Rajita Sinha, PhD
Foundations Fund Professor of Psychiatry and Professor in the Child Study Center and of NeuroscienceCards
Appointments
Additional Titles
Deputy Chair of Psychiatry for Psychology, Psychiatry
Director, Yale Interdisciplinary Stress Center
Chief, Psychology Section in Psychiatry
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Appointments
Additional Titles
Deputy Chair of Psychiatry for Psychology, Psychiatry
Director, Yale Interdisciplinary Stress Center
Chief, Psychology Section in Psychiatry
Contact Info
Appointments
Additional Titles
Deputy Chair of Psychiatry for Psychology, Psychiatry
Director, Yale Interdisciplinary Stress Center
Chief, Psychology Section in Psychiatry
Contact Info
About
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Titles
Foundations Fund Professor of Psychiatry and Professor in the Child Study Center and of Neuroscience
Deputy Chair of Psychiatry for Psychology, Psychiatry; Director, Yale Interdisciplinary Stress Center; Chief, Psychology Section in Psychiatry
Biography
Rajita Sinha, Ph.D. is the Foundations Fund Endowed Professor in Psychiatry, and Professor in Neuroscience and in Child Study at the Yale University School of Medicine. She is a licensed Clinical Psychologist and Clinical Neuroscientist, Deputy Chair of Psychiatry for Psychology and Chief of the Psychology Section in Psychiatry. She is the founding director of the Yale Interdisciplinary Stress Center that focuses on understanding the neurobiology and psychology of stress, trauma and resilient versus vulnerable biobehavioral coping mechanisms that promote neuropsychiatric diseases such as alcohol use disorders, substance use disorders, chronic pain, PTSD and other chronic diseases. She has developed novel stress, pain and craving provocation paradigms to understand mechanisms that drive these states and related pathologies and their impact on clinical addiction outcomes in alcohol use disorder, substance use disorders and related conditions. Her lab also develops and tests novel pharmacologic and integrative behavioral approaches to address chronic stress and addiction relapse risk to improve addiction treatment outcomes. These objectives are being accomplished through a series of NIH funded research projects and she has published widely on these topics. She is the 2020 recipient of the Research Society on Alcoholism's Distinguished Researcher Award, and the 2020 recipient of the James Tharpe Award for outstanding contributions to Addiction Research. She has served on many NIH special emphasis panels, review committees and workshops, presented at numerous national and international conferences, and her work is widely cited.
Appointments
Psychiatry
ProfessorPrimaryNeuroscience
ProfessorSecondary
Other Departments & Organizations
- Center for Brain & Mind Health
- Connecticut Mental Health Center
- Diabetes Research Center
- Division of Addictions
- Division of Substance Abuse
- MR Core
- Neuroscience
- Neuroscience Research Training Program (NRTP)
- Psychiatry
- Psychology Section
- Psychotherapy Development Center
- South Asian Studies
- Stress & Addiction Clinical Research Program
- Yale Center for the Science of Cannabis and Cannabinoids
- Yale Obesity Research Center (Y-Weight)
- Yale Stress Center
- Yale Ventures
- Yale-Drug use, Addiction, and HIV prevention Research Scholars (DAHRS)
Education & Training
- PhD
- Yale University, Psychology/Clinical Respecialization (1992)
- PhD
- Oklahoma University Health Sciences Center (1990)
Research
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Overview
Medical Research Interests
ORCID
0000-0003-3012-4349
Research at a Glance
Yale Co-Authors
Publications Timeline
Research Interests
Verica Milivojevic, PhD
Nia Fogelman, PhD
Dongju Seo, PhD
Stephanie Wemm, PhD
Zachary Harvanek, MD, PhD
Chiang-Shan Ray Li, MD, PhD
