My research and scholarly contributions involve mainly the imaging of the pediatric chest and abdomen. This is a field that, although exciting, historically has attracted relatively few investigators and little funding. Consequently, discoveries in this area usually lag their adult counterparts. My research and educational endeavors aim to close that gap, taking advantage of the cutting-edge equipment available at Yale Diagnostic Radiology.
Specialized Terms: Neonatal imaging; hi-resolution ultrasound applications; pediatric oncology
I have co-authored studies on the use of ultrasound in the evaluation of the neonatal gastrointestinal tract. Necrotizing enterocolitis (NEC) is the most common neonatal gastrointestinal emergency, potentially leading to death. Its diagnosis has traditionally relied on radiographs. My colleagues and I have recently shown that ultrasound can be used for early diagnosis of NEC , when the radiographs are still nonspecific. That discovery may potentially impact on disease outcome, as early diagnosis and treatment have been shown to decrease morbidity and mortality. On a previous study  we had shown that ultrasound can be used to stratify patients and identify those that may need surgery, before corresponding changes are apparent on radiographs. That study has been pivotal in helping establish the clinical use of ultrasound in NEC, has won a Walter E. Berdon award for best paper published in Pediatric Radiology, and has stimulated an extensive body of subsequent related research (more than 140 citations to date).
I have co-authored two studies on the use of practice MRI [3, 4], showing that young children can often successfully undergo MRI scans without sedation or anesthesia, if coached on a mock scanner. One of these studies has won a Walter E. Berdon award for best paper published in Pediatric Radiology. These studies have helped to disseminate the concept of MRI preparation as a replacement to sedation or anesthesia, with more than 160 citations to date.
I have co-authored two studies on the computed tomography (CT) evaluation of pulmonary nodules in pediatric oncology patients [5, 6]. One study showed that no CT finding can differentiate benign from malignant nodules in children. The other study showed that computer-aided detection software is able to detect pulmonary nodules missed by radiologists, making it potentially useful as a second reader. These studies have advanced the knowledge of interpretation of pulmonary nodules on pediatric CT, with 60 citations to date. One of them has won a Walter E. Berdon award for best paper published in Pediatric Radiology.
Currently I am working with colleagues within and outside Yale on projects that entail novel uses of high-resolution ultrasound in neonates and critically-ill children.
Abdomen; Neoplasms by Histologic Type; Pediatrics; Radiology