Cicero Torres Silva, MD
Research & Publications
Biography
News
Research Summary
My research and scholarly contributions involve mainly the imaging of the pediatric chest and abdomen. This is a field that, although exciting, historically has attracted relatively few investigators and little funding. Consequently, discoveries in this area usually lag their adult counterparts. My research and educational endeavors aim to close that gap, taking advantage of the cutting-edge equipment available at Yale Diagnostic Radiology.
Specialized Terms: Neonatal imaging; hi-resolution ultrasound applications; pediatric oncology
Extensive Research Description
I have co-authored studies on the use of ultrasound in the evaluation of the neonatal gastrointestinal tract. Necrotizing enterocolitis (NEC) is the most common neonatal gastrointestinal emergency, potentially leading to death. Its diagnosis has traditionally relied on radiographs. My colleagues and I have recently shown that ultrasound can be used for early diagnosis of NEC [1], when the radiographs are still nonspecific. That discovery may potentially impact on disease outcome, as early diagnosis and treatment have been shown to decrease morbidity and mortality. On a previous study [2] we had shown that ultrasound can be used to stratify patients and identify those that may need surgery, before corresponding changes are apparent on radiographs. That study has been pivotal in helping establish the clinical use of ultrasound in NEC, has won a Walter E. Berdon award for best paper published in Pediatric Radiology, and has stimulated an extensive body of subsequent related research (more than 140 citations to date).
I have co-authored two studies on the use of practice MRI [3, 4], showing that young children can often successfully undergo MRI scans without sedation or anesthesia, if coached on a mock scanner. One of these studies has won a Walter E. Berdon award for best paper published in Pediatric Radiology. These studies have helped to disseminate the concept of MRI preparation as a replacement to sedation or anesthesia, with more than 160 citations to date.
I have co-authored two studies on the computed tomography (CT) evaluation of pulmonary nodules in pediatric oncology patients [5, 6]. One study showed that no CT finding can differentiate benign from malignant nodules in children. The other study showed that computer-aided detection software is able to detect pulmonary nodules missed by radiologists, making it potentially useful as a second reader. These studies have advanced the knowledge of interpretation of pulmonary nodules on pediatric CT, with 60 citations to date. One of them has won a Walter E. Berdon award for best paper published in Pediatric Radiology.
Currently I am working with colleagues within and outside Yale on projects that entail novel uses of high-resolution ultrasound in neonates and critically-ill children.
Coauthors
Research Interests
Abdomen; Neoplasms by Histologic Type; Pediatrics; Radiology
Selected Publications
- Ultrasound for Midgut Malrotation and Midgut Volvulus: AJR Expert Panel Narrative Review.Nguyen HN, Navarro OM, Bloom DA, Feinstein KA, Guillerman RP, Munden MM, Sammer MBK, Silva CT. Ultrasound for Midgut Malrotation and Midgut Volvulus: AJR Expert Panel Narrative Review. American Journal Of Roentgenology 2022, 218: 931-939. PMID: 35107311, DOI: 10.2214/ajr.21.27242.
- Artificial Intelligence Algorithm Improves Radiologist Performance in Skeletal Age Assessment: A Prospective Multicenter Randomized Controlled Trial.Eng DK, Khandwala NB, Long J, Fefferman NR, Lala SV, Strubel NA, Milla SS, Filice RW, Sharp SE, Towbin AJ, Francavilla ML, Kaplan SL, Ecklund K, Prabhu SP, Dillon BJ, Everist BM, Anton CG, Bittman ME, Dennis R, Larson DB, Seekins JM, Silva CT, Zandieh AR, Langlotz CP, Lungren MP, Halabi SS. Artificial Intelligence Algorithm Improves Radiologist Performance in Skeletal Age Assessment: A Prospective Multicenter Randomized Controlled Trial. Radiology 2021, 301: 692-699. PMID: 34581608, DOI: 10.1148/radiol.2021204021.
- The course of the duodenum: what path should we take? Reply to Binu et al.Nguyen HN, Silva CT, Guillerman RP, Navarro OM, Van Tassel D, Sammer MBK. The course of the duodenum: what path should we take? Reply to Binu et al. Pediatric Radiology 2021, 51: 2101-2101. PMID: 34415359, DOI: 10.1007/s00247-021-05164-y.
