Ramanaiah Mamillapalli, PhD
Research ScientistCards
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Research
Publications
2026
Circulating transfer RNA-derived fragment abundance after experimental endometriosis induction in baboons
Surmann H, Mamillapalli R, Joshi N, Burns G, Fazleabas A, Taylor H. Circulating transfer RNA-derived fragment abundance after experimental endometriosis induction in baboons. Molecular Human Reproduction 2026, 32: gaag032. PMID: 42184293, DOI: 10.1093/molehr/gaag032.Peer-Reviewed Original ResearchEpigenetic biomarkers of progestin-resistance in endometriosis
Cevik E, Mamillapalli R, Sferruzza G, Mamillapalli P, Taylor H. Epigenetic biomarkers of progestin-resistance in endometriosis. Biomarker Research 2026, 14: 32. PMID: 41851763, PMCID: PMC12998148, DOI: 10.1186/s40364-026-00907-1.Commentaries, Editorials and LettersNon-respondersMethylation signaturesDifferentially methylated CpG sitesEnzymatic methyl-seqTreatment responseEpigenetic biomarkersProgestin resistanceWhole-genome methylation analysisDNA methylation signaturesNoninvasive biomarkersPrediction of treatment responseNon-invasive predictive biomarkersProgestin-based therapyEstrogen-dependent inflammatory disorderReceiver operating curve analysisMethyl-SeqInadequate symptom reliefOperating Curve analysisProspective cohort studyReproductive age womenCandidate genesPersonalized treatment decisionsCpG sitesMethylation profilesMethylated genesRedefining the contribution of retrograde menstruation to endometriosis: single-cell analysis of endometriotic lesions suggests a process more complex than simple autografting
Mamillapalli R, Pyneni K, Watson K, Habata S, Gawde N, Taylor H. Redefining the contribution of retrograde menstruation to endometriosis: single-cell analysis of endometriotic lesions suggests a process more complex than simple autografting. Molecular Medicine 2026, 32: 41. PMID: 41714950, PMCID: PMC13020223, DOI: 10.1186/s10020-026-01442-3.Peer-Reviewed Original ResearchEndometriotic lesionsPeritoneal implantsPeritoneal cavityNatural killer (NK) cellsGreen fluorescent proteinDevelopment of endometriotic lesionsImplantation of endometriumWild type miceDevelopment of endometriosisSingle cell suspensionsInfiltration of circulating cellsSingle-cell sequencing analysisTransplanted endometriumUterine allograftPelvic painDonor miceRetrograde menstruationT cellsUterine tissueImmune cellsType miceB cellsGynecological disordersEndometriosis cellsSingle-cell analysisSex-specific differences in liver DNA methylation patterns and epigenetic aging in mice
Apelian S, Mamillapalli R, Ucar A, Gawde N, Taylor H. Sex-specific differences in liver DNA methylation patterns and epigenetic aging in mice. AJP Gastrointestinal And Liver Physiology 2026, 330: g361-g367. PMID: 41697067, DOI: 10.1152/ajpgi.00322.2025.Peer-Reviewed Original ResearchConceptsDNA methylation patternsMethylation patternsCpG sitesMethylation ratioCpG lociMethylation differencesSex-specific differencesGenomic DNADNA methylation-based predictorsEpigenetic ageEpigenetic changesDisease susceptibilityDNASexual dimorphismGenesBisulfite-convertedEpigenetic clocksCpGFemale miceBiological ageMethylationYoung miceAged C57BL/6 miceMiceSex differences
2025
Endometrial Injury and Its Rescue by Mesenchymal Stem Cells Is Dependent on Estrous Cycle Phase
Mamillapalli R, Liu Y, Zhou Y, Tal R, Taylor H. Endometrial Injury and Its Rescue by Mesenchymal Stem Cells Is Dependent on Estrous Cycle Phase. Journal Of Cellular And Molecular Medicine 2025, 29: e70966. PMID: 41294044, PMCID: PMC12648297, DOI: 10.1111/jcmm.70966.Peer-Reviewed Original ResearchConceptsMarrow-derived mesenchymal stem cellsEndometrial injuryEstrous cycle phaseMSC treatmentAsherman's syndromeMarrow-derived mesenchymal stem cell treatmentDiestrus phaseMesenchymal stem cellsTherapeutic effectAdministration of bone marrow-derived mesenchymal stem cellsStem cellsBM-derived cellsBM-MSC groupCD45+ cellsUterine scarPregnancy outcomesBone marrow-derived mesenchymal stem cellsEndometrial repairSurgical curettageMSC engraftmentUterine functionBone marrowMurine modelFertility outcomesIL-1BIdentifying serum microRNAs as biomarkers for endometriosis in adolescents and young adults
