Bone morphogenetic proteins prevent bone marrow stromal cell-mediated oligodendroglial differentiation of transplanted adult neural progenitor cells in the injured spinal cord
Sandner B, Rivera FJ, Caioni M, Nicholson L, Eckstein V, Bogdahn U, Aigner L, Blesch A, Weidner N. Bone morphogenetic proteins prevent bone marrow stromal cell-mediated oligodendroglial differentiation of transplanted adult neural progenitor cells in the injured spinal cord. Stem Cell Research 2013, 11: 758-771. PMID: 23770801, DOI: 10.1016/j.scr.2013.05.003.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBone Marrow TransplantationBone Morphogenetic Protein 2Bone Morphogenetic Protein 4Cell DifferentiationFemaleHumansImmunohistochemistryMesenchymal Stem Cell TransplantationMesenchymal Stem CellsNeural Stem CellsOligodendrogliaRatsRats, Inbred F344Rats, Sprague-DawleyRats, TransgenicSpinal Cord InjuriesConceptsGrafted neural progenitor cellsNeural progenitor cellsBone marrow stromal cellsAdult neural progenitor cellsOligodendroglial differentiationSpinal cordEffect of BMSCsAdult Fischer 344 ratsLoss of oligodendrogliaProgenitor cellsSpinal cord injuryFischer 344 ratsAdult bone marrowOligodendrogenic effectFunctional recoveryCord injuryLesion cavityInjury siteMarrow stromal cellsBone marrowStromal cellsOligodendrogliaBone morphogenetic protein 2/4Rapid upregulationVivo experiments