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Nadia Ameen, MBBS

Professor of Pediatrics (Gastroenterology)
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Additional Titles

Affiliated Faculty, Yale Institute for Global Health

Contact Info

Pediatric Gastroenterology & Hepatology

PO Box 208064

New Haven, CT 06520-8064

United States

About

Titles

Professor of Pediatrics (Gastroenterology)

Affiliated Faculty, Yale Institute for Global Health

Biography

I am a URM physician-scientist and Professor of Pediatrics (Gastroenterology), Cellular and Molecular Physiology at the Yale University School of Medicine. I have led an NIH-supported laboratory for over 2 decades and trained multiple undergraduate students, post-docs, medical students and research scientists, the majority of whom come from under-represented backgrounds. My research interest is focused on mechanisms responsible for diarrheal diseases. My lab primarily investigates mechanisms regulating the CFTR chloride channel in the intestine and how these are linked to genetic, and non-genetic diarrheal diseases and Cystic Fibrosis (CF). We elucidated trafficking mechanisms regulating CFTR that are implicated in diarrhea that are the basis for successful drug therapies to treat constipation and increase intestinal fluidity (Linaclotide, Lubiprostone). Currently, we investigate kinase signaling mechanisms responsible for regulating CFTR in genetic and non genetic diarrheal diseases and CF affecting newborns and children.

My clinical practice is focused on food and gut health in children to treat and prevent obesity, and chronic lifestyle diseases. We promote the use of healthy food for prevention of intestinal diseases in children, provide nutritional consultation, and design culturally sensitive diets for parents. We provide conventional standard of care along side nutritional promotion as needed, but focus on foods, exercise, stress reduction and lifestyle as a primary modalities for disease treatment and prevention.

Appointments

Other Departments & Organizations

Education & Training

MBBS
University of West Indies (1985)

Research

Overview

Our early studies focussed on identification of trafficking as a major mechanism regulating CFTR in the intestine and its relevance to secretory diarrhea. More recently, we investigate a rare genetic diarrheal disease that affect new borns, Microvillus Inclusion Disease(MVID). We were first to show that MVID results from an apical trafficking defect. Current investigations are elucidating kinase signaling mechanisms regulating ion transport that result in diarrhea in MVID.

Medical Subject Headings (MeSH)

Antidiarrheals; Intestinal Diseases

Research at a Glance

Yale Co-Authors

Frequent collaborators of Nadia Ameen's published research.

Publications

2024

2023

2022

2021

Academic Achievements & Community Involvement

  • activity

    Physiological Reports

  • honor

    NASPGHAN Award for Study of Disorders Associated with Carbohydrate Malabsorption

Get In Touch

Contacts

Academic Office Number
Appointment Number
Mailing Address

Pediatric Gastroenterology & Hepatology

PO Box 208064

New Haven, CT 06520-8064

United States

Locations