Joao P. De Aquino, MD
Assistant Professor of Psychiatry; Assistant Chief of the Clinical Neuroscience Research Unit (CNRU), Psychiatry
Research & Publications
Biography
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Coauthors
Selected Publications
- Developing non-opioid therapeutics to alleviate pain among persons with opioid use disorder: a review of the human evidenceOliveira, D., Fontenele, R., Weleff, J., Sofuoglu, M., & De Aquino, J. P. (2023). Developing non-opioid therapeutics to alleviate pain among persons with opioid use disorder: a review of the human evidence. International Review of Psychiatry, 1-20.
- Alleviation of Opioid Withdrawal by Cannabis and Delta-9-Tetrahydrocannabinol: A Systematic Review of Observational and Experimental Human StudiesDe Aquino JP, Bahji A, Gomez OG, Sofuoglu M. Alleviation of Opioid Withdrawal by Cannabis and Delta-9-Tetrahydrocannabinol: A Systematic Review of Observational and Experimental Human Studies. Drug and Alcohol Dependence.
- Opioid-induced analgesia among persons with opioid use disorder receiving methadone or buprenorphine: A systematic review of experimental pain studiesDe Aquino JP, Parida S, Avila-Quintero VJ, Flores J, Compton P, Hickey T, Gómez O, Sofuoglu M. Opioid-induced analgesia among persons with opioid use disorder receiving methadone or buprenorphine: A systematic review of experimental pain studies. Drug And Alcohol Dependence 2021, 228: 109097. PMID: 34601272, PMCID: PMC8595687, DOI: 10.1016/j.drugalcdep.2021.109097.
- Delta-9-tetrahydrocannabinol modulates pain sensitivity among persons receiving opioid agonist therapy for opioid use disorder: A within-subject, randomized, placebo-controlled laboratory studyDe Aquino, JP, Meyerovich, J, Xie, CZ, et al. Delta-9-tetrahydrocannabinol modulates pain sensitivity among persons receiving opioid agonist therapy for opioid use disorder: A within-subject, randomized, placebo-controlled laboratory study. Addiction Biology. 2023; 28 (9):e13317. doi:10.1111/adb.13317
- Highs and lows of cannabinoid-dopamine interactions: effects of genetic variability and pharmacological modulation of catechol-O-methyl transferase on the acute response to delta-9-tetrahydrocannabinol in humansRanganathan M, De Aquino JP, Cortes-Briones JA, Radhakrishnan R, Pittman B, Bhakta S, D’Souza D. Highs and lows of cannabinoid-dopamine interactions: effects of genetic variability and pharmacological modulation of catechol-O-methyl transferase on the acute response to delta-9-tetrahydrocannabinol in humans. Psychopharmacology 2019, 236: 3209-3219. PMID: 31187152, DOI: 10.1007/s00213-019-05273-5.
- Pharmacological treatment of pain among persons with opioid addiction: A systematic review and meta‐analysis with implications for drug developmentDe Aquino JP, Flores JM, Avila‐Quintero V, Compton P, Sofuoglu M. Pharmacological treatment of pain among persons with opioid addiction: A systematic review and meta‐analysis with implications for drug development. Addiction Biology 2020, 26: e12964. PMID: 32974993, DOI: 10.1111/adb.12964.
- Feasibility and effects of galantamine on cognition in humans with cannabis use disorderSugarman DE, De Aquino JP, Poling J, Sofuoglu M. Feasibility and effects of galantamine on cognition in humans with cannabis use disorder. Pharmacology Biochemistry And Behavior 2019, 181: 86-92. PMID: 31082417, PMCID: PMC6545124, DOI: 10.1016/j.pbb.2019.05.004.
- Cocaine Use Disorder (CUD): Current Clinical PerspectivesSchwartz EKC, Wolkowicz NR, De Aquino JP, MacLean RR, Sofuoglu M. Cocaine Use Disorder (CUD): Current Clinical Perspectives. Substance Abuse And Rehabilitation 2022, 13: 25-46. PMID: 36093428, PMCID: PMC9451050, DOI: 10.2147/sar.s337338.
