Timothy Nottoli, PhD
Senior Research Scientist in Comparative MedicineCards
About
Research
Publications
2025
GDF3 promotes adipose tissue macrophage-mediated inflammation via altered chromatin accessibility during aging
Jang I, Carey A, Kruglov V, Nguyen K, Misialek J, Cholensky S, Smith D, Bai S, Nottoli T, Bernlohr D, Lutsey P, Camell C. GDF3 promotes adipose tissue macrophage-mediated inflammation via altered chromatin accessibility during aging. Nature Aging 2025, 6: 127-142. PMID: 41398392, PMCID: PMC12823384, DOI: 10.1038/s43587-025-01034-6.Peer-Reviewed Original ResearchA versatile cohesion manipulation system probes female reproductive age-related egg aneuploidy
Leem J, Lemonnier T, Khutsaidze A, Tian L, Xing X, Bai S, Nottoli T, Mogessie B. A versatile cohesion manipulation system probes female reproductive age-related egg aneuploidy. Nature Aging 2025, 5: 2215-2227. PMID: 41184483, PMCID: PMC12618256, DOI: 10.1038/s43587-025-00997-w.Peer-Reviewed Original ResearchAuthor Correction: CpG island turnover events predict evolutionary changes in enhancer activity
Kocher A, Dutrow E, Uebbing S, Yim K, Larios M, Baumgartner M, Nottoli T, Noonan J. Author Correction: CpG island turnover events predict evolutionary changes in enhancer activity. Genome Biology 2025, 26: 363. PMID: 41126355, PMCID: PMC12548154, DOI: 10.1186/s13059-025-03834-w.Commentaries, Editorials and LettersCell-type-specific dysregulation of gene expression due to Chd8 haploinsufficiency during mouse cortical development
Yim K, Baumgartner M, Krenzer M, Larios M, Hill-TerĂ¡n G, Nottoli T, Muhle R, Noonan J. Cell-type-specific dysregulation of gene expression due to Chd8 haploinsufficiency during mouse cortical development. Cell Genomics 2025, 5: 100986. PMID: 40967226, PMCID: PMC12648110, DOI: 10.1016/j.xgen.2025.100986.Peer-Reviewed Original ResearchHeterozygosity for neurodevelopmental disorder-associated TRIO variants yields distinct deficits in behavior, neuronal development, and synaptic transmission in mice
Ishchenko Y, Jeng A, Feng S, Nottoli T, Manriquez-Rodriguez C, Nguyen K, Carrizales M, Vitarelli M, Corcoran E, Greer C, Myers S, Koleske A. Heterozygosity for neurodevelopmental disorder-associated TRIO variants yields distinct deficits in behavior, neuronal development, and synaptic transmission in mice. ELife 2025, 13: rp103620. PMID: 40488445, PMCID: PMC12148328, DOI: 10.7554/elife.103620.Peer-Reviewed Original ResearchHeterozygosity for neurodevelopmental disorder-associated TRIO variants yields distinct deficits in behavior, neuronal development, and synaptic transmission in mice
Ishchenko Y, Jeng A, Feng S, Nottoli T, Manriquez-Rodriguez C, Nguyen K, Carrizales M, Vitarelli M, Corcoran E, Greer C, Myers S, Koleske A. Heterozygosity for neurodevelopmental disorder-associated TRIO variants yields distinct deficits in behavior, neuronal development, and synaptic transmission in mice. ELife 2025, 13 DOI: 10.7554/elife.103620.3.Peer-Reviewed Original ResearchCas12a-knock-in mice for multiplexed genome editing, disease modelling and immune-cell engineering
Tang K, Zhou L, Tian X, Fang S, Vandenbulcke E, Du A, Shen J, Cao H, Zhou J, Chen K, Kim H, Luo Z, Xin S, Lin S, Park D, Yang L, Zhang Y, Suzuki K, Majety M, Ling X, Lam S, Chow R, Ren P, Tao B, Li K, Codina A, Dai X, Shang X, Bai S, Nottoli T, Levchenko A, Booth C, Liu C, Fan R, Dong M, Zhou X, Chen S. Cas12a-knock-in mice for multiplexed genome editing, disease modelling and immune-cell engineering. Nature Biomedical Engineering 2025, 9: 1290-1308. PMID: 40114032, PMCID: PMC12360953, DOI: 10.1038/s41551-025-01371-2.Peer-Reviewed Original Research
2024
Evolutionary Innovations in Conserved Regulatory Elements Associate With Developmental Genes in Mammals
Uebbing S, Kocher A, Baumgartner M, Ji Y, Bai S, Xing X, Nottoli T, Noonan J. Evolutionary Innovations in Conserved Regulatory Elements Associate With Developmental Genes in Mammals. Molecular Biology And Evolution 2024, 41: msae199. PMID: 39302728, PMCID: PMC11465374, DOI: 10.1093/molbev/msae199.Peer-Reviewed Original ResearchCellular stiffness sensing through talin 1 in tissue mechanical homeostasis
Chanduri M, Kumar A, Weiss D, Emuna N, Barsukov I, Shi M, Tanaka K, Wang X, Datye A, Kanyo J, Collin F, Lam T, Schwarz U, Bai S, Nottoli T, Goult B, Humphrey J, Schwartz M. Cellular stiffness sensing through talin 1 in tissue mechanical homeostasis. Science Advances 2024, 10: eadi6286. PMID: 39167642, PMCID: PMC11338229, DOI: 10.1126/sciadv.adi6286.Peer-Reviewed Original ResearchCpG island turnover events predict evolutionary changes in enhancer activity
Kocher A, Dutrow E, Uebbing S, Yim K, Rosales Larios M, Baumgartner M, Nottoli T, Noonan J. CpG island turnover events predict evolutionary changes in enhancer activity. Genome Biology 2024, 25: 156. PMID: 38872220, PMCID: PMC11170920, DOI: 10.1186/s13059-024-03300-z.Peer-Reviewed Original Research
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