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Matthew J Girgenti, PhD

Associate Research Scientist, Psychiatry

Contact Information

Matthew J Girgenti, PhD

Mailing Address

  • 34 Park Street


    New Haven, CT, 06508

    United States


Dr. Matt Girgenti’s research interests broadly center on integration of high-throughput biological data, particularly gene expression and proteomics in large rodent and human-based studies.  He works largely at the intersection of transcriptomics, bioinformatics, molecular biology, and animal behavior leveraging large datasets to better understand how changes in genomic signatures associate with brain dysregulation in disease.  His research consists of broad and often overlapping domains: 1) identifying molecular signatures related to causes and consequences of PTSD and depression in human postmortem brain tissue, 2) developing molecular tools to measure transcriptomic and proteomic changes in postmortem tissue, and 3) using animal models to identify molecular changes in neuronal subtypes after chronic and traumatic stress or rapid antidepressant administration.   

In 2019 Dr. Girgenti joined the oversight board of the VA National PTSD brain bank as a member of the Traumatic Stress Brain Research Study Group.  He was recently awarded a VA Career Development Award (CDA) and a Brain & Behavior Research Foundation (NARSAD) young investigator award to study the molecular intersections of PTSD and suicide in postmortem brain tissue.  He was promoted to Associate Research Scientist at Yale School of Medicine and is concurrently a Research Biologist at the West Haven VA Hospital.  

Education & Training

  • PhD
    University of Connecticut (2015)
  • BS
    Fairfield University, Molecular Biology (2002)

Honors & Recognition

AwardAwarding OrganizationDate
NARSAD Young InvestigatorBrain and Behavior Research Foundation2020
VISN1 Career Development AwardUS Department of Veterans Affairs2019
NIDA/Yale Neuroproteomics Pilot AwardNIDA/Yale Neuroproteomics Core2017

Professional Service

National PTSD Brain Bank, US Department of Veterans AffairsBoard Member2019 - Present

Departments & Organizations