
Psychiatry
Primary
Titles
Director of Stress Epigenetics, Yale Stress Center
Contact Info
About
Titles
Professor of Psychiatry
Director of Stress Epigenetics, Yale Stress CenterBiography
Dr. Xu is a Professor of Psychiatry at Yale School of Medicine and holds a position as Staff Psychiatrist at the VA Connecticut Healthcare System. Her research is dedicated to exploring the complex interactions between stress and the epigenome, aiming to uncover how these interactions contribute to the development of stress-related symptoms and disorders such as substance use. This important work has led Dr. Xu to investigate a broad spectrum of behavioral and medical conditions in diverse populations. Dr. Xu is engaged in the field of social epigenomics that helps us understanding the biological underpinnings of the effects of social environments on health.
Appointments
Psychiatry
ProfessorPrimaryBiomedical Informatics & Data Science
ProfessorSecondary
Other Departments & Organizations
- Biomedical Informatics & Data Science
- Division of Addictions
- Division of Mental Health Services
- Neuroscience Research Training Program (NRTP)
- Psychiatry
- Xu Lab
- Yale Center for the Science of Cannabis and Cannabinoids
- Yale Stress Center
- Yale Ventures
- Yale-UPR Integrated HIV Basic and Clinical Sciences Initiative
Education & Training
- Resident
- Yale School of Medicine (2011)
- MD
- West China College of Medicine, Sichuan University (2007)
Research
Overview
Medical Subject Headings (MeSH)
Genetics, Behavioral; Mental Disorders
ORCID
0000-0003-2628-2061
Research at a Glance
Yale Co-Authors
Frequent collaborators of Ke Xu's published research.
Publications Timeline
A big-picture view of Ke Xu's research output by year.
Rajita Sinha, PhD
Amy Justice, MD, PhD
Zachary Harvanek, MD/PhD
Christopher T Rentsch, PhD, FISPE
Hang Zhou, PhD
Joel Gelernter, MD
25Publications
8Citations
Publications
Frequent Cocaine Use is Associated with Larger HIV Latent Reservoir Size
Aouizerat B, Garcia J, Domingues C, Xu K, Quach B, Page G, Konkle-Parker D, Bolivar H, Lahiri C, Golub E, Cohen M, Kassaye S, DeHovitz J, Kuniholm M, Archin N, Tien P, Hancock D, Johnson E. Frequent Cocaine Use is Associated with Larger HIV Latent Reservoir Size. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2024 DOI: 10.1097/qai.0000000000003472.Peer-Reviewed Original ResearchConceptsHIV latent reservoirImpact of cocaine useCocaine useT cellsAssociated with higher HIV viral loadHigher HIV viral loadSelf-reported cocaine useHIV DNA assaysLatent reservoir sizeRapid HIV progressionVirologically suppressed womenHIV viral loadFrequent cocaine useVirally suppressed PLWHHistory of HIVLatent reservoirAntiretroviral therapyHIV progressionLongitudinal cohort studyViral loadCocaine usersNever usersIntact provirusesCohort studyCD4Childhood adversity, accelerated GrimAge, and associated health consequences
Harvanek Z, Kudinova A, Wong S, Xu K, Brick L, Daniels T, Marsit C, Burt A, Sinha R, Tyrka A. Childhood adversity, accelerated GrimAge, and associated health consequences. Journal Of Behavioral Medicine 2024, 1-14. PMID: 38762606, DOI: 10.1007/s10865-024-00496-0.Peer-Reviewed Original ResearchAltmetricConceptsBody mass indexChildhood Trauma QuestionnaireGrimAge accelerationEarly life stressChildhood adversityAssociated with higher body mass indexCross-sectional cohort of adultsMetabolic healthEffect of body mass indexHigher body mass indexPhysical health problemsLife stressCohort of adultsAssociated health consequencesEffects of early life stressMetabolic health effectsModerating effect of body mass indexChildhood Trauma Questionnaire subscalesCross-sectional cohortCardiometabolic healthAccelerated GrimAgeCardiometabolic diseasesMedical illnessHealth consequencesMass indexAuthor Correction: A multi-ancestry genetic study of pain intensity in 598,339 veterans
