Research & Publications
Jeanne Hendrickson studies complications of transfusion therapy, including the development of immune responses to antigens expressed on transfused blood products. Millions of blood products are transfused annually, and immune responses to transfused red blood cells or platelets or white blood cells may complicate future transfusions, pregnancies, or organ transplantation. Factors influencing alloimmunization, including those on the donor and recipient sides of the equation, are studied. Environmental and genetic variables that impact the intersections of innate and adaptive immunity are also studied. Some studies involve reductionist models with expression of authentic human blood group antigens, whereas others are more translational/patient focused.
Extensive Research Description
Please pubmed search Hendrickson JE to see the range of topics the Hendrickson lab is interested in. In general, the lab is interested in investigating clinically relevant issues in transfusion medicine using basic science models and translational research tools.
Cellular therapy; Red blood cell alloimmunization
Anemia, Sickle Cell; Blood Transfusion; Hematology; Immune Tolerance; Plasmapheresis; Pregnancy Complications, Hematologic; Immunity, Humoral; Transfusion Medicine