Adjunct faculty typically have an academic or research appointment at another institution and contribute or collaborate with one or more School of Medicine faculty members or programs.
Adjunct rank detailsJanice Jin Hwang, MD
Assistant Professor AdjunctAbout
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Titles
Assistant Professor Adjunct
Biography
Dr. Hwang is an endocrinologist and Assistant Professor in the Division of Endocrinology at the Yale School of Medicine. She graduated magna cum laude from Princeton University in 2001 with a major in molecular biology followed by Harvard Medical School in 2006. She completed her residency training in Internal Medicine at the Beth Israel Deaconess Medical Center in Boston, MA and also served as a Chief Medical Resident. Dr. Hwang received her fellowship training in Endocrinology and Metabolism at Massachusetts General Hospital and moved to Yale in 2012 to continue her research training with Dr. Robert Sherwin. Her academic interests are at the intersection of metabolism, neuroscience and imaging. Her research focuses on using advanced brain imaging modalities such as functional MRI and magnetic resonance spectroscopy coupled with classic investigative techniques in metabolism to understand the effects of diabetes and obesity on the brain. Her research has been supported by the National Institutes of Health, the Yale Diabetes Research Center, the Endocrine Fellows Foundation, and the American Diabetes Association. She is the recipient of several awards for her research including the Marilyn Fishman Award for Diabetes Research, the Metabolism Junior Investigator award as well as a Yale Center for Clinical Investigation Junior Faculty Scholars Award.
Appointments
Endocrinology
Assistant Professor AdjunctPrimary
Other Departments & Organizations
- Diabetes Research Center
- Endocrinology
- Internal Medicine
- Obesity Research Working Group
Education & Training
- MHS
- Yale University (2017)
- Research Fellow
- Yale School of Medicine (2014)
- Clinical and Research Fellow
- Massachusetts General Hospital (2012)
- Residency
- Beth Israel Deaconess Medical Center (2009)
- MD
- Harvard Medical School (2006)
- AB
- Princeton University, Molecular Biology (2001)
Research
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Overview
Medical Research Interests
ORCID
0000-0002-8395-5659
Research at a Glance
Yale Co-Authors
Publications Timeline
Research Interests
Elizabeth Sanchez Rangel, MD
Graeme Mason, PhD
Renata Belfort De Aguiar, MD, PhD
Douglas Rothman, PhD
Jason Bini, PhD
Ania Jastreboff, MD, PhD
Obesity
Diabetes Mellitus, Type 2
Diabetes Mellitus, Type 1
Neuroimaging
Publications
2026
Impact of obesity on aromatic amino acids and brain glucose during acute hyperglycemia
Matson B, Gunawan F, Rothman D, Mason G, Ilkayeva O, Newgard C, Hwang J. Impact of obesity on aromatic amino acids and brain glucose during acute hyperglycemia. AJP Endocrinology And Metabolism 2026, 330: e346-e355. PMID: 41638639, PMCID: PMC13036701, DOI: 10.1152/ajpendo.00463.2025.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsAcute hyperglycemiaBrain glucose levelsPlasma concentrationsPlasma amino acidsInsulin resistanceGlucose levelsBrain glucoseMass spectrometry-based metabolomicsEarly markersMarkers of insulin resistancePlasma concentrations of aromatic amino acidsHealthy adultsPlasma concentrations of amino acidsPeripheral metabolic changesImpact of obesityAssociated with insulin resistanceEarly insulin resistanceConcentrations of aromatic amino acidsBranched chain amino acidsPlasma glucagon levelsBrain oxidative stressType 2 diabetesChain amino acidsResponse to hyperglycemiaLean controls
2025
Association of Insulin Resistance and Insulin Secretion Indices and Glucose Metrics From Continuous Glucose Monitoring in People With Obesity.
