Weiwei (Wendy) Wang
Biotechnology Associate – 2Cards
About
Research
Publications
2026
Urine Metabolism Biomarkers Predict Preterm Infant Adiposity at Hospital Discharge
Buck C, McCollum S, Wang W, Lam T, Taylor S, Shabanova V. Urine Metabolism Biomarkers Predict Preterm Infant Adiposity at Hospital Discharge. Molecular Nutrition & Food Research 2026, 70: e70431. PMID: 41817366, PMCID: PMC12981208, DOI: 10.1002/mnfr.70431.Peer-Reviewed Original ResearchConceptsInfant adiposityDM groupTriceps skin fold thicknessHospital dischargeUrinary metabolite patternsMid-arm circumferenceSkin fold thicknessBody composition assessmentEarly metabolic changesUrinary amino acidsPostnatal adiposityPreterm groupGestational ageNewborn periodMetabolomics assayArm circumferencePretermFold thicknessUrinary metabolitesInfantsMetabolite patternsMetabolic changesAcylcarnitine concentrationsComposition assessmentUrine samples
2025
TurboID‐Mediated Profiling of Glioblastoma‐Derived Extracellular Vesicle Cargo Proteins
Russo M, Norton E, Ulloa‐Navas M, Zarco N, Wang W, Lam T, Quiñones‐Hinojosa A, Belzil V, Guerrero‐Cázares H. TurboID‐Mediated Profiling of Glioblastoma‐Derived Extracellular Vesicle Cargo Proteins. Journal Of Extracellular Vesicles 2025, 14: e70158. PMID: 40985879, PMCID: PMC12456098, DOI: 10.1002/jev2.70158.Peer-Reviewed Original ResearchConceptsBrain tumor-initiating cellsEfficient biotinylationProteomic analysisExtracellular vesiclesLabeling of proteinsSubventricular zoneHuman brain tumor-initiating cellsEV-mediated communicationNon-cancer cellsTumor-initiating cellsEV protein cargoBehavior of recipient cellsAggressive primary brain tumorPrimary brain tumorDiverse cargoesProtein cargoLimited survival rateTurboIDEV proteinsIdentification of biomarkersPotential therapeutic targetGBM-derived extracellular vesiclesTherapy resistanceTumor microenvironmentRecipient cellsThe Proteomic Landscape of Parkin-Deficient and Parkin-Overexpressing Rat Nucleus Accumbens: An Insight into the Role of Parkin in Methamphetamine Use Disorder
Sharma A, Atasi T, Collin F, Wang W, Lam T, Garcia-Milian R, Arroum T, Pham L, Hüttemann M, Moszczynska A. The Proteomic Landscape of Parkin-Deficient and Parkin-Overexpressing Rat Nucleus Accumbens: An Insight into the Role of Parkin in Methamphetamine Use Disorder. Biomolecules 2025, 15: 958. PMID: 40723830, PMCID: PMC12292523, DOI: 10.3390/biom15070958.Peer-Reviewed Original ResearchConceptsMETH use disorderMethamphetamine use disorderNucleus accumbensAddictive behaviorsUse disorderAdult Long-Evans male ratsLong-Evans male ratsProteomic landscapeRat nucleus accumbensMale ratsFDA-approved pharmacotherapiesActin cytoskeleton dynamicsYoung adult male ratsDrug targetsAdult male ratsAMPA receptor traffickingRat modelLabel-free proteomicsGABAergic neurotransmissionCytoskeleton dynamicsMethamphetamineUbiquitinated proteinsMitochondrial respirationAccumbensParkin deficiencyA multi-omic approach implicates novel protein dysregulation in post-traumatic stress disorder
Wang J, Liu Y, Li H, Nguyen T, Soto-Vargas J, Wilson R, Wang W, Lam T, Zhang C, Lin C, Lewis D, Glausier J, Holtzheimer P, Friedman M, Williams K, Picciotto M, Nairn A, Krystal J, Duman R, Young K, Zhao H, Girgenti M. A multi-omic approach implicates novel protein dysregulation in post-traumatic stress disorder. Genome Medicine 2025, 17: 43. PMID: 40301990, PMCID: PMC12042318, DOI: 10.1186/s13073-025-01473-1.Peer-Reviewed Original ResearchConceptsPost-traumatic stress disorderDorsolateral prefrontal cortexPsychiatric disordersAutism spectrum disorderPrefrontal cortexDepressive disorderStress disorderGamma-aminobutyric acidGenome-wide association studiesPTSD brainsGenome-wide measurementsStudies of postmortem brainsSubgenual prefrontal cortexDisabling psychiatric disorderMultiple psychiatric disordersPrefrontal cortical areasPTSD casesHuman brain studiesBrain regionsSpectrum disorderGABAergic processesPostmortem brainsMDDProtein co-expression modulesProteomic profilingUnbiased CSF Proteomics in Patients With Idiopathic Normal Pressure Hydrocephalus to Identify Molecular Signatures and Candidate Biomarkers
