Graciela Krikun, PhD
Research Scientist in Obstetrics, Gynecology, and Reproductive SciencesCards
About
Research
Publications
2024
A NOVEL CHIMERIC IMMUNOCONJUGATE MOLECULE (ICON3) SUPPRESSES ENDOMETRIOSIS IN A MURINE MODEL
Garg A, Mamillapalli R, Krikun G, Habata S, Atwani R, Taylor H. A NOVEL CHIMERIC IMMUNOCONJUGATE MOLECULE (ICON3) SUPPRESSES ENDOMETRIOSIS IN A MURINE MODEL. Fertility And Sterility 2024, 122: e337-e338. DOI: 10.1016/j.fertnstert.2024.08.065.Peer-Reviewed Original ResearchBone marrow mesenchymal stem cell-derived exosomes shuttle microRNAs to endometrial stromal fibroblasts that promote tissue proliferation /regeneration/ and inhibit differentiation
Bonavina G, Mamillapalli R, Krikun G, Zhou Y, Gawde N, Taylor H. Bone marrow mesenchymal stem cell-derived exosomes shuttle microRNAs to endometrial stromal fibroblasts that promote tissue proliferation /regeneration/ and inhibit differentiation. Stem Cell Research & Therapy 2024, 15: 129. PMID: 38693588, PMCID: PMC11064399, DOI: 10.1186/s13287-024-03716-1.Peer-Reviewed Original ResearchConceptsMiR-100-5pMiR-100MiR-21Transmission electron microscopyMiR-143MiR-143-3pMiR-21-5pEndometrial stromal fibroblastsStromal fibroblastsMicroRNAsExtracellular vesiclesElectron microscopyCell-free regenerative therapyNanoparticle tracking analysisMiRNAsBone marrow mesenchymal stem cell-derived exosomesBone marrow-derived stem cellsMesenchymal stem cell-derived exosomesStem cell-derived exosomesDelivery of microRNAsMarrow-derived stem cellsAssociated with several signaling pathwaysMediators of tissue repairMethodsExtracellular vesiclesUnpaired t-test
1998
Matrix Metalloproteinase and Matrix Metalloproteinase Inhibitor Expression in Endometrial Stromal Cells during Progestin-Initiated Decidualization and Menstruation-Related Progestin Withdrawal**This work was supported in part by grants from the National Institutes of Health R29-HD29540–01A1 and HD-94–23 (to C.J.L.). Portions of this work were presented at the 44th Annual Meeting of the Society for Gynecologic Investigation. (Lockwood CJ, Krikun G, Hausknecht V, Wang E-Y, Ziegler D, Schatz F, Effects of RU 486 on endometrial stromal cell matrix metalloproteinase and matrix metalloproteinase inhibitor expression. Proceedings of the 44th Annual Meeting of the Society of Gynecologic Investigation, San Diego, CA, 1997, Abstract 220.
Lockwood C, Krikun G, Hausknecht V, Papp C, Schatz F. Matrix Metalloproteinase and Matrix Metalloproteinase Inhibitor Expression in Endometrial Stromal Cells during Progestin-Initiated Decidualization and Menstruation-Related Progestin Withdrawal**This work was supported in part by grants from the National Institutes of Health R29-HD29540–01A1 and HD-94–23 (to C.J.L.). Portions of this work were presented at the 44th Annual Meeting of the Society for Gynecologic Investigation. (Lockwood CJ, Krikun G, Hausknecht V, Wang E-Y, Ziegler D, Schatz F, Effects of RU 486 on endometrial stromal cell matrix metalloproteinase and matrix metalloproteinase inhibitor expression. Proceedings of the 44th Annual Meeting of the Society of Gynecologic Investigation, San Diego, CA, 1997, Abstract 220. Endocrinology 1998, 139: 4607-4613. DOI: 10.1210/en.139.11.4607.Peer-Reviewed Original ResearchSociety for Gynecologic InvestigationExpression of MMP-1Endometrial stromal cellsMMP-1 expressionGynecological investigationSteroid withdrawalImplanting trophoblastEndovascular invasionInhibitor expressionStromal cellsLocal hemorrhageMatrix metalloproteinasesMMP-1Enhanced expressionInhibition of MMP-1 expressionNational InstituteTranscriptional Regulation of the Tissue Factor Gene by Progestins in Human Endometrial Stromal Cells
Krikun G. Transcriptional Regulation of the Tissue Factor Gene by Progestins in Human Endometrial Stromal Cells. The Journal Of Clinical Endocrinology & Metabolism 1998, 83: 926-930. DOI: 10.1210/jc.83.3.926.Peer-Reviewed Original Research
1993
Glucocorticoid suppression of human placental fibronectin expression: implications in uterine-placental adherence
Guller S, Wozniak R, Krikun G, Burnham J, Kaplan P, Lockwood C. Glucocorticoid suppression of human placental fibronectin expression: implications in uterine-placental adherence. Endocrinology 1993, 133: 1139-1146. DOI: 10.1210/en.133.3.1139.Peer-Reviewed Original ResearchTreatment of cytotrophoblastsIncreased levels of glucocorticoidsEffects of glucocorticoidsHuman term placentaLevels of glucocorticoidsPlacental functionExtracellular matrix protein synthesisHuman parturitionAssociated with parturitionTerm placentaMultiple extracellular matrix proteinsPlacental fibronectinDexamethasone treatmentCytotrophoblastMatrix protein synthesisDexamethasoneGlucocorticoidExtracellular matrix proteinsCell-associated materialImmunoprecipitation studiesOnfFNLevels of total proteinMessenger RNANorthern blottingOncofetal epitope
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