Vash-Margita A, Mamillapalli R, Pyneni K, Morgenstern D, Taylor H. Identifying serum microRNAs as biomarkers for endometriosis in adolescents and young adults. Reproductive Biology And Endocrinology 2025, 23: 166. PMID: 41286884, PMCID: PMC12752412, DOI: 10.1186/s12958-025-01502-z.Peer-Reviewed Original ResearchGynecologic surgeryAdolescent patientsEarly diseasePrevention of disease progressionControl groupProspective clinical studyYoung adult patientsSerum of adolescentsReproductive age womenSignatures of microRNAsPelvic painMean BMINon-invasive diagnosisLaparoscopic surgeryAdult patientsGynecological disordersEndometriosisAcademic medical centerClinical studiesBarriers to diagnosisDisease progressionSurgical informationAdolescent womenEarly diagnosisNoninvasive biomarkersMicroRNAs associated with adenomyosis promote endometrial epithelial cell migration via MMP-2 and MMP-9 upregulation
Zipponi M, Camboni A, Mamillapalli R, Taylor H, Dolmans M. MicroRNAs associated with adenomyosis promote endometrial epithelial cell migration via MMP-2 and MMP-9 upregulation. Biology Of Reproduction 2025, 114: 827-834. PMID: 41222064, PMCID: PMC13017560, DOI: 10.1093/biolre/ioaf231.Peer-Reviewed Original ResearchEndometrial epithelial cellsMMP-9 mRNA expressionEndometrial epithelial cell migrationMMP-9MMP-2Matrix metalloproteinasesStromal cellsMRNA expressionPresence of endometrial tissuePrimary endometrial epithelial cellsChronic pelvic painMatrix metalloproteinase upregulationMMP-9 upregulationMiR-451aMiR-150Cell migrationPelvic painAbnormal bleedingEpithelial cell migrationAdenomyosis treatmentAdenomyosis patientsExtracellular matrix remodelingGynecological disordersEndometrial tissueAdenomyosisIL-6 Inhibits Invasion in a Murine Model of Endometriosis
Han E, Mamillapalli R, Cevik E, Gawde N, Thomas K, Taylor H. IL-6 Inhibits Invasion in a Murine Model of Endometriosis. Reproductive Sciences 2025, 32: 3557-3566. PMID: 41120690, DOI: 10.1007/s43032-025-01984-7.Peer-Reviewed Original ResearchConceptsSignaling pathwayIL-6 signaling pathwayAnti-IL-6RJAK/STAT signalingMolecular mechanismsIL-6N-cadherinP38 MAPKMurine modelAnti-IL-6 receptor monoclonal antibodyMolecular targetsPathwayAnti-IL-6R antibodyMurine model of endometriosisPresence of endometrial tissueModel of endometriosisPathophysiology of endometriosisC57BL/6 female miceInvasionIsotype control groupReproductive age womenMonoclonal antibodiesNon-invasive therapyMediated pathwayParadoxical roleUse of AMD3100 for bone marrow–derived mesenchymal stem cell mobilization in the treatment of murine Asherman's syndrome
Flores V, Delis P, Mamillapalli R, Taylor H. Use of AMD3100 for bone marrow–derived mesenchymal stem cell mobilization in the treatment of murine Asherman's syndrome. F&S Science 2025, 6: 475-482. PMID: 40818715, DOI: 10.1016/j.xfss.2025.08.003.Peer-Reviewed Original ResearchAsherman's syndromePreterm ruptureAS inductionMurine modelProgenitor cellsMesenchymal stem cell mobilizationMice treated with AMD3100Preterm rupture of membranesAMD3100-treated miceRupture of membranesOptimal timingStem cell mobilizationBone marrow transplantationTreatment groupsLevels of CXCL12Source of progenitor cellsRecurrent pregnancy lossEndometrial progenitor cellsBMD-MSCsLikelihood of pregnancyHysteroscopic adhesiolysisPlacental abruptionUterine repairSevere ASMarrow transplantationThe role of long non-coding ribonucleic acid HOXA11-AS in endometriosis therapy
Mamillapalli R, Gawde N, Fay M, Atwani R, Moridi I, Taylor H. The role of long non-coding ribonucleic acid HOXA11-AS in endometriosis therapy. Reproductive Biology And Endocrinology 2025, 23: 83. PMID: 40457415, PMCID: PMC12128536, DOI: 10.1186/s12958-025-01420-0.Peer-Reviewed Original ResearchConceptsHOXA11-ASHOXA11-AS expressionEutopic endometriumLong non-coding RNAsEctopic endometriotic lesionsEndometriotic cell linesInvasion of endometriosisEndometrial stromal cellsReal-time polymerase chain reactionNon-coding RNAsEndometriotic lesionsEndometriosis therapyEndometriosis patientsNormal endometriumProgestin responsivenessEndometrial developmentTreatment responsePolymerase chain reactionQuantitative real-time polymerase chain reactionEndometriosisEndometriosis treatmentMethodsTissue samplesStromal cellsPotential target genesEndometrium
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