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Marie Egan, MD

Professor of Pediatrics (Respiratory) and of Cellular And Molecular Physiology
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Additional Titles

Director, Cystic Fibrosis Center

Vice Chair for Research, Department of Pediatrics

Contact Info

Pediatric Pulmonology, Allergy, Immunology & Sleep Medicine

PO Box 208064

New Haven, CT 06520-8064

United States

About

Titles

Professor of Pediatrics (Respiratory) and of Cellular And Molecular Physiology

Director, Cystic Fibrosis Center; Vice Chair for Research, Department of Pediatrics

Appointments

Education & Training

Fellow
The Eudowood Division of Pediatric Respiratory Sciences, Johns Hopkins Hospital (1992)
Resident
Johns Hopkins Hospital (1989)
Intern
The Johns Hopkins Hospital (1987)
MD
Mount Sinai School of Medicine (1986)

Research

Overview

Dr. Egan’s primary research interest is to understand the regulation of ion transport across the airway epithelia in health and disease. Transepithelial ion transport is responsible for maintaining the airway surface fluid, i.e. the periciliary fluid layer, which controls mucociliary clearance. Abnormalities in the ion channels and regulators of these channels can alter mucociliary clearance, leading to retained secretions, mucus plugging, infection, and lung destruction, as seen in cystic fibrosis. In CF, it is the abnormal function of the cystic fibrosis transmembrane conductance regulator (CFTR), a multifunctional protein encoded by the gene that is affected in cystic fibrosis (CF) that underlies the abnormal ion transport in affected organs.

The Egan lab uses a variety of electrophysiologic techniques to examine how CFTR expression affects transepithelial ion transport in airway epithelial cells. They have shown that CFTR can modulate other ion channels and, as its name implies, act as a conductance regulator. In addition, the laboratory is interested in examining how mutations in CFTR affect its ability to function. Lastly, the epithelium interacts with the airway microenvironment and primary immune cells to propagate disease. Dr. Egan has shown that CFTR functions in primary immune cells and this function is altered in CF contributing to disease.

The Egan lab has worked collaboratively to bring forth innovative platforms that could have great impact on CF patients such as gene editing.

Specialized Terms: Cystic fibrosis clinical studies; Cystic fibrosis basic science research (ion transport, Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) function) ion transport; Cystic fibrosis translational research studies (strategies to bypass or correct the basic defect) gene editing, immune response , pediatrics

Medical Subject Headings (MeSH)

Adaptive Immunity; Airway Management; Bacterial Infections; Clinical Trial; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Epithelial Cells; Gene Editing; Genetic Code; Immunity, Innate; Inflammation; Lung; Macrophages; Macrophages, Alveolar; Microbiology; Nanoparticles; Pediatrics; Peptide Nucleic Acids; Physiology; Pseudomonas aeruginosa; Translational Research, Biomedical

Research at a Glance

Yale Co-Authors

Frequent collaborators of Marie Egan's published research.

Publications

2024

2023

Clinical Trials

Current Trials

Academic Achievements & Community Involvement

  • activity

    The Charles Hood Child Health Research Committee

  • activity

    NIH

  • honor

    Hartwell Individual Biomedical Research Award

  • honor

    Society of Pediatric Research, Membership Secretary

  • honor

    Society of Distinguished Teachers

Clinical Care

Get In Touch

Contacts

Academic Office Number
Appointment Number
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Clinic Fax Number
Mailing Address

Pediatric Pulmonology, Allergy, Immunology & Sleep Medicine

PO Box 208064

New Haven, CT 06520-8064

United States

Locations

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