- Helpful or Harmful? The Therapeutic Potential of Medications with Varying Degrees of Abuse Liability in the Treatment of Substance Use DisordersMartins B, Rutland W, De Aquino JP, Kazer BL, Funaro M, Potenza MN, Angarita GA. Helpful or Harmful? The Therapeutic Potential of Medications with Varying Degrees of Abuse Liability in the Treatment of Substance Use Disorders. Current Addiction Reports 2022, 9: 647-659. PMID: 35990796, PMCID: PMC9376579, DOI: 10.1007/s40429-022-00432-9.
- Development of pulsed intravenous nicotine infusions as a model for inhaled nicotine in humansDe Aquino JP, DeVito EE, Xie C, Meyerovich J, Parida S, Gueorguieva R, Sofuoglu M. Development of pulsed intravenous nicotine infusions as a model for inhaled nicotine in humans. Psychopharmacology 2022, 239: 2809-2818. PMID: 35554617, DOI: 10.1007/s00213-022-06162-0.
- Buprenorphine Treatment of Fentanyl-Related Opioid Use Disorder.Jegede O, Parida S, De Aquino JP. Buprenorphine Treatment of Fentanyl-Related Opioid Use Disorder. The Primary Care Companion For CNS Disorders 2022, 24 PMID: 35486939, DOI: 10.4088/pcc.21cr03163.
- Multimodal Correlates of Cannabis Use among U.S. Veterans with Bipolar Disorder: An Integrated Study of Clinical, Cognitive, and Functional OutcomesSelloni A, Bhatia G, Ranganathan M, De Aquino JP. Multimodal Correlates of Cannabis Use among U.S. Veterans with Bipolar Disorder: An Integrated Study of Clinical, Cognitive, and Functional Outcomes. Journal Of Dual Diagnosis 2022, 18: 81-91. PMID: 35430960, PMCID: PMC9794455, DOI: 10.1080/15504263.2022.2053264.
- Brain Correlates of the Alcohol Use Disorder Pharmacotherapy Response: A Systematic Review of Neuroimaging Studies.Florence L, Lassi DLS, Kortas GT, Lima DR, de Azevedo-Marques Périco C, Andrade AG, Torales J, Ventriglio A, De Berardis D, De Aquino JP, Castaldelli-Maia JM. Brain Correlates of the Alcohol Use Disorder Pharmacotherapy Response: A Systematic Review of Neuroimaging Studies. Brain Sciences 2022, 12 PMID: 35326342, PMCID: PMC8946664, DOI: 10.3390/brainsci12030386.
- Impact of delivery rate on the acute response to intravenous nicotine: A human laboratory study with implications for regulatory scienceDe Aquino JP, MacLean RR, Gueorguieva R, DeVito EE, Eid T, Sofuoglu M. Impact of delivery rate on the acute response to intravenous nicotine: A human laboratory study with implications for regulatory science. Addiction Biology 2022, 27: e13161. PMID: 35229960, PMCID: PMC8903077, DOI: 10.1111/adb.13161.
- Buprenorphine treatment of fentanyl-related opioid use disorderJegede O, Parida S, De Aquino JP. Buprenorphine treatment of fentanyl-related opioid use disorder. Prim Care Companion CNS Disord. 2022;24(3):21cr03163.
- Letter to the Editor: Cannabis as a Solution to the Opioid Crisis: Is the Cart Before the Horse Again?De Aquino JP, Bahji A, D'Souza DC. Letter to the Editor: Cannabis as a Solution to the Opioid Crisis: Is the Cart Before the Horse Again? Cannabis And Cannabinoid Research 2021, 7: 898-900. PMID: 34714101, PMCID: PMC9784580, DOI: 10.1089/can.2021.0155.