Toikumo S, Vickers-Smith R, Jinwala Z, Xu H, Saini D, Hartwell E, Pavicic M, Sullivan K, Xu K, Jacobson D, Gelernter J, Rentsch C, Stahl E, Cheatle M, Zhou H, Waxman S, Justice A, Kember R, Kranzler H. Author Correction: A multi-ancestry genetic study of pain intensity in 598,339 veterans. Nature Medicine 2024, 1-1. PMID: 38714900, DOI: 10.1038/s41591-024-03024-4.Peer-Reviewed Original ResearchAltmetricGreater Stress and Trauma Mediate Race-Related Differences in Epigenetic Age Between Black and White Young Adults in a Community Sample
Holloway T, Harvanek Z, Xu K, Gordon D, Sinha R. Greater Stress and Trauma Mediate Race-Related Differences in Epigenetic Age Between Black and White Young Adults in a Community Sample. Biological Psychiatry 2024, 95: s41. DOI: 10.1016/j.biopsych.2024.02.104.Peer-Reviewed Original Research353. Methylation of CRHR1 and CRHR2 is Associated With Lifetime Adversity, HPA-Axis Signaling Changes, and Obesity
Harvanek Z, Zhang X, Xu K, Sinha R. 353. Methylation of CRHR1 and CRHR2 is Associated With Lifetime Adversity, HPA-Axis Signaling Changes, and Obesity. Biological Psychiatry 2024, 95: s244. DOI: 10.1016/j.biopsych.2024.02.852.Peer-Reviewed Original ResearchStudy on Raman scattering spectroscopy of Mn-doped GaN grown by the ammonothermal method
Lu W, Li T, Ren G, Xia Z, Xie K, Li S, Shen L, Xu K. Study on Raman scattering spectroscopy of Mn-doped GaN grown by the ammonothermal method. CrystEngComm 2024, 26: 2166-2171. DOI: 10.1039/d4ce00093e.Peer-Reviewed Original ResearchCitationsConceptsRaman scattering spectroscopyValence stateGlow discharge mass spectrometryValence state of MnAmmonothermal methodX-ray photoelectron spectroscopyStates of MnGaN crystalsDoping of MnInteraction potential energyRaman scattering spectraDoping of MgPhotoelectron spectroscopyMn 2+Mn-doped GaNMass spectrometryMn 3X-rayScattering spectroscopyCrystalUnintentional dopingSpectroscopyPotential energyValenceGaNDNA methylation‐based telomere length is associated with HIV infection, physical frailty, cancer, and all‐cause mortality
Liang X, Aouizerat B, So‐Armah K, Cohen M, Marconi V, Xu K, Justice A. DNA methylation‐based telomere length is associated with HIV infection, physical frailty, cancer, and all‐cause mortality. Aging Cell 2024, e14174. PMID: 38629454, DOI: 10.1111/acel.14174.Peer-Reviewed Original ResearchCitationsAltmetricConceptsCancer prevalenceAll-cause mortalityVeterans Aging Cohort Study Biomarker CohortMortality riskPhysiological frailtyVACS IndexIncreased risk of all-cause mortalityRisk of all-cause mortalityCancer registry dataHigher cancer prevalenceHIV infectionElectronic medical recordsSelf-reported raceCoronary heart diseaseAssociated with HIV infectionIndicator of cellular agingPhysical frailtyRegistry dataSmoking statusWomen's Interagency HIV Study cohortAlcohol consumptionShorter TLTelomere lengthMedical recordsPeripheral blood mononuclear cellsInvestigation and analysis of the current status of transjugular intrahepatic portosystemic shunt treatment for portal hypertension in China
