Michael Murrell
Associate Professor TenureCards
About
Research
Publications
2026
Crosslinked F-actin networks regulate load-dependent energy conversion
Sakamoto R, Sun Z, Murrell M. Crosslinked F-actin networks regulate load-dependent energy conversion. Communications Biology 2026 PMID: 41807603, DOI: 10.1038/s42003-026-09843-0.Peer-Reviewed Original ResearchMotor proteinsActin-crosslinking proteinsF-actin networkCellular energy conversionLoad-dependent behaviorActin crosslinkingFilament polarityActomyosin networkEnergy conversionFilament cytoskeletonCytoskeletal architectureHydrolysis of adenosine triphosphateCrosslinking proteinsAdenosine triphosphateCellular environmentEmbryonic developmentATP consumptionProteinMechanical power generationActinMechanical propertiesNetwork stiffnessCrosslinked networkForce generationPower generationTopological control of spontaneous failure in active nematic solids
Chen S, Ricci M, Tabatabai A, Sun Z, Witthaus S, Shankar S, Nitzan M, Murrell M. Topological control of spontaneous failure in active nematic solids. Nature Materials 2026, 1-8. PMID: 41741734, DOI: 10.1038/s41563-026-02493-x.Peer-Reviewed Original ResearchDefect-mediated mechanismTopological defectsNon-equilibrium forcesActive solidsTopological design principlesNematic orderControlled breakageCrack openingEnergy influxMaterial tearingQuadrupoleSpontaneous failureInternal stressActive materialNematic solidsFracture modelNetwork elasticityMechanical failureExperimental dataTopology controlTopological structureFilament clustersSolidsDesign principlesCrack
2025
Feedback between F-actin organization and active stress governs criticality and energy localization in the cell cytoskeleton
Sun Z, Zimmerberg N, Kelly P, Floyd C, Papoian G, Murrell M. Feedback between F-actin organization and active stress governs criticality and energy localization in the cell cytoskeleton. Nature Physics 2025, 21: 1290-1302. DOI: 10.1038/s41567-025-02919-4.Peer-Reviewed Original ResearchF-actin organizationF-actinNucleation-promoting factorsMyosin II motorsF-actin filamentsDynamic structural reorganizationActin cytoskeletonCytoskeletal dynamicsCellular self-organizationCell cytoskeletonBiological processesSelf-organized criticalityLiving cellsMolecular motorsCytoskeletonEnergy localizationSystem in vitroActinCondensed-matter systemsMyosinFeedback loopDistribution of energy releaseForce propagationAnderson localizationMechanical modesIlluminating active matter by harnessing light for modular flow control
Murrell M. Illuminating active matter by harnessing light for modular flow control. Nature Materials 2025, 24: 489-490. PMID: 40114035, DOI: 10.1038/s41563-025-02181-2.Peer-Reviewed Original Research
2024
Author Correction: Mechanical power is maximized during contractile ring-like formation in a biomimetic dividing cell model
Sakamoto R, Murrell M. Author Correction: Mechanical power is maximized during contractile ring-like formation in a biomimetic dividing cell model. Nature Communications 2024, 15: 10512. PMID: 39627221, PMCID: PMC11615347, DOI: 10.1038/s41467-024-54985-6.Commentaries, Editorials and LettersSubstrate geometry and topography induce F-actin reorganization and chiral alignment in an adherent model cortex
Sakamoto R, Murrell M. Substrate geometry and topography induce F-actin reorganization and chiral alignment in an adherent model cortex. Cell Reports Physical Science 2024, 5: 102338. DOI: 10.1016/j.xcrp.2024.102338.Peer-Reviewed Original ResearchF-actin organizationF-actin networkF-actinF-actin reorganizationSubstrate featuresActin cortexCytoskeletal organizationGiant unilamellar vesiclesIntracellular signalingCell adhesionGeometry sensingLiposome shapeCell membraneMembrane deformationUnilamellar vesiclesAdherent liposomeCellsActinOrganizationVesiclesAdhesionLiposomesCofilin-Mediated Filament Softening and Crosslinking Counterbalance to Enhance Actin Network Flexibility
Sun Z, Murrell M. Cofilin-Mediated Filament Softening and Crosslinking Counterbalance to Enhance Actin Network Flexibility. Physical Review Letters 2024, 133: 218402. PMID: 39642486, DOI: 10.1103/physrevlett.133.218402.Peer-Reviewed Original ResearchActin-binding proteinsF-actin networkF-actinCrosslinking proteinsF-actin crosslinking proteinCrosslinks F-actinF-actin filamentsTransmission of mechanical forcesCofilin concentrationFilamentous-actinAccessory proteinsCell cytoskeletonCell divisionCell shapeCofilinBinding proteinCell migrationFilament flexibilityProteinDisulfide bondsFilament levelFilamentsCellsMechanical forcesLow pHMechanical power is maximized during contractile ring-like formation in a biomimetic dividing cell model
Sakamoto R, Murrell M. Mechanical power is maximized during contractile ring-like formation in a biomimetic dividing cell model. Nature Communications 2024, 15: 9731. PMID: 39523366, PMCID: PMC11551154, DOI: 10.1038/s41467-024-53228-y.Peer-Reviewed Original ResearchConceptsMyosin-induced stressContractile ring assemblyCell division mechanismActin filamentsActin cortexCleavage furrowDivision planeActomyosin flowsGiant unilamellar vesiclesRing assemblyCell divisionMyosin activityContractile ring-like structureShape changesRing-like structureDivision mechanismEnergetic costSymmetric divisionActinRing-like formationCell modelUnilamellar vesiclesIn vitro modelFurrowCellsEnergy partitioning in the cell cortex
Chen S, Seara D, Michaud A, Kim S, Bement W, Murrell M. Energy partitioning in the cell cortex. Nature Physics 2024, 20: 1824-1832. PMID: 41675559, PMCID: PMC12889973, DOI: 10.1038/s41567-024-02626-6.Peer-Reviewed Original ResearchCell cortexEntropy production rateGAP expressionCortical actin filamentsRho GTPase pathwayGTPase pathwayMyosin IIActin filamentsDiversity patternsEnergy partitioningRhoOnsager reciprocityCell phenotypeProtein expressionThermodynamic equilibriumCellsSpiral travelling waveProduction rateTemporal dynamicsLiving systemsActinEnergyWavePhenotypeActivityComposite branched and linear F-actin maximize myosin-induced membrane shape changes in a biomimetic cell model
Sakamoto R, Murrell M. Composite branched and linear F-actin maximize myosin-induced membrane shape changes in a biomimetic cell model. Communications Biology 2024, 7: 840. PMID: 38987288, PMCID: PMC11236970, DOI: 10.1038/s42003-024-06528-4.Peer-Reviewed Original ResearchConceptsF-actin networkF-actinF-actin architectureMembrane shape changesCell shape changesActivity of myosinInduce membrane deformationActomyosin contractilityShape changesActin cortexActomyosin cortexGiant unilamellar vesiclesActinMembrane deformationUnilamellar vesiclesCell modelNo-slip boundariesForce generationActomyosinMyosinVesiclesForce transmission