- Buprenorphine Microinduction: Logistical Barriers and the Need for Convergent EvidenceDe Aquino JP, Parida S, Sofuoglu M. Buprenorphine Microinduction: Logistical Barriers and the Need for Convergent Evidence. Clinical Drug Investigation 2021, 41: 665-665. PMID: 34106434, DOI: 10.1007/s40261-021-01049-y.
- The Pharmacology of Buprenorphine Microinduction for Opioid Use DisorderDe Aquino JP, Parida S, Sofuoglu M. The Pharmacology of Buprenorphine Microinduction for Opioid Use Disorder. Clinical Drug Investigation 2021, 41: 425-436. PMID: 33818748, PMCID: PMC8020374, DOI: 10.1007/s40261-021-01032-7.
- Case report: Increasing the frequency of intramuscular naltrexone administration in a high risk patient with opioid use disorder.Wright M, De Aquino JP, Bystrak T. Case report: Increasing the frequency of intramuscular naltrexone administration in a high risk patient with opioid use disorder. Substance Abuse : Official Publication Of The Association For Medical Education And Research In Substance Abuse 2021, 1-7. PMID: 33689592, DOI: 10.1080/08897077.2021.1876811.
- Opioid-Induced Analgesia Among Persons with Opioid Use Disorder Receiving Methadone or Buprenorphine: A Systematic Review of Experimental Pain StudiesJoao P. De Aquino, Suprit Parida, Victor J. Avila-Quintero, Jose Flores, R.N. Peggy Compton, Thomas Hickey, Oscar Gómez, Mehmet Sofuoglu. Opioid-Induced Analgesia Among Persons with Opioid Use Disorder Receiving Methadone or Buprenorphine: A Systematic Review of Experimental Pain Studies. Drug and Alcohol Dependence. 109097. ISSN 0376-8716.
- Cannabis as a Solution to the Opioid Crisis: Is the Cart Before the Horse Again?De Aquino JP, Bahji A, D'Souza DC (2021) Letter to the Editor: Cannabis as a solution to the opioid crisis: Is the cart before the horse again?, Cannabis and Cannabinoid Research X:X, 1–3, DOI: 10.1089/can.2021.0155.
- Impact of delivery rate on the acute response to intravenous nicotine: A human laboratory study with implications for regulatory scienceDe Aquino, JP, MacLean, RR, Gueorguieva, R, DeVito, EE, Eid, T, Sofuoglu, M. Impact of delivery rate on the acute response to intravenous nicotine: A human laboratory study with implications for regulatory science. Addiction Biology. 2022; 27 (2):e13161. doi:10.1111/adb.13161
- Impact of cannabis on non-medical opioid use and symptoms of posttraumatic stress disorder: a nationwide longitudinal VA studyDe Aquino JP, Sofuoglu M, Stefanovics EA, Rosenheck RA. Impact of cannabis on non-medical opioid use and symptoms of posttraumatic stress disorder: a nationwide longitudinal VA study. The American Journal Of Drug And Alcohol Abuse 2020, 46: 812-822. PMID: 33035104, DOI: 10.1080/00952990.2020.1818248.
- Rapid Transition From Methadone to Buprenorphine Utilizing a Micro-dosing Protocol in the Outpatient Veteran Affairs Setting.De Aquino JP, Fairgrieve C, Klaire S, Garcia-Vassallo G. Rapid Transition From Methadone to Buprenorphine Utilizing a Micro-dosing Protocol in the Outpatient Veteran Affairs Setting. Journal Of Addiction Medicine 2020 PMID: 32011408, DOI: 10.1097/ADM.0000000000000618.
- Perpetual Hunger: The Neurobiological Consequences of Long-Term Opioid UseBommersbach T, Ross DA, De Aquino JP. Perpetual Hunger: The Neurobiological Consequences of Long-Term Opioid Use. Biological Psychiatry 2020, 87: e1-e3. PMID: 31806086, PMCID: PMC7830805, DOI: 10.1016/j.biopsych.2019.10.007.
