Lisa Parikh, MD
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Appointments
Endocrinology
Primary
Contact Info
Yale School of Medicine
300 Cedar St
New Haven, CT 06510
United States
About
Titles
Assistant Professor of Medicine (Endocrinology)
Appointments
Endocrinology
Assistant ProfessorPrimary
Other Departments & Organizations
Education & Training
- Fellowship
- Yale University School of Medicine (2017)
- Residency
- New York University School of Medicine (2013)
- MD
- Tulane University School of Medicine (2010)
- BA
- Northwestern University (2005)
Board Certifications
Endocrinology Diabetes & Metabolism
- Certification Organization
- ABIM
- Original Certification Date
- 2016
Internal Medicine
- Certification Organization
- ABIM
- Original Certification Date
- 2013
Research
Research at a Glance
Yale Co-Authors
Frequent collaborators of Lisa Parikh's published research.
Publications Timeline
A big-picture view of Lisa Parikh's research output by year.
Janice Jin Hwang, MD
Todd Constable, PhD
Dongju Seo, PhD
Rajita Sinha, PhD
Ania Jastreboff, MD, PhD
Catherine Yeckel, PhD
10Publications
148Citations
Publications
2022
Stress-level glucocorticoids increase fasting hunger and decrease cerebral blood flow in regions regulating eating
Bini J, Parikh L, Lacadie C, Hwang JJ, Shah S, Rosenberg SB, Seo D, Lam K, Hamza M, De Aguiar RB, Constable T, Sherwin RS, Sinha R, Jastreboff AM. Stress-level glucocorticoids increase fasting hunger and decrease cerebral blood flow in regions regulating eating. NeuroImage Clinical 2022, 36: 103202. PMID: 36126514, PMCID: PMC9486604, DOI: 10.1016/j.nicl.2022.103202.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsCerebral blood flowRegional cerebral blood flowBlood flowMetabolic hormonesRandomized double-blind cross-over designDouble-blind cross-over designStress level glucocorticoidsPrimary sensory cortexPerfusion magnetic resonanceCross-over designMedial temporal gyrusWhole-brain voxelMedial brainstemSaline daysOvernight infusionCBF responseHunger ratingsPlasma insulinGlucocorticoid effectsHedonic signalsObesity riskLimbic regionsFood intakeNeural regulationDistinct brain networks
2020
Characterizing the Effects of Diabetes and Obesity on Insulin and Leptin Levels amongst Pregnant Women
Johnson AW, Snegovskikh D, Parikh L, DeAguiar RB, Han CS, Hwang JJ. Characterizing the Effects of Diabetes and Obesity on Insulin and Leptin Levels amongst Pregnant Women. American Journal Of Perinatology 2020, 37: 1094-1101. PMID: 32120424, DOI: 10.1055/s-0040-1702988.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsDiabetes mellitusLeptin levelsCerebrospinal fluidLean mothersPlasma ratioMaternal cerebrospinal fluidMaternal metabolic environmentElective cesarean deliveryImpact of obesityCord blood insulinEffect of diabetesLow cerebrospinal fluidUncomplicated singleton pregnanciesMaternal plasma ratioArtery plasmaDM mothersCesarean deliveryObese patientsSingleton pregnanciesFetal exposureBlood insulinLower cordPregnant womenMaternal brainLean individuals
2019
Differential Resting State Connectivity Responses to Glycemic State in Type 1 Diabetes
