Nadya Dimitrova, PhD
Associate Professor on Term of Molecular, Cellular and Developmental BiologyCards
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Associate Professor on Term of Molecular, Cellular and Developmental Biology
Biography
Nadya Dimitrova is an Assistant Professor in the Department of Molecular, Cellular, and Developmental Biology at Yale University. Her research focuses on the functional characterization of tumor suppressor and oncogenic long non-coding RNAs and their roles in the regulation of the cancer transcriptome. Originally from Sofia, Bulgaria, Nadya graduated with an Sc.B. in Biochemistry from Brown University in 2002. She joined the graduate program at The Rockefeller University and in 2009 received a Ph.D. for her work on the signaling and repair of dysfunctional telomeres in the laboratory of Dr. Titia de Lange. For her graduate work, Nadya was awarded the Harold M. Weintraub Graduate Student Award. As a postdoctoral fellow, Nadya joined the laboratory of Dr. Tyler Jacks at the Koch Institute for Integrative Cancer Research at MIT where she developed genetic mouse models to study long non-coding RNAs in cancer biology. Nadya is the recipient of the HHMI Predoctoral Fellowship, the Damon Runyon Postdoctoral Fellowship Award, the Lung Cancer Research Foundation 2016 Scientific Merit Award, the V Scholar Award, and the Pew-Stewart Scholar for Cancer Research Award.
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Genetics
Associate Professor on TermSecondary
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Education & Training
- PhD
- The Rockefeller University (2009)
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ORCID
0000-0002-5983-1496- View Lab Website
Nadya Dimitrova Lab
Research at a Glance
Yale Co-Authors
Publications Timeline
Antariksh Tyagi, PhD
Camila Robles-Oteiza
Clara Liao, BA
James Knight, PhD
Katerina Politi, PhD
Publications
2025
Long noncoding RNA-dependent control of Myc transcriptional bursting
Li Q, Dilsavor C, Gahramanov V, Floyd E, Ding J, Glynn J, Chiotakakos I, Olivero C, Zamudio J, Dimitrova N. Long noncoding RNA-dependent control of Myc transcriptional bursting. Cell Reports 2025, 44: 116439. PMID: 41105511, PMCID: PMC12606467, DOI: 10.1016/j.celrep.2025.116439.Peer-Reviewed Original ResearchCitationsAltmetricActivation of Pvt1b isoform contributes to local Pvt1 abundance to repress Myc during stress
Li Q, Olivero C, Floyd E, Ding J, Dangelmaier E, Knight J, Dimitrova N. Activation of Pvt1b isoform contributes to local Pvt1 abundance to repress Myc during stress. PLOS Genetics 2025, 21: e1011790. PMID: 40743223, PMCID: PMC12312954, DOI: 10.1371/journal.pgen.1011790.Peer-Reviewed Original ResearchCitationsAltmetric
2024
Challenges in LncRNA Biology: Views and Opinions
Adjeroh D, Zhou X, Paschoal A, Dimitrova N, Derevyanchuk E, Shkurat T, Loeb J, Martinez I, Lipovich L. Challenges in LncRNA Biology: Views and Opinions. Non-Coding RNA 2024, 10: 43. PMID: 39195572, PMCID: PMC11357347, DOI: 10.3390/ncrna10040043.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitationsAltmetricOverexpression of Malat1 drives metastasis through inflammatory reprogramming of the tumor microenvironment
