Sean Gu, MD/PhD
Clinical Fellow; Instructor, Pathology & Laboratory Medicine
Research & Publications
Biography
News
Coauthors
Selected Publications
- Thrombocytopathy and endotheliopathy: crucial contributors to COVID-19 thromboinflammationGu SX, Tyagi T, Jain K, Gu VW, Lee SH, Hwa JM, Kwan JM, Krause DS, Lee AI, Halene S, Martin KA, Chun HJ, Hwa J. Thrombocytopathy and endotheliopathy: crucial contributors to COVID-19 thromboinflammation. Nature Reviews Cardiology 2020, 18: 194-209. PMID: 33214651, PMCID: PMC7675396, DOI: 10.1038/s41569-020-00469-1.
- Proteomic Profiling of Different Antiphospholipid Antibody-Positive Phenotypes: Results from Antiphospholipid Syndrome Alliance for Clinical Trials and International Networking (APS ACTION) RegistryPine A, Butt A, Garcia-Milian R, Gu S, Restrepo V, Chock Y, Hwa J, Tormey C, Rinder H, Goshua G, Belmont H, Bertolaccini M, Branch D, Erhan D, Kello N, Knight J, Petri M, Willis R, Lee A, Sharda A. Proteomic Profiling of Different Antiphospholipid Antibody-Positive Phenotypes: Results from Antiphospholipid Syndrome Alliance for Clinical Trials and International Networking (APS ACTION) Registry. Blood 2023, 142: 2575. DOI: 10.1182/blood-2023-185232.
- Fishing for “complements” with vascular organoid models of microvascular diseaseGu S, Yarovinsky T, Hwa J. Fishing for “complements” with vascular organoid models of microvascular disease. Cell Stem Cell 2023, 30: 1285-1286. PMID: 37802032, DOI: 10.1016/j.stem.2023.09.004.
- Helicobacter pylori–negative mucosa-associated lymphoid tissue (MALT) lymphoma of the stomach: A clinicopathologic analysisGu S, Siddon A, Huntington S, Jain D. Helicobacter pylori–negative mucosa-associated lymphoid tissue (MALT) lymphoma of the stomach: A clinicopathologic analysis. American Journal Of Clinical Pathology 2023, 160: 612-619. PMID: 37556379, PMCID: PMC10691190, DOI: 10.1093/ajcp/aqad088.
- P1637: PROTEOMIC PROFILING OF DIFFERENT ANTIPHOSPHOLIPID ANTIBODY‐POSITIVE PHENOTYPES: RESULTS FROM ANTIPHOSPHOLIPID SYNDROME ALLIANCE FOR CLINICAL TRIALS AND INTERNATIONAL NETWORKING (APS ACTION) REGISTRYButt A, Garcia-Milian R, Goshua G, Gu S, Hwa J, Chun H, Belmont H, Kello N, Branch D, Petri M, Knight J, Willis R, Bertolaccini M, Erkan D, Lee A, Sharda A, Pine A. P1637: PROTEOMIC PROFILING OF DIFFERENT ANTIPHOSPHOLIPID ANTIBODY‐POSITIVE PHENOTYPES: RESULTS FROM ANTIPHOSPHOLIPID SYNDROME ALLIANCE FOR CLINICAL TRIALS AND INTERNATIONAL NETWORKING (APS ACTION) REGISTRY. HemaSphere 2023, 7: e160607f. PMCID: PMC10429839, DOI: 10.1097/01.hs9.0000973420.16060.7f.
- Insights into platelet pharmacology from a cryo-EM structure of the ABCC4 transporterSharda A, Gu S, Hwa J. Insights into platelet pharmacology from a cryo-EM structure of the ABCC4 transporter. Nature Cardiovascular Research 2023, 2: 606-608. PMID: 37655224, PMCID: PMC10470688, DOI: 10.1038/s44161-023-00293-z.
- SOD2 in platelets: with age comes responsibilityJain K, Gu S, Hwa J. SOD2 in platelets: with age comes responsibility. Journal Of Thrombosis And Haemostasis 2023, 21: 1077-1081. PMID: 36716965, DOI: 10.1016/j.jtha.2023.01.016.
- Plasma Proteomic Profiling Illustrates Endothelial and Complement Signature in Patients with Alcohol-Associated CirrhosisAllen C, Butt A, Zhao X, Li F, Bahel P, Chang C, Chun H, Gu S, Hwa J, Jakab S, Chen B, Garcia-Tsao G, Rinder H, To U, McConnell M, Lee A, Pine A. Plasma Proteomic Profiling Illustrates Endothelial and Complement Signature in Patients with Alcohol-Associated Cirrhosis. Blood 2022, 140: 8382-8383. DOI: 10.1182/blood-2022-162633.
- High-multiplexing quantitative CodePlex proteomic profiling of platelets in triple-negative breast cancer (TNBC) patients and healthy subjects.Han E, Gu S, Steinle M, Gu V, Tyagi T, Mackay S, Hwa J, Zhou J. High-multiplexing quantitative CodePlex proteomic profiling of platelets in triple-negative breast cancer (TNBC) patients and healthy subjects. Journal Of Clinical Oncology 2022, 40: e15017-e15017. DOI: 10.1200/jco.2022.40.16_suppl.e15017.