Parikh L, Seo D, Lacadie C, Belfort-Deaguiar R, Groskreutz D, Hamza M, Dai F, Scheinost D, Sinha R, Constable R, Sherwin R, Hwang JJ. Differential Resting State Connectivity Responses to Glycemic State in Type 1 Diabetes. The Journal Of Clinical Endocrinology & Metabolism 2019, 105: dgz004. PMID: 31511876, PMCID: PMC6936965, DOI: 10.1210/clinem/dgz004.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsState functional connectivityHealthy controlsDefault mode networkType 1 diabetes mellitusFunctional connectivityImpact of T1DMAcademic medical centerAngular gyrus connectivityBlood oxygenation levelState connectivity patternsFunctional connectivity analysisHyperinsulinemic euglycemicHypoglycemic unawarenessHypoglycemia unawarenessDiabetes mellitusHypoglycemic clampHypoglycemia awarenessFunctional outcomeMild hypoglycemiaGlycemic stateObservational studyMedical CenterT1DMHC volunteersType 1Differential resting state connectivity responses to glycemic state in type 1 diabetes
Parikh L, Seo D, Lacadie C, Belfort-DeAguiar R, Groskreutz D, Hamza M, Dai F, Scheinost D, Sinha R, Constable R, Sherwin R, Hwang J. Differential resting state connectivity responses to glycemic state in type 1 diabetes. The Journal Of Clinical Endocrinology & Metabolism 2019 DOI: 10.1210/jcem/dgz004.Peer-Reviewed Original ResearchCitationsConceptsType 1 diabetesState functional connectivityHealthy controlsDefault mode networkFunctional connectivityImpact of T1DMHealthy control volunteersAcademic medical centerAngular gyrus connectivityState connectivity patternsFunctional connectivity analysisHyperinsulinemic euglycemicHypoglycemic unawarenessHypoglycemia unawarenessHypoglycemic clampHypoglycemia awarenessFunctional outcomeControl volunteersMild hypoglycemiaGlycemic stateObservational studyMedical CenterT1DMHypoglycemiaNeurocognitive consequencesIn a Free-Living Setting, Obesity Is Associated With Greater Food Intake in Response to a Similar Premeal Glucose Nadir
Kim J, Lam W, Wang Q, Parikh L, Elshafie A, Sanchez-Rangel E, Schmidt C, Li F, Hwang J, Belfort-DeAguiar R. In a Free-Living Setting, Obesity Is Associated With Greater Food Intake in Response to a Similar Premeal Glucose Nadir. The Journal Of Clinical Endocrinology & Metabolism 2019, 104: 3911-3919. PMID: 31087061, PMCID: PMC6667277, DOI: 10.1210/jc.2019-00240.Peer-Reviewed Original ResearchCitationsAltmetricConceptsFood intakeGlucose levelsNW individualsOB individualsPremeal glucoseCGM glucose levelsNormal-weight individualsBlood glucose levelsContinuous glucose-monitoring systemGreater food intakeInterstitial glucose levelsGlucose-monitoring systemGlucose nadirsWeight individualsGlucose profilesObeseFood logsEffect of glucoseHealthy individualsFree-Living SettingsIntakePostprandial ratesObesityLevel stimuliPredictive effect
2018
Hypoglycemia Unawareness in T1DM Is Associated with Altered Brain Default Mode Network Connectivity
GROSKREUTZ D, HWANG J, SEO D, LACADIE C, PARIKH L, BELFORT-DEAGUIAR R, SCHEINOST D, SINHA R, CONSTABLE T, SHERWIN R. Hypoglycemia Unawareness in T1DM Is Associated with Altered Brain Default Mode Network Connectivity. Diabetes 2018, 67 DOI: 10.2337/db18-11-lb.Peer-Reviewed Original ResearchConceptsDefault mode networkHypoglycemia awarenessDMN connectivityAvoidance of hypoglycemiaDefault mode network connectivityHypoglycemia symptom scoresMode network connectivityBrain connectivity patternsBOLD-fMRI scanningMannKind CorporationT1DM individualsHypoglycemia unawarenessHypoglycemic clampSymptom scoresRegeneron PharmaceuticalsGlaxoSmithKline plcPlasma cortisolState connectivityMode networkFMRI scanningHypoglycemiaElicit changesBrainFunctional networksConnectivity patternsHyperinsulinemia Invokes Greater Brain Perfusion in Reward and Motivation Regions in Obesity