- High potency synthetic opioids: Curbing the third wave of the opioid crisisParida S, De Aquino JP, Sofuoglu M. High potency synthetic opioids: Curbing the third wave of the opioid crisis. Neuroscience & Biobehavioral Reviews 2019, 106: 9-10. PMID: 31251966, DOI: 10.1016/j.neubiorev.2019.06.019.
- Adverse Consequences of Co-Occurring Opioid Use Disorder and Cannabis Use Disorder Compared to Opioid Use Disorder OnlyDe Aquino JP, Sofuoglu M, Stefanovics E, Rosenheck R. Adverse Consequences of Co-Occurring Opioid Use Disorder and Cannabis Use Disorder Compared to Opioid Use Disorder Only. The American Journal Of Drug And Alcohol Abuse 2019, 45: 527-537. PMID: 31112429, DOI: 10.1080/00952990.2019.1607363.
- Effects of haloperidol on the delta-9-tetrahydrocannabinol response in humans: a responder analysisGupta S, De Aquino JP, D’Souza D, Ranganathan M. Effects of haloperidol on the delta-9-tetrahydrocannabinol response in humans: a responder analysis. Psychopharmacology 2019, 236: 2635-2640. PMID: 30919005, PMCID: PMC6697616, DOI: 10.1007/s00213-019-05235-x.
- Enhancement of Medical Student Attitudes in the Treatment of Patients with Substance Use Disorders: a Follow-up StudyDe Aquino JP, Moore DT, Wilkins K, Fuehrlein B. Enhancement of Medical Student Attitudes in the Treatment of Patients with Substance Use Disorders: a Follow-up Study. Academic Psychiatry 2019, 43: 350-351. PMID: 30756269, DOI: 10.1007/s40596-019-01038-6.
- Cannabinoids and Pain: Weeding Out Undesired Effects With a Novel Approach to AnalgesiaDe Aquino JP, Ross DA. Cannabinoids and Pain: Weeding Out Undesired Effects With a Novel Approach to Analgesia. Biological Psychiatry 2018, 84: e67-e69. PMID: 30360776, PMCID: PMC6697049, DOI: 10.1016/j.biopsych.2018.09.003.
- The Psychiatric Consequences of CannabinoidsDe Aquino JP, Sherif M, Radhakrishnan R, Cahill JD, Ranganathan M, D'Souza D. The Psychiatric Consequences of Cannabinoids. Clinical Therapeutics 2018, 40: 1448-1456. PMID: 29678279, DOI: 10.1016/j.clinthera.2018.03.013.
- Kraepelin’s Crumbling Twin Pillars: Using Biology to Reconstruct Psychiatric Nosology From the Bottom UpDe Aquino JP, Ross DA. Kraepelin’s Crumbling Twin Pillars: Using Biology to Reconstruct Psychiatric Nosology From the Bottom Up. Biological Psychiatry 2017, 82: e71-e74. PMID: 29031920, PMCID: PMC5714270, DOI: 10.1016/j.biopsych.2017.09.008.
- The potential interaction between clopidogrel and proton pump inhibitors: a systematic review.Lima JP, Brophy JM. The potential interaction between clopidogrel and proton pump inhibitors: a systematic review. BMC Medicine 2010, 8: 81. PMID: 21134261, PMCID: PMC3016262, DOI: 10.1186/1741-7015-8-81.
- Conflicting evidence: what's a clinician to do?de Aquino Lima JP, Brophy JM. Conflicting evidence: what's a clinician to do? Annals Of Internal Medicine 2010, 153: 413-5. PMID: 20855806, DOI: 10.7326/0003-4819-153-6-201009210-00011.
Clinical Trials
| Conditions | Study Title |
|---|---|
| Diseases of the Nervous System; Genetics - Adult; Genetics - Pediatric; Mental Health & Behavioral Research | Brain Emotion Circuitry-Targeted Self-Monitoring and Regulation Therapy (BE-SMART) |