Stress, Psychological
Substance-Related Disorders
Chronic Disease
Neurobiology
Publications
2026
Effects of the Neuroactive Steroid Precursor Pregnenolone on Stress- and Alcohol Cue–Provoked Pain Responses in Individuals With Alcohol Use Disorder
Quinlan R, Gao H, Sinha R, Milivojevic V. Effects of the Neuroactive Steroid Precursor Pregnenolone on Stress- and Alcohol Cue–Provoked Pain Responses in Individuals With Alcohol Use Disorder. Experimental And Clinical Psychopharmacology 2026 PMID: 42258258, PMCID: PMC13251320, DOI: 10.1037/pha0000862.Peer-Reviewed Original ResearchConceptsAlcohol use disorderAlcohol cravingUse disorderAssociated with alcohol cravingPrecursor pregnenoloneCue-related cravingTreatment-seeking menAlcohol use outcomesNeuroactive steroid levelsStress response dysregulationExposure to stressPain responseChronic alcohol useBetween-subjects factorWithin-subject factorsAlcohol cuesAnxiety responsesImagery conditionCravingGABAergic activitySelf-report of painAnxietySelf-ReportAlcohol usePositive associationAlterations in glucose and insulin resistance following stress and alcohol cues predict alcohol craving in those with AUD and obesity: A preliminary study
Harvanek Z, Milivojevic V, Hart R, Sinha R. Alterations in glucose and insulin resistance following stress and alcohol cues predict alcohol craving in those with AUD and obesity: A preliminary study. Alcohol Clinical And Experimental Research 2026, 50: e70283. PMID: 42101823, DOI: 10.1111/acer.70283.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsAlcohol use disorderAlcohol cravingLaboratory sessionsAssessment of alcohol cravingAlcohol use disorder groupCue-related cravingNeutral-relaxing cuesHealthy controlsChronic alcohol useAlcohol cuesUse disorderExposed to stressCravingRisk of relapseHC groupGlucagon-like peptide 1 receptor agonistsAlcohol useInsulin resistancePeptide 1 receptor agonistsLinear mixed modelsHypothesis-generating resultsMechanistic overlapGLP-1 agonistsAlcohol intakeBlood glucose control7. The Neurosteroid Pregnenolone Effects on Stress- And Cue- Provoked Alcohol Craving Associations With Drinking Outcomes in Individuals With Alcohol Use Disorder
Sakmar E, Wemm S, Fogelman N, Sinha R, Milivojevic V. 7. The Neurosteroid Pregnenolone Effects on Stress- And Cue- Provoked Alcohol Craving Associations With Drinking Outcomes in Individuals With Alcohol Use Disorder. Biological Psychiatry 2026, 99: s102. DOI: 10.1016/j.biopsych.2026.03.241.Peer-Reviewed Original Research381. Effects of Daily 8-WEEK Exogenous Pregnenolone Treatment on Downstream Metabolite Levels in Individuals With Alcohol Use Disorder
Milivojevic V, Fogelman N, Sinha R. 381. Effects of Daily 8-WEEK Exogenous Pregnenolone Treatment on Downstream Metabolite Levels in Individuals With Alcohol Use Disorder. Biological Psychiatry 2026, 99: s263. DOI: 10.1016/j.biopsych.2026.03.615.Peer-Reviewed Original ResearchPerceived Social Support Moderates the Response to Stress and Alcohol Cue During Early Abstinence from Alcohol
Goldstein S, Sinha R, Fox H. Perceived Social Support Moderates the Response to Stress and Alcohol Cue During Early Abstinence from Alcohol. Biological Psychiatry Global Open Science 2026, 100762. DOI: 10.1016/j.bpsgos.2026.100762.Peer-Reviewed Original ResearchConceptsResponse to stressImagery exposureEarly abstinenceSocial supportStroop performanceTreatment-seeking alcohol-dependent individualsCortisol response to stressAlcohol cue exposureAlcohol-dependent individualsInpatient treatment programMaladaptive stress responsesWeeks of abstinenceNo group differencesAcute psychological stressIntensive treatment approachesAcute stress responseAlcohol cuesCue reactivitySubjective cravingCue exposureNicotine cravingAlcohol dependenceDependent individualsCue conditionNegative mood326. Lifetime Adversity Partially Mediates Relationships Between Neighborhood Deprivation and Biological Aging