Guo H, Niu M, Shao H, Han X, Zhao J, Sun J, Fang Z, Xiong B, Zhu X, Ren W, Yuan M, Yu S, Lyu W, Zhang X, Zhang C, Li L, Luo X, Song Y, Ma Y, Dang T, Xiang H, Jin Y, Xue H, Jin G, Li X, Li J, Zhou S, Yu C, He S, Yu L, Zu H, Ma J, Lei Y, Xu K, Qi X. Investigation and analysis of the current status of transjugular intrahepatic portosystemic shunt treatment for portal hypertension in China. Chinese Journal Of Radiology 2024, 58: 437-443. DOI: 10.3760/cma.j.cn112149-20231113-00384.Peer-Reviewed Original ResearchConceptsTransjugular intrahepatic portosystemic shuntTransjugular intrahepatic portosystemic shunt treatmentPortal hypertensionPortal pressure gradient measurementCavernous transformationConventional anticoagulationPressure gradient measurementIndications of transjugular intrahepatic portosystemic shuntFollow-upTIPS operationPortal vein cavernous transformationTransjugular intrahepatic portosystemic shunt stentDuration of anticoagulationTreat portal hypertensionPostoperative follow-upIntrahepatic portosystemic shuntPrevention of rebleedingRoutine follow-upEarly-TIPSSurgical indicationsDomestic instrumentsShunt treatmentPortosystemic shuntPortal veinEmbolic materialComputationally inferred cell-type specific epigenome-wide DNA methylation analysis unveils distinct methylation patterns among immune cells for HIV infection in three cohorts
Zhang X, Hu Y, Vandenhoudt R, Yan C, Marconi V, Cohen M, Wang Z, Justice A, Aouizerat B, Xu K. Computationally inferred cell-type specific epigenome-wide DNA methylation analysis unveils distinct methylation patterns among immune cells for HIV infection in three cohorts. PLOS Pathogens 2024, 20: e1012063. PMID: 38466776, PMCID: PMC10957090, DOI: 10.1371/journal.ppat.1012063.Peer-Reviewed Original ResearchAltmetricConceptsCD4+ T cellsEpigenome-wide association studiesPeripheral blood mononuclear cellsHIV infectionHIV pathogenesisT cellsCpG sitesNatural killer (NK) cellsCell typesAssociated with HIV infectionCD8+ T cellsMethylation patternsCpG methylationDNA methylationEpigenome-wide DNA methylation analysisBlood mononuclear cellsImmune cell typesDifferentially methylated CpG sitesUnique CpG sitesDifferential CpG methylationDNA methylation analysisSignificant CpG sitesArray-based methodsGene set enrichment analysisComputational deconvolution methodsNano-indentation study of dislocation evolution in GaN-based laser diodes
Chen J, Su X, Wang G, Niu M, Li X, Xu K. Nano-indentation study of dislocation evolution in GaN-based laser diodes. Discover Nano 2024, 19: 40. PMID: 38453741, PMCID: PMC10920521, DOI: 10.1186/s11671-024-03983-0.Peer-Reviewed Original ResearchConceptsSlip systemsBasal slip systemNano-indentation studiesBehavior of dislocationsNano-indentation techniquePyramidal slip planesDensity of dislocationsP-GaN layerDislocation evolutionGaN-based laser diodesMismatch stressBurgers vectorGaN-based LDSlip planesLaser diodeMulti-LayerMotion behaviorStrained layersDislocationLayer
Clinical Trials
Current Trials
A longitudinal study of the effects of cannabis exposure on neuro-development in adolescents and young adults
HIC ID2000024543RoleSub InvestigatorPrimary Completion Date01/31/2021Recruiting ParticipantsGenderBothAge13 years - 25 years
Academic Achievements and Community Involvement
honor Lustman Resident Research Award: the first place
Yale School of Medicine AwardDetails06/10/2011United Stateshonor APA/Merck &Co Early Academic Career Research Award
National AwardDetails05/12/2011United States
Links & Media
News
- May 20, 2024Source: Journal of Behavioral Medicine
Childhood Adversity, Accelerated GrimAge, and Associated Health Consequences
- December 07, 2023
VA/Yale Researchers Lead Multi-ancestry Study of Genetics of Problematic Alcohol Use
- July 24, 2023Source: Neurobiology of Stress
Greater Stress and Trauma Mediate Race-Related Differences in Epigenetic Age Between Black and White Young Adults in a Community Sample
- March 15, 2022
Alcohol Consumption Changes the Aging Clock
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