- A guide to molecular and functional investigations of platelets to bridge basic and clinical sciencesTyagi T, Jain K, Gu S, Qiu M, Gu V, Melchinger H, Rinder H, Martin K, Gardiner E, Lee A, Tang W, Hwa J. A guide to molecular and functional investigations of platelets to bridge basic and clinical sciences. Nature Cardiovascular Research 2022, 1: 223-237. PMID: 37502132, PMCID: PMC10373053, DOI: 10.1038/s44161-022-00021-z.
- Proteomic Profiles of Cytokine Release Syndromes Following Lisocabtagene Maraleucel and Idecabtagene VicleucelMirza A, Pine A, Rasheed Y, Hamouche R, Leveille E, Goshua G, Gu S, Liu Y, VanOudenhove J, Bar N, Neparidze N, Foss F, Gowda L, Isufi I, Halene S, Lee A, Seropian S. Proteomic Profiles of Cytokine Release Syndromes Following Lisocabtagene Maraleucel and Idecabtagene Vicleucel. Blood 2022, 140: 10410-10412. DOI: 10.1182/blood-2022-168374.
- Thinking outside the cavity: Effusion lymphoma primary to bone marrowGu SX, Pan Z, Xu ML. Thinking outside the cavity: Effusion lymphoma primary to bone marrow. Clinical Case Reports 2021, 9: e04100. PMID: 34026143, PMCID: PMC8136446, DOI: 10.1002/ccr3.4100.
- Evaluation of Aerosolized Epoprostenol in COVID-19 ARDS PatientsAmmar M, Gu SX, Jiang W, Zhao H, Ammar A, Johnson J, Owusu K, Deshpande R, Siner J, Hwa J. Evaluation of Aerosolized Epoprostenol in COVID-19 ARDS Patients. Critical Care Medicine 49(1):p 5, January 2021. DOI: 10.1097/01.ccm.0000726064.02960.52
- Inflammation mediated platelet hyperactivity in aging.Gu SX, Dayal S. Inflammation mediated platelet hyperactivity in aging. Annals Of Blood 2020, 5 PMID: 32524077, PMCID: PMC7286603, DOI: 10.21037/aob.2020.03.01.
- Memantine Protects From Exacerbation of Ischemic Stroke and Blood Brain Barrier Disruption in Mild But Not Severe Hyperhomocysteinemia.Gu SX, Sonkar VK, Katare PB, Kumar R, Kruger WD, Arning E, Bottiglieri T, Lentz SR, Dayal S. Memantine Protects From Exacerbation of Ischemic Stroke and Blood Brain Barrier Disruption in Mild But Not Severe Hyperhomocysteinemia. Journal Of The American Heart Association 2020, 9: e013368. PMID: 32067580, PMCID: PMC7070222, DOI: 10.1161/JAHA.119.013368.
- Whole-Exome Sequencing in Evaluation of Thrombophilia: Characterization of Novel Genetic VariantsGu S, Shevell L, Tormey C, Rinder H, Lee A. Whole-Exome Sequencing in Evaluation of Thrombophilia: Characterization of Novel Genetic Variants. American Journal Of Clinical Pathology 2019, 152: s35-s35. DOI: 10.1093/ajcp/aqz112.066.
- Targeting platelet EPCR for better therapeutic factor VIIa activity.Gu SX, Lentz SR. Targeting platelet EPCR for better therapeutic factor VIIa activity. Journal Of Thrombosis And Haemostasis : JTH 2018, 16: 1814-1816. PMID: 29982998, PMCID: PMC6156984, DOI: 10.1111/jth.14231.
- Fibrin films: overlooked hemostatic barriers against microbial infiltration.Gu SX, Lentz SR. Fibrin films: overlooked hemostatic barriers against microbial infiltration. The Journal Of Clinical Investigation 2018, 128: 3243-3245. PMID: 29939163, PMCID: PMC6063499, DOI: 10.1172/JCI121858.
- Cystathionine β Synthase Deficiency Exacerbates Cerebral Ischemia Reperfusion Injury Through Activation of the NMDA Receptor and Loss of Blood Brain Barrier Integrity in MiceGu SX, Sonkar V, Kumar R, Erland A, Bottiglieri T, Kruger W, Lentz S, Dayal S. Cystathionine β Synthase Deficiency Exacerbates Cerebral Ischemia Reperfusion Injury Through Activation of the NMDA Receptor and Loss of Blood Brain Barrier Integrity in Mice. Stroke. 2018;49(Suppl_1):AWMP80-AWMP. doi: doi:10.1161/str.49.suppl_1.WMP80.
- Deficiency in Nox2-containing NADPH Oxidase Decreases Susceptibility to Venous Thrombosis in MiceSonkar VK, Kumar R, Gu S, Doddapattar P, Lentz SR, Dayal S. Genetic Deficiency in Nox2-containing NADPH Oxidase Decreases Susceptibility to Venous Thrombosis in Mice. Arteriosclerosis, Thrombosis, and Vascular Biology. 2018;38(Suppl_1):A305-A. doi: doi:10.1161/atvb.38.suppl_1.305.
