Homeostasis of the intestinal immune system. The development of inflammatory bowel disease appears to be related to the uncontrolled activation of immune cells within the specialized immune system of the intestine. We are addressing mechanisms regulating intestinal immune homeostasis and the dysregulation that occurs with intestinal inflammation through studies in mouse models of disease and through the use of primary cells from healthy individuals and patients with Crohn’s disease and ulcerative colitis. We seek to understand both innate and adaptive immune pathways that contribute to these diseases. Further, we utilize the genetic discoveries in inflammatory bowel disease to guide these studies, such that we focus on understanding the immunological consequences of genetic variants (e.g. NOD2, IL23/Th17 pathway, JAK/STAT pathway, TNFSF15, IRF5, RNF186, LACC1, RNF186, MTMR3, ICOS) implicated in either increasing or decreasing the likelihood of developing human inflammatory bowel disease.
Key Phrases: Regulation of the intestinal immune system; Genetics and immunobiology of inflammatory bowel disease; host:microbe interactions.
Colitis, Ulcerative; Crohn Disease; Genetics; Immune System; Immunity, Innate; Inflammation; Intestines; Molecular Biology; T-Lymphocytes; Inflammatory Bowel Diseases