Paul Gravel
Associate Research ScientistCards
About
Research
Publications
2021
Dopamine D2/3 receptor availability in cocaine use disorder individuals with obesity as measured by [11C]PHNO PET
Matuskey D, Angarita GA, Worhunsky P, Koohsari S, Gravel P, Pittman B, Gaiser EC, Gallezot JD, Nabulsi N, Huang Y, Carson RE, Potenza MN, Malison RT. Dopamine D2/3 receptor availability in cocaine use disorder individuals with obesity as measured by [11C]PHNO PET. Drug And Alcohol Dependence 2021, 220: 108514. PMID: 33454626, PMCID: PMC7889720, DOI: 10.1016/j.drugalcdep.2021.108514.Peer-Reviewed Original Research
2020
Neuroimaging of Obsessive-Compulsive Disorder: Insights into Serotonergic Mechanisms
Lissemore J, Booij L, Leyton M, Gravel P, Sookman D, Nordahl T, Benkelfat C. Neuroimaging of Obsessive-Compulsive Disorder: Insights into Serotonergic Mechanisms. 2020, 457-478. DOI: 10.1007/978-3-030-57231-0_13.Peer-Reviewed Original ResearchSelective serotonin reuptake inhibitorsObsessive-compulsive disorderSerotonin synthesis capacityPositron emission tomographyHealthy controlsPET studiesOCD patientsSerotonin reuptake inhibitorsMost PET studiesBorderline personality disorderCognitive behavior therapySymptom onsetSerotonergic mechanismsClinical benefitSerotonergic toneSerotonergic alterationsSynthesis capacityEmission tomographySuicide attemptsSerotonin transporterPersonality disorderBehavior therapyGroup differencesDisordersPatientsDopaminergic Plasticity in the Bilateral Hippocampus Following Threat Reversal in Humans
Lissemore J, Nagano-Saito A, Smart K, Gravel P, Leyton M, Benkelfat C. Dopaminergic Plasticity in the Bilateral Hippocampus Following Threat Reversal in Humans. Scientific Reports 2020, 10: 7627. PMID: 32376865, PMCID: PMC7203150, DOI: 10.1038/s41598-020-63977-7.Peer-Reviewed Original ResearchConceptsPositron emission tomographyBilateral anterior hippocampusThreat reversalDopamine D2/3 receptor availabilityGreater dopamine releaseD2/3 receptor availabilityStress-related disordersClear clinical relevanceDopaminergic plasticityDopaminergic neurotransmissionHigh-resolution positron emission tomographyBilateral hippocampusDopamine releaseHealthy volunteersNeurochemical mechanismsHealthy humansPET scansClinical relevanceReceptor availabilityModerate evidenceAnterior hippocampusEmission tomographyFirst preliminary evidenceHippocampusDiminished abilityEffects of TOF Resolution Models on Edge Artifacts in PET Reconstruction From Limited-Angle Data
Gravel P, Li Y, Matej S. Effects of TOF Resolution Models on Edge Artifacts in PET Reconstruction From Limited-Angle Data. IEEE Transactions On Radiation And Plasma Medical Sciences 2020, 4: 603-612. PMID: 33163754, PMCID: PMC7643853, DOI: 10.1109/trpms.2020.2989209.Peer-Reviewed Original Research
2019
Effects of TOF Resolution Models on Edge Artifacts in PET Reconstruction from Limited Angle Data
Gravel P, Li Y, Matej S. Effects of TOF Resolution Models on Edge Artifacts in PET Reconstruction from Limited Angle Data. 2019, 00: 1-3. DOI: 10.1109/nss/mic42101.2019.9059970.Peer-Reviewed Original ResearchSpatially-variant image-based modeling of PSF deformations with application to a limited angle geometry from a dual-panel breast-PET imager
Gravel P, Surti S, Krishnamoorthy S, Karp J, Matej S. Spatially-variant image-based modeling of PSF deformations with application to a limited angle geometry from a dual-panel breast-PET imager. Physics In Medicine And Biology 2019, 64: 225015. PMID: 31569078, PMCID: PMC7236960, DOI: 10.1088/1361-6560/ab4914.Peer-Reviewed Original ResearchConceptsRealistic breast modelResolution modelingConsiderable deformationImage-based modelingDeformationSystem configurationPoint spread functionLimited angle geometryDirect image reconstructionBreast modelFlight methodRMSE valuesAngle geometryConsistent performanceOverall errorPerformanceModelingAccurate lesion locationImage reconstructionConsiderable improvementReconstructed imagesQuantitative performanceDeconvolution methodHigh-count dataLow-count data