- Whole-exome sequencing in evaluation of patients with venous thromboembolismLee EJ, Dykas DJ, Leavitt AD, Camire RM, Ebberink E, García de Frutos P, Gnanasambandan K, Gu SX, Huntington JA, Lentz SR, Mertens K, Parish CR, Rezaie AR, Sayeski PP, Cromwell C, Bar N, Halene S, Neparidze N, Parker TL, Burns AJ, Dumont A, Yao X, Chaar CIO, Connors JM, Bale AE, Lee AI. Whole-exome sequencing in evaluation of patients with venous thromboembolism. Blood Advances 2017, 1: 1224-1237. PMID: 29296762, PMCID: PMC5728544, DOI: 10.1182/bloodadvances.2017005249.
- Deficiency of Cystathionine beta Synthase Alters Blood Brain Barrier Integrity and Exacerbates Cerebral Ischemia Reperfusion Injury in MiceGu SX, Sonkar V, Kruger WD, Bottiglieri T, Lentz SR, Dayal S. Deficiency of Cystathionine beta Synthase Alters Blood Brain Barrier Integrity and Exacerbates Cerebral Ischemia Reperfusion Injury in Mice. Arteriosclerosis, Thrombosis, and Vascular Biology. 2017;37(suppl_1):A146-A. doi: doi:10.1161/atvb.37.suppl_1.146.
- Protein methionine oxidation augments reperfusion injury in acute ischemic stroke.Gu SX, Blokhin IO, Wilson KM, Dhanesha N, Doddapattar P, Grumbach IM, Chauhan AK, Lentz SR. Protein methionine oxidation augments reperfusion injury in acute ischemic stroke. JCI Insight 2016, 1 PMID: 27294204, PMCID: PMC4902298, DOI: 10.1172/jci.insight.86460.
- Deletion of Methionine Sulfoxide Reductase A Does Not Affect Atherothrombosis but Promotes Neointimal Hyperplasia and Extracellular Signal-Regulated Kinase 1/2 Signaling.Klutho PJ, Pennington SM, Scott JA, Wilson KM, Gu SX, Doddapattar P, Xie L, Venema AN, Zhu LJ, Chauhan AK, Lentz SR, Grumbach IM. Deletion of Methionine Sulfoxide Reductase A Does Not Affect Atherothrombosis but Promotes Neointimal Hyperplasia and Extracellular Signal-Regulated Kinase 1/2 Signaling. Arteriosclerosis, Thrombosis, And Vascular Biology 2015, 35: 2594-604. PMID: 26449752, PMCID: PMC4662651, DOI: 10.1161/ATVBAHA.115.305857.
- Deficiency of superoxide dismutase impairs protein C activation and enhances susceptibility to experimental thrombosis.Dayal S, Gu SX, Hutchins RD, Wilson KM, Wang Y, Fu X, Lentz SR. Deficiency of superoxide dismutase impairs protein C activation and enhances susceptibility to experimental thrombosis. Arteriosclerosis, Thrombosis, And Vascular Biology 2015, 35: 1798-804. PMID: 26069236, PMCID: PMC4514539, DOI: 10.1161/ATVBAHA.115.305963.
- Regulation of thrombosis and vascular function by protein methionine oxidation.Gu SX, Stevens JW, Lentz SR. Regulation of thrombosis and vascular function by protein methionine oxidation. Blood 2015, 125: 3851-9. PMID: 25900980, PMCID: PMC4473114, DOI: 10.1182/blood-2015-01-544676.
- Endogenous Superoxide Dismutase Protects From Impaired Generation of Activated Protein C and Enhanced Susceptibility to Experimental Thrombosis in MiceDayal S, Gu SX, Wilson KM, Hutchins R, Lentz SR. Abstract 34: Endogenous Superoxide Dismutase Protects From Impaired Generation of Activated Protein C and Enhanced Susceptibility to Experimental Thrombosis in Mice. Arteriosclerosis, Thrombosis, and Vascular Biology. 2014;34(suppl_1):A34-A. doi: doi:10.1161/atvb.34.suppl_1.34.
- Transport kinetics and selectivity of HpUreI, the urea channel from Helicobacter pylori.Gray LR, Gu SX, Quick M, Khademi S. Transport kinetics and selectivity of HpUreI, the urea channel from Helicobacter pylori. Biochemistry 2011, 50: 8656-63. PMID: 21877689, PMCID: PMC5497592, DOI: 10.1021/bi200887a.
- Supramolecular catalysis in the organic solid state through dry grinding.Sokolov AN, Bucar DK, Baltrusaitis J, Gu SX, MacGillivray LR. Supramolecular catalysis in the organic solid state through dry grinding. Angewandte Chemie (International Ed. In English) 2010, 49: 4273-7. PMID: 20446324, DOI: 10.1002/anie.201000874.