Martinez-Terroba E, Plasek-Hegde L, Chiotakakos I, Li V, de Miguel F, Robles-Oteiza C, Tyagi A, Politi K, Zamudio J, Dimitrova N. Overexpression of Malat1 drives metastasis through inflammatory reprogramming of the tumor microenvironment. Science Immunology 2024, 9: eadh5462-eadh5462. PMID: 38875320, PMCID: PMC12087577, DOI: 10.1126/sciimmunol.adh5462.Peer-Reviewed Original ResearchCitationsAltmetricTherapeutic Inhibition of LincRNA-p21 Protects Against Cardiac Hypertrophy
Wang Y, Zhang M, Wang R, Lin J, Ma Q, Guo H, Huang H, Liang Z, Cao Y, Zhang X, Lu Y, Liu J, Xiao F, Yan H, Dimitrova N, Huang Z, Mably J, Pu W, Wang D. Therapeutic Inhibition of LincRNA-p21 Protects Against Cardiac Hypertrophy. Circulation Research 2024, 135: 434-449. PMID: 38864216, PMCID: PMC11257812, DOI: 10.1161/circresaha.123.323356.Peer-Reviewed Original ResearchCitationsAltmetricTranscription regulation by long non-coding RNAs: mechanisms and disease relevance
Ferrer J, Dimitrova N. Transcription regulation by long non-coding RNAs: mechanisms and disease relevance. Nature Reviews Molecular Cell Biology 2024, 25: 396-415. PMID: 38242953, PMCID: PMC11045326, DOI: 10.1038/s41580-023-00694-9.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitationsAltmetric
2021
The p53 transcriptional response across tumor types reveals core and senescence-specific signatures modulated by long noncoding RNAs
Tesfaye E, Martinez-Terroba E, Bendor J, Winkler L, Olivero C, Chen K, Feldser DM, Zamudio JR, Dimitrova N. The p53 transcriptional response across tumor types reveals core and senescence-specific signatures modulated by long noncoding RNAs. Proceedings Of The National Academy Of Sciences Of The United States Of America 2021, 118: e2025539118. PMID: 34326251, PMCID: PMC8346867, DOI: 10.1073/pnas.2025539118.Peer-Reviewed Original ResearchCitationsAltmetricMeSH KeywordsAnimalsCarcinogenesisCell Line, TumorCell ProliferationCellular SenescenceDNA DamageE2F Transcription FactorsGene Expression Regulation, NeoplasticGenome-Wide Association StudyMiceNeoplasmsProto-Oncogene Proteins c-mycRNA, Long NoncodingSignal TransductionStress, PhysiologicalTumor Suppressor Protein p53
2020
Identification and characterization of functional long noncoding RNAs in cancer
Olivero CE, Dimitrova N. Identification and characterization of functional long noncoding RNAs in cancer. The FASEB Journal 2020, 34: 15630-15646. PMID: 33058262, PMCID: PMC7756267, DOI: 10.1096/fj.202001951r.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitationsAltmetricp53 Activates the Long Noncoding RNA Pvt1b to Inhibit Myc and Suppress Tumorigenesis
Olivero CE, MartÃnez-Terroba E, Zimmer J, Liao C, Tesfaye E, Hooshdaran N, Schofield JA, Bendor J, Fang D, Simon MD, Zamudio JR, Dimitrova N. p53 Activates the Long Noncoding RNA Pvt1b to Inhibit Myc and Suppress Tumorigenesis. Molecular Cell 2020, 77: 761-774.e8. PMID: 31973890, PMCID: PMC7184554, DOI: 10.1016/j.molcel.2019.12.014.Peer-Reviewed Original ResearchCitationsAltmetricMeSH KeywordsAnimalsCarcinogenesisCell LineCell ProliferationCells, CulturedChromatinEnhancer Elements, GeneticGene Expression RegulationHumansLung NeoplasmsMiceMice, Inbred C57BLPromoter Regions, GeneticProto-Oncogene MasProto-Oncogene Proteins c-mycRNA, Long NoncodingStress, PhysiologicalTumor Suppressor Protein p53
2018
Chapter 16 Genetic Variations of Long Noncoding RNAs in Cancer
Dimitrova N. Chapter 16 Genetic Variations of Long Noncoding RNAs in Cancer. 2018, 289-308. DOI: 10.1016/b978-0-12-811022-5.00016-4.BooksCitations
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