Cell adhesion molecule IGPR-1 activates AMPK connecting cell adhesion to autophagy
Amraei R, Alwani T, Ho R, Aryan Z, Wang S, Rahimi N. Cell adhesion molecule IGPR-1 activates AMPK connecting cell adhesion to autophagy. Journal Of Biological Chemistry 2020, 295: 16691-16699. PMID: 32978258, PMCID: PMC7864065, DOI: 10.1074/jbc.ra120.014790.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid MotifsAMP-Activated Protein KinasesAnimalsAutophagyAutophagy-Related Protein-1 HomologBeclin-1CD28 AntigensCell AdhesionHEK293 CellsHumansI-kappa B KinaseIntracellular Signaling Peptides and ProteinsLipopolysaccharidesMicroscopy, FluorescenceMicrotubule-Associated ProteinsPhosphorylationPrimatesRNA, Guide, KinetoplastidaSirolimusSubstrate SpecificityConceptsIGPR-1Cell adhesionCell adhesion molecule IGPR-1Proline-rich receptor-1Serine/threonine kinaseKey serine/threonine kinaseAmino acid starvationBeclin-1Phosphorylation of AMPThreonine kinaseAutophagy stimuliKinase assaysLC3-II levelsCellular stressNutrient deprivationProtein kinaseCell adhesion moleculeProtein ULK1IκB kinase βEndothelial barrier functionKinase βCellular assaysPhosphorylationSubsequent activationCell detachmentCOVID-19, Renin-Angiotensin System and Endothelial Dysfunction
Amraei R, Rahimi N. COVID-19, Renin-Angiotensin System and Endothelial Dysfunction. Cells 2020, 9: 1652. PMID: 32660065, PMCID: PMC7407648, DOI: 10.3390/cells9071652.Peer-Reviewed Original ResearchConceptsRenin-angiotensin systemSARS-CoV-2Acute respiratory distress syndromeSARS-CoV-2 infectionEndothelial dysfunctionVascular damageCell adhesion moleculeSARS-CoV-2-induced acute respiratory distress syndromeCOVID-19Pre-existing endothelial dysfunctionSARS-CoV-2 entryRespiratory distress syndromeEndothelial cell injuryRole of ACE2Coronavirus disease 2019 (COVID-19) outbreakNovel coronavirus disease 2019 (COVID-19) outbreakCD209/DC-SIGNSARS-CoV-2 virusNew therapeutic strategiesDisease 2019 outbreakHuman vascular endotheliumGlobal public healthHost cellsAngiotensin fragmentsDistress syndrome