Belfort-DeAguiar R, Yeckel C, Elshafie A, Comarella A, Hwang J. Association of Insulin Resistance and Insulin Secretion Indices and Glucose Metrics From Continuous Glucose Monitoring in People With Obesity. Diabetes Care 2025, 49: 152-160. PMID: 41418028, PMCID: PMC12719714, DOI: 10.2337/dc25-1395.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsBiomarkers of Glycolysis and the Tricarboxylic Acid Cycle in Youth with and without Obesity
Refugjati E, Li Z, Umano G, Galuppo B, Van Name M, Samuels S, Kang G, Barbieri E, Hwang J, Santoro N. Biomarkers of Glycolysis and the Tricarboxylic Acid Cycle in Youth with and without Obesity. Hormone Research In Paediatrics 2025, 1-6. PMID: 41411205, PMCID: PMC12749259, DOI: 10.1159/000548624.Peer-Reviewed Original ResearchAltmetricConceptsProton-density fat fractionPlasma concentrationsMetabolic consequencesInsulin resistancePrevalence of childhood obesityAdipose tissue insulin resistanceTissue insulin resistanceType 2 diabetesDevelopment of insulin resistanceLiver proton-density fat fractionExcess adiposityMetabolomic analysisChildhood obesityLevels of glucoseMetabolic dysregulationObesityPlasma concentrations of lactateCardiovascular diseaseFat fractionTricarboxylic acidConcentrations of lactateGlucose utilizationYoung adultsTricarboxylic acid cycle intermediatesAdiposeMeasurement of brain glucose metabolism in obesity and diabetes
Hwang J, Bini J, Belfort-DeAguiar R. Measurement of brain glucose metabolism in obesity and diabetes. Diabetologia 2025, 68: 1879-1888. PMID: 40711543, PMCID: PMC12361331, DOI: 10.1007/s00125-025-06491-7.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitationsAltmetricMeSH Keywords and ConceptsConceptsBrain glucose metabolismNon-invasive neuroimaging techniquesMeasures of brain glucose metabolismGlucose metabolismNeuroimaging techniquesPathological state of diabetesPositron emission tomographyBrain imagingBrainState of diabetesEmission tomographyPathological statesPhysiological manipulationsInsulin levels
2024
Low‐calorie diet‐induced weight loss is associated with altered brain connectivity and food desire in obesity
Hoang H, Lacadie C, Hwang J, Lam K, Elshafie A, Rosenberg S, Watt C, Sinha R, Constable R, Savoye M, Seo D, Belfort‐DeAguiar R. Low‐calorie diet‐induced weight loss is associated with altered brain connectivity and food desire in obesity. Obesity 2024, 32: 1362-1372. PMID: 38831482, PMCID: PMC11211061, DOI: 10.1002/oby.24046.Peer-Reviewed Original ResearchCitationsAltmetricConceptsFunctional magnetic resonance imagingIntrinsic connectivity distributionDiet-induced weight lossBrain connectivityAssociated with altered brain connectivityLow-calorie dietEating behavior changesShort-term low-calorie dietRight hippocampusTemporal cortexBrain networksWeight lossBrain clustersEffects of diet-induced weight lossGroup differencesFood desireGlucose levelsDiagnosis of type 2 diabetesBehavioral changesMagnetic resonance imagingType 2 diabetesBrainLeptin levelsFood intakeResonance imagingDeficits in brain glucose transport among younger adults with obesity
Gunawan F, Matson B, Coppoli A, Jiang L, Ding Y, Perry R, Sanchez‐Rangel E, DeAguiar R, Behar K, Rothman D, Mason G, Hwang J. Deficits in brain glucose transport among younger adults with obesity. Obesity 2024, 32: 1329-1338. PMID: 38764181, PMCID: PMC11966602, DOI: 10.1002/oby.24034.Peer-Reviewed Original ResearchCitationsAltmetricConceptsBrain glucose transportLean participantsMarkers of insulin resistanceMagnetic resonance spectroscopy scansEffect of obesityAssociated with alterationsLong-term brain functionCerebral glucose metabolic rateGlucose transportGlucose metabolic rateCardiometabolic comorbiditiesBrain energy utilizationPeripheral markersHyperglycemic clampInsulin resistanceObesityBrain glucose uptakeHuman findingsEating behaviorsYounger ageYoung healthy participantsNeurocognitive functionGlucose transport capacityBrain functionNonesterified fatty acids
