Barani Kumar Rajendran
Associate Research Scientist in Pathology
Research & Publications
Biography
Research Summary
Cancer Research; Bioinformatics; Precision Medicine; Cancer immunology; Biomarkers Discovery
Extensive Research Description
Bioinformatics; Next Generation Sequencing (NGS), Single-cell Research; Precision medicine; Cancer Immunology, Computational Biology; Genomics; Computational Structural Biology, Spatial Transcriptomics.
Coauthors
Selected Publications
- Abstract 101: A novel humanized mouse model recapitulates the unique TME found in patients with HIV-associated NSCLCJuric M, Kaufmann G, Zhu L, Ranjan K, Agrawal K, Rajendran B, Rajashekar J, Zhao H, Kluger Y, Emu B, Schalper K, Kumar P, Flavell R, Chiorazzi M. Abstract 101: A novel humanized mouse model recapitulates the unique TME found in patients with HIV-associated NSCLC. Cancer Research 2024, 84: 101-101. DOI: 10.1158/1538-7445.am2024-101.
- Abstract 4893: Role of MGMT expression in the genomic landscape and immunogenicity in human colorectal carcinomasRajendran B, Zhang J, Desai S, Gibson J, DiPalermo J, LoRusso P, Kong Y, Zhao H, Cecchini M, Schalper K. Abstract 4893: Role of MGMT expression in the genomic landscape and immunogenicity in human colorectal carcinomas. Cancer Research 2024, 84: 4893-4893. DOI: 10.1158/1538-7445.am2024-4893.
- Wnt5 controls splenic myelopoiesis and neutrophil functional ambivalency during DSS-induced colitisLuan Y, Hu J, Wang Q, Wang X, Li W, Qu R, Yang C, Rajendran B, Zhou H, Liu P, Zhang N, Shi Y, Liu Y, Tang W, Lu J, Wu D. Wnt5 controls splenic myelopoiesis and neutrophil functional ambivalency during DSS-induced colitis. Cell Reports 2024, 43: 113934. PMID: 38461416, DOI: 10.1016/j.celrep.2024.113934.
- The CUL5 E3 ligase complex negatively regulates central signaling pathways in CD8+ T cellsLiao X, Li W, Zhou H, Rajendran B, Li A, Ren J, Luan Y, Calderwood D, Turk B, Tang W, Liu Y, Wu D. The CUL5 E3 ligase complex negatively regulates central signaling pathways in CD8+ T cells. Nature Communications 2024, 15: 603. PMID: 38242867, PMCID: PMC10798966, DOI: 10.1038/s41467-024-44885-0.
- 606 IMpower110: Tertiary lymphoid structures (TLS) and clinical outcomes in advanced non-small cell lung cancer (NSCLC) treated with first-line atezolizumab or chemotherapySrivastava M, Gayevskiy V, Ma V, Estay I, Rodas M, Rajendran B, Hoang T, Ballinger M, Amin R, Herbst R, Marinis F, Giaccone G, Jassem J, Spigel D, Schalper K, Koeppen H, Shames D, Johnston R, Giltnane J, Nabet B. 606 IMpower110: Tertiary lymphoid structures (TLS) and clinical outcomes in advanced non-small cell lung cancer (NSCLC) treated with first-line atezolizumab or chemotherapy. 2023, a690-a690. DOI: 10.1136/jitc-2023-sitc2023.0606.
- Biomarkers and biosensors for early cancer diagnosis, monitoring and prognosisWahab M, Palaniyandi T, Ravi M, viswanathan S, Baskar G, Surendran H, Gangadharan S, Rajendran B. Biomarkers and biosensors for early cancer diagnosis, monitoring and prognosis. Pathology - Research And Practice 2023, 250: 154812. PMID: 37741139, DOI: 10.1016/j.prp.2023.154812.
- Pharmacological effect of gold nanoparticles from red algae Halymenia venusta on A549 cell lineBaskar G, Palaniyandi T, Viswanathan S, Wahab M, Surendran H, Ravi M, Rajendran B, Govindasamy G, Sivaji A, Kaliamoorthy S. Pharmacological effect of gold nanoparticles from red algae Halymenia venusta on A549 cell line. Inorganic Chemistry Communications 2023, 155: 111005. DOI: 10.1016/j.inoche.2023.111005.
- Role of homeobox d10 gene targeted signaling pathways in cancersSurendran H, Palaniyandi T, Natarajan S, Hari R, Viwanathan S, Baskar G, Abdul Wahab M, Ravi M, Rajendran B. Role of homeobox d10 gene targeted signaling pathways in cancers. Pathology - Research And Practice 2023, 248: 154643. PMID: 37406379, DOI: 10.1016/j.prp.2023.154643.