de Geus M, Wu C, Dodge H, Leslie S, Wang W, Lam T, Kahle K, Chan D, Kivisäkk P, Nairn A, Arnold S, Carlyle B. Unbiased CSF Proteomics in Patients With Idiopathic Normal Pressure Hydrocephalus to Identify Molecular Signatures and Candidate Biomarkers. Neurology 2025, 104: e213375. PMID: 39951680, PMCID: PMC11837848, DOI: 10.1212/wnl.0000000000213375.Peer-Reviewed Original ResearchConceptsNeuronal pentraxin receptorIdiopathic normal pressure hydrocephalusTranscriptome dataAlzheimer's diseaseDifferential expression of proteinsGene ontology analysisDifferential expression analysisGene Set Enrichment AnalysisDownregulation of proteinsDifferentially expressed proteinsNormal pressure hydrocephalusBiological process enrichmentExpression of proteinsPotential disease biomarkersOntology analysisProteomic analysis of CSFPathophysiology of idiopathic normal pressure hydrocephalusProteomic analysisProteomic studiesProcess of immune responseEnrichment analysisExpression analysisPressure hydrocephalusDifferential expressionDiagnosis of idiopathic normal pressure hydrocephalusAlterations in newborn metabolite patterns with preterm birth and diabetes in pregnancy
Buck C, McCollum S, Wang W, Lam T, Taylor S, Shabanova V. Alterations in newborn metabolite patterns with preterm birth and diabetes in pregnancy. Pediatric Research 2025, 98: 1023-1032. PMID: 39824937, PMCID: PMC12267566, DOI: 10.1038/s41390-025-03844-1.Peer-Reviewed Original ResearchPreterm infantsCardiometabolic outcomesMetabolite patternsStudy of termMetabolic changesInfluence of prematuritySkin fold thickness measurementsCohort of infantsUnique metabolic signatureNon-DM groupAdipose developmentExposure to diabetesArm circumference measurementsBody composition assessmentAssociated with adiposityBody fat percentAdverse growthDM exposurePreterm birthTargeted metabolomicsInfant bloodTerm groupDM groupGA groupPreterm
2024
Machine learning on unbiased proteomics of cerebrospinal fluid uncovers differential molecular signatures of Alzheimer’s disease and Normal Pressure Hydrocephalus
de Geus M, Wu C, Dodge H, Leslie S, Wang W, Lam T, Nairn A, Kivisäkk P, Arnold S, Carlyle B. Machine learning on unbiased proteomics of cerebrospinal fluid uncovers differential molecular signatures of Alzheimer’s disease and Normal Pressure Hydrocephalus. Alzheimer's & Dementia 2024, 20: e091783. PMCID: PMC11714358, DOI: 10.1002/alz.091783.Peer-Reviewed Original ResearchGene Set Enrichment AnalysisAlzheimer's diseaseSignatures of Alzheimer's diseasePathology of ADMolecular signaturesPathways related to glycolysisNormal pressure hydrocephalusImmune response pathwaysGene setsResponse pathwaysData-independent acquisition mass spectrometryMolecular-level investigationsEnrichment analysisProteomic investigationsCerebrospinal fluidMetabolic processesProteome quantificationProteinBERNN: Enhancing classification of Liquid Chromatography Mass Spectrometry data with batch effect removal neural networks
Pelletier S, Leclercq M, Roux-Dalvai F, de Geus M, Leslie S, Wang W, Lam T, Nairn A, Arnold S, Carlyle B, Precioso F, Droit A. BERNN: Enhancing classification of Liquid Chromatography Mass Spectrometry data with batch effect removal neural networks. Nature Communications 2024, 15: 3777. PMID: 38710683, PMCID: PMC11074280, DOI: 10.1038/s41467-024-48177-5.Peer-Reviewed Original ResearchConceptsLC-MS experimentsLC-MSLiquid chromatography mass spectrometry dataComplex biological samplesMass spectrometry dataLiquid chromatography mass spectrometryChromatography mass spectrometryMass spectrometrySpectrometry dataEffective removalBiological samplesExperimental conditionsBatch effect removalSample processing protocolBatch effectsSpectrometryBatch effect correction methodsCorrecting batch effectsRemoval of batch effects
2023
Mass spectrometry on cerebrospinal fluid uncovers association of novel glycolysis biomarkers with Alzheimer’s disease in a complex clinical cohort
de Geus M, Leslie S, Wang W, Lam T, Broekman M, Neefjes S, Nairn A, Carlyle B, Arnold S. Mass spectrometry on cerebrospinal fluid uncovers association of novel glycolysis biomarkers with Alzheimer’s disease in a complex clinical cohort. Alzheimer's & Dementia 2023, 19 DOI: 10.1002/alz.078466.Peer-Reviewed Original ResearchAlzheimer's diseaseMild cognitive impairmentHospital neurology serviceNon-AD diagnosesDiagnostic lumbar puncturePrognosis of ADCerebrospinal fluid biomarkersClinic cohortFurther mechanistic studiesNeurology serviceFDG-PETBrain metabolismFluid biomarkersLumbar puncturePatient cohortClinical indicationsDisease progressionATN biomarkersClinical cohortTreatment responseComplex cohortBackground DiagnosisCSF samplesTreatment efficacyLinear regression analysisMicrobiome Depletion Increases Fentanyl Self-Administration and Alters the Striatal Proteome Through Short-Chain Fatty Acids
Hofford R, Meckel K, Wiser E, Wang W, Sens J, Kim M, Godino A, Lam T, Kiraly D. Microbiome Depletion Increases Fentanyl Self-Administration and Alters the Striatal Proteome Through Short-Chain Fatty Acids. ENeuro 2023, 11: eneuro.0388-23.2023. PMID: 38164564, PMCID: PMC10875718, DOI: 10.1523/eneuro.0388-23.2023.Peer-Reviewed Original Research