- Age-Dependent Heterogeneity in the Efficacy of Prophylaxis With Enoxaparin Against Catheter-Associated Thrombosis in Critically Ill Children: A Post Hoc Analysis of a Bayesian Phase 2b Randomized Clinical Trial.Faustino EVS, Raffini LJ, Hanson SJ, Cholette JM, Pinto MG, Li S, Kandil SB, Nellis ME, Shabanova V, Silva CT, Tala JA, McPartland T, Spinella PC. Age-Dependent Heterogeneity in the Efficacy of Prophylaxis With Enoxaparin Against Catheter-Associated Thrombosis in Critically Ill Children: A Post Hoc Analysis of a Bayesian Phase 2b Randomized Clinical Trial. Critical Care Medicine 2021, 49: e369-e380. PMID: 33566465, PMCID: PMC7979442, DOI: 10.1097/ccm.0000000000004848.
- Untwisting the complexity of midgut malrotation and volvulus ultrasoundNguyen HN, Navarro OM, Guillerman RP, Silva CT, Sammer MBK. Untwisting the complexity of midgut malrotation and volvulus ultrasound. Pediatric Radiology 2021, 51: 658-668. PMID: 33398405, DOI: 10.1007/s00247-020-04876-x.
- Efficacy of Early Prophylaxis Against Catheter-Associated Thrombosis in Critically Ill Children: A Bayesian Phase 2b Randomized Clinical Trial.Faustino EVS, Shabanova V, Raffini LJ, Kandil SB, Li S, Pinto MG, Cholette JM, Hanson SJ, Nellis ME, Silva CT, Chima R, Sharathkumar A, Thomas KA, McPartland T, Tala JA, Spinella PC. Efficacy of Early Prophylaxis Against Catheter-Associated Thrombosis in Critically Ill Children: A Bayesian Phase 2b Randomized Clinical Trial. Critical Care Medicine 2020, 49: e235-e246. PMID: 33372745, PMCID: PMC7902342, DOI: 10.1097/ccm.0000000000004784.
- Pearls and Pitfalls in Pediatric Thyroid ImagingSilva CT, Navarro OM. Pearls and Pitfalls in Pediatric Thyroid Imaging. Seminars In Ultrasound CT And MRI 2020, 41: 421-432. PMID: 32980089, DOI: 10.1053/j.sult.2020.05.007.
- Terminal Ileitis Presenting With a Spontaneously Reduced Ileocolic Intussusception Diagnosed by Point-of-Care Ultrasonography.Riera A, Langhan M, Silva CT. Terminal Ileitis Presenting With a Spontaneously Reduced Ileocolic Intussusception Diagnosed by Point-of-Care Ultrasonography. Pediatric Emergency Care 2019, 36: e30-e32. PMID: 31433363, DOI: 10.1097/pec.0000000000001879.
- Reevaluation of FAST Sensitivity in Pediatric Blunt Abdominal Trauma PatientsRiera A, Hayward H, Silva C, Chen L. Reevaluation of FAST Sensitivity in Pediatric Blunt Abdominal Trauma Patients. Pediatric Emergency Care 2019, 37: e1012-e1019. PMID: 31356479, DOI: 10.1097/pec.0000000000001877.
- Providing Expert Pediatric Teleradiology Services Around the Globe: The World Federation of Pediatric Imaging ExperienceOtero HJ, Andronikou S, Grassi DC, Silva CT. Providing Expert Pediatric Teleradiology Services Around the Globe: The World Federation of Pediatric Imaging Experience. Journal Of The American College Of Radiology 2019, 17: 53-55. PMID: 31278921, DOI: 10.1016/j.jacr.2019.06.006.
- Effect of Reader and Patient Parameters on the Performance of Last-Image-Hold for Fluoroscopic Grading of Vesicoureteric Reflux.Mian AY, Mills IP, Sheridan AD, Ehrlich LJ, Baker KE, Tilak G, Staib LH, Silva CT. Effect of Reader and Patient Parameters on the Performance of Last-Image-Hold for Fluoroscopic Grading of Vesicoureteric Reflux. American Journal Of Roentgenology 2019, 212: 968-975. PMID: 30807219, DOI: 10.2214/ajr.18.20273.
- Epidemiology of Lower Extremity Deep Venous Thrombosis in Critically Ill AdolescentsFaustino EVS, Shabanova V, Pinto MG, Li S, Trakas E, Miksa M, Gertz S, Polikoff LA, Napolitano M, Brudnicki AR, Tala JA, Silva CT, Investigators T, Miksa M, Taragin B, Blickman J, Taillie E, Trakas E, Balasco A, Herliczek T, Polikoff L, Dovi G, Napolitano M, Gertz S, Riordan M, Zasa J, Brudnicki A, Eldridge P, Li S, Pinto M, Faustino E, Silva C, Tala J. Epidemiology of Lower Extremity Deep Venous Thrombosis in Critically Ill Adolescents. The Journal Of Pediatrics 2018, 201: 176-183.e2. PMID: 29891258, DOI: 10.1016/j.jpeds.2018.05.006.