- Recent and advanced therapy for oral cancerBaskar G, Palaniyandi T, Viswanathan S, Wahab M, Surendran H, Ravi M, Sivaji A, Rajendran B, Natarajan S, Govindasamy G. Recent and advanced therapy for oral cancer. Biotechnology And Bioengineering 2023, 120: 3105-3115. PMID: 37243814, DOI: 10.1002/bit.28452.
- Abstract 6762: Tumor immune microenvironment &genomic features of non-small cell lung carcinomas in patients with HIV (PWH)Desai S, Ranjan K, Salahuddin S, Yusuf R, Gu J, Tang D, Kong Y, Rajendran B, Zhao H, Kluger Y, Goldberg S, Emu B, Schalper K. Abstract 6762: Tumor immune microenvironment &genomic features of non-small cell lung carcinomas in patients with HIV (PWH). Cancer Research 2023, 83: 6762-6762. DOI: 10.1158/1538-7445.am2023-6762.
- Integrated transcriptome and trajectory analysis of cutaneous T-cell lymphoma identifies putative precancer populationsRen J, Qu R, Rahman N, Lewis J, King A, Liao X, Mirza F, Carlson K, Huang Y, Gigante S, Evans B, Rajendran B, Xu S, Wang G, Foss F, Damsky W, Kluger Y, Krishnaswamy S, Girardi M. Integrated transcriptome and trajectory analysis of cutaneous T-cell lymphoma identifies putative precancer populations. Blood Advances 2023, 7: 445-457. PMID: 35947128, PMCID: PMC9979716, DOI: 10.1182/bloodadvances.2022008168.
- Insights of Endocytosis Signaling in Health and DiseasePathak C, Vaidya F, Waghela B, Jaiswara P, Gupta V, Kumar A, Rajendran B, Ranjan K. Insights of Endocytosis Signaling in Health and Disease. International Journal Of Molecular Sciences 2023, 24: 2971. PMID: 36769293, PMCID: PMC9918140, DOI: 10.3390/ijms24032971.
- Green synthesis of gold nanoparticles using Halymenia pseudofloresii extracts and their antioxidant, antimicrobial, and anti-cancer activitiesPalaniyandi T, Viswanathan S, Prabhakaran P, Baskar G, Wahab M, Sivaji A, Ravi M, Rajendran B, Moovendhan M, Surendran H, Kumarasamy S. Green synthesis of gold nanoparticles using Halymenia pseudofloresii extracts and their antioxidant, antimicrobial, and anti-cancer activities. Biomass Conversion And Biorefinery 2023, 1-12. DOI: 10.1007/s13399-023-03873-y.
- Biosynthesis of iron nanoparticles using brown algae Spatoglossum asperum and its antioxidant and anticancer activities through in vitro and in silico studiesPalaniyandi T, Baskar G, V B, Viswanathan S, Abdul Wahab M, Govindaraj M, Sivaji A, Rajendran B, Kaliamoorthy S. Biosynthesis of iron nanoparticles using brown algae Spatoglossum asperum and its antioxidant and anticancer activities through in vitro and in silico studies. Particulate Science And Technology 2023, 41: 916-929. DOI: 10.1080/02726351.2022.2159900.
- Synthesis, characterization, cytotoxicity, and antimicrobial studies of green synthesized silver nanoparticles using red seaweed Champia parvulaViswanathan S, Palaniyandi T, Shanmugam R, Karunakaran S, Pandi M, Wahab M, Baskar G, Rajendran B, Sivaji A, Moovendhan M. Synthesis, characterization, cytotoxicity, and antimicrobial studies of green synthesized silver nanoparticles using red seaweed Champia parvula. Biomass Conversion And Biorefinery 2023, 14: 7387-7400. DOI: 10.1007/s13399-023-03775-z.
- Prospect and retrospect of 3D bio-printingPrabhakaran P, Palaniyandi T, Kanagavalli B, kumar V, Hari R, Sandhiya V, Baskar G, Rajendran B, Sivaji A. Prospect and retrospect of 3D bio-printing. Acta Histochemica 2022, 124: 151932. PMID: 36027838, DOI: 10.1016/j.acthis.2022.151932.
- Gene expressions and their significance in organoid cultures obtained from breast cancer patient-derived biopsiesPranav P, Palaniyandi T, Baskar G, Ravi M, Rajendran B, Sivaji A, Ranganathan M. Gene expressions and their significance in organoid cultures obtained from breast cancer patient-derived biopsies. Acta Histochemica 2022, 124: 151910. PMID: 35667159, DOI: 10.1016/j.acthis.2022.151910.
- Biogenic synthesis of gold nanoparticles using red seaweed Champia parvula and its anti-oxidant and anticarcinogenic activity on lung cancerViswanathan S, Palaniyandi T, Kannaki P, Shanmugam R, Baskar G, Rahaman A, Paul L, Rajendran B, Sivaji A. Biogenic synthesis of gold nanoparticles using red seaweed Champia parvula and its anti-oxidant and anticarcinogenic activity on lung cancer. Particulate Science And Technology 2022, 41: 241-249. DOI: 10.1080/02726351.2022.2074926.
