Tom Morse, PhD
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Neuroscience
Primary
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Associate Research Scientist in Neuroscience
Appointments
Neuroscience
Associate Research ScientistPrimary
Other Departments & Organizations
- Neuroscience
- Shepherd Lab
Education & Training
- PhD
- University of Colorado at Boulder (1990)
- MS
- University of Colorado at Boulder (1989)
- BS
- Oberlin College (1985)
Research
Research at a Glance
Yale Co-Authors
Frequent collaborators of Tom Morse's published research.
Publications Timeline
A big-picture view of Tom Morse's research output by year.
Robert McDougal, PhD
Jaime Grutzendler, MD
Lei Tong, PhD
Michael J Higley, MD/PhD
Rixin Wang, PhD
6Publications
561Citations
Publications
2022
PLD3 affects axonal spheroids and network defects in Alzheimer’s disease
Yuan P, Zhang M, Tong L, Morse T, McDougal R, Ding H, Chan D, Cai Y, Grutzendler J. PLD3 affects axonal spheroids and network defects in Alzheimer’s disease. Nature 2022, 612: 328-337. PMID: 36450991, PMCID: PMC9729106, DOI: 10.1038/s41586-022-05491-6.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsAxonal spheroidsAlzheimer's diseaseConduction blockadeNeural circuit abnormalitiesNeural network dysfunctionAmyloid removalCircuit abnormalitiesAge-dependent accumulationNetwork dysfunctionEndolysosomal vesiclesMouse modelNeuronal overexpressionCognitive declineAxonal connectivityDiseasePrecise mechanismBlockadePLD3Neural network functionSpheroid growthSevere disruptionCurrent sinkVoltage imagingSize-dependent mannerDysfunction
2016
Respiration Gates Sensory Input Responses in the Mitral Cell Layer of the Olfactory Bulb
Short SM, Morse TM, McTavish TS, Shepherd GM, Verhagen JV. Respiration Gates Sensory Input Responses in the Mitral Cell Layer of the Olfactory Bulb. PLOS ONE 2016, 11: e0168356. PMID: 28005923, PMCID: PMC5179112, DOI: 10.1371/journal.pone.0168356.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsMitral cell layerOlfactory bulbCell layerPeriod of inhalationOdor processingGranule cell layerGranule cell inhibitionSingle-unit recordingsMitral/Inhibitory responsesUnit recordingsAction potentialsMTC responsesRespiratory cycleCell inhibitionSensory processingDiscrete sensory inputsInhibitory mechanismSensory responsesSensory inputInhalationMechanism of inhibitionInhibitory activityInhibitionSensoryTwenty years of ModelDB and beyond: building essential modeling tools for the future of neuroscience
McDougal RA, Morse TM, Carnevale T, Marenco L, Wang R, Migliore M, Miller PL, Shepherd GM, Hines ML. Twenty years of ModelDB and beyond: building essential modeling tools for the future of neuroscience. Journal Of Computational Neuroscience 2016, 42: 1-10. PMID: 27629590, PMCID: PMC5279891, DOI: 10.1007/s10827-016-0623-7.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsComputational neuroscience modelsHigh performance computationEssential modeling toolUser experienceData-based modelsPerformance computationModelDBGraphical toolUser-friendly databaseModeling toolsResearch topicNeuroscience modelsCollect dataNew challengesNeuron modelingConvenient venueMassive developmentComplex modelsNew technologiesLarge research groupsRunning modelFuture of neuroscienceUsersMultiple scalesModel of interest
2013
Compartmentalization of GABAergic Inhibition by Dendritic Spines
Chiu CQ, Lur G, Morse TM, Carnevale NT, Ellis-Davies GC, Higley MJ. Compartmentalization of GABAergic Inhibition by Dendritic Spines. Science 2013, 340: 759-762. PMID: 23661763, PMCID: PMC3752161, DOI: 10.1126/science.1234274.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsGABAergic inhibitionDendritic spinesPerisomatic inhibitory synapsesPyramidal cell dendritesTwo-photon calcium imagingAction potential outputAcid-mediated inhibitionIndividual dendritic spinesGABAergic controlGABAergic synapsesPyramidal neuronsCell dendritesInhibitory synapsesNeuronal activityCalcium imagingSpine headsInhibitory actionNeocortexInhibitionSpineSynapsesCompartmentalized controlCritical roleSignalingPostsynaptic
2010
Abnormal Excitability of Oblique Dendrites Implicated in Early Alzheimer's: A Computational Study
Morse TM, Carnevale NT, Mutalik PG, Migliore M, Shepherd GM. Abnormal Excitability of Oblique Dendrites Implicated in Early Alzheimer's: A Computational Study. Frontiers In Neural Circuits 2010, 4: 16. PMID: 20725509, PMCID: PMC2901152, DOI: 10.3389/fncir.2010.00016.Peer-Reviewed Original ResearchCitationsAltmetricConceptsOblique dendritesCognitive functionEarly Alzheimer'sPyramidal cell dendritesAmyloid beta proteinNeural basisAbnormal excitabilityPyramidal dendritesProximal dendritesDistal dendritesCell dendritesApical trunkAnimal modelsElectrophysiological studiesAction potentialsOblique branchHyperexcitabilityExcessive calcium concentrationsCalcium concentrationEarly exposureIntegrative propertiesBeta proteinEarly declineRecording sitesAlzheimer's
2008
ModelDB in computational neuroscience education - a research tool as interactive educational media.
Morse TM. ModelDB in computational neuroscience education - a research tool as interactive educational media. Brains, Minds & Media : Journal Of New Media In Neural And Cognitive Science And Education 2008, 3: bmm1409. PMID: 25089156, PMCID: PMC4117215.Peer-Reviewed Original ResearchCitations
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