GROSKREUTZ D, SINHA R, LACADIE C, LAM W, HAMZA M, SCHMIDT C, SEO D, HWANG J, BELFORT-DEAGUIAR R, LEVENTHAL J, ROSENBERG S, PARIKH L, CONSTABLE T, SHERWIN R, JASTREBOFF A. Hyperinsulinemia Invokes Greater Brain Perfusion in Reward and Motivation Regions in Obesity. Diabetes 2018, 67 DOI: 10.2337/db18-365-or.Peer-Reviewed Original ResearchAltmetricConceptsCerebral blood flowElevated insulin levelsInsulin levelsFunctional magnetic resonance imagingLean humansObese humansHour oral glucose tolerance testOral glucose tolerance testSetting of hyperinsulinemiaGlucose tolerance testEuglycemic hyperinsulinemic clampEffect of hyperinsulinemiaAnterior cingulate cortexMagnetic resonance imagingWhole-brain analysisFood-seeking behaviorMiddle temporal gyrusMannKind CorporationCBF responseCNS effectsSatiety factorTolerance testBrain perfusionOB groupLN groupGlycemic Variability from CGM Correlates with Indices of Glucose Metabolism in Healthy Obesity but Not in Type 2 Diabetes
ELSHAFIE A, LAM W, PARIKH L, RANGEL E, SCHMIDT C, HWANG J, YECKEL C, SHERWIN R, BELFORT-DEAGUIAR R. Glycemic Variability from CGM Correlates with Indices of Glucose Metabolism in Healthy Obesity but Not in Type 2 Diabetes. Diabetes 2018, 67 DOI: 10.2337/db18-82-lb.Peer-Reviewed Original ResearchConceptsGlucose infusion rateInsulin secretion-sensitivity index-2Beta-cell functionContinuous overlapping net glycemic actionGlucose variabilityContinuous glucose monitorT2D subjectsObese subjectsInsulin levelsGV indicesGlucose metabolismCell functionInsulin sensitivity indexType 2 diabetesGlycemic Risk AssessmentCGM indicesHealthy obesityMannKind CorporationHealthy obeseOB subjectsGlycemic excursionsInsulin resistanceIncremental AUCGlycemic variabilityRegeneron PharmaceuticalsHypoglycemia unawareness in type 1 diabetes suppresses brain responses to hypoglycemia
Hwang JJ, Parikh L, Lacadie C, Seo D, Lam W, Hamza M, Schmidt C, Dai F, Sejling AS, Belfort-DeAguiar R, Constable RT, Sinha R, Sherwin R. Hypoglycemia unawareness in type 1 diabetes suppresses brain responses to hypoglycemia. Journal Of Clinical Investigation 2018, 128: 1485-1495. PMID: 29381484, PMCID: PMC5873861, DOI: 10.1172/jci97696.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsMild hypoglycemiaHypoglycemia awarenessType 1 diabetes mellitus patientsPrefrontal cortexHormonal counterregulatory responsesDiabetes mellitus patientsImpaired hypoglycemia awarenessAltered activation patternsAngular gyrusType 1 diabetesBlood glucose levelsHypoglycemia-induced changesBrain responsesBrain activityHypoglycemia symptom scoresAlters brain activityClinical Translational Science AwardsHyperinsulinemic euglycemicHypoglycemia unawarenessCounterregulatory responsesHypoglycemic clampMellitus patientsMRI brainSymptom scoresNondiabetic individuals
2017
Blunted rise in brain glucose levels during hyperglycemia in adults with obesity and T2DM
Hwang JJ, Jiang L, Hamza M, Rangel E, Dai F, Belfort-DeAguiar R, Parikh L, Koo BB, Rothman DL, Mason G, Sherwin RS. Blunted rise in brain glucose levels during hyperglycemia in adults with obesity and T2DM. JCI Insight 2017, 2: e95913. PMID: 29046482, PMCID: PMC5846903, DOI: 10.1172/jci.insight.95913.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsGlucose levelsPlasma free fatty acid levelsSimilar plasma glucose levelsFree fatty acid levelsCerebral glucose metabolismPlasma glucose levelsBrain glucose levelsFatty acid levelsAltered feeding behaviorGlucose incrementHyperglycemic clampBrain glucoseCerebral functionLean participantsOccipital lobeRodent modelsGlucose metabolismObesityT2DMGlucose responseHyperglycemiaNeurocognitive consequencesSimilar findingsAcid levelsIntracerebral glucose
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Yale School of Medicine
300 Cedar St
New Haven, CT 06510
United States