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Kanika Jain, PhD

Associate Research Scientist

Research & Publications
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Selected Publications

Unfolded Protein Response Differentially Modulates the Platelet PhenotypeJain K, Tyagi T, Du J, Hu X, Patell K, Martin KA, Hwa J. Unfolded Protein Response Differentially Modulates the Platelet Phenotype Circulation Research 2022, 131: 290-307. PMID: 35862006, PMCID: PMC9357223, DOI: 10.1161/circresaha.121.320530.
A guide to molecular and functional investigations of platelets to bridge basic and clinical sciencesTyagi T, Jain K, Gu S, Qiu M, Gu V, Melchinger H, Rinder H, Martin K, Gardiner E, Lee A, Tang W, Hwa J. A guide to molecular and functional investigations of platelets to bridge basic and clinical sciences Nature Cardiovascular Research 2022, 1: 223-237. DOI: 10.1038/s44161-022-00021-z.
Thrombocytopathy and endotheliopathy: crucial contributors to COVID-19 thromboinflammationGu SX, Tyagi T, Jain K, Gu VW, Lee SH, Hwa JM, Kwan JM, Krause DS, Lee AI, Halene S, Martin KA, Chun HJ, Hwa J. Thrombocytopathy and endotheliopathy: crucial contributors to COVID-19 thromboinflammation Nature Reviews Cardiology 2020, 18: 194-209. PMID: 33214651, PMCID: PMC7675396, DOI: 10.1038/s41569-020-00469-1.
Age associated non-linear regulation of redox homeostasis in the anucleate platelet: Implications for CVD risk patientsJain K, Tyagi T, Patell K, Xie Y, Kadado AJ, Lee SH, Yarovinsky T, Du J, Hwang J, Martin KA, Testani J, Ionescu CN, Hwa J. Age associated non-linear regulation of redox homeostasis in the anucleate platelet: Implications for CVD risk patients EBioMedicine 2019, 44: 28-40. PMID: 31130473, PMCID: PMC6604369, DOI: 10.1016/j.ebiom.2019.05.022.
Platelet-derived TLT-1 promotes tumor progression by suppressing CD8+ T cellsTyagi T, Jain K, Yarovinsky TO, Chiorazzi M, Du J, Castro C, Griffin J, Korde A, Martin KA, Takyar SS, Flavell RA, Patel AA, Hwa J. Platelet-derived TLT-1 promotes tumor progression by suppressing CD8+ T cells Journal Of Experimental Medicine 2022, 220: e20212218. PMID: 36305874, DOI: 10.1084/jem.20212218.
High Altitude Induced Thrombosis: Challenges and Recent Advancements in Pathogenesis and ManagementTyagi T, Jain K. High Altitude Induced Thrombosis: Challenges and Recent Advancements in Pathogenesis and Management 2022, 85-101. DOI: 10.1007/978-981-19-1008-1_6.
A guide to molecular and functional investigations of platelets to bridge basic and clinical sciencesTyagi, T., Jain, K., Gu, S.X. et al. A guide to molecular and functional investigations of platelets to bridge basic and clinical sciences. Nat Cardiovasc Res 1, 223–237 (2022). https://doi.org/10.1038/s44161-022-00021-z
Low-dose Aspirin prevents hypertension and cardiac fibrosis when thromboxane A2 is unrestrainedD'Agostino I, Tacconelli S, Bruno A, Contursi A, Mucci L, Hu X, Xie Y, Chakraborty R, Jain K, Sacco A, Zucchelli M, Landolfi R, Dovizio M, Falcone L, Ballerini P, Hwa J, Patrignani P. Low-dose Aspirin prevents hypertension and cardiac fibrosis when thromboxane A2 is unrestrained Pharmacological Research 2021, 170: 105744. PMID: 34182131, DOI: 10.1016/j.phrs.2021.105744.
“CO”ping With a Sticky SituationJain K, Tyagi T, Hwa J. “CO”ping With a Sticky Situation Arteriosclerosis Thrombosis And Vascular Biology 2020, 40: 2344-2345. PMID: 32966131, PMCID: PMC7517721, DOI: 10.1161/atvbaha.120.315158.
Role of Platelet Mitochondria: Life in a Nucleus-Free ZoneMelchinger H, Jain K, Tyagi T, Hwa J. Role of Platelet Mitochondria: Life in a Nucleus-Free Zone Frontiers In Cardiovascular Medicine 2019, 6: 153. PMID: 31737646, PMCID: PMC6828734, DOI: 10.3389/fcvm.2019.00153.
Mitochondrial MsrB2 serves as a switch and transducer for mitophagyLee SH, Lee S, Du J, Jain K, Ding M, Kadado AJ, Atteya G, Jaji Z, Tyagi T, Kim W, Herzog RI, Patel A, Ionescu CN, Martin KA, Hwa J. Mitochondrial MsrB2 serves as a switch and transducer for mitophagy EMBO Molecular Medicine 2019, 11: e10409. PMID: 31282614, PMCID: PMC6685081, DOI: 10.15252/emmm.201910409.
Amelioration of ER stress by 4-phenylbutyric acid reduces chronic hypoxia induced cardiac damage and improves hypoxic tolerance through upregulation of HIF-1α.Jain K, Suryakumar G, Ganju L, Singh SB. Amelioration of ER stress by 4-phenylbutyric acid reduces chronic hypoxia induced cardiac damage and improves hypoxic tolerance through upregulation of HIF-1α. Vascular Pharmacology 2016, 83: 36-46. PMID: 27058435, DOI: 10.1016/j.vph.2016.03.004.
Myocardial ER chaperone activation and protein degradation occurs due to synergistic, not individual, cold and hypoxic stress.Jain K, Suryakumar G, Prasad R, Singh SN, Ganju L. Myocardial ER chaperone activation and protein degradation occurs due to synergistic, not individual, cold and hypoxic stress. Biochimie 2013, 95: 1897-908. PMID: 23816873, DOI: 10.1016/j.biochi.2013.06.018.

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