LaShae Nicholson
Postdoctoral Associate (Neuroscience)DownloadHi-Res Photo
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Titles
Postdoctoral Associate (Neuroscience)
Education & Training
- PhD
- Goethe-Universität Frankfurt, Biology / Neuroscience
Research
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Overview
Medical Research Interests
Alzheimer Disease; Metabolic Syndrome
Public Health Interests
Aging; Bioinformatics; Metabolomics
ORCID
0000-0002-5171-181X
Research at a Glance
Yale Co-Authors
Frequent collaborators of LaShae Nicholson's published research.
Publications Timeline
A big-picture view of LaShae Nicholson's research output by year.
Research Interests
Research topics LaShae Nicholson is interested in exploring.
Stephen Strittmatter, MD, PhD, AB
Le Zhang, PhD
Takuya Toyonaga, MD, PhD
Chang Su
Daniel Holden
David A. Hafler, MD, FANA, MSc
14Publications
411Citations
Alzheimer Disease
Publications
2026
Single-cell transcriptomic atlas of Alzheimer's disease middle temporal gyrus reveals region, cell type, and sex specificity of gene expression with novel genetic risk for MERTK in female.
Zhang L, Liu T, He C, Russo A, Coffey S, Yin D, Hsu I, Zhang C, Ye Y, Su C, Spurrier J, Nicholson L, Kunkle B, Martin E, Rodriguez O, Gomez L, Chang R, Ghosh S, Gopal P, Hafler D, Zhao H, Strittmatter S. Single-cell transcriptomic atlas of Alzheimer's disease middle temporal gyrus reveals region, cell type, and sex specificity of gene expression with novel genetic risk for MERTK in female. Journal Of Alzheimer’s Disease 2026, 13872877261480719. PMID: 42678676, DOI: 10.1177/13872877261480719.Peer-Reviewed Original ResearchCitationsInsulin resistance alters cortical inhibitory neurons and microglia to exacerbate Alzheimer’s knock-in mouse phenotypes
Nicholson L, Tang S, Karra T, Abouelatta H, Strittmatter S. Insulin resistance alters cortical inhibitory neurons and microglia to exacerbate Alzheimer’s knock-in mouse phenotypes. Molecular Neurodegeneration 2026, 21: 44. PMID: 42237401, PMCID: PMC13459496, DOI: 10.1186/s13024-026-00946-0.Peer-Reviewed Original ResearchAltmetric
2025
Axon Regeneration and Functional Recovery after Spinal Cord Injury is Enhanced by Allele-Specific ApoE Neuronal Action through LRP8
Axon Regeneration and Functional Recovery after Spinal Cord Injury is Enhanced by Allele-Specific ApoE Neuronal Action through LRP8 Ramakrishnan Kannan, Xingxing Wang, LaShae Nicholson, Nancy Z. Lin, Elisa M. Howard, Atrayee Basu, Ines Ingabire, Yuichi Sekine, Stephen M. Strittmatter bioRxiv 2025.10.10.681747; doi: https://doi.org/10.1101/2025.10.10.681747Peer-Reviewed Original ResearchInsulin resistance alters cortical inhibitory neurons and microglia to exacerbate Alzheimer's knock-in mouse phenotypes.
Nicholson L, Tang SJ, Karra T, Abouelatta H, Strittmatter SM. Insulin resistance alters cortical inhibitory neurons and microglia to exacerbate Alzheimer's knock-in mouse phenotypes. BioRxiv 2025 PMID: 40964391, DOI: 10.1101/2025.09.05.674487.Peer-Reviewed Original Research
2023
Neuronal transcriptome, tau and synapse loss in Alzheimer’s knock-in mice require prion protein
Stoner A, Fu L, Nicholson L, Toyonaga T, Spurrier J, Laird W, Cai Z, Strittmatter S. Neuronal transcriptome, tau and synapse loss in Alzheimer’s knock-in mice require prion protein. Alzheimer's Research & Therapy 2023, 15: 201. PMID: 37968719, PMCID: PMC10647125, DOI: 10.1186/s13195-023-01345-z.Peer-Reviewed Original ResearchCitationsAltmetric
2022
Reversal of synapse loss in Alzheimer mouse models by targeting mGluR5 to prevent synaptic tagging by C1Q
Spurrier J, Nicholson L, Fang XT, Stoner AJ, Toyonaga T, Holden D, Siegert TR, Laird W, Allnutt MA, Chiasseu M, Brody AH, Takahashi H, Pérez-Cañamás A, Sadasivam P, Li S, Zhang L, Huang YH, Carson RE, Cai Z, Strittmatter SM. Reversal of synapse loss in Alzheimer mouse models by targeting mGluR5 to prevent synaptic tagging by C1Q. Science Translational Medicine 2022, 14: eabi8593-eabi8593. PMID: 35648810, PMCID: PMC9554345, DOI: 10.1126/scitranslmed.abi8593.Peer-Reviewed Original ResearchCitationsAltmetric
2020
Whole-Cell Photobleaching Reveals Time-Dependent Compartmentalization of Soluble Proteins by the Axon Initial Segment
Nicholson L, Gervasi N, Falières T, Leroy A, Miremont D, Zala D, Hanus C. Whole-Cell Photobleaching Reveals Time-Dependent Compartmentalization of Soluble Proteins by the Axon Initial Segment. Frontiers In Cellular Neuroscience 2020, 14: 180. PMID: 32754013, PMCID: PMC7366827, DOI: 10.3389/fncel.2020.00180.Peer-Reviewed Original ResearchCitationsAltmetric
2019
VEGF/VEGFR2 signaling regulates hippocampal axon branching during development
Luck R, Urban S, Karakatsani A, Harde E, Sambandan S, Nicholson L, Haverkamp S, Mann R, Martin-Villalba A, Schuman EM, Acker-Palmer A, de Almodóvar C. VEGF/VEGFR2 signaling regulates hippocampal axon branching during development. ELife 2019, 8: e49818. PMID: 31868583, PMCID: PMC6927742, DOI: 10.7554/elife.49818.Peer-Reviewed Original ResearchCitationsAltmetricEphrinB2 regulates VEGFR2 during dendritogenesis and hippocampal circuitry development
Harde E, Nicholson L, Cuadrado B, Bissen D, Wigge S, Urban S, Segarra M, de Almodóvar C, Acker-Palmer A. EphrinB2 regulates VEGFR2 during dendritogenesis and hippocampal circuitry development. ELife 2019, 8: e49819. PMID: 31868584, PMCID: PMC6927743, DOI: 10.7554/elife.49819.Peer-Reviewed Original ResearchCitationsAltmetric
2017
Regulated viral BDNF delivery in combination with Schwann cells promotes axonal regeneration through capillary alginate hydrogels after spinal cord injury
Liu S, Sandner B, Schackel T, Nicholson L, Chtarto A, Tenenbaum L, Puttagunta R, Müller R, Weidner N, Blesch A. Regulated viral BDNF delivery in combination with Schwann cells promotes axonal regeneration through capillary alginate hydrogels after spinal cord injury. Acta Biomaterialia 2017, 60: 167-180. PMID: 28735026, DOI: 10.1016/j.actbio.2017.07.024.Peer-Reviewed Original ResearchCitationsAltmetric
Academic Achievements & Community Involvement
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Honors
honor BRAINS Fellow
09/01/2024Other AwardUniversity of WashingtonDetailsUnited Stateshonor Career MODE Fellow
03/01/2024Other AwardColumbia UniversityDetailsUnited Stateshonor Kavli Postdoctoral Fellowship
10/13/2023Yale University AwardKavliDetailsUnited States
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