- Abusive fracture incidence over three decades at a level 1 pediatric trauma centerSharkey MS, Buesser KE, Gaither JR, Tate V, Cooperman DR, Moles RL, Silva CT, Ehrlich LJ, Leventhal JM. Abusive fracture incidence over three decades at a level 1 pediatric trauma center. Child Abuse & Neglect 2017, 76: 364-371. PMID: 29195174, DOI: 10.1016/j.chiabu.2017.11.008.
- Inter-rater reliability of physical abuse determinations in young children with fracturesBuesser KE, Leventhal JM, Gaither JR, Tate V, Cooperman DR, Moles RL, Silva CT, Ehrlich LJ, Sharkey MS. Inter-rater reliability of physical abuse determinations in young children with fractures. Child Abuse & Neglect 2017, 72: 140-146. PMID: 28802910, DOI: 10.1016/j.chiabu.2017.08.001.
- Assessment of a modified technique for air delivery during fluoroscopic-monitored pneumatic intussusception reductionJindal G, Graeber BL, Staib LH, Silva CT. Assessment of a modified technique for air delivery during fluoroscopic-monitored pneumatic intussusception reduction. Pediatric Radiology 2017, 47: 1594-1598. PMID: 28681232, DOI: 10.1007/s00247-017-3920-z.
- Congenital Cystic Lung LesionsHardee S, Tuzovic L, Silva CT, Cowles RA, Copel J, Morotti RA. Congenital Cystic Lung Lesions. Pediatric And Developmental Pathology 2017, 20: 403-410. PMID: 28812458, DOI: 10.1177/1093526617698604.
- 602Faustino E, Li S, Pinto M, Trakas E, Gertz S, Miksa M, Silva C. 602. Critical Care Medicine 2016, 44: 227. DOI: 10.1097/01.ccm.0000509279.64732.0c.
- CONGENITAL CYSTIC LUNG LESIONS: EVOLUTION FROM IN-UTERO TO PATHOLOGY DIAGNOSIS - A MULTIDISCIPLINARY APPROACHHardee S, Tuzovic L, Silva C, Cowles R, Copel J, Morotti R. CONGENITAL CYSTIC LUNG LESIONS: EVOLUTION FROM IN-UTERO TO PATHOLOGY DIAGNOSIS - A MULTIDISCIPLINARY APPROACH. Pediatric And Developmental Pathology 2016 DOI: 10.2350/16-05-1815-oa.1.
- Saving the starfish: World Federation of Pediatric Imaging (WFPI) development, work to date, and membership feedback on international outreachDehaye A, Silva CT, Darge K, Prabhu SP, Andronikou S, Laya BF, Coley BD, Boechat MI. Saving the starfish: World Federation of Pediatric Imaging (WFPI) development, work to date, and membership feedback on international outreach. Pediatric Radiology 2016, 46: 452-461. PMID: 26994001, DOI: 10.1007/s00247-016-3587-x.
- Duodenal intussusception secondary to web presenting as recurrent pancreatitis in a 7-year-old girlTu LH, Villalona GA, Cowles RA, Silva CT. Duodenal intussusception secondary to web presenting as recurrent pancreatitis in a 7-year-old girl. Pediatric Radiology 2015, 46: 426-429. PMID: 26553449, DOI: 10.1007/s00247-015-3481-y.
- Diagnostic accuracy of point-of-care ultrasound for catheter-related thrombosis in childrenLi S, Silva CT, Brudnicki AR, Baker KE, Tala JA, Pinto MG, Polikoff LA, Qin L, Faustino EV, Northeast Pediatric Critical Care Research Consortium. Diagnostic accuracy of point-of-care ultrasound for catheter-related thrombosis in children. Pediatric Radiology 2015, 46: 219-228. PMID: 26440129, PMCID: PMC4738063, DOI: 10.1007/s00247-015-3467-9.
- Factor VIII May Predict Catheter-Related Thrombosis in Critically Ill ChildrenFaustino EV, Li S, Silva CT, Pinto MG, Qin L, Tala JA, Rinder HM, Kupfer GM, Shapiro ED. Factor VIII May Predict Catheter-Related Thrombosis in Critically Ill Children. Pediatric Critical Care Medicine 2015, 16: 497-504. PMID: 25828784, PMCID: PMC4497863, DOI: 10.1097/pcc.0000000000000409.