- Development of patient derived organoids for cancer drug screening applicationsBaskar G, Palaniyandi T, Viswanathan S, Rajendran B, Ravi M, Sivaji A. Development of patient derived organoids for cancer drug screening applications. Acta Histochemica 2022, 124: 151895. PMID: 35486967, DOI: 10.1016/j.acthis.2022.151895.
- Biomedical potential of silver nanoparticles capped with active ingredients of Hypnea valentiae, red algae speciesViswanathan S, Palaniyandi T, Shanmugam R, M T, Rajendran B, Sivaji A. Biomedical potential of silver nanoparticles capped with active ingredients of Hypnea valentiae, red algae species. Particulate Science And Technology 2021, 40: 686-696. DOI: 10.1080/02726351.2021.1992059.
- Molecular landscape and subtype-specific therapeutic response of nasopharyngeal carcinoma revealed by integrative pharmacogenomicsDing R, Chen P, Rajendran B, Lyu X, Wang H, Bao J, Zeng J, Hao W, Sun H, Wong A, Valecha M, Yang E, Su S, Choi T, Liu S, Chan K, Yang L, Wu J, Miao K, Chen Q, Shim J, Xu X, Deng C. Molecular landscape and subtype-specific therapeutic response of nasopharyngeal carcinoma revealed by integrative pharmacogenomics. Nature Communications 2021, 12: 3046. PMID: 34031426, PMCID: PMC8144567, DOI: 10.1038/s41467-021-23379-3.
- Accelerating precision anti-cancer therapy by time-lapse and label-free 3D tumor slice culture platformXing F, Liu Y, Huang S, Lyu X, Su S, Chan U, Wu P, Yan Y, Ai N, Li J, Zhao M, Rajendran B, Liu J, Shao F, Sun H, Choi T, Zhu W, Luo G, Liu S, Xu D, Chan K, Zhao Q, Miao K, Luo K, Ge W, Xu X, Wang G, Liu T, Deng C. Accelerating precision anti-cancer therapy by time-lapse and label-free 3D tumor slice culture platform. Theranostics 2021, 11: 9415-9430. PMID: 34646378, PMCID: PMC8490519, DOI: 10.7150/thno.59533.
- Ethnic-specific BRCA1/2 variation within Asia population: evidence from over 78 000 cancer and 40 000 non-cancer cases of Indian, Chinese, Korean and Japanese populationsBhaskaran S, Huang T, Rajendran B, Guo M, Luo J, Qin Z, Zhao B, Chian J, Li S, Wang S. Ethnic-specific BRCA1/2 variation within Asia population: evidence from over 78 000 cancer and 40 000 non-cancer cases of Indian, Chinese, Korean and Japanese populations. Journal Of Medical Genetics 2020, 58: 752-759. PMID: 32963034, DOI: 10.1136/jmedgenet-2020-107299.
- NOTCH1 activation compensates BRCA1 deficiency and promotes triple-negative breast cancer formationMiao K, Lei J, Valecha M, Zhang A, Xu J, Wang L, Lyu X, Chen S, Miao Z, Zhang X, Su S, Shao F, Rajendran B, Bao J, Zeng J, Sun H, Chen P, Tan K, Chen Q, Wong K, Xu X, Deng C. NOTCH1 activation compensates BRCA1 deficiency and promotes triple-negative breast cancer formation. Nature Communications 2020, 11: 3256. PMID: 32591500, PMCID: PMC7320176, DOI: 10.1038/s41467-020-16936-9.
- Pharmacoinformatic Approach to Explore the Antidote Potential of Phytochemicals on Bungarotoxin from Indian Krait, Bungarus caeruleusRajendran B, Suresh M, Bhaskaran S, Harshitha Y, Gaur U, Kwok H. Pharmacoinformatic Approach to Explore the Antidote Potential of Phytochemicals on Bungarotoxin from Indian Krait, Bungarus caeruleus. Computational And Structural Biotechnology Journal 2018, 16: 450-461. PMID: 30455855, PMCID: PMC6231056, DOI: 10.1016/j.csbj.2018.10.005.
- comprehensive genomic meta-analysis identifies confirmatory role of OBSCN gene in breast tumorigenesisRajendran B, Deng C. comprehensive genomic meta-analysis identifies confirmatory role of OBSCN gene in breast tumorigenesis. Oncotarget 2017, 5: 102263-102276. PMID: 29254242, PMCID: PMC5731952, DOI: 10.18632/oncotarget.20404.
- Characterization of potential driver mutations involved in human breast cancer by computational approachesRajendran B, Deng C. Characterization of potential driver mutations involved in human breast cancer by computational approaches. Oncotarget 2017, 5: 50252-50272. PMID: 28477017, PMCID: PMC5564847, DOI: 10.18632/oncotarget.17225.