Loss of MINAR2 impairs motor function and causes Parkinson’s disease-like symptoms in mice
Ho R, Amraei R, De La Cena K, Sutherland E, Mortazavi F, Stein T, Chitalia V, Rahimi N. Loss of MINAR2 impairs motor function and causes Parkinson’s disease-like symptoms in mice. Brain Communications 2020, 2: fcaa047. PMID: 32954300, PMCID: PMC7425422, DOI: 10.1093/braincomms/fcaa047.Peer-Reviewed Original ResearchReceptor 2Parkinson's spectrum disordersDisease-like symptomsPars compactaΑ-synuclein protein expressionTyrosine hydroxylase-positive neuronsSubstantia nigra pars compactaFrontal lobe brainParkinson's disease-like symptomsLewy body dementiaImpairs motor functionSevere motor deficitsPrimary clinical symptomsReceptor 2 expressionKnockout mouse brainMotor control impairmentsSpectrum disorderCommon human neurodegenerative diseasesΑ-synuclein aggregationMotor deficitsClinical symptomsDopaminergic neuronsSpontaneous locomotorClinical hallmarkMotor function