- Prevalence of post‐thrombotic syndrome after cardiac catheterizationLuceri MJ, Tala JA, Weismann CG, Silva CT, Faustino EV. Prevalence of post‐thrombotic syndrome after cardiac catheterization. Pediatric Blood & Cancer 2015, 62: 1222-1227. PMID: 25663038, PMCID: PMC4433560, DOI: 10.1002/pbc.25438.
- Postnatal sonographic spectrum of prenatally detected abdominal and pelvic cysts.Silva CT, Engel C, Cross SN, Copel JE, Morotti RA, Baker KE, Goodman TR. Postnatal sonographic spectrum of prenatally detected abdominal and pelvic cysts. American Journal Of Roentgenology 2014, 203: w684-96. PMID: 25415735, DOI: 10.2214/ajr.13.12371.
- Blood glucose as a marker of venous thromboembolism in critically ill childrenTala JA, Silva CT, Pemira S, Vidal E, Faustino EV. Blood glucose as a marker of venous thromboembolism in critically ill children. Journal Of Thrombosis And Haemostasis 2014, 12: 891-896. PMID: 24708410, PMCID: PMC4055532, DOI: 10.1111/jth.12583.
- Satisfactions and frustrations of a volunteer tele-reader for the World Federation of Pediatric ImagingSilva CT. Satisfactions and frustrations of a volunteer tele-reader for the World Federation of Pediatric Imaging. Pediatric Radiology 2014, 44: 656-656. PMID: 24854929, DOI: 10.1007/s00247-014-2970-8.
- ABSTRACT 114Faustino E, Li S, Pinto M, Polikoff L, Tala J, Silva C, Shapiro E. ABSTRACT 114. Pediatric Critical Care Medicine 2014, 15: 31. DOI: 10.1097/01.pcc.0000448840.20300.dd.
- A prospective comparison of intestinal sonography and abdominal radiographs in a neonatal intensive care unitSilva CT, Daneman A, Navarro OM, Moineddin R, Levine D, Moore AM. A prospective comparison of intestinal sonography and abdominal radiographs in a neonatal intensive care unit. Pediatric Radiology 2013, 43: 1453-1463. PMID: 24026851, DOI: 10.1007/s00247-013-2777-z.
- Intestinal Blood Flow by Doppler Ultrasound: The Impact of Gestational Age and Time from First Enteral Feeding in Preterm NeonatesThompson A, Silva CT, Gork AS, Wang D, Ehrenkranz RA. Intestinal Blood Flow by Doppler Ultrasound: The Impact of Gestational Age and Time from First Enteral Feeding in Preterm Neonates. American Journal Of Perinatology 2013, 31: 261-268. PMID: 23729284, DOI: 10.1055/s-0033-1347365.
- Underutilized Ultrasound Applications in the Neonatal Intensive Care UnitEngel C, Silva C, Baker K, Goodman TR. Underutilized Ultrasound Applications in the Neonatal Intensive Care Unit. Ultrasound Quarterly 2012, 28: 299-304. PMID: 23143111, DOI: 10.1097/ruq.0b013e31827496e5.
- Incidence and Acute Complications of Asymptomatic Central Venous Catheter–Related Deep Venous Thrombosis in Critically Ill ChildrenFaustino EV, Spinella PC, Li S, Pinto MG, Stoltz P, Tala J, Card ME, Northrup V, Baker KE, Goodman TR, Chen L, Silva CT. Incidence and Acute Complications of Asymptomatic Central Venous Catheter–Related Deep Venous Thrombosis in Critically Ill Children. The Journal Of Pediatrics 2012, 162: 387-391. PMID: 22883418, PMCID: PMC3575007, DOI: 10.1016/j.jpeds.2012.06.059.
- Early assessment of the efficacy of digital infrared thermal imaging in pediatric extremity traumaSilva CT, Naveed N, Bokhari S, Baker KE, Staib LH, Ibrahim SM, Muchantef K, Goodman TR. Early assessment of the efficacy of digital infrared thermal imaging in pediatric extremity trauma. Emergency Radiology 2012, 19: 203-209. PMID: 22362422, DOI: 10.1007/s10140-012-1027-2.
- Pediatric Ocular SonographySilva CT, Brockley CR, Crum A, Mandelstam SA. Pediatric Ocular Sonography. Seminars In Ultrasound CT And MRI 2011, 32: 14-27. PMID: 21277488, DOI: 10.1053/j.sult.2010.09.005.