2022
Pathophysiology and management of hypoglycemia in diabetes
Sanchez‐Rangel E, Deajon‐Jackson J, Hwang JJ. Pathophysiology and management of hypoglycemia in diabetes. Annals Of The New York Academy Of Sciences 2022, 1518: 25-46. PMID: 36202764, DOI: 10.1111/nyas.14904.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitationsAltmetricMeSH Keywords and ConceptsConceptsType 1 diabetes mellitusCounter-regulatory hormonal responsesMechanism of hypoglycemiaDuration of diabetesManageable chronic diseaseOptimal glycemic controlManagement of hypoglycemiaTreatment of hypoglycemiaNew insulin formulationsDiscovery of insulinGlycemic controlDiabetes mellitusTherapeutic optionsBrain glucoseChronic diseasesNovel therapiesDiabetes managementHypoglycemiaPharmacologic targetHormonal responsesInsulin formulationsDiabetesPatientsCurrent literatureDelivery devicesStress-level glucocorticoids increase fasting hunger and decrease cerebral blood flow in regions regulating eating
Bini J, Parikh L, Lacadie C, Hwang JJ, Shah S, Rosenberg SB, Seo D, Lam K, Hamza M, De Aguiar RB, Constable T, Sherwin RS, Sinha R, Jastreboff AM. Stress-level glucocorticoids increase fasting hunger and decrease cerebral blood flow in regions regulating eating. NeuroImage Clinical 2022, 36: 103202. PMID: 36126514, PMCID: PMC9486604, DOI: 10.1016/j.nicl.2022.103202.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsCerebral blood flowRegional cerebral blood flowBlood flowMetabolic hormonesRandomized double-blind cross-over designDouble-blind cross-over designStress level glucocorticoidsPrimary sensory cortexPerfusion magnetic resonanceCross-over designMedial temporal gyrusWhole-brain voxelMedial brainstemSaline daysOvernight infusionCBF responseHunger ratingsPlasma insulinGlucocorticoid effectsHedonic signalsObesity riskLimbic regionsFood intakeNeural regulationDistinct brain networksInsulin increases placental triglyceride as a potential mechanism for fetal adiposity in maternal obesity
Anam AK, Cooke KM, Dratver MB, O'Bryan JV, Perley LE, Guller SM, Hwang JJ, Taylor HS, Goedeke L, Kliman HJ, Vatner DF, Flannery CA. Insulin increases placental triglyceride as a potential mechanism for fetal adiposity in maternal obesity. Molecular Metabolism 2022, 64: 101574. PMID: 35970449, PMCID: PMC9440306, DOI: 10.1016/j.molmet.2022.101574.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsDe novo lipogenesisFetal adiposityFatty acid uptakeMaternal obesityObese womenNormal weightExcess adiposityVillous explantsInsulin receptorNewborns of mothersNormal-weight womenAcid uptakePlacental villous explantsTranscription factor SREBP-1Insulin-like growth factor 2Effect of insulinFatty acid oxidationPlacental triglyceridesPlacental responsesElevated triglyceridesMaternal hyperglycemiaWeight womenGrowth factor 2Diabetes riskPlacental metabolismReversibility of brain glucose kinetics in type 2 diabetes mellitus
Sanchez-Rangel E, Gunawan F, Jiang L, Savoye M, Dai F, Coppoli A, Rothman DL, Mason GF, Hwang JJ. Reversibility of brain glucose kinetics in type 2 diabetes mellitus. Diabetologia 2022, 65: 895-905. PMID: 35247067, PMCID: PMC8960594, DOI: 10.1007/s00125-022-05664-y.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsType 2 diabetesBrain glucose levelsGlucose levelsHyperglycaemic clampGlycaemic controlBrain glucoseUncontrolled type 2 diabetesType 2 diabetes mellitusConclusions/interpretationThese findingsAims/hypothesisWePlasma glucose levelsLinear mixed-effects regression modelsMixed-effects regression modelsContinuous glucose monitoringMinimal weight changeMagnitude of improvementAge 44.8MethodsEight individualsSD HbA1cDiabetes mellitusCerebral glucoseInterpretationThese findingsWeek interventionRegimen intensificationPost intervention
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