2018
Spatially-Variant Image-Based Modeling of PSF Deformations with Application to Limited Angle Dual-Panel Breast-PET Data
Gravel P, Surti S, Krishnamoorthy S, Karp J, Matej S. Spatially-Variant Image-Based Modeling of PSF Deformations with Application to Limited Angle Dual-Panel Breast-PET Data. 2018, 00: 1-3. DOI: 10.1109/nssmic.2018.8824650.Peer-Reviewed Original ResearchBrain serotonin synthesis capacity in obsessive-compulsive disorder: effects of cognitive behavioral therapy and sertraline
Lissemore J, Sookman D, Gravel P, Berney A, Barsoum A, Diksic M, Nordahl T, Pinard G, Sibon I, Cottraux J, Leyton M, Benkelfat C. Brain serotonin synthesis capacity in obsessive-compulsive disorder: effects of cognitive behavioral therapy and sertraline. Translational Psychiatry 2018, 8: 82. PMID: 29666372, PMCID: PMC5904107, DOI: 10.1038/s41398-018-0128-4.Peer-Reviewed Original ResearchConceptsSerotonin synthesis capacitySelective serotonin reuptake inhibitorsCognitive behavioral therapyObsessive-compulsive disorderPartial respondersTreatment modalitiesMedication-free OCD patientsBehavioral therapyOCD patientsSerotonin reuptake inhibitorsWeeks of treatmentRegional tracer uptakePost-treatment changesPositron emission tomographySynthesis capacityClinical improvementSSRI treatmentReuptake inhibitorsSertraline treatmentSymptom improvementRaphe nucleusNeurochemical changesSerotonergic toneSymptom responseEffective treatment
2017
Quantification of brain cholinergic denervation in Alzheimer’s disease using PET imaging with [18F]-FEOBV
Aghourian M, Legault-Denis C, Soucy J, Rosa-Neto P, Gauthier S, Kostikov A, Gravel P, Bédard M. Quantification of brain cholinergic denervation in Alzheimer’s disease using PET imaging with [18F]-FEOBV. Molecular Psychiatry 2017, 22: 1531-1538. PMID: 28894304, DOI: 10.1038/mp.2017.183.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAlzheimer DiseaseAmyloid beta-PeptidesBrainCase-Control StudiesCholinergic AgentsCholinergic NeuronsFemaleFluorodeoxyglucose F18HumansMaleMiddle AgedPiperidinesPositron-Emission TomographyPresynaptic TerminalsRadioactive TracersVesicular Acetylcholine Transport ProteinsConceptsMini-Mental State ExaminationStandardized uptake value ratioAlzheimer's diseaseCortical areasPresynaptic cholinergic nerve terminalsAmyloid-beta tracerNumerous cortical areasCognitive scalesCholinergic nerve terminalsUptake value ratioVesicular acetylcholine transporterMultiple cortical areasNew PET radiotracersVoxel-wise t-testsCholinergic denervationCholinergic terminalsCholinergic degenerationControl subjectsAD patientsCholinergic lossNerve terminalsAD groupHealthy subjectsAcetylcholine transporterAD subjectsAltered Regional Cerebral Blood Flow in Idiopathic Hypersomnia
Boucetta S, Montplaisir J, Zadra A, Lachapelle F, Soucy J, Gravel P, Dang-Vu T. Altered Regional Cerebral Blood Flow in Idiopathic Hypersomnia. Sleep 2017, 40: zsx140. PMID: 28958044, DOI: 10.1093/sleep/zsx140.Peer-Reviewed Original ResearchConceptsRegional cerebral blood flowCerebral blood flowIdiopathic hypersomniaBlood flowMedial prefrontal cortexSingle photon emissionDaytime sleepinessAltered regional cerebral blood flowRegional cerebral blood flow distributionRegional cerebral blood flow changesCerebral blood flow decreasesRegional cerebral blood flow decreasesCerebral blood flow distributionPrefrontal cortexCerebral blood flow changesBlood flow decreaseBrain perfusion patternsExcessive daytime sleepinessEye movement sleepBlood flow changesBlood flow distributionTemporo-occipital cortexAcute sleep deprivationPhoton emissionPosterior cingulate cortex
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