- A unique case of rhabdoid tumor presenting as hemoperitoneum in an infantMalhotra Y, Fitzgerald TN, Jubinsky PT, Harper H, Silva CT, Zambrano E, Diefenbach KA, Moss RL, Bhandari V. A unique case of rhabdoid tumor presenting as hemoperitoneum in an infant. Journal Of Pediatric Surgery 2011, 46: 247-251. PMID: 21238679, DOI: 10.1016/j.jpedsurg.2010.08.051.
- ReplySilva C, Amaral J, Moineddin R, Doda W, Babyn P. Reply. American Journal Of Roentgenology 2010, 195: w309-w310. DOI: 10.2214/ajr.10.4692.
- CT characteristics of lung nodules present at diagnosis of extrapulmonary malignancy in children.Silva CT, Amaral JG, Moineddin R, Doda W, Babyn PS. CT characteristics of lung nodules present at diagnosis of extrapulmonary malignancy in children. American Journal Of Roentgenology 2010, 194: 772-8. PMID: 20173158, DOI: 10.2214/ajr.09.2490.
- Do additional views improve the diagnostic performance of cervical spine radiography in pediatric trauma?Silva CT, Doria AS, Traubici J, Moineddin R, Davila J, Shroff M. Do additional views improve the diagnostic performance of cervical spine radiography in pediatric trauma? American Journal Of Roentgenology 2010, 194: 500-8. PMID: 20093616, DOI: 10.2214/ajr.09.2837.
- Computer-aided detection for the identification of pulmonary nodules in pediatric oncology patients: initial experienceHelm EJ, Silva CT, Roberts HC, Manson D, Seed MT, Amaral JG, Babyn PS. Computer-aided detection for the identification of pulmonary nodules in pediatric oncology patients: initial experience. Pediatric Radiology 2009, 39: 685-693. PMID: 19418048, DOI: 10.1007/s00247-009-1259-9.
- Cardiac tamponade: appearance on CTSilva CT, Baker K. Cardiac tamponade: appearance on CT. Pediatric Radiology 2009, 39: 523-523. PMID: 19277626, DOI: 10.1007/s00247-009-1207-8.
- Case 137: Pneumonia and bronchiectasis secondary to unrecognized peanut impaction.Torres de Amorim e Silva CJ, Fink AM. Case 137: Pneumonia and bronchiectasis secondary to unrecognized peanut impaction. Radiology 2008, 248: 1080-2. PMID: 18710997, DOI: 10.1148/radiol.2483050725.
- Reviewing the process of preparing children for MRI.Hallowell LM, Stewart SE, de Amorim E Silva CT, Ditchfield MR. Reviewing the process of preparing children for MRI. Pediatric Radiology 2008, 38: 271-9. PMID: 18084752, DOI: 10.1007/s00247-007-0704-x.
- ReplyDaneman A, Navarro O, Silva C. Reply. Pediatric Radiology 2007, 37: 1181-1181. DOI: 10.1007/s00247-007-0642-7.
- Correlation of sonographic findings and outcome in necrotizing enterocolitisSilva CT, Daneman A, Navarro OM, Moore AM, Moineddin R, Gerstle JT, Mittal A, Brindle M, Epelman M. Correlation of sonographic findings and outcome in necrotizing enterocolitis. Pediatric Radiology 2007, 37: 274-282. PMID: 17225155, DOI: 10.1007/s00247-006-0393-x.
- Practice MRI: reducing the need for sedation and general anaesthesia in children undergoing MRI.de Amorim e Silva CJ, Mackenzie A, Hallowell LM, Stewart SE, Ditchfield MR. Practice MRI: reducing the need for sedation and general anaesthesia in children undergoing MRI. Australasian Radiology 2006, 50: 319-23. PMID: 16884416, DOI: 10.1111/j.1440-1673.2006.01590.x.
- Pulmonary capillary haemangiomatosis in a premature infant.Silva CJ, Massie J, Mandelstam SA. Pulmonary capillary haemangiomatosis in a premature infant. Pediatric Radiology 2005, 35: 635-40. PMID: 15714310, DOI: 10.1007/s00247-004-1374-6.
- Does the endoscopic technique of ureterocele incision matter?Ben Meir D, Silva CJ, Rao P, Chiang D, Dewan PA. Does the endoscopic technique of ureterocele incision matter? The Journal Of Urology 2004, 172: 684-6. PMID: 15247761, DOI: 10.1097/01.ju.0000129228.92805.31.
Clinical Trials
Conditions | Study Title |
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Diseases of the Cardiovascular System | Catheter-Related Early Thromboprophylaxis With Enoxaparin Studies (CRETE) |