Koirala A, Shields J, Vijan A, Wemm S, Xu K, Ku B, Sinha R, Harvanek Z. 326. Lifetime Adversity Partially Mediates Relationships Between Neighborhood Deprivation and Biological Aging. Biological Psychiatry 2026, 99: s239-s240. DOI: 10.1016/j.biopsych.2026.03.560.Peer-Reviewed Original Research205. Lifetime Adversity is Associated With DNA Methylation at Obesity-Associated Genes
Stevens A, Jastreboff A, Xu K, Sinha R, Harvanek Z. 205. Lifetime Adversity is Associated With DNA Methylation at Obesity-Associated Genes. Biological Psychiatry 2026, 99: s186-s187. DOI: 10.1016/j.biopsych.2026.03.439.Peer-Reviewed Original Research196. Social Connection Partially Mediates the Relationship Between Chronic Stress and Health in Adults
Vijan A, Shields J, Koirala A, Sinha R, Harvanek Z. 196. Social Connection Partially Mediates the Relationship Between Chronic Stress and Health in Adults. Biological Psychiatry 2026, 99: s182-s183. DOI: 10.1016/j.biopsych.2026.03.430.Peer-Reviewed Original ResearchConceptsExamining the moderating role of intolerance of uncertainty on pain tolerance and craving in patients with chronic pain and alcohol use disorder
Radoman M, Heilner E, McGowan C, Neree-Thompson B, Sakmar E, Sinha R. Examining the moderating role of intolerance of uncertainty on pain tolerance and craving in patients with chronic pain and alcohol use disorder. Alcohol 2026, 132: 62. DOI: 10.1016/j.alcohol.2026.01.095.Peer-Reviewed Original ResearchThe impact of intolerance of uncertainty on neural correlates of stress cue reactivity in chronic pain and alcohol use disorder
Radoman M, Lacadie C, Sinha R. The impact of intolerance of uncertainty on neural correlates of stress cue reactivity in chronic pain and alcohol use disorder. Alcohol 2026, 132: 74. DOI: 10.1016/j.alcohol.2026.01.145.Peer-Reviewed Original Research
Clinical Trials
Current Trials
Prazosin for Alcohol Use Disorder
IRB ID2000029805RolePrincipal InvestigatorPrimary Completion Date01/15/2026Recruiting ParticipantsGenderBothAge18 years - 70 yearsCharacterizing Subjective and Physiological Responses to Stress and Pain and Cognitive Learning and Executive Function
IRB ID2000026626RolePrincipal InvestigatorPrimary Completion Date06/30/2023Recruiting ParticipantsGenderBothAge18 years - 50 years
News & Links
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Media
- Higher the cumulative stress exposure, greater the reduction in brain volume in specific regions of the medial, anterior and lateral prefrontal cortex, and in the insula and striatum (shown in yellow blobs). These are regions involved in emotion, reward and motivation processing. Ansel et al., Biological Psychiatry 2011.
News
- June 30, 2026
Women’s Health Research at Yale and SWHR’s Symposium Highlights the Power of Collaboration to Advance Women’s Health Research
- June 08, 2026
Fehon Awarded 2026 Sidney J. Blatt Faculty Award
- June 05, 2026Source: Drug and Alcohol Dependence
Pilot Trial: Pregnenolone Reduces Provoked Craving and Cocaine Use in Men and Women with Cocaine Use Disorder
- May 11, 2026Source: Alcohol Clinical and Experimental Research
Study: Alterations in Glucose and Insulin Resistance Following Stress and Alcohol Cues Predict Alcohol Craving in Those with AUD and Obesity
Related Links
- AARP Bulletin Today on how stress can impact your health - Published 5/1/2009
- Even in the healthy, stress causes brain to shrink, Yale study shows
- Gender in the mix: Under stress, men crave alcohol more than women do - The Los Angeles Times, Health section (5/19/08)
- Link between stress and alcohol craving in alcoholics struggling to achieve recovery - Neuropsychopharmacology, 6/18